CA2314431A1 - Dosages de depistage utilises pour detecter et diagnostiquer le virus de la grippe - Google Patents

Dosages de depistage utilises pour detecter et diagnostiquer le virus de la grippe Download PDF

Info

Publication number
CA2314431A1
CA2314431A1 CA002314431A CA2314431A CA2314431A1 CA 2314431 A1 CA2314431 A1 CA 2314431A1 CA 002314431 A CA002314431 A CA 002314431A CA 2314431 A CA2314431 A CA 2314431A CA 2314431 A1 CA2314431 A1 CA 2314431A1
Authority
CA
Canada
Prior art keywords
influenza virus
neuraminidase
specific
assay
substrate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002314431A
Other languages
English (en)
Inventor
Donald L. Heefner
Charles M. Zepp
Paul D. Rubin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sunovion Pharmaceuticals Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2314431A1 publication Critical patent/CA2314431A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/0054—Means for coding or tagging the apparatus or the reagents
    • B01J2219/00572—Chemical means
    • B01J2219/00576—Chemical means fluorophore
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Wood Science & Technology (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Food Science & Technology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)

Abstract

Cette invention concerne des systèmes de dépistage rapides et spécifiques utilisés pour détecter et diagnostiquer des infections provoquées par le virus de la grippe, dans lesquels on évalue la présence de la neuraminidase du virus de la grippe; ainsi qu'un système de dépistage rapide, spécifique et à haute capacité permettant d'identifier de nouveaux agent qui modulent l'activité de la neuraminidase du virus de la grippe. Cette invention concerne également un système de dépistage rapide, spécifique et à haute capacité qui permet d'identifier de nouveaux agents qui interagissent avec la neuraminidase du virus de la grippe.
CA002314431A 1997-12-18 1998-12-18 Dosages de depistage utilises pour detecter et diagnostiquer le virus de la grippe Abandoned CA2314431A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6803597P 1997-12-18 1997-12-18
US60/068,035 1997-12-18
PCT/US1998/026945 WO1999031280A1 (fr) 1997-12-18 1998-12-18 Dosages de depistage utilises pour detecter et diagnostiquer le virus de la grippe

Publications (1)

Publication Number Publication Date
CA2314431A1 true CA2314431A1 (fr) 1999-06-24

Family

ID=22080019

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002314431A Abandoned CA2314431A1 (fr) 1997-12-18 1998-12-18 Dosages de depistage utilises pour detecter et diagnostiquer le virus de la grippe

Country Status (6)

Country Link
EP (1) EP1038037A4 (fr)
JP (1) JP2002508193A (fr)
CN (1) CN1285003A (fr)
AU (1) AU1927899A (fr)
CA (1) CA2314431A1 (fr)
WO (1) WO1999031280A1 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6555698B1 (en) * 1998-11-17 2003-04-29 Tropix, Inc. Chemiluminescent substrates for neuraminidase, assays for detection of neuraminidase and kits therefor
US6627396B1 (en) * 1999-10-28 2003-09-30 The Regents Of The University Of California Influenza sensor
WO2006025983A2 (fr) * 2004-07-26 2006-03-09 The Regents Of The University Of California Conjugues a substrat marque pour identifier des inhibiteurs d'enzyme
ATE447180T1 (de) * 2004-12-14 2009-11-15 Arkray Inc Verfahren zur vorbehandlung von proben sowie immuntestverfahren unter dessen verwendung
CN100368560C (zh) * 2005-09-22 2008-02-13 广州华银医药科技有限公司 一种呼吸道病原体的实时荧光聚合酶链式反应检测方法
CA2627323A1 (fr) * 2005-10-25 2007-05-03 Mnd Diagnostic Ltd. Compositions permettant de detecter les virus de la grippe et kits et methodes reposant sur l'utilisation desdites compositions
EP2062944A1 (fr) * 2007-11-20 2009-05-27 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Colorants hydrosolubles à base de rylène, procédés pour leur préparation et utilisations en tant qu'étiquettes fluorescentes pour biomolécules
CA2908028C (fr) 2013-04-01 2022-10-18 Becton, Dickinson And Company Methodes et trousses de diagnostic de la grippe
JP7016136B2 (ja) 2016-09-05 2022-02-04 国立研究開発法人科学技術振興機構 病原性微生物検出のための方法及びキット
JP7329851B2 (ja) * 2018-03-02 2023-08-21 国立研究開発法人科学技術振興機構 酵素反応生成物の検出方法
JP7158645B2 (ja) * 2018-10-05 2022-10-24 広陵化学工業株式会社 検体採取スワブ
US20220145407A1 (en) * 2019-03-05 2022-05-12 Japan Science And Technology Agency Method and kit for detecting influenza virus, and method for diagnosing influenza virus infection

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2450877A1 (fr) * 1979-03-06 1980-10-03 Inst Nat Sante Rech Med Nouveaux tests par agglutination pour la detection des virus de la grippe, et reactifs pour la realisation de ces tests
US4978614A (en) * 1988-10-26 1990-12-18 Tropix, Inc. Method of detecting a substance using enzymatically-induced decomposition of dioxetanes
US5663055A (en) * 1989-12-29 1997-09-02 Oklahoma Medical Research Foundation Methods for diagnosing human influenza and 4-position modified chromogenic N-acetylneuraminic acid substrated for use therein
US5252458A (en) * 1990-12-31 1993-10-12 Symex Corp. Method for visually detecting the presence of a virus in a clinical specimen
HU223099B1 (hu) * 1996-03-01 2004-03-29 Biota Scientific Managemant Pty. Ltd. Eljárás influenzavírus kimutatására és az eljárásban alkalmazható vegyületek
US5719020A (en) * 1996-09-25 1998-02-17 Oklahoma Medical Research Foundation 4,7-dialkoxy N-acetylneuraminic acid derivatives and methods for detection of influenza type A and B viruses in clinical specimens

Also Published As

Publication number Publication date
EP1038037A4 (fr) 2003-02-12
CN1285003A (zh) 2001-02-21
JP2002508193A (ja) 2002-03-19
WO1999031280A1 (fr) 1999-06-24
AU1927899A (en) 1999-07-05
EP1038037A1 (fr) 2000-09-27

Similar Documents

Publication Publication Date Title
Richman et al. Rapid viral diagnosis
Disney et al. The use of carbohydrate microarrays to study carbohydrate-cell interactions and to detect pathogens
CN1091447C (zh) 4,7－二烷氧基n－乙酰基神经氨酸衍生物及其在临床样本中检测流行性感冒a型和b型病毒的方法
CA2314431A1 (fr) Dosages de depistage utilises pour detecter et diagnostiquer le virus de la grippe
US20090220941A1 (en) Compositions for- detecting of influenza viruses and kits and methods using same
JP2002508507A (ja) 新規な生物学的標的および創薬リード構造体の同時同定方法
US8232378B2 (en) Compositions and methods for the identification of inhibitors of protein synthesis
US11092565B2 (en) Electrochemical methods and compounds for the detection of enzymes
US7527934B2 (en) Labeled substrate conjugates for identifying enzyme inhibitors
US10962529B1 (en) Fluorescent probe based biosensor and assay for the detection of SARS-CoV-2
Yamanaka et al. Infectivity and pathogenicity of canine H3N8 influenza A virus in horses
US8758996B2 (en) Optimized probes and primers and methods of using same for the binding, detection, differentiation, isolation and sequencing of influenza A; influenza B; novel influenza A/H1N1; and a novel influenza A/H1N1 RNA sequence mutation associated with oseltamivir resistance
Alhadrami et al. Peptide substrate screening for the diagnosis of SARS-CoV-2 using fluorescence resonance energy transfer (FRET) assay
US11851698B2 (en) Method for pathogen identification
Slack et al. Triazole-linked transition state analogs as selective inhibitors against V. cholerae sialidase
US20090088331A1 (en) Influenza virus nucleic acid microarray and method of use
US20090246754A1 (en) Optimized probes and primers and methods of using same for the detection and quantitation of bk virus
Hľasová et al. Lectin-based assay for the determination of the inhibition activity of small molecule inhibitors of neuraminidases
Park et al. Activity-based screening system for the discovery of neuraminidase inhibitors using protein chip technology
Ying et al. One‐Bead–One‐Inhibitor–One‐Substrate Screening of Neuraminidase Activity
Rabinowitz et al. A Fluorogenic Green Merocyanine-Based Probe to Detect Heparanase-1 Activity
Gattani et al. Evaluation of catalytic activity of human and animal origin viral neuraminidase: Current prospect
Chen et al. Techniques used for the discovery of therapeutic compounds: The case of SARS
Das Design and development of small molecule based biosensors for detection of pathogens
CA2868812A1 (fr) Sondes et amorces optimisees et procedes d'utilisation de celles-ci pour la liaison, la detection, la differenciation, l'isolement et le sequencage du virus de l'herpes simplex

Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued
FZDE Discontinued

Effective date: 20031218