CA2313587A1 - Capsule for controlled release of active substances - Google Patents
Capsule for controlled release of active substances Download PDFInfo
- Publication number
- CA2313587A1 CA2313587A1 CA 2313587 CA2313587A CA2313587A1 CA 2313587 A1 CA2313587 A1 CA 2313587A1 CA 2313587 CA2313587 CA 2313587 CA 2313587 A CA2313587 A CA 2313587A CA 2313587 A1 CA2313587 A1 CA 2313587A1
- Authority
- CA
- Canada
- Prior art keywords
- capsule
- acid
- capsules
- polymers
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000002775 capsule Substances 0.000 title claims abstract description 230
- 239000013543 active substance Substances 0.000 title claims abstract description 47
- 238000013270 controlled release Methods 0.000 title claims abstract description 15
- 239000000463 material Substances 0.000 claims abstract description 43
- 239000000126 substance Substances 0.000 claims abstract description 43
- 238000004140 cleaning Methods 0.000 claims abstract description 31
- 238000006243 chemical reaction Methods 0.000 claims abstract description 12
- 238000003860 storage Methods 0.000 claims abstract description 5
- 239000000203 mixture Substances 0.000 claims description 101
- 229920000642 polymer Polymers 0.000 claims description 59
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 39
- 102000004190 Enzymes Human genes 0.000 claims description 35
- 108090000790 Enzymes Proteins 0.000 claims description 35
- 239000002253 acid Substances 0.000 claims description 28
- 239000004753 textile Substances 0.000 claims description 28
- 229920001223 polyethylene glycol Polymers 0.000 claims description 27
- 150000002170 ethers Chemical class 0.000 claims description 18
- 239000002202 Polyethylene glycol Substances 0.000 claims description 14
- 239000012190 activator Substances 0.000 claims description 11
- 239000007844 bleaching agent Substances 0.000 claims description 11
- 150000007513 acids Chemical class 0.000 claims description 10
- 239000002537 cosmetic Substances 0.000 claims description 10
- 150000002191 fatty alcohols Chemical class 0.000 claims description 10
- 239000004094 surface-active agent Substances 0.000 claims description 10
- 238000004061 bleaching Methods 0.000 claims description 7
- 229920001451 polypropylene glycol Polymers 0.000 claims description 6
- 239000003054 catalyst Substances 0.000 claims description 5
- 230000003287 optical effect Effects 0.000 claims description 5
- 239000002979 fabric softener Substances 0.000 claims description 4
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims description 4
- 239000004698 Polyethylene Substances 0.000 claims description 3
- 239000002736 nonionic surfactant Substances 0.000 claims description 3
- 229920003169 water-soluble polymer Polymers 0.000 claims description 3
- 238000000034 method Methods 0.000 abstract description 18
- 238000005406 washing Methods 0.000 abstract description 17
- 230000008569 process Effects 0.000 abstract description 16
- -1 carrageenan Chemical class 0.000 description 62
- 229920002678 cellulose Polymers 0.000 description 48
- 235000010980 cellulose Nutrition 0.000 description 45
- 239000003599 detergent Substances 0.000 description 43
- 239000000047 product Substances 0.000 description 43
- 239000001913 cellulose Substances 0.000 description 38
- 229940088598 enzyme Drugs 0.000 description 34
- 229920001577 copolymer Polymers 0.000 description 32
- 239000000178 monomer Substances 0.000 description 29
- 150000002148 esters Chemical class 0.000 description 24
- 108091005804 Peptidases Proteins 0.000 description 20
- 239000004365 Protease Substances 0.000 description 20
- 229920002472 Starch Polymers 0.000 description 20
- 235000019698 starch Nutrition 0.000 description 20
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 19
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 18
- 150000003839 salts Chemical class 0.000 description 18
- 150000001875 compounds Chemical class 0.000 description 17
- 239000004615 ingredient Substances 0.000 description 17
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 16
- 125000004432 carbon atom Chemical group C* 0.000 description 16
- 150000001735 carboxylic acids Chemical class 0.000 description 16
- 239000003086 colorant Substances 0.000 description 16
- 238000004851 dishwashing Methods 0.000 description 16
- 239000003205 fragrance Substances 0.000 description 16
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 15
- 229910052783 alkali metal Inorganic materials 0.000 description 15
- 239000008107 starch Substances 0.000 description 15
- 239000007789 gas Substances 0.000 description 14
- 229920001567 vinyl ester resin Polymers 0.000 description 14
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 13
- 239000003795 chemical substances by application Substances 0.000 description 13
- 238000009472 formulation Methods 0.000 description 13
- 230000002366 lipolytic effect Effects 0.000 description 13
- 239000002245 particle Substances 0.000 description 13
- LDHQCZJRKDOVOX-UHFFFAOYSA-N trans-crotonic acid Natural products CC=CC(O)=O LDHQCZJRKDOVOX-UHFFFAOYSA-N 0.000 description 13
- 229920002245 Dextrose equivalent Polymers 0.000 description 12
- 108090001060 Lipase Proteins 0.000 description 12
- 102000004882 Lipase Human genes 0.000 description 12
- 239000004367 Lipase Substances 0.000 description 12
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 12
- 235000019421 lipase Nutrition 0.000 description 12
- 239000003921 oil Substances 0.000 description 12
- 235000019198 oils Nutrition 0.000 description 12
- 229920001277 pectin Polymers 0.000 description 12
- 235000019419 proteases Nutrition 0.000 description 12
- 108010065511 Amylases Proteins 0.000 description 11
- 102000013142 Amylases Human genes 0.000 description 11
- 235000019418 amylase Nutrition 0.000 description 11
- LDHQCZJRKDOVOX-NSCUHMNNSA-N crotonic acid Chemical compound C\C=C\C(O)=O LDHQCZJRKDOVOX-NSCUHMNNSA-N 0.000 description 11
- 230000000694 effects Effects 0.000 description 11
- 239000007788 liquid Substances 0.000 description 11
- 230000008961 swelling Effects 0.000 description 11
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 11
- 150000001298 alcohols Chemical class 0.000 description 10
- 229910017052 cobalt Inorganic materials 0.000 description 10
- 239000010941 cobalt Substances 0.000 description 10
- 239000001814 pectin Substances 0.000 description 10
- 235000010987 pectin Nutrition 0.000 description 10
- 229920002451 polyvinyl alcohol Polymers 0.000 description 10
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 10
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 description 9
- 229920003086 cellulose ether Polymers 0.000 description 9
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 9
- 239000000835 fiber Substances 0.000 description 9
- 239000002609 medium Substances 0.000 description 9
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 9
- 229920001897 terpolymer Polymers 0.000 description 9
- GJCOSYZMQJWQCA-UHFFFAOYSA-N 9H-xanthene Chemical compound C1=CC=C2CC3=CC=CC=C3OC2=C1 GJCOSYZMQJWQCA-UHFFFAOYSA-N 0.000 description 8
- 244000303965 Cyamopsis psoralioides Species 0.000 description 8
- 229920001353 Dextrin Polymers 0.000 description 8
- 239000004375 Dextrin Substances 0.000 description 8
- 108010010803 Gelatin Proteins 0.000 description 8
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 8
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 8
- 102000035195 Peptidases Human genes 0.000 description 8
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 8
- 229920001525 carrageenan Polymers 0.000 description 8
- 229920006317 cationic polymer Polymers 0.000 description 8
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 description 8
- 235000019425 dextrin Nutrition 0.000 description 8
- 239000008273 gelatin Substances 0.000 description 8
- 229920000159 gelatin Polymers 0.000 description 8
- 235000019322 gelatine Nutrition 0.000 description 8
- 235000011852 gelatine desserts Nutrition 0.000 description 8
- 230000007062 hydrolysis Effects 0.000 description 8
- 238000006460 hydrolysis reaction Methods 0.000 description 8
- 229920001296 polysiloxane Polymers 0.000 description 8
- 239000000843 powder Substances 0.000 description 8
- 229910052723 transition metal Inorganic materials 0.000 description 8
- 229920001285 xanthan gum Polymers 0.000 description 8
- 102000004157 Hydrolases Human genes 0.000 description 7
- 108090000604 Hydrolases Proteins 0.000 description 7
- 239000002535 acidifier Substances 0.000 description 7
- 150000001340 alkali metals Chemical class 0.000 description 7
- 235000010418 carrageenan Nutrition 0.000 description 7
- 239000000679 carrageenan Substances 0.000 description 7
- 229940113118 carrageenan Drugs 0.000 description 7
- 239000000470 constituent Substances 0.000 description 7
- 230000006378 damage Effects 0.000 description 7
- 239000000975 dye Substances 0.000 description 7
- 239000008103 glucose Substances 0.000 description 7
- 230000007246 mechanism Effects 0.000 description 7
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 7
- 229920006395 saturated elastomer Polymers 0.000 description 7
- 108010084185 Cellulases Proteins 0.000 description 6
- 102000005575 Cellulases Human genes 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 6
- 229920002907 Guar gum Polymers 0.000 description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- BGRWYDHXPHLNKA-UHFFFAOYSA-N Tetraacetylethylenediamine Chemical compound CC(=O)N(C(C)=O)CCN(C(C)=O)C(C)=O BGRWYDHXPHLNKA-UHFFFAOYSA-N 0.000 description 6
- 230000009471 action Effects 0.000 description 6
- 125000000217 alkyl group Chemical group 0.000 description 6
- 229940025131 amylases Drugs 0.000 description 6
- 235000010417 guar gum Nutrition 0.000 description 6
- 125000005394 methallyl group Chemical group 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 6
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 6
- 229920002126 Acrylic acid copolymer Polymers 0.000 description 5
- 239000004382 Amylase Substances 0.000 description 5
- 108010059892 Cellulase Proteins 0.000 description 5
- 239000004971 Cross linker Substances 0.000 description 5
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 5
- 229920000881 Modified starch Polymers 0.000 description 5
- 229920000289 Polyquaternium Polymers 0.000 description 5
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 5
- KKEYFWRCBNTPAC-UHFFFAOYSA-N Terephthalic acid Chemical compound OC(=O)C1=CC=C(C(O)=O)C=C1 KKEYFWRCBNTPAC-UHFFFAOYSA-N 0.000 description 5
- 230000002378 acidificating effect Effects 0.000 description 5
- 125000001931 aliphatic group Chemical group 0.000 description 5
- 125000002091 cationic group Chemical group 0.000 description 5
- 238000000576 coating method Methods 0.000 description 5
- 235000014113 dietary fatty acids Nutrition 0.000 description 5
- 239000000194 fatty acid Substances 0.000 description 5
- 229930195729 fatty acid Natural products 0.000 description 5
- 150000004676 glycans Chemical class 0.000 description 5
- 229910052748 manganese Inorganic materials 0.000 description 5
- 239000011572 manganese Substances 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 235000019426 modified starch Nutrition 0.000 description 5
- 229920000058 polyacrylate Polymers 0.000 description 5
- 229920001515 polyalkylene glycol Polymers 0.000 description 5
- 238000006116 polymerization reaction Methods 0.000 description 5
- 229920001282 polysaccharide Polymers 0.000 description 5
- 239000005017 polysaccharide Substances 0.000 description 5
- 235000019422 polyvinyl alcohol Nutrition 0.000 description 5
- 239000007787 solid Substances 0.000 description 5
- ZGZHWIAQICBGKN-UHFFFAOYSA-N 1-nonanoylpyrrolidine-2,5-dione Chemical compound CCCCCCCCC(=O)N1C(=O)CCC1=O ZGZHWIAQICBGKN-UHFFFAOYSA-N 0.000 description 4
- HGINCPLSRVDWNT-UHFFFAOYSA-N Acrolein Chemical compound C=CC=O HGINCPLSRVDWNT-UHFFFAOYSA-N 0.000 description 4
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 4
- 102000004316 Oxidoreductases Human genes 0.000 description 4
- 108090000854 Oxidoreductases Proteins 0.000 description 4
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 4
- 229920002125 Sokalan® Polymers 0.000 description 4
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 4
- UAOKXEHOENRFMP-ZJIFWQFVSA-N [(2r,3r,4s,5r)-2,3,4,5-tetraacetyloxy-6-oxohexyl] acetate Chemical compound CC(=O)OC[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](OC(C)=O)C=O UAOKXEHOENRFMP-ZJIFWQFVSA-N 0.000 description 4
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 description 4
- 150000001299 aldehydes Chemical class 0.000 description 4
- 108090000637 alpha-Amylases Proteins 0.000 description 4
- 239000007864 aqueous solution Substances 0.000 description 4
- 229940106157 cellulase Drugs 0.000 description 4
- 238000001816 cooling Methods 0.000 description 4
- 238000005260 corrosion Methods 0.000 description 4
- 230000007797 corrosion Effects 0.000 description 4
- YIOJGTBNHQAVBO-UHFFFAOYSA-N dimethyl-bis(prop-2-enyl)azanium Chemical class C=CC[N+](C)(C)CC=C YIOJGTBNHQAVBO-UHFFFAOYSA-N 0.000 description 4
- 238000004090 dissolution Methods 0.000 description 4
- 238000005886 esterification reaction Methods 0.000 description 4
- UIWXSTHGICQLQT-UHFFFAOYSA-N ethenyl propanoate Chemical compound CCC(=O)OC=C UIWXSTHGICQLQT-UHFFFAOYSA-N 0.000 description 4
- 150000004665 fatty acids Chemical class 0.000 description 4
- 229920000578 graft copolymer Polymers 0.000 description 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 4
- 239000003112 inhibitor Substances 0.000 description 4
- 150000002576 ketones Chemical class 0.000 description 4
- 239000003960 organic solvent Substances 0.000 description 4
- 239000002304 perfume Substances 0.000 description 4
- 229920000191 poly(N-vinyl pyrrolidone) Polymers 0.000 description 4
- 229920005646 polycarboxylate Polymers 0.000 description 4
- 229920006324 polyoxymethylene Polymers 0.000 description 4
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 4
- 229910052709 silver Inorganic materials 0.000 description 4
- 239000004332 silver Substances 0.000 description 4
- 239000011734 sodium Substances 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 150000003624 transition metals Chemical class 0.000 description 4
- OSCJHTSDLYVCQC-UHFFFAOYSA-N 2-ethylhexyl 4-[[4-[4-(tert-butylcarbamoyl)anilino]-6-[4-(2-ethylhexoxycarbonyl)anilino]-1,3,5-triazin-2-yl]amino]benzoate Chemical compound C1=CC(C(=O)OCC(CC)CCCC)=CC=C1NC1=NC(NC=2C=CC(=CC=2)C(=O)NC(C)(C)C)=NC(NC=2C=CC(=CC=2)C(=O)OCC(CC)CCCC)=N1 OSCJHTSDLYVCQC-UHFFFAOYSA-N 0.000 description 3
- QPRQEDXDYOZYLA-UHFFFAOYSA-N 2-methylbutan-1-ol Chemical compound CCC(C)CO QPRQEDXDYOZYLA-UHFFFAOYSA-N 0.000 description 3
- MSXVEPNJUHWQHW-UHFFFAOYSA-N 2-methylbutan-2-ol Chemical compound CCC(C)(C)O MSXVEPNJUHWQHW-UHFFFAOYSA-N 0.000 description 3
- QXWUJRONCAPLLL-UHFFFAOYSA-N 2-prop-2-enoxyacetic acid Chemical compound OC(=O)COCC=C QXWUJRONCAPLLL-UHFFFAOYSA-N 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- IMROMDMJAWUWLK-UHFFFAOYSA-N Ethenol Chemical compound OC=C IMROMDMJAWUWLK-UHFFFAOYSA-N 0.000 description 3
- 229920003134 Eudragit® polymer Polymers 0.000 description 3
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 3
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 3
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 3
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 3
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 3
- 239000008186 active pharmaceutical agent Substances 0.000 description 3
- 125000003342 alkenyl group Chemical group 0.000 description 3
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical group OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 description 3
- 150000001408 amides Chemical class 0.000 description 3
- 150000003863 ammonium salts Chemical class 0.000 description 3
- 125000000129 anionic group Chemical group 0.000 description 3
- 229920006318 anionic polymer Polymers 0.000 description 3
- 239000012736 aqueous medium Substances 0.000 description 3
- 150000001565 benzotriazoles Chemical class 0.000 description 3
- BTANRVKWQNVYAZ-UHFFFAOYSA-N butan-2-ol Chemical compound CCC(C)O BTANRVKWQNVYAZ-UHFFFAOYSA-N 0.000 description 3
- 150000001720 carbohydrates Chemical class 0.000 description 3
- 239000003093 cationic surfactant Substances 0.000 description 3
- 150000001768 cations Chemical class 0.000 description 3
- 150000001805 chlorine compounds Chemical class 0.000 description 3
- 239000011248 coating agent Substances 0.000 description 3
- 230000008602 contraction Effects 0.000 description 3
- 238000007334 copolymerization reaction Methods 0.000 description 3
- XCJYREBRNVKWGJ-UHFFFAOYSA-N copper(II) phthalocyanine Chemical compound [Cu+2].C12=CC=CC=C2C(N=C2[N-]C(C3=CC=CC=C32)=N2)=NC1=NC([C]1C=CC=CC1=1)=NC=1N=C1[C]3C=CC=CC3=C2[N-]1 XCJYREBRNVKWGJ-UHFFFAOYSA-N 0.000 description 3
- 239000008406 cosmetic ingredient Substances 0.000 description 3
- 230000001419 dependent effect Effects 0.000 description 3
- 239000007884 disintegrant Substances 0.000 description 3
- 239000007903 gelatin capsule Substances 0.000 description 3
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 3
- 125000003147 glycosyl group Chemical group 0.000 description 3
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 3
- 238000010348 incorporation Methods 0.000 description 3
- 238000004900 laundering Methods 0.000 description 3
- 229920002521 macromolecule Polymers 0.000 description 3
- 239000011159 matrix material Substances 0.000 description 3
- 229920003145 methacrylic acid copolymer Polymers 0.000 description 3
- 229920000609 methyl cellulose Polymers 0.000 description 3
- 239000001923 methylcellulose Substances 0.000 description 3
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 3
- LNOPIUAQISRISI-UHFFFAOYSA-N n'-hydroxy-2-propan-2-ylsulfonylethanimidamide Chemical compound CC(C)S(=O)(=O)CC(N)=NO LNOPIUAQISRISI-UHFFFAOYSA-N 0.000 description 3
- 230000003647 oxidation Effects 0.000 description 3
- 238000007254 oxidation reaction Methods 0.000 description 3
- 150000004965 peroxy acids Chemical class 0.000 description 3
- 150000002989 phenols Chemical class 0.000 description 3
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 3
- 239000004584 polyacrylic acid Substances 0.000 description 3
- 229920002689 polyvinyl acetate Polymers 0.000 description 3
- 229910052700 potassium Inorganic materials 0.000 description 3
- 235000018102 proteins Nutrition 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 238000007493 shaping process Methods 0.000 description 3
- 238000006467 substitution reaction Methods 0.000 description 3
- 239000000758 substrate Substances 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 229910052719 titanium Inorganic materials 0.000 description 3
- 229910052720 vanadium Inorganic materials 0.000 description 3
- WQZGKKKJIJFFOK-SVZMEOIVSA-N (+)-Galactose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-SVZMEOIVSA-N 0.000 description 2
- LIKMAJRDDDTEIG-UHFFFAOYSA-N 1-hexene Chemical compound CCCCC=C LIKMAJRDDDTEIG-UHFFFAOYSA-N 0.000 description 2
- WQNHWIYLCRZRLR-UHFFFAOYSA-N 2-(3-hydroxy-2,5-dioxooxolan-3-yl)acetic acid Chemical compound OC(=O)CC1(O)CC(=O)OC1=O WQNHWIYLCRZRLR-UHFFFAOYSA-N 0.000 description 2
- WRMNZCZEMHIOCP-UHFFFAOYSA-N 2-phenylethanol Chemical compound OCCC1=CC=CC=C1 WRMNZCZEMHIOCP-UHFFFAOYSA-N 0.000 description 2
- JSIAIROWMJGMQZ-UHFFFAOYSA-N 2h-triazol-4-amine Chemical class NC1=CNN=N1 JSIAIROWMJGMQZ-UHFFFAOYSA-N 0.000 description 2
- MXLMTQWGSQIYOW-UHFFFAOYSA-N 3-methyl-2-butanol Chemical compound CC(C)C(C)O MXLMTQWGSQIYOW-UHFFFAOYSA-N 0.000 description 2
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 2
- 229920000945 Amylopectin Polymers 0.000 description 2
- 229920000856 Amylose Polymers 0.000 description 2
- 241000193422 Bacillus lentus Species 0.000 description 2
- 241000194108 Bacillus licheniformis Species 0.000 description 2
- 244000063299 Bacillus subtilis Species 0.000 description 2
- 235000014469 Bacillus subtilis Nutrition 0.000 description 2
- ZCTQGTTXIYCGGC-UHFFFAOYSA-N Benzyl salicylate Chemical compound OC1=CC=CC=C1C(=O)OCC1=CC=CC=C1 ZCTQGTTXIYCGGC-UHFFFAOYSA-N 0.000 description 2
- UYWQUFXKFGHYNT-UHFFFAOYSA-N Benzylformate Chemical compound O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 description 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 2
- RTMBGDBBDQKNNZ-UHFFFAOYSA-L C.I. Acid Blue 3 Chemical compound [Ca+2].C1=CC(N(CC)CC)=CC=C1C(C=1C(=CC(=C(O)C=1)S([O-])(=O)=O)S([O-])(=O)=O)=C1C=CC(=[N+](CC)CC)C=C1.C1=CC(N(CC)CC)=CC=C1C(C=1C(=CC(=C(O)C=1)S([O-])(=O)=O)S([O-])(=O)=O)=C1C=CC(=[N+](CC)CC)C=C1 RTMBGDBBDQKNNZ-UHFFFAOYSA-L 0.000 description 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 2
- 235000013162 Cocos nucifera Nutrition 0.000 description 2
- 244000060011 Cocos nucifera Species 0.000 description 2
- 102000008186 Collagen Human genes 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 2
- 244000251987 Coprinus macrorhizus Species 0.000 description 2
- 235000001673 Coprinus macrorhizus Nutrition 0.000 description 2
- 229920000742 Cotton Polymers 0.000 description 2
- 241000219748 Cyamopsis Species 0.000 description 2
- AEMOLEFTQBMNLQ-YMDCURPLSA-N D-galactopyranuronic acid Chemical group OC1O[C@H](C(O)=O)[C@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-YMDCURPLSA-N 0.000 description 2
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 2
- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 108090000371 Esterases Proteins 0.000 description 2
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 2
- 239000005977 Ethylene Substances 0.000 description 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 2
- 241000233866 Fungi Species 0.000 description 2
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 description 2
- GLZPCOQZEFWAFX-UHFFFAOYSA-N Geraniol Chemical compound CC(C)=CCCC(C)=CCO GLZPCOQZEFWAFX-UHFFFAOYSA-N 0.000 description 2
- 241001480714 Humicola insolens Species 0.000 description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 2
- QIGBRXMKCJKVMJ-UHFFFAOYSA-N Hydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 description 2
- 108010028688 Isoamylase Proteins 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- BTJXBZZBBNNTOV-UHFFFAOYSA-N Linalyl benzoate Chemical compound CC(C)=CCCC(C)(C=C)OC(=O)C1=CC=CC=C1 BTJXBZZBBNNTOV-UHFFFAOYSA-N 0.000 description 2
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 2
- PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 description 2
- BAPJBEWLBFYGME-UHFFFAOYSA-N Methyl acrylate Chemical compound COC(=O)C=C BAPJBEWLBFYGME-UHFFFAOYSA-N 0.000 description 2
- AMQJEAYHLZJPGS-UHFFFAOYSA-N N-Pentanol Chemical compound CCCCCO AMQJEAYHLZJPGS-UHFFFAOYSA-N 0.000 description 2
- 108700020962 Peroxidase Proteins 0.000 description 2
- 102000003992 Peroxidases Human genes 0.000 description 2
- 229920000691 Poly[bis(2-chloroethyl) ether-alt-1,3-bis[3-(dimethylamino)propyl]urea] Polymers 0.000 description 2
- 229920000805 Polyaspartic acid Polymers 0.000 description 2
- 229920000604 Polyethylene Glycol 200 Polymers 0.000 description 2
- 108010059820 Polygalacturonase Proteins 0.000 description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
- 229920000297 Rayon Polymers 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 241000187392 Streptomyces griseus Species 0.000 description 2
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 2
- 108090000787 Subtilisin Proteins 0.000 description 2
- QYKIQEUNHZKYBP-UHFFFAOYSA-N Vinyl ether Chemical class C=COC=C QYKIQEUNHZKYBP-UHFFFAOYSA-N 0.000 description 2
- ACRPXCXKILJIJN-KCDKBNATSA-N [(2r,3s,4r,5r)-1,2,4,5-tetrahydroxy-6-oxohexan-3-yl] hydrogen sulfate Chemical compound OC[C@@H](O)[C@H](OS(O)(=O)=O)[C@H](O)[C@@H](O)C=O ACRPXCXKILJIJN-KCDKBNATSA-N 0.000 description 2
- 150000001252 acrylic acid derivatives Chemical class 0.000 description 2
- 239000001361 adipic acid Substances 0.000 description 2
- 235000011037 adipic acid Nutrition 0.000 description 2
- 239000008272 agar Substances 0.000 description 2
- 229910000288 alkali metal carbonate Inorganic materials 0.000 description 2
- 150000008041 alkali metal carbonates Chemical class 0.000 description 2
- 125000005263 alkylenediamine group Polymers 0.000 description 2
- 102000004139 alpha-Amylases Human genes 0.000 description 2
- 230000000845 anti-microbial effect Effects 0.000 description 2
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- GGNQRNBDZQJCCN-UHFFFAOYSA-N benzene-1,2,4-triol Chemical compound OC1=CC=C(O)C(O)=C1 GGNQRNBDZQJCCN-UHFFFAOYSA-N 0.000 description 2
- QRUDEWIWKLJBPS-UHFFFAOYSA-N benzotriazole Chemical compound C1=CC=C2N[N][N]C2=C1 QRUDEWIWKLJBPS-UHFFFAOYSA-N 0.000 description 2
- 239000012964 benzotriazole Substances 0.000 description 2
- QUKGYYKBILRGFE-UHFFFAOYSA-N benzyl acetate Chemical compound CC(=O)OCC1=CC=CC=C1 QUKGYYKBILRGFE-UHFFFAOYSA-N 0.000 description 2
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 239000001045 blue dye Substances 0.000 description 2
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 2
- 239000004327 boric acid Substances 0.000 description 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 2
- 229910052794 bromium Inorganic materials 0.000 description 2
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 150000004649 carbonic acid derivatives Chemical class 0.000 description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
- 150000001732 carboxylic acid derivatives Chemical group 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- YCIMNLLNPGFGHC-UHFFFAOYSA-N catechol Chemical compound OC1=CC=CC=C1O YCIMNLLNPGFGHC-UHFFFAOYSA-N 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 239000000460 chlorine Substances 0.000 description 2
- 229910052801 chlorine Inorganic materials 0.000 description 2
- NEHNMFOYXAPHSD-UHFFFAOYSA-N citronellal Chemical compound O=CCC(C)CCC=C(C)C NEHNMFOYXAPHSD-UHFFFAOYSA-N 0.000 description 2
- QMVPMAAFGQKVCJ-UHFFFAOYSA-N citronellol Chemical compound OCCC(C)CCC=C(C)C QMVPMAAFGQKVCJ-UHFFFAOYSA-N 0.000 description 2
- 150000001868 cobalt Chemical class 0.000 description 2
- 229920001436 collagen Polymers 0.000 description 2
- 239000013065 commercial product Substances 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- 235000008504 concentrate Nutrition 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- 229910052802 copper Inorganic materials 0.000 description 2
- 108010005400 cutinase Proteins 0.000 description 2
- 230000003111 delayed effect Effects 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- CEJLBZWIKQJOAT-UHFFFAOYSA-N dichloroisocyanuric acid Chemical compound ClN1C(=O)NC(=O)N(Cl)C1=O CEJLBZWIKQJOAT-UHFFFAOYSA-N 0.000 description 2
- 229940079919 digestives enzyme preparation Drugs 0.000 description 2
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 2
- ZOESAMNEZGSOPU-UHFFFAOYSA-L disodium;4-[4-[acetyl(methyl)amino]-2-sulfonatoanilino]-1-amino-9,10-dioxoanthracene-2-sulfonate Chemical compound [Na+].[Na+].[O-]S(=O)(=O)C1=CC(N(C(C)=O)C)=CC=C1NC1=CC(S([O-])(=O)=O)=C(N)C2=C1C(=O)C1=CC=CC=C1C2=O ZOESAMNEZGSOPU-UHFFFAOYSA-L 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 230000002255 enzymatic effect Effects 0.000 description 2
- 230000032050 esterification Effects 0.000 description 2
- 238000006266 etherification reaction Methods 0.000 description 2
- RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 description 2
- 108010093305 exopolygalacturonase Proteins 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000011049 filling Methods 0.000 description 2
- 239000006260 foam Substances 0.000 description 2
- 239000010794 food waste Substances 0.000 description 2
- 238000010528 free radical solution polymerization reaction Methods 0.000 description 2
- 125000000524 functional group Chemical group 0.000 description 2
- 229930182830 galactose Natural products 0.000 description 2
- LNTHITQWFMADLM-UHFFFAOYSA-N gallic acid Chemical compound OC(=O)C1=CC(O)=C(O)C(O)=C1 LNTHITQWFMADLM-UHFFFAOYSA-N 0.000 description 2
- 238000005227 gel permeation chromatography Methods 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- LEQAOMBKQFMDFZ-UHFFFAOYSA-N glyoxal Chemical compound O=CC=O LEQAOMBKQFMDFZ-UHFFFAOYSA-N 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 239000000665 guar gum Substances 0.000 description 2
- 229960002154 guar gum Drugs 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- ZSIAUFGUXNUGDI-UHFFFAOYSA-N hexan-1-ol Chemical compound CCCCCCO ZSIAUFGUXNUGDI-UHFFFAOYSA-N 0.000 description 2
- 229930195733 hydrocarbon Natural products 0.000 description 2
- 150000002430 hydrocarbons Chemical class 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 2
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 239000003999 initiator Substances 0.000 description 2
- 238000003780 insertion Methods 0.000 description 2
- 230000037431 insertion Effects 0.000 description 2
- 229910052742 iron Inorganic materials 0.000 description 2
- PHTQWCKDNZKARW-UHFFFAOYSA-N isoamylol Chemical compound CC(C)CCO PHTQWCKDNZKARW-UHFFFAOYSA-N 0.000 description 2
- ZXEKIIBDNHEJCQ-UHFFFAOYSA-N isobutanol Chemical compound CC(C)CO ZXEKIIBDNHEJCQ-UHFFFAOYSA-N 0.000 description 2
- TWNIBLMWSKIRAT-VFUOTHLCSA-N levoglucosan Chemical group O[C@@H]1[C@@H](O)[C@H](O)[C@H]2CO[C@@H]1O2 TWNIBLMWSKIRAT-VFUOTHLCSA-N 0.000 description 2
- 239000003446 ligand Substances 0.000 description 2
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 description 2
- CDOSHBSSFJOMGT-UHFFFAOYSA-N linalool Chemical compound CC(C)=CCCC(C)(O)C=C CDOSHBSSFJOMGT-UHFFFAOYSA-N 0.000 description 2
- UWKAYLJWKGQEPM-LBPRGKRZSA-N linalyl acetate Chemical compound CC(C)=CCC[C@](C)(C=C)OC(C)=O UWKAYLJWKGQEPM-LBPRGKRZSA-N 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 230000005923 long-lasting effect Effects 0.000 description 2
- 239000011777 magnesium Substances 0.000 description 2
- 229910052749 magnesium Inorganic materials 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 229940099596 manganese sulfate Drugs 0.000 description 2
- 235000007079 manganese sulphate Nutrition 0.000 description 2
- 239000011702 manganese sulphate Substances 0.000 description 2
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 2
- SQQMAOCOWKFBNP-UHFFFAOYSA-L manganese(II) sulfate Chemical compound [Mn+2].[O-]S([O-])(=O)=O SQQMAOCOWKFBNP-UHFFFAOYSA-L 0.000 description 2
- 230000010534 mechanism of action Effects 0.000 description 2
- JZMJDSHXVKJFKW-UHFFFAOYSA-M methyl sulfate(1-) Chemical compound COS([O-])(=O)=O JZMJDSHXVKJFKW-UHFFFAOYSA-M 0.000 description 2
- XJRBAMWJDBPFIM-UHFFFAOYSA-N methyl vinyl ether Chemical compound COC=C XJRBAMWJDBPFIM-UHFFFAOYSA-N 0.000 description 2
- 229940016286 microcrystalline cellulose Drugs 0.000 description 2
- 239000008108 microcrystalline cellulose Substances 0.000 description 2
- 102000035118 modified proteins Human genes 0.000 description 2
- 108091005573 modified proteins Proteins 0.000 description 2
- 150000002762 monocarboxylic acid derivatives Chemical class 0.000 description 2
- JMXROTHPANUTOJ-UHFFFAOYSA-H naphthol green b Chemical compound [Na+].[Na+].[Na+].[Fe+3].C1=C(S([O-])(=O)=O)C=CC2=C(N=O)C([O-])=CC=C21.C1=C(S([O-])(=O)=O)C=CC2=C(N=O)C([O-])=CC=C21.C1=C(S([O-])(=O)=O)C=CC2=C(N=O)C([O-])=CC=C21 JMXROTHPANUTOJ-UHFFFAOYSA-H 0.000 description 2
- 239000005445 natural material Substances 0.000 description 2
- 125000004433 nitrogen atom Chemical group N* 0.000 description 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 2
- 229910052756 noble gas Inorganic materials 0.000 description 2
- 230000001590 oxidative effect Effects 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 125000004430 oxygen atom Chemical group O* 0.000 description 2
- 238000004806 packaging method and process Methods 0.000 description 2
- JYVLIDXNZAXMDK-UHFFFAOYSA-N pentan-2-ol Chemical compound CCCC(C)O JYVLIDXNZAXMDK-UHFFFAOYSA-N 0.000 description 2
- AQIXEPGDORPWBJ-UHFFFAOYSA-N pentan-3-ol Chemical compound CCC(O)CC AQIXEPGDORPWBJ-UHFFFAOYSA-N 0.000 description 2
- MDHYEMXUFSJLGV-UHFFFAOYSA-N phenethyl acetate Chemical compound CC(=O)OCCC1=CC=CC=C1 MDHYEMXUFSJLGV-UHFFFAOYSA-N 0.000 description 2
- PATMLLNMTPIUSY-UHFFFAOYSA-N phenoxysulfonyl 7-methyloctanoate Chemical compound CC(C)CCCCCC(=O)OS(=O)(=O)OC1=CC=CC=C1 PATMLLNMTPIUSY-UHFFFAOYSA-N 0.000 description 2
- XNGIFLGASWRNHJ-UHFFFAOYSA-N phthalic acid Chemical compound OC(=O)C1=CC=CC=C1C(O)=O XNGIFLGASWRNHJ-UHFFFAOYSA-N 0.000 description 2
- 229920000172 poly(styrenesulfonic acid) Polymers 0.000 description 2
- 229920000151 polyglycol Polymers 0.000 description 2
- 239000010695 polyglycol Substances 0.000 description 2
- 229920005862 polyol Polymers 0.000 description 2
- 239000011591 potassium Substances 0.000 description 2
- WQGWDDDVZFFDIG-UHFFFAOYSA-N pyrogallol Chemical compound OC1=CC=CC(O)=C1O WQGWDDDVZFFDIG-UHFFFAOYSA-N 0.000 description 2
- 125000001453 quaternary ammonium group Chemical group 0.000 description 2
- 150000003254 radicals Chemical class 0.000 description 2
- GHMLBKRAJCXXBS-UHFFFAOYSA-N resorcinol Chemical compound OC1=CC=CC(O)=C1 GHMLBKRAJCXXBS-UHFFFAOYSA-N 0.000 description 2
- PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 description 2
- 239000002455 scale inhibitor Substances 0.000 description 2
- 239000002002 slurry Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 159000000000 sodium salts Chemical class 0.000 description 2
- 239000011973 solid acid Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 238000010557 suspension polymerization reaction Methods 0.000 description 2
- 229920001059 synthetic polymer Polymers 0.000 description 2
- RUVINXPYWBROJD-ONEGZZNKSA-N trans-anethole Chemical compound COC1=CC=C(\C=C\C)C=C1 RUVINXPYWBROJD-ONEGZZNKSA-N 0.000 description 2
- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 description 2
- 150000003852 triazoles Chemical class 0.000 description 2
- 230000000007 visual effect Effects 0.000 description 2
- DTCCYSMPUUYHOF-LHQXNBGVSA-N (2e,4e)-n-benzyl-2-cyano-5-(3,4-dihydroxyphenyl)penta-2,4-dienamide Chemical compound C1=C(O)C(O)=CC=C1\C=C\C=C(/C#N)C(=O)NCC1=CC=CC=C1 DTCCYSMPUUYHOF-LHQXNBGVSA-N 0.000 description 1
- 239000001490 (3R)-3,7-dimethylocta-1,6-dien-3-ol Substances 0.000 description 1
- FFLHFURRPPIZTQ-UHFFFAOYSA-N (5-acetyloxy-2,5-dihydrofuran-2-yl) acetate Chemical compound CC(=O)OC1OC(OC(C)=O)C=C1 FFLHFURRPPIZTQ-UHFFFAOYSA-N 0.000 description 1
- ZQEOKONOFKQRIR-NUEKZKHPSA-N (5R,6R,7R)-3,5,6-triacetyl-3,5,6,7-tetrahydroxy-7-(hydroxymethyl)nonane-2,4,8-trione Chemical compound C(C)(=O)[C@@]([C@]([C@@](C(C(O)(C(C)=O)C(C)=O)=O)(O)C(C)=O)(O)C(C)=O)(O)CO ZQEOKONOFKQRIR-NUEKZKHPSA-N 0.000 description 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 description 1
- QMVPMAAFGQKVCJ-SNVBAGLBSA-N (R)-(+)-citronellol Natural products OCC[C@H](C)CCC=C(C)C QMVPMAAFGQKVCJ-SNVBAGLBSA-N 0.000 description 1
- UCTWMZQNUQWSLP-VIFPVBQESA-N (R)-adrenaline Chemical compound CNC[C@H](O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-VIFPVBQESA-N 0.000 description 1
- CDOSHBSSFJOMGT-JTQLQIEISA-N (R)-linalool Natural products CC(C)=CCC[C@@](C)(O)C=C CDOSHBSSFJOMGT-JTQLQIEISA-N 0.000 description 1
- GUYIZQZWDFCUTA-UHFFFAOYSA-N (pentadecachlorophthalocyaninato(2-))-copper Chemical compound [Cu+2].N1=C([N-]2)C3=C(Cl)C(Cl)=C(Cl)C(Cl)=C3C2=NC(C2=C(Cl)C(Cl)=C(Cl)C(Cl)=C22)=NC2=NC(C2=C(Cl)C(Cl)=C(Cl)C(Cl)=C22)=NC2=NC2=C(C(Cl)=C(C(Cl)=C3)Cl)C3=C1[N-]2 GUYIZQZWDFCUTA-UHFFFAOYSA-N 0.000 description 1
- YYMCVDNIIFNDJK-XFQWXJFMSA-N (z)-1-(3-fluorophenyl)-n-[(z)-(3-fluorophenyl)methylideneamino]methanimine Chemical compound FC1=CC=CC(\C=N/N=C\C=2C=C(F)C=CC=2)=C1 YYMCVDNIIFNDJK-XFQWXJFMSA-N 0.000 description 1
- JCIIKRHCWVHVFF-UHFFFAOYSA-N 1,2,4-thiadiazol-5-amine;hydrochloride Chemical compound Cl.NC1=NC=NS1 JCIIKRHCWVHVFF-UHFFFAOYSA-N 0.000 description 1
- 150000005206 1,2-dihydroxybenzenes Chemical class 0.000 description 1
- XCMDVRAWAIYDEE-UHFFFAOYSA-N 1,2-diphenyl-3h-pyrazole Chemical group C1C=CN(C=2C=CC=CC=2)N1C1=CC=CC=C1 XCMDVRAWAIYDEE-UHFFFAOYSA-N 0.000 description 1
- YRIZYWQGELRKNT-UHFFFAOYSA-N 1,3,5-trichloro-1,3,5-triazinane-2,4,6-trione Chemical compound ClN1C(=O)N(Cl)C(=O)N(Cl)C1=O YRIZYWQGELRKNT-UHFFFAOYSA-N 0.000 description 1
- BCMCBBGGLRIHSE-UHFFFAOYSA-N 1,3-benzoxazole Chemical compound C1=CC=C2OC=NC2=C1 BCMCBBGGLRIHSE-UHFFFAOYSA-N 0.000 description 1
- HHBCEKAWSILOOP-UHFFFAOYSA-N 1,3-dibromo-1,3,5-triazinane-2,4,6-trione Chemical compound BrN1C(=O)NC(=O)N(Br)C1=O HHBCEKAWSILOOP-UHFFFAOYSA-N 0.000 description 1
- KEQGZUUPPQEDPF-UHFFFAOYSA-N 1,3-dichloro-5,5-dimethylimidazolidine-2,4-dione Chemical compound CC1(C)N(Cl)C(=O)N(Cl)C1=O KEQGZUUPPQEDPF-UHFFFAOYSA-N 0.000 description 1
- WEERVPDNCOGWJF-UHFFFAOYSA-N 1,4-bis(ethenyl)benzene Chemical compound C=CC1=CC=C(C=C)C=C1 WEERVPDNCOGWJF-UHFFFAOYSA-N 0.000 description 1
- 150000005208 1,4-dihydroxybenzenes Chemical class 0.000 description 1
- LYPVKWMHGFMDPD-UHFFFAOYSA-N 1,5-diacetyl-1,3,5-triazinane-2,4-dione Chemical compound CC(=O)N1CN(C(C)=O)C(=O)NC1=O LYPVKWMHGFMDPD-UHFFFAOYSA-N 0.000 description 1
- WCIQNYOXLZQQMU-UHFFFAOYSA-N 1-Phenylethyl propanoate Chemical compound CCC(=O)OC(C)C1=CC=CC=C1 WCIQNYOXLZQQMU-UHFFFAOYSA-N 0.000 description 1
- FEFQUIPMKBPKAR-UHFFFAOYSA-N 1-benzoylazepan-2-one Chemical compound C=1C=CC=CC=1C(=O)N1CCCCCC1=O FEFQUIPMKBPKAR-UHFFFAOYSA-N 0.000 description 1
- UKDKWYQGLUUPBF-UHFFFAOYSA-N 1-ethenoxyhexadecane Chemical compound CCCCCCCCCCCCCCCCOC=C UKDKWYQGLUUPBF-UHFFFAOYSA-N 0.000 description 1
- QJJDJWUCRAPCOL-UHFFFAOYSA-N 1-ethenoxyoctadecane Chemical compound CCCCCCCCCCCCCCCCCCOC=C QJJDJWUCRAPCOL-UHFFFAOYSA-N 0.000 description 1
- RTBFRGCFXZNCOE-UHFFFAOYSA-N 1-methylsulfonylpiperidin-4-one Chemical compound CS(=O)(=O)N1CCC(=O)CC1 RTBFRGCFXZNCOE-UHFFFAOYSA-N 0.000 description 1
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical compound C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 description 1
- BEWCNXNIQCLWHP-UHFFFAOYSA-N 2-(tert-butylamino)ethyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCNC(C)(C)C BEWCNXNIQCLWHP-UHFFFAOYSA-N 0.000 description 1
- FLUWAIIVLCVEKF-UHFFFAOYSA-N 2-Methyl-1-phenyl-2-propanyl acetate Chemical compound CC(=O)OC(C)(C)CC1=CC=CC=C1 FLUWAIIVLCVEKF-UHFFFAOYSA-N 0.000 description 1
- MJTPMXWJHPOWGH-UHFFFAOYSA-N 2-Phenoxyethyl isobutyrate Chemical compound CC(C)C(=O)OCCOC1=CC=CC=C1 MJTPMXWJHPOWGH-UHFFFAOYSA-N 0.000 description 1
- LSZBMXCYIZBZPD-UHFFFAOYSA-N 2-[(1-hydroperoxy-1-oxohexan-2-yl)carbamoyl]benzoic acid Chemical compound CCCCC(C(=O)OO)NC(=O)C1=CC=CC=C1C(O)=O LSZBMXCYIZBZPD-UHFFFAOYSA-N 0.000 description 1
- LCZVSXRMYJUNFX-UHFFFAOYSA-N 2-[2-(2-hydroxypropoxy)propoxy]propan-1-ol Chemical compound CC(O)COC(C)COC(C)CO LCZVSXRMYJUNFX-UHFFFAOYSA-N 0.000 description 1
- AKWFJQNBHYVIPY-UHFFFAOYSA-N 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol Chemical compound OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO AKWFJQNBHYVIPY-UHFFFAOYSA-N 0.000 description 1
- PCANHPMMPLOBDQ-UHFFFAOYSA-N 2-[2-[4-[4-[2-(4-chlorophenyl)ethenyl]phenyl]phenyl]ethenyl]benzenesulfonic acid Chemical class OS(=O)(=O)C1=CC=CC=C1C=CC1=CC=C(C=2C=CC(C=CC=3C=CC(Cl)=CC=3)=CC=2)C=C1 PCANHPMMPLOBDQ-UHFFFAOYSA-N 0.000 description 1
- JTXMVXSTHSMVQF-UHFFFAOYSA-N 2-acetyloxyethyl acetate Chemical compound CC(=O)OCCOC(C)=O JTXMVXSTHSMVQF-UHFFFAOYSA-N 0.000 description 1
- ZILZQZGAJNDJIY-UHFFFAOYSA-N 2-chloro-5-[2-[4-[4-[2-(4-chloro-3-sulfophenyl)ethenyl]phenyl]phenyl]ethenyl]benzenesulfonic acid Chemical class C1=C(Cl)C(S(=O)(=O)O)=CC(C=CC=2C=CC(=CC=2)C=2C=CC(C=CC=3C=C(C(Cl)=CC=3)S(O)(=O)=O)=CC=2)=C1 ZILZQZGAJNDJIY-UHFFFAOYSA-N 0.000 description 1
- WREFNFTVBQKRGZ-UHFFFAOYSA-N 2-decylbutanediperoxoic acid Chemical compound CCCCCCCCCCC(C(=O)OO)CC(=O)OO WREFNFTVBQKRGZ-UHFFFAOYSA-N 0.000 description 1
- XEEYSDHEOQHCDA-UHFFFAOYSA-N 2-methylprop-2-ene-1-sulfonic acid Chemical compound CC(=C)CS(O)(=O)=O XEEYSDHEOQHCDA-UHFFFAOYSA-N 0.000 description 1
- SSONCJTVDRSLNK-UHFFFAOYSA-N 2-methylprop-2-enoic acid;hydrochloride Chemical compound Cl.CC(=C)C(O)=O SSONCJTVDRSLNK-UHFFFAOYSA-N 0.000 description 1
- SLRMQYXOBQWXCR-UHFFFAOYSA-N 2154-56-5 Chemical compound [CH2]C1=CC=CC=C1 SLRMQYXOBQWXCR-UHFFFAOYSA-N 0.000 description 1
- MMINFSMURORWKH-UHFFFAOYSA-N 3,6-dioxabicyclo[6.2.2]dodeca-1(10),8,11-triene-2,7-dione Chemical class O=C1OCCOC(=O)C2=CC=C1C=C2 MMINFSMURORWKH-UHFFFAOYSA-N 0.000 description 1
- YNJSNEKCXVFDKW-UHFFFAOYSA-N 3-(5-amino-1h-indol-3-yl)-2-azaniumylpropanoate Chemical class C1=C(N)C=C2C(CC(N)C(O)=O)=CNC2=C1 YNJSNEKCXVFDKW-UHFFFAOYSA-N 0.000 description 1
- BXAAQNFGSQKPDZ-UHFFFAOYSA-N 3-[1,2,2-tris(prop-2-enoxy)ethoxy]prop-1-ene Chemical compound C=CCOC(OCC=C)C(OCC=C)OCC=C BXAAQNFGSQKPDZ-UHFFFAOYSA-N 0.000 description 1
- UNDXPKDBFOOQFC-UHFFFAOYSA-N 4-[2-nitro-4-(trifluoromethyl)phenyl]morpholine Chemical compound [O-][N+](=O)C1=CC(C(F)(F)F)=CC=C1N1CCOCC1 UNDXPKDBFOOQFC-UHFFFAOYSA-N 0.000 description 1
- DBCAQXHNJOFNGC-UHFFFAOYSA-N 4-bromo-1,1,1-trifluorobutane Chemical compound FC(F)(F)CCCBr DBCAQXHNJOFNGC-UHFFFAOYSA-N 0.000 description 1
- MBZRJSQZCBXRGK-UHFFFAOYSA-N 4-tert-Butylcyclohexyl acetate Chemical compound CC(=O)OC1CCC(C(C)(C)C)CC1 MBZRJSQZCBXRGK-UHFFFAOYSA-N 0.000 description 1
- YGUMVDWOQQJBGA-UHFFFAOYSA-N 5-[(4-anilino-6-morpholin-4-yl-1,3,5-triazin-2-yl)amino]-2-[2-[4-[(4-anilino-6-morpholin-4-yl-1,3,5-triazin-2-yl)amino]-2-sulfophenyl]ethenyl]benzenesulfonic acid Chemical class C=1C=C(C=CC=2C(=CC(NC=3N=C(N=C(NC=4C=CC=CC=4)N=3)N3CCOCC3)=CC=2)S(O)(=O)=O)C(S(=O)(=O)O)=CC=1NC(N=C(N=1)N2CCOCC2)=NC=1NC1=CC=CC=C1 YGUMVDWOQQJBGA-UHFFFAOYSA-N 0.000 description 1
- XSVSPKKXQGNHMD-UHFFFAOYSA-N 5-bromo-3-methyl-1,2-thiazole Chemical compound CC=1C=C(Br)SN=1 XSVSPKKXQGNHMD-UHFFFAOYSA-N 0.000 description 1
- 101710179734 6,7-dimethyl-8-ribityllumazine synthase 2 Proteins 0.000 description 1
- CJIJXIFQYOPWTF-UHFFFAOYSA-N 7-hydroxycoumarin Natural products O1C(=O)C=CC2=CC(O)=CC=C21 CJIJXIFQYOPWTF-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 229920000178 Acrylic resin Polymers 0.000 description 1
- 239000004925 Acrylic resin Substances 0.000 description 1
- 101000740449 Bacillus subtilis (strain 168) Biotin/lipoyl attachment protein Proteins 0.000 description 1
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 description 1
- 235000016068 Berberis vulgaris Nutrition 0.000 description 1
- 241000335053 Beta vulgaris Species 0.000 description 1
- 241000219310 Beta vulgaris subsp. vulgaris Species 0.000 description 1
- 241000717739 Boswellia sacra Species 0.000 description 1
- 240000007436 Cananga odorata Species 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- 108010008885 Cellulose 1,4-beta-Cellobiosidase Proteins 0.000 description 1
- 229910052684 Cerium Inorganic materials 0.000 description 1
- NPBVQXIMTZKSBA-UHFFFAOYSA-N Chavibetol Natural products COC1=CC=C(CC=C)C=C1O NPBVQXIMTZKSBA-UHFFFAOYSA-N 0.000 description 1
- QDHHCQZDFGDHMP-UHFFFAOYSA-N Chloramine Chemical class ClN QDHHCQZDFGDHMP-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 241000206575 Chondrus crispus Species 0.000 description 1
- 244000223760 Cinnamomum zeylanicum Species 0.000 description 1
- WTEVQBCEXWBHNA-UHFFFAOYSA-N Citral Natural products CC(C)=CCCC(C)=CC=O WTEVQBCEXWBHNA-UHFFFAOYSA-N 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- 235000008733 Citrus aurantifolia Nutrition 0.000 description 1
- 235000019499 Citrus oil Nutrition 0.000 description 1
- 241000195493 Cryptophyta Species 0.000 description 1
- 229920000858 Cyclodextrin Polymers 0.000 description 1
- GUBGYTABKSRVRQ-CUHNMECISA-N D-Cellobiose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-CUHNMECISA-N 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 description 1
- PHOQVHQSTUBQQK-SQOUGZDYSA-N D-glucono-1,5-lactone Chemical compound OC[C@H]1OC(=O)[C@H](O)[C@@H](O)[C@@H]1O PHOQVHQSTUBQQK-SQOUGZDYSA-N 0.000 description 1
- AEMOLEFTQBMNLQ-AQKNRBDQSA-N D-glucopyranuronic acid Chemical compound OC1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-AQKNRBDQSA-N 0.000 description 1
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- IEPRKVQEAMIZSS-UHFFFAOYSA-N Di-Et ester-Fumaric acid Natural products CCOC(=O)C=CC(=O)OCC IEPRKVQEAMIZSS-UHFFFAOYSA-N 0.000 description 1
- 239000004641 Diallyl-phthalate Substances 0.000 description 1
- IEPRKVQEAMIZSS-WAYWQWQTSA-N Diethyl maleate Chemical compound CCOC(=O)\C=C/C(=O)OCC IEPRKVQEAMIZSS-WAYWQWQTSA-N 0.000 description 1
- 229920005682 EO-PO block copolymer Polymers 0.000 description 1
- 239000005770 Eugenol Substances 0.000 description 1
- 241000220485 Fabaceae Species 0.000 description 1
- 239000004863 Frankincense Substances 0.000 description 1
- 239000005792 Geraniol Substances 0.000 description 1
- GLZPCOQZEFWAFX-YFHOEESVSA-N Geraniol Natural products CC(C)=CCC\C(C)=C/CO GLZPCOQZEFWAFX-YFHOEESVSA-N 0.000 description 1
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 229920001479 Hydroxyethyl methyl cellulose Polymers 0.000 description 1
- SHBUUTHKGIVMJT-UHFFFAOYSA-N Hydroxystearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OO SHBUUTHKGIVMJT-UHFFFAOYSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 241000234269 Liliales Species 0.000 description 1
- 240000006240 Linum usitatissimum Species 0.000 description 1
- 235000004431 Linum usitatissimum Nutrition 0.000 description 1
- 101710186609 Lipoyl synthase 2 Proteins 0.000 description 1
- 101710122908 Lipoyl synthase 2, chloroplastic Proteins 0.000 description 1
- 101710101072 Lipoyl synthase 2, mitochondrial Proteins 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 229920002774 Maltodextrin Polymers 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 235000010654 Melissa officinalis Nutrition 0.000 description 1
- 244000062730 Melissa officinalis Species 0.000 description 1
- 235000006679 Mentha X verticillata Nutrition 0.000 description 1
- 235000002899 Mentha suaveolens Nutrition 0.000 description 1
- 235000001636 Mentha x rotundifolia Nutrition 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 1
- 229910003202 NH4 Inorganic materials 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 229920000305 Nylon 6,10 Polymers 0.000 description 1
- 239000004435 Oxo alcohol Substances 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- QVHMSMOUDQXMRS-UHFFFAOYSA-N PPG n4 Chemical compound CC(O)COC(C)COC(C)COC(C)CO QVHMSMOUDQXMRS-UHFFFAOYSA-N 0.000 description 1
- 241000282372 Panthera onca Species 0.000 description 1
- SJEYSFABYSGQBG-UHFFFAOYSA-M Patent blue Chemical compound [Na+].C1=CC(N(CC)CC)=CC=C1C(C=1C(=CC(=CC=1)S([O-])(=O)=O)S([O-])(=O)=O)=C1C=CC(=[N+](CC)CC)C=C1 SJEYSFABYSGQBG-UHFFFAOYSA-M 0.000 description 1
- 244000046052 Phaseolus vulgaris Species 0.000 description 1
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 1
- JPYHHZQJCSQRJY-UHFFFAOYSA-N Phloroglucinol Natural products CCC=CCC=CCC=CCC=CCCCCC(=O)C1=C(O)C=C(O)C=C1O JPYHHZQJCSQRJY-UHFFFAOYSA-N 0.000 description 1
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical class OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- LGRFSURHDFAFJT-UHFFFAOYSA-N Phthalic anhydride Natural products C1=CC=C2C(=O)OC(=O)C2=C1 LGRFSURHDFAFJT-UHFFFAOYSA-N 0.000 description 1
- 229920002845 Poly(methacrylic acid) Polymers 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- 229920002556 Polyethylene Glycol 300 Polymers 0.000 description 1
- 229920002560 Polyethylene Glycol 3000 Polymers 0.000 description 1
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 1
- UVMRYBDEERADNV-UHFFFAOYSA-N Pseudoeugenol Natural products COC1=CC(C(C)=C)=CC=C1O UVMRYBDEERADNV-UHFFFAOYSA-N 0.000 description 1
- LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 description 1
- LCTONWCANYUPML-UHFFFAOYSA-N Pyruvic acid Chemical group CC(=O)C(O)=O LCTONWCANYUPML-UHFFFAOYSA-N 0.000 description 1
- 241000206572 Rhodophyta Species 0.000 description 1
- 229910008051 Si-OH Inorganic materials 0.000 description 1
- 229910006358 Si—OH Inorganic materials 0.000 description 1
- 235000021536 Sugar beet Nutrition 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 description 1
- 235000011941 Tilia x europaea Nutrition 0.000 description 1
- 241000589636 Xanthomonas campestris Species 0.000 description 1
- SZEJJURKOHIFBI-DPYQTVNSSA-N [(2r,3s,4s,5r)-3,4,5,6-tetrahydroxy-1-oxohexan-2-yl] hydrogen sulfate Chemical compound OC[C@@H](O)[C@H](O)[C@H](O)[C@H](C=O)OS(O)(=O)=O SZEJJURKOHIFBI-DPYQTVNSSA-N 0.000 description 1
- LMETVDMCIJNNKH-UHFFFAOYSA-N [(3,7-Dimethyl-6-octenyl)oxy]acetaldehyde Chemical compound CC(C)=CCCC(C)CCOCC=O LMETVDMCIJNNKH-UHFFFAOYSA-N 0.000 description 1
- 238000005299 abrasion Methods 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000006359 acetalization reaction Methods 0.000 description 1
- 229940022663 acetate Drugs 0.000 description 1
- 229960000583 acetic acid Drugs 0.000 description 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 1
- 229920006322 acrylamide copolymer Polymers 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 125000003158 alcohol group Chemical group 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 150000008044 alkali metal hydroxides Chemical class 0.000 description 1
- 229910052910 alkali metal silicate Inorganic materials 0.000 description 1
- 150000008055 alkyl aryl sulfonates Chemical class 0.000 description 1
- 150000008051 alkyl sulfates Chemical class 0.000 description 1
- 229940045714 alkyl sulfonate alkylating agent Drugs 0.000 description 1
- 150000008052 alkyl sulfonates Chemical class 0.000 description 1
- 125000002947 alkylene group Chemical group 0.000 description 1
- 125000000304 alkynyl group Chemical group 0.000 description 1
- QUMXDOLUJCHOAY-UHFFFAOYSA-N alpha-methylbenzyl acetate Natural products CC(=O)OC(C)C1=CC=CC=C1 QUMXDOLUJCHOAY-UHFFFAOYSA-N 0.000 description 1
- WUOACPNHFRMFPN-UHFFFAOYSA-N alpha-terpineol Chemical compound CC1=CCC(C(C)(C)O)CC1 WUOACPNHFRMFPN-UHFFFAOYSA-N 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O ammonium group Chemical class [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
- 229940011037 anethole Drugs 0.000 description 1
- 150000008064 anhydrides Chemical class 0.000 description 1
- JFCQEDHGNNZCLN-UHFFFAOYSA-N anhydrous glutaric acid Natural products OC(=O)CCCC(O)=O JFCQEDHGNNZCLN-UHFFFAOYSA-N 0.000 description 1
- 125000002490 anilino group Chemical group [H]N(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
- 239000003945 anionic surfactant Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 229940027983 antiseptic and disinfectant quaternary ammonium compound Drugs 0.000 description 1
- PYMYPHUHKUWMLA-WDCZJNDASA-N arabinose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)C=O PYMYPHUHKUWMLA-WDCZJNDASA-N 0.000 description 1
- 150000004982 aromatic amines Chemical class 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 239000012298 atmosphere Substances 0.000 description 1
- 125000004429 atom Chemical group 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 238000005452 bending Methods 0.000 description 1
- 150000008366 benzophenones Chemical class 0.000 description 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 description 1
- 235000019400 benzoyl peroxide Nutrition 0.000 description 1
- 229940007550 benzyl acetate Drugs 0.000 description 1
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical class [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 1
- 108010047754 beta-Glucosidase Proteins 0.000 description 1
- 102000006995 beta-Glucosidase Human genes 0.000 description 1
- JGQFVRIQXUFPAH-UHFFFAOYSA-N beta-citronellol Natural products OCCC(C)CCCC(C)=C JGQFVRIQXUFPAH-UHFFFAOYSA-N 0.000 description 1
- 229920002988 biodegradable polymer Polymers 0.000 description 1
- 239000004621 biodegradable polymer Substances 0.000 description 1
- 108010064866 biozym Proteins 0.000 description 1
- QUDWYFHPNIMBFC-UHFFFAOYSA-N bis(prop-2-enyl) benzene-1,2-dicarboxylate Chemical compound C=CCOC(=O)C1=CC=CC=C1C(=O)OCC=C QUDWYFHPNIMBFC-UHFFFAOYSA-N 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 229910021538 borax Inorganic materials 0.000 description 1
- FZJUFJKVIYFBSY-UHFFFAOYSA-N bourgeonal Chemical compound CC(C)(C)C1=CC=C(CCC=O)C=C1 FZJUFJKVIYFBSY-UHFFFAOYSA-N 0.000 description 1
- 238000012662 bulk polymerization Methods 0.000 description 1
- 230000009172 bursting Effects 0.000 description 1
- PVEOYINWKBTPIZ-UHFFFAOYSA-N but-3-enoic acid Chemical compound OC(=O)CC=C PVEOYINWKBTPIZ-UHFFFAOYSA-N 0.000 description 1
- JHIWVOJDXOSYLW-UHFFFAOYSA-N butyl 2,2-difluorocyclopropane-1-carboxylate Chemical compound CCCCOC(=O)C1CC1(F)F JHIWVOJDXOSYLW-UHFFFAOYSA-N 0.000 description 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical class OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 150000007942 carboxylates Chemical class 0.000 description 1
- 150000001244 carboxylic acid anhydrides Chemical class 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 108010085318 carboxymethylcellulase Proteins 0.000 description 1
- 239000012876 carrier material Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical class NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
- 229920002301 cellulose acetate Polymers 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 150000008280 chlorinated hydrocarbons Chemical class 0.000 description 1
- 150000001851 cinnamic acid derivatives Chemical class 0.000 description 1
- 235000017803 cinnamon Nutrition 0.000 description 1
- 239000001507 cistus ladaniferus l. oil Substances 0.000 description 1
- 229940043350 citral Drugs 0.000 description 1
- 229930003633 citronellal Natural products 0.000 description 1
- 235000000983 citronellal Nutrition 0.000 description 1
- 235000000484 citronellol Nutrition 0.000 description 1
- 235000020971 citrus fruits Nutrition 0.000 description 1
- 239000010500 citrus oil Substances 0.000 description 1
- 239000010633 clary sage oil Substances 0.000 description 1
- 239000010634 clove oil Substances 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 238000005056 compaction Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 230000000536 complexating effect Effects 0.000 description 1
- 150000004695 complexes Chemical class 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 125000004093 cyano group Chemical group *C#N 0.000 description 1
- 229940019836 cyclamen aldehyde Drugs 0.000 description 1
- 229940097362 cyclodextrins Drugs 0.000 description 1
- 230000009849 deactivation Effects 0.000 description 1
- DTPCFIHYWYONMD-UHFFFAOYSA-N decaethylene glycol Chemical compound OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO DTPCFIHYWYONMD-UHFFFAOYSA-N 0.000 description 1
- UNWDCFHEVIWFCW-UHFFFAOYSA-N decanediperoxoic acid Chemical compound OOC(=O)CCCCCCCCC(=O)OO UNWDCFHEVIWFCW-UHFFFAOYSA-N 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- SQIFACVGCPWBQZ-UHFFFAOYSA-N delta-terpineol Natural products CC(C)(O)C1CCC(=C)CC1 SQIFACVGCPWBQZ-UHFFFAOYSA-N 0.000 description 1
- 239000008121 dextrose Substances 0.000 description 1
- 239000012933 diacyl peroxide Substances 0.000 description 1
- 125000004177 diethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 229940095104 dimethyl benzyl carbinyl acetate Drugs 0.000 description 1
- PMPJQLCPEQFEJW-GNTLFSRWSA-L disodium;2-[(z)-2-[4-[4-[(z)-2-(2-sulfonatophenyl)ethenyl]phenyl]phenyl]ethenyl]benzenesulfonate Chemical class [Na+].[Na+].[O-]S(=O)(=O)C1=CC=CC=C1\C=C/C1=CC=C(C=2C=CC(\C=C/C=3C(=CC=CC=3)S([O-])(=O)=O)=CC=2)C=C1 PMPJQLCPEQFEJW-GNTLFSRWSA-L 0.000 description 1
- FPVGTPBMTFTMRT-UHFFFAOYSA-L disodium;2-amino-5-[(4-sulfonatophenyl)diazenyl]benzenesulfonate Chemical compound [Na+].[Na+].C1=C(S([O-])(=O)=O)C(N)=CC=C1N=NC1=CC=C(S([O-])(=O)=O)C=C1 FPVGTPBMTFTMRT-UHFFFAOYSA-L 0.000 description 1
- VTIIJXUACCWYHX-UHFFFAOYSA-L disodium;carboxylatooxy carbonate Chemical compound [Na+].[Na+].[O-]C(=O)OOC([O-])=O VTIIJXUACCWYHX-UHFFFAOYSA-L 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000012990 dithiocarbamate Substances 0.000 description 1
- 150000004659 dithiocarbamates Chemical class 0.000 description 1
- BRDYCNFHFWUBCZ-UHFFFAOYSA-N dodecaneperoxoic acid Chemical compound CCCCCCCCCCCC(=O)OO BRDYCNFHFWUBCZ-UHFFFAOYSA-N 0.000 description 1
- GMSCBRSQMRDRCD-UHFFFAOYSA-N dodecyl 2-methylprop-2-enoate Chemical compound CCCCCCCCCCCCOC(=O)C(C)=C GMSCBRSQMRDRCD-UHFFFAOYSA-N 0.000 description 1
- 238000011143 downstream manufacturing Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000007720 emulsion polymerization reaction Methods 0.000 description 1
- GMQPCAHXQLIQLH-UHFFFAOYSA-N ethenyl 3-(2-oxopyrrolidin-1-yl)prop-2-enoate Chemical compound C=COC(=O)C=CN1CCCC1=O GMQPCAHXQLIQLH-UHFFFAOYSA-N 0.000 description 1
- MEGHWIAOTJPCHQ-UHFFFAOYSA-N ethenyl butanoate Chemical compound CCCC(=O)OC=C MEGHWIAOTJPCHQ-UHFFFAOYSA-N 0.000 description 1
- GLVVKKSPKXTQRB-UHFFFAOYSA-N ethenyl dodecanoate Chemical compound CCCCCCCCCCCC(=O)OC=C GLVVKKSPKXTQRB-UHFFFAOYSA-N 0.000 description 1
- AFSIMBWBBOJPJG-UHFFFAOYSA-N ethenyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC=C AFSIMBWBBOJPJG-UHFFFAOYSA-N 0.000 description 1
- HFSINNZUXBJLIB-UHFFFAOYSA-N ethyl 2-(methylamino)-2-phenylacetate Chemical compound CCOC(=O)C(NC)C1=CC=CC=C1 HFSINNZUXBJLIB-UHFFFAOYSA-N 0.000 description 1
- STVZJERGLQHEKB-UHFFFAOYSA-N ethylene glycol dimethacrylate Substances CC(=C)C(=O)OCCOC(=O)C(C)=C STVZJERGLQHEKB-UHFFFAOYSA-N 0.000 description 1
- 229960002217 eugenol Drugs 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 235000019233 fast yellow AB Nutrition 0.000 description 1
- 239000001148 ferula galbaniflua oil terpeneless Substances 0.000 description 1
- 238000005429 filling process Methods 0.000 description 1
- 238000009501 film coating Methods 0.000 description 1
- 239000007888 film coating Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000001530 fumaric acid Substances 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
- 229940074391 gallic acid Drugs 0.000 description 1
- 235000004515 gallic acid Nutrition 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- WTEVQBCEXWBHNA-JXMROGBWSA-N geranial Chemical compound CC(C)=CCC\C(C)=C\C=O WTEVQBCEXWBHNA-JXMROGBWSA-N 0.000 description 1
- 229940113087 geraniol Drugs 0.000 description 1
- 239000012362 glacial acetic acid Substances 0.000 description 1
- 230000009477 glass transition Effects 0.000 description 1
- 239000000174 gluconic acid Substances 0.000 description 1
- 235000012208 gluconic acid Nutrition 0.000 description 1
- 235000012209 glucono delta-lactone Nutrition 0.000 description 1
- 229960003681 gluconolactone Drugs 0.000 description 1
- 229960001031 glucose Drugs 0.000 description 1
- 229940097043 glucuronic acid Drugs 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 229960000587 glutaral Drugs 0.000 description 1
- 239000001087 glyceryl triacetate Substances 0.000 description 1
- 235000013773 glyceryl triacetate Nutrition 0.000 description 1
- VPVSTMAPERLKKM-UHFFFAOYSA-N glycoluril Chemical compound N1C(=O)NC2NC(=O)NC21 VPVSTMAPERLKKM-UHFFFAOYSA-N 0.000 description 1
- 125000001046 glycoluril group Chemical group [H]C12N(*)C(=O)N(*)C1([H])N(*)C(=O)N2* 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 150000002338 glycosides Chemical class 0.000 description 1
- 229940015043 glyoxal Drugs 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 239000004519 grease Substances 0.000 description 1
- 229910052735 hafnium Inorganic materials 0.000 description 1
- 239000007902 hard capsule Substances 0.000 description 1
- 125000005842 heteroatom Chemical group 0.000 description 1
- 150000001469 hydantoins Chemical class 0.000 description 1
- 150000002433 hydrophilic molecules Chemical class 0.000 description 1
- 150000004679 hydroxides Chemical class 0.000 description 1
- 229920013821 hydroxy alkyl cellulose Polymers 0.000 description 1
- WPFVBOQKRVRMJB-UHFFFAOYSA-N hydroxycitronellal Chemical compound O=CCC(C)CCCC(C)(C)O WPFVBOQKRVRMJB-UHFFFAOYSA-N 0.000 description 1
- 150000002460 imidazoles Chemical class 0.000 description 1
- 150000003949 imides Chemical class 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 150000002484 inorganic compounds Chemical class 0.000 description 1
- 229910010272 inorganic material Inorganic materials 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 238000012690 ionic polymerization Methods 0.000 description 1
- 229930002839 ionone Natural products 0.000 description 1
- 150000002499 ionone derivatives Chemical class 0.000 description 1
- 238000010409 ironing Methods 0.000 description 1
- VYFOAVADNIHPTR-UHFFFAOYSA-N isatoic anhydride Chemical compound NC1=CC=CC=C1CO VYFOAVADNIHPTR-UHFFFAOYSA-N 0.000 description 1
- 239000010656 jasmine oil Substances 0.000 description 1
- 239000001851 juniperus communis l. berry oil Substances 0.000 description 1
- 150000003951 lactams Chemical class 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- SDQFDHOLCGWZPU-UHFFFAOYSA-N lilial Chemical compound O=CC(C)CC1=CC=C(C(C)(C)C)C=C1 SDQFDHOLCGWZPU-UHFFFAOYSA-N 0.000 description 1
- 239000004571 lime Substances 0.000 description 1
- 235000001510 limonene Nutrition 0.000 description 1
- 229940087305 limonene Drugs 0.000 description 1
- 229930007744 linalool Natural products 0.000 description 1
- UWKAYLJWKGQEPM-UHFFFAOYSA-N linalool acetate Natural products CC(C)=CCCC(C)(C=C)OC(C)=O UWKAYLJWKGQEPM-UHFFFAOYSA-N 0.000 description 1
- 239000000865 liniment Substances 0.000 description 1
- 239000012263 liquid product Substances 0.000 description 1
- SXQCTESRRZBPHJ-UHFFFAOYSA-M lissamine rhodamine Chemical compound [Na+].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=C(S([O-])(=O)=O)C=C1S([O-])(=O)=O SXQCTESRRZBPHJ-UHFFFAOYSA-M 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 229940041290 mannose Drugs 0.000 description 1
- 150000002704 mannoses Chemical group 0.000 description 1
- 125000000311 mannosyl group Chemical group C1([C@@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 108010003855 mesentericopeptidase Proteins 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 108010020132 microbial serine proteinases Proteins 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000003094 microcapsule Substances 0.000 description 1
- 210000001724 microfibril Anatomy 0.000 description 1
- 238000003801 milling Methods 0.000 description 1
- 229910052750 molybdenum Inorganic materials 0.000 description 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 description 1
- YRDNVESFWXDNSI-UHFFFAOYSA-N n-(2,4,4-trimethylpentan-2-yl)prop-2-enamide Chemical compound CC(C)(C)CC(C)(C)NC(=O)C=C YRDNVESFWXDNSI-UHFFFAOYSA-N 0.000 description 1
- RIBHHEHYFNEILN-UHFFFAOYSA-N n-tert-butylprop-2-enamide;ethyl prop-2-enoate;prop-2-enoic acid Chemical compound OC(=O)C=C.CCOC(=O)C=C.CC(C)(C)NC(=O)C=C RIBHHEHYFNEILN-UHFFFAOYSA-N 0.000 description 1
- 229920005615 natural polymer Polymers 0.000 description 1
- KPSSIOMAKSHJJG-UHFFFAOYSA-N neopentyl alcohol Chemical compound CC(C)(C)CO KPSSIOMAKSHJJG-UHFFFAOYSA-N 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000001006 nitroso dye Substances 0.000 description 1
- 150000002835 noble gases Chemical class 0.000 description 1
- SXLLDUPXUVRMEE-UHFFFAOYSA-N nonanediperoxoic acid Chemical compound OOC(=O)CCCCCCCC(=O)OO SXLLDUPXUVRMEE-UHFFFAOYSA-N 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 230000009965 odorless effect Effects 0.000 description 1
- 229920001542 oligosaccharide Polymers 0.000 description 1
- 150000002482 oligosaccharides Chemical class 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 150000002923 oximes Chemical class 0.000 description 1
- RUVINXPYWBROJD-UHFFFAOYSA-N para-methoxyphenyl Natural products COC1=CC=C(C=CC)C=C1 RUVINXPYWBROJD-UHFFFAOYSA-N 0.000 description 1
- 235000011837 pasties Nutrition 0.000 description 1
- 239000004177 patent blue V Substances 0.000 description 1
- HVAMZGADVCBITI-UHFFFAOYSA-M pent-4-enoate Chemical compound [O-]C(=O)CCC=C HVAMZGADVCBITI-UHFFFAOYSA-M 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- XCRBXWCUXJNEFX-UHFFFAOYSA-N peroxybenzoic acid Chemical compound OOC(=O)C1=CC=CC=C1 XCRBXWCUXJNEFX-UHFFFAOYSA-N 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940067107 phenylethyl alcohol Drugs 0.000 description 1
- 229940096826 phenylmercuric acetate Drugs 0.000 description 1
- QCDYQQDYXPDABM-UHFFFAOYSA-N phloroglucinol Chemical compound OC1=CC(O)=CC(O)=C1 QCDYQQDYXPDABM-UHFFFAOYSA-N 0.000 description 1
- 229960001553 phloroglucinol Drugs 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- 235000011007 phosphoric acid Nutrition 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 150000003016 phosphoric acids Chemical class 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 150000003021 phthalic acid derivatives Chemical class 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 239000010665 pine oil Substances 0.000 description 1
- 239000001738 pogostemon cablin oil Substances 0.000 description 1
- 229920001983 poloxamer Polymers 0.000 description 1
- 229920000233 poly(alkylene oxides) Polymers 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 108010064470 polyaspartate Proteins 0.000 description 1
- 229920006294 polydialkylsiloxane Polymers 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 239000005077 polysulfide Substances 0.000 description 1
- 229920001021 polysulfide Polymers 0.000 description 1
- 150000008117 polysulfides Polymers 0.000 description 1
- 229910000343 potassium bisulfate Inorganic materials 0.000 description 1
- WSHYKIAQCMIPTB-UHFFFAOYSA-M potassium;2-oxo-3-(3-oxo-1-phenylbutyl)chromen-4-olate Chemical compound [K+].[O-]C=1C2=CC=CC=C2OC(=O)C=1C(CC(=O)C)C1=CC=CC=C1 WSHYKIAQCMIPTB-UHFFFAOYSA-M 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 239000011164 primary particle Substances 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- FJWSMXKFXFFEPV-UHFFFAOYSA-N prop-2-enamide;hydrochloride Chemical compound Cl.NC(=O)C=C FJWSMXKFXFFEPV-UHFFFAOYSA-N 0.000 description 1
- NPSSWQJHYLDCNV-UHFFFAOYSA-N prop-2-enoic acid;hydrochloride Chemical compound Cl.OC(=O)C=C NPSSWQJHYLDCNV-UHFFFAOYSA-N 0.000 description 1
- KNBBFJHBEXCHFY-UHFFFAOYSA-N prop-2-enoic acid;trimethyl-[3-(prop-2-enoylamino)propyl]azanium;chloride Chemical compound [Cl-].OC(=O)C=C.C[N+](C)(C)CCCNC(=O)C=C KNBBFJHBEXCHFY-UHFFFAOYSA-N 0.000 description 1
- ZQMAPKVSTSACQB-UHFFFAOYSA-N prop-2-enyl dodecanoate Chemical compound CCCCCCCCCCCC(=O)OCC=C ZQMAPKVSTSACQB-UHFFFAOYSA-N 0.000 description 1
- HPCIWDZYMSZAEZ-UHFFFAOYSA-N prop-2-enyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC=C HPCIWDZYMSZAEZ-UHFFFAOYSA-N 0.000 description 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- 239000012264 purified product Substances 0.000 description 1
- 229940079877 pyrogallol Drugs 0.000 description 1
- 229940076788 pyruvate Drugs 0.000 description 1
- 150000003856 quaternary ammonium compounds Chemical class 0.000 description 1
- 229940032044 quaternium-18 Drugs 0.000 description 1
- FZUOVNMHEAPVBW-UHFFFAOYSA-L quinoline yellow ws Chemical compound [Na+].[Na+].O=C1C2=CC=CC=C2C(=O)C1C1=NC2=C(S([O-])(=O)=O)C=C(S(=O)(=O)[O-])C=C2C=C1 FZUOVNMHEAPVBW-UHFFFAOYSA-L 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000007342 radical addition reaction Methods 0.000 description 1
- 239000002964 rayon Substances 0.000 description 1
- 230000001603 reducing effect Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 239000005871 repellent Substances 0.000 description 1
- 230000002940 repellent Effects 0.000 description 1
- 239000010666 rose oil Substances 0.000 description 1
- 235000019719 rose oil Nutrition 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
- 150000003902 salicylic acid esters Chemical class 0.000 description 1
- 239000010671 sandalwood oil Substances 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 150000004760 silicates Chemical class 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 235000017550 sodium carbonate Nutrition 0.000 description 1
- 239000012418 sodium perborate tetrahydrate Substances 0.000 description 1
- 229940045872 sodium percarbonate Drugs 0.000 description 1
- 229910000031 sodium sesquicarbonate Inorganic materials 0.000 description 1
- 235000018341 sodium sesquicarbonate Nutrition 0.000 description 1
- 239000004328 sodium tetraborate Substances 0.000 description 1
- 235000010339 sodium tetraborate Nutrition 0.000 description 1
- RPACBEVZENYWOL-XFULWGLBSA-M sodium;(2r)-2-[6-(4-chlorophenoxy)hexyl]oxirane-2-carboxylate Chemical compound [Na+].C=1C=C(Cl)C=CC=1OCCCCCC[C@]1(C(=O)[O-])CO1 RPACBEVZENYWOL-XFULWGLBSA-M 0.000 description 1
- IBDSNZLUHYKHQP-UHFFFAOYSA-N sodium;3-oxidodioxaborirane;tetrahydrate Chemical compound O.O.O.O.[Na+].[O-]B1OO1 IBDSNZLUHYKHQP-UHFFFAOYSA-N 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- PJANXHGTPQOBST-UHFFFAOYSA-N stilbene Chemical group C=1C=CC=CC=1C=CC1=CC=CC=C1 PJANXHGTPQOBST-UHFFFAOYSA-N 0.000 description 1
- 230000002311 subsequent effect Effects 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 239000001384 succinic acid Substances 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 150000003460 sulfonic acids Chemical class 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 229950009390 symclosene Drugs 0.000 description 1
- 229920002994 synthetic fiber Polymers 0.000 description 1
- 239000012209 synthetic fiber Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 230000009967 tasteless effect Effects 0.000 description 1
- KUCOHFSKRZZVRO-UHFFFAOYSA-N terephthalaldehyde Chemical compound O=CC1=CC=C(C=O)C=C1 KUCOHFSKRZZVRO-UHFFFAOYSA-N 0.000 description 1
- 108010075550 termamyl Proteins 0.000 description 1
- 150000003505 terpenes Chemical class 0.000 description 1
- 235000007586 terpenes Nutrition 0.000 description 1
- 229940116411 terpineol Drugs 0.000 description 1
- JLZUZNKTTIRERF-UHFFFAOYSA-N tetraphenylethylene Chemical group C1=CC=CC=C1C(C=1C=CC=CC=1)=C(C=1C=CC=CC=1)C1=CC=CC=C1 JLZUZNKTTIRERF-UHFFFAOYSA-N 0.000 description 1
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 1
- 150000003568 thioethers Chemical class 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- LOIYMIARKYCTBW-OWOJBTEDSA-N trans-urocanic acid Chemical compound OC(=O)\C=C\C1=CNC=N1 LOIYMIARKYCTBW-OWOJBTEDSA-N 0.000 description 1
- LOIYMIARKYCTBW-UHFFFAOYSA-N trans-urocanic acid Natural products OC(=O)C=CC1=CNC=N1 LOIYMIARKYCTBW-UHFFFAOYSA-N 0.000 description 1
- 238000005809 transesterification reaction Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 229960002622 triacetin Drugs 0.000 description 1
- 150000003918 triazines Chemical class 0.000 description 1
- ZKWDCFPLNQTHSH-UHFFFAOYSA-N tribromoisocyanuric acid Chemical compound BrN1C(=O)N(Br)C(=O)N(Br)C1=O ZKWDCFPLNQTHSH-UHFFFAOYSA-N 0.000 description 1
- OEIXGLMQZVLOQX-UHFFFAOYSA-N trimethyl-[3-(prop-2-enoylamino)propyl]azanium;chloride Chemical compound [Cl-].C[N+](C)(C)CCCNC(=O)C=C OEIXGLMQZVLOQX-UHFFFAOYSA-N 0.000 description 1
- WCTAGTRAWPDFQO-UHFFFAOYSA-K trisodium;hydrogen carbonate;carbonate Chemical compound [Na+].[Na+].[Na+].OC([O-])=O.[O-]C([O-])=O WCTAGTRAWPDFQO-UHFFFAOYSA-K 0.000 description 1
- ORHBXUUXSCNDEV-UHFFFAOYSA-N umbelliferone Chemical compound C1=CC(=O)OC2=CC(O)=CC=C21 ORHBXUUXSCNDEV-UHFFFAOYSA-N 0.000 description 1
- HFTAFOQKODTIJY-UHFFFAOYSA-N umbelliferone Natural products Cc1cc2C=CC(=O)Oc2cc1OCC=CC(C)(C)O HFTAFOQKODTIJY-UHFFFAOYSA-N 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 239000010679 vetiver oil Substances 0.000 description 1
- KOZCZZVUFDCZGG-UHFFFAOYSA-N vinyl benzoate Chemical compound C=COC(=O)C1=CC=CC=C1 KOZCZZVUFDCZGG-UHFFFAOYSA-N 0.000 description 1
- ZFNVDHOSLNRHNN-UHFFFAOYSA-N xi-3-(4-Isopropylphenyl)-2-methylpropanal Chemical compound O=CC(C)CC1=CC=C(C(C)C)C=C1 ZFNVDHOSLNRHNN-UHFFFAOYSA-N 0.000 description 1
- 150000003752 zinc compounds Chemical class 0.000 description 1
- 229910052726 zirconium Inorganic materials 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D17/00—Detergent materials or soaps characterised by their shape or physical properties
- C11D17/04—Detergent materials or soaps characterised by their shape or physical properties combined with or containing other objects
- C11D17/041—Compositions releasably affixed on a substrate or incorporated into a dispensing means
- C11D17/042—Water soluble or water disintegrable containers or substrates containing cleaning compositions or additives for cleaning compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D17/00—Detergent materials or soaps characterised by their shape or physical properties
- C11D17/0039—Coated compositions or coated components in the compositions, (micro)capsules
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/0005—Other compounding ingredients characterised by their effect
- C11D3/0052—Gas evolving or heat producing compositions
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Detergent Compositions (AREA)
Abstract
Capsules with a controlled release system which releases an active substance at a desired point in time and may be used in machine washing and cleaning processes and releases the active substance at a predetermined point in time of the washing process have an aperture in the capsule wall for emergence of the components contained therein and comprise (A) a substance apt to destroy the capsule wall by reaction with the capsule material and/or with a further substance, (B) a gas which under storage conditions does not react with the contents of the capsule, and (C) active substance.
Description
CAPSULE FOR CONTROLLED RELEASE OF ACTIVE SUBSTANCES
Field of the Invention The present invention relates to a capsule for the con trolled release of active substances and in particular to the use of this capsule in laundry detergent, cleaning product, and surfactant compositions and in pharmaceutical and cosmetic preparations.
Background of the Invention Capsules for the controlled release of active sub-stances are known from a multiplicity of applications.
Within the pharmaceutical segment there are systems featuring what is known as delayed release, i.e., the active substances are released after a predetermined space of time following oral intake. In the case of what is known as controlled release, metering of the release of the active substances takes place within a predetermined organ. One generally customary system is the release of the active substances in the gut, with the capsules comprising a material which is resistant to gastric fluid but soluble in the gut. The capsules dissolve in the gut and the active substance is released there.
A further field of use of encapsulated active sub-stances is that of laundry detergents and cleaning products. Finished compositions frequently include sensitive substances which may be destroyed by other components under storage conditions. These substances may be incorporated in encapsulated form into the compositions. The encapsulated materials are generally enveloped by a water-soluble shell which is dissolved by the washing water, with release ensuing.
In the known capsules, the dissolution process begins immediately, so that the rate of release of the active substances is dependent on the dissolution rate of the capsule material.
Field of the Invention The present invention relates to a capsule for the con trolled release of active substances and in particular to the use of this capsule in laundry detergent, cleaning product, and surfactant compositions and in pharmaceutical and cosmetic preparations.
Background of the Invention Capsules for the controlled release of active sub-stances are known from a multiplicity of applications.
Within the pharmaceutical segment there are systems featuring what is known as delayed release, i.e., the active substances are released after a predetermined space of time following oral intake. In the case of what is known as controlled release, metering of the release of the active substances takes place within a predetermined organ. One generally customary system is the release of the active substances in the gut, with the capsules comprising a material which is resistant to gastric fluid but soluble in the gut. The capsules dissolve in the gut and the active substance is released there.
A further field of use of encapsulated active sub-stances is that of laundry detergents and cleaning products. Finished compositions frequently include sensitive substances which may be destroyed by other components under storage conditions. These substances may be incorporated in encapsulated form into the compositions. The encapsulated materials are generally enveloped by a water-soluble shell which is dissolved by the washing water, with release ensuing.
In the known capsules, the dissolution process begins immediately, so that the rate of release of the active substances is dependent on the dissolution rate of the capsule material.
If the components are to be added only in one particular part of the washing process, i.e., in a specific wash cycle, then these components are usually metered by way of corresponding devices arranged in the washing machines. Domestic washing machines, for example, include reserve compartments for the prewash, the main wash, and the rinse cycle. A dishwasher machine includes reserve compartments for the detergent, and another for the rinse aid.
The field of laundry detergents and cleaning products is virtually devoid of capsules which, as in the pharmaceutical segment, are able to utilize the different pH environments within the body. Generally, the pH levels within the individual wash cycles are very similar. These cycles also show similar fluctuations in temperature in the heating and cooling phases. The prior art discloses no system which permits controlled release of the active substance in a sub-sequent wash or rinse cycle.
Summary of the Invention It is an object of the present invention to provide a capsule having a controlled release system that releases an active substance at a desired point in time, i.e., at a predetermined site, following its supply. A particular object of the invention is to provide a capsule which may be used in machine washing and cleaning processes and which releases the active substance at a predetermined point in time in the washing process.
The invention accordingly provides a capsule for the controlled release of active substance, comprising (A) a substance apt to destroy the capsule wall by means' of chemical reaction with the capsule material and/or with a further substance, (B) a gas which under storage conditions does not react with the other components present in the capsule, and (C) active substance, the capsule shell having an aperture for the emergence of one of the constituents present therein.
The capsule of the invention is suitable for a multiplicity of applications within the pharmaceutical and cosmetic segment and also for use in machine laundry detergents and cleaning products, especially in compositions for textile laundry and for the machine cleaning of kitchen- and tableware.
Detailed Description of the Invention The term "capsule" in the context of the present invention is not restricted to receptacles having the form of the capsules known from pharmacy. Rather, in the context of the present invention, the term "capsule" denotes receptacles whose walls are sufficiently stable to withstand the volume expansion and subsequent contraction to the extent that the external medium is able to pass into the receptacle's interior. In addition to the cylindrical capsules with hemispherical ends that are known from pharmacy, other geometries are of course also realizable in accordance with the invention, in particular, for example, tubular bags made of hard films, spherical, cube-shaped or tetrahedral packaging forms, etc.
By means of appropriate combination of the materials of capsule wall and ingredients it is possible to produce tailored capsules of the invention. The active substance and the capsule material may also be chosen, for example, such that the active substance destroys the material of the capsule. In this specific case, substance A and substance C would be identical.
The field of laundry detergents and cleaning products is virtually devoid of capsules which, as in the pharmaceutical segment, are able to utilize the different pH environments within the body. Generally, the pH levels within the individual wash cycles are very similar. These cycles also show similar fluctuations in temperature in the heating and cooling phases. The prior art discloses no system which permits controlled release of the active substance in a sub-sequent wash or rinse cycle.
Summary of the Invention It is an object of the present invention to provide a capsule having a controlled release system that releases an active substance at a desired point in time, i.e., at a predetermined site, following its supply. A particular object of the invention is to provide a capsule which may be used in machine washing and cleaning processes and which releases the active substance at a predetermined point in time in the washing process.
The invention accordingly provides a capsule for the controlled release of active substance, comprising (A) a substance apt to destroy the capsule wall by means' of chemical reaction with the capsule material and/or with a further substance, (B) a gas which under storage conditions does not react with the other components present in the capsule, and (C) active substance, the capsule shell having an aperture for the emergence of one of the constituents present therein.
The capsule of the invention is suitable for a multiplicity of applications within the pharmaceutical and cosmetic segment and also for use in machine laundry detergents and cleaning products, especially in compositions for textile laundry and for the machine cleaning of kitchen- and tableware.
Detailed Description of the Invention The term "capsule" in the context of the present invention is not restricted to receptacles having the form of the capsules known from pharmacy. Rather, in the context of the present invention, the term "capsule" denotes receptacles whose walls are sufficiently stable to withstand the volume expansion and subsequent contraction to the extent that the external medium is able to pass into the receptacle's interior. In addition to the cylindrical capsules with hemispherical ends that are known from pharmacy, other geometries are of course also realizable in accordance with the invention, in particular, for example, tubular bags made of hard films, spherical, cube-shaped or tetrahedral packaging forms, etc.
By means of appropriate combination of the materials of capsule wall and ingredients it is possible to produce tailored capsules of the invention. The active substance and the capsule material may also be chosen, for example, such that the active substance destroys the material of the capsule. In this specific case, substance A and substance C would be identical.
For the release of the active substance from the capsule it is not necessary for the entire capsule wall to be destroyed. Rather, for emergence of the contents from the capsule, it is sufficient for the substance A
to destroy parts of the capsule wall, thereby permitting the substance C (which may be identical with A) to emerge from the capsule.
The aperture that is present, in accordance with the invention, in the capsule shell and which effects the release mechanism described hereinbelow may initially be closed. All that is necessary then is for the part closing the aperture to dissolve under the ambient conditions of the application, or for the aperture to open up in another way, so that the activity may begin.
The release mechanism of the capsule of the invention is essentially temperature-dependent and makes use of the volume expansion of gases under increasing temperature. The capsule of the invention is particularly suitable for use in an aqueous medium which in the course of the application is heated and then cooled again. If the capsule of the invention is added at room temperature to an aqueous environment which is subsequently heated, the gas volume within the capsule expands and a small amount of the components A, B and/or C present therein emerges via the aperture in the capsule wall. If the system cools back down after the heating process is at an end, and/or if cold water is supplied to the external environment of the capsule, then there is a volume contraction of the gas.
Simultaneously with the volume contraction, substance from outside, in the aqueous medium water, is taken in via the aperture in the capsule wall. The incoming water dissolves the component A, or reacts with it, as a result of which a medium develops within the capsule that leads to the destruction or dissolution of the capsule wall. Simultaneously with, or following, the destruction of the capsule wall, the active substance C
is released.
The shape of the capsule is arbitrary; however, it has proven advantageous if the capsule is of slightly elongated design. In an elongated shape, the solid ingredients accumulate in the bottom part and, when the capsule is used in an aqueous medium, are located below the water level. In an embodiment of this kind, the aperture in the capsule wall should also be below the water level.
The wall of the capsule of the invention should be such that it is initially inert and insoluble with respect to the external medium into which the capsule is introduced at the time of application (for example, water), and with respect to the components A, B and C
present within the capsule, but at high and/or low pH
values is soluble and may be destroyed, at least partially, by mechanical forces such as stirring, pressure, or abrasion. Examples of suitable materials are polymers which are soluble or dispersible in the alkaline or acidic range. Examples of suitable polymers are modified polysaccharides such as carrageenan, guar, pectin, xanthan, partially hydrolyzed cellulose, cellulose acetate, hydroxyethyl-, hydroxypropyl- and hydroxybutylcellulose, methylcellulose, and the like.
Mention may further be made of proteins and modified proteins, such as gelatin. Further suitable polymers include acrylates and acrylate polymers. These materials are described later on below.
In order to meet the abovementioned requirements imposed on the capsule wall, it may be necessary to use combinations of different wall materials or else to employ a multilayer construction of the wall from different wall materials.
to destroy parts of the capsule wall, thereby permitting the substance C (which may be identical with A) to emerge from the capsule.
The aperture that is present, in accordance with the invention, in the capsule shell and which effects the release mechanism described hereinbelow may initially be closed. All that is necessary then is for the part closing the aperture to dissolve under the ambient conditions of the application, or for the aperture to open up in another way, so that the activity may begin.
The release mechanism of the capsule of the invention is essentially temperature-dependent and makes use of the volume expansion of gases under increasing temperature. The capsule of the invention is particularly suitable for use in an aqueous medium which in the course of the application is heated and then cooled again. If the capsule of the invention is added at room temperature to an aqueous environment which is subsequently heated, the gas volume within the capsule expands and a small amount of the components A, B and/or C present therein emerges via the aperture in the capsule wall. If the system cools back down after the heating process is at an end, and/or if cold water is supplied to the external environment of the capsule, then there is a volume contraction of the gas.
Simultaneously with the volume contraction, substance from outside, in the aqueous medium water, is taken in via the aperture in the capsule wall. The incoming water dissolves the component A, or reacts with it, as a result of which a medium develops within the capsule that leads to the destruction or dissolution of the capsule wall. Simultaneously with, or following, the destruction of the capsule wall, the active substance C
is released.
The shape of the capsule is arbitrary; however, it has proven advantageous if the capsule is of slightly elongated design. In an elongated shape, the solid ingredients accumulate in the bottom part and, when the capsule is used in an aqueous medium, are located below the water level. In an embodiment of this kind, the aperture in the capsule wall should also be below the water level.
The wall of the capsule of the invention should be such that it is initially inert and insoluble with respect to the external medium into which the capsule is introduced at the time of application (for example, water), and with respect to the components A, B and C
present within the capsule, but at high and/or low pH
values is soluble and may be destroyed, at least partially, by mechanical forces such as stirring, pressure, or abrasion. Examples of suitable materials are polymers which are soluble or dispersible in the alkaline or acidic range. Examples of suitable polymers are modified polysaccharides such as carrageenan, guar, pectin, xanthan, partially hydrolyzed cellulose, cellulose acetate, hydroxyethyl-, hydroxypropyl- and hydroxybutylcellulose, methylcellulose, and the like.
Mention may further be made of proteins and modified proteins, such as gelatin. Further suitable polymers include acrylates and acrylate polymers. These materials are described later on below.
In order to meet the abovementioned requirements imposed on the capsule wall, it may be necessary to use combinations of different wall materials or else to employ a multilayer construction of the wall from different wall materials.
The capsule wall has an aperture for the emergence of constituents present in the capsule. This aperture should be of a size such that, at the time of volume expansion, at least one of the constituents present in the capsule is able to emerge, so as to avoid the capsule bursting as a result of the overpressure which forms. The size of this aperture is preferably less than 1 mm, in particular less than 0.5 mm. The component A is selected such that entry of external medium into the capsule is followed by dissolution or destruction of the capsule wall - for example, by the formation of an aqueous solution which has a pH which is aggressive for the capsule wall, or by the reaction of the component A with water to form a gas as a result of which, within the capsule, an overpressure is developed which leads ultimately to the destruction of the capsule and the release of the active substance.
In one preferred embodiment of the present invention, the component A is a solid acid and one material of the capsule wall is an acid-soluble polymer. Solid or crystalline acids used are preferably those which do not give off any water of crystallization at the process temperatures, examples being sulfamic acid, citric acid, and Na,KHS04. As acidifying agents it is also possible, for example, to use boric acid and also further alkali metal hydrogen sulfates, alkali metal dihydrogen phosphates, and other inorganic salts.
Preference, however, is given to the use of organic acidifying agents, with citric acid being a particularly preferred acidifying agent. The other solid mono-, oligo- and polycarboxylic acids, however, in particular may also be used. Preferred in turn from this group are tartaric acid, succinic acid, malonic acid, adipic acid, malefic acid, fumaric acid, oxalic acid, and polyacrylic acid. Organic sulfonic acids such as sulfamic acid may likewise be used. A commercially available acidifying agent which may likewise be used with preference in the context of the present invention is Sokalan~ DCS (trademark of BASF) , a mixture of succinic acid (max. 31% by weight), glutaric acid (max. 50% by weight), and adipic acid (max. 33% by weight ) .
In another embodiment, the component A is a substance which gives an alkaline reaction with water, and the material of the capsule wall is a polymer which is soluble in the alkaline range. Examples of solid substances which give alkaline reactions in aqueous solution are hydroxides, carbonates, hydrogen carbonates, and/or silicates, preference being given to alkali metal hydroxides, alkali metal carbonates, alkali metal hydrogen carbonates, alkali metal sesquicarbonates, alkali metal silicates, alkali metal metasilicates, and mixtures of the abovementioned substances. For the purposes of this invention, preference is given among the alkali metal salts to the potassium and in particular the sodium salts, especially sodium carbonate, sodium hydrogen carbonate, and sodium sesquicarbonate.
In a further embodiment of the present invention, the release takes place, as already mentioned above, by the formation of gas in the interior of the capsule and subsequent destruction as a result of the overpressure.
In this embodiment, the component A is a substance or a mixture of substances which reacts with the incoming water to form gas. Examples of possible substances are a combination of carbonates, such as alkali metal carbonates and alkali metal hydrogen carbonates, and a solid acid, e.g., citric acid, succinic acid, or one or more of the abovementioned acidifying agents, or cobalt ammine complexes in combination with resorcinol, an example which may be mentioned of an appropriate cobalt ammine complex being [Co (NH3) SCl] C12.
_ g _ A third possible release mechanism for the active substance C is the use of swelling agents as component A. As suitable swelling agents, mention may be made of cellulose and cellulose derivatives, which when water penetrates the capsule swell and lead to destruction and thus to the release of the active substance. Swelling agents, which because of their action are also referred to, inter alia, as disintegrants, increase in volume on ingress of water, with firstly an increase in their own volume (swelling) and secondly the possibility, by way of the release of gases, for the generation of a pressure which bursts the capsule and causes it to break down into relatively small particles. Examples of well-known swelling agents are synthetic polymers such as polyvinylpyrrolidone (PVP) or natural polymers and/or modified natural substances such as cellulose and starch and their derivatives, alginates, or casein derivatives.
Preferred swelling agents used in the context of the present invention are those based on cellulose. Pure cellulose has the formal empirical composition (C6HloOs) n and, considered formally, is a (3-1,4-polyacetal of cellobiose, which itself is constructed of two molecules of glucose. Suitable celluloses consist of from about 500 to 5000 glucose units and, accordingly, have average molecular masses of from 50,000 to 500,000. Cellulose-based swelling agents which may be used also include, in the context of the present invention, cellulose derivatives obtainable by polymer-analogous reactions from cellulose. Such chemically modified celluloses include, for example, products of esterifications and etherifications in which hydroxy hydrogen atoms have been substituted. However, celluloses in which the hydroxy groups have been replaced by functional groups not attached by an oxygen atom may also be used as cellulose derivatives. The group of cellulose derivatives embraces, for example, _ g _ alkali metal celluloses, carboxymethylcellulose (CMC), cellulose esters and cellulose ethers, and amino-celluloses. Said cellulose derivatives are preferably not used alone as cellulose-based disintegrants but instead are used in a mixture with cellulose. The cellulose derivative content of these mixtures is preferably less than 50% by weight, with particular preference less than 20% by weight, based on the cellulose-based swelling agent. The particularly preferred cellulose-based swelling agent used is pure cellulose, free from cellulose derivatives.
The cellulose used as the swelling agent is preferably not incorporated into the capsule in finely divided form but instead is converted before its introduction into a coarser form, by granulation or compaction, for example. The particle sizes of such disintegrants are usually above 200 Vim, preferably between 300 and 1600 ~m to the extent of at least 90% by weight, and~in particular between 400 and 1200 ~m to the extent of at least 90% by weight.
As a further cellulose-based swelling agent, or as a constituent of this component, it is possible to use microcrystalline cellulose. This microcrystalline cellulose is obtained by partial hydrolysis of celluloses under conditions which attack only the amorphous regions (approximately 30% of the total cellulose mass) of the celluloses and break them up completely but leave the crystalline regions (approximately 70%) intact. Subsequent deaggregation of the microfine celluloses resulting from the hydrolysis yields the microcrystalline celluloses, which have primary particle sizes of approximately 5 ~m and may be compacted, for example, to granules having an average particle size of 200 Vim.
One further possible release mechanism for the active substance C is the use of enzymes as component A. These enzymes may, for example, be coated in which case the coating dissolves after slight ingress of water into the capsule interior, after which the enzymes break down the capsule material and thus release the active substance C. Suitable enzymes for use, in dependence on the capsule material, are all common enzymes such as proteases, amylases, cellulases, etc., which may additionally possess a function in the wash or cleaning cycle. These enzymes are described at length later on below.
As active substance C it is possible to use any substances for which controlled release is desired. In the field of drugs, any desired active substances are suitable.
In the laundry detergents and cleaning products, the kind of substances incorporated in capsule form are in particular those which under normal conditions are not stable and/or are intended for use in a later stage of the washing process. Examples of active substances incorporated in the form of capsules into laundry detergents and cleaning products are rinse-aid surfactants, textile treatment compositions (fabric softeners), enzymes, bleaches, bleaching catalysts, bleach activators, optical brighteners, dyes, fragrances, corrosion inhibitors, etc.
The abovementioned rinse-aid surfactants, which are used in particular in the machine washing of kitchen-and tableware, and the textile treatment compositions, such as fabric softener components, which find applica-tion in the laundering of textiles, are components which in machine washing and cleaning processes are not added until a process stage which follows the actual washing operation. Suitable rinse-aid surfactants are all nonionic surfactants, but especially fatty alcohol polyethylene glycol ethers, fatty alcohol polyethylene/polypropylene glycol ethers, mixed ethers and/or hydroxyalkyl polyethylene glycol ethers.
Examples of fatty alcohol polyethylene glycol ethers are those with the formula (I) RIO-{CH2CHZO~,,H (I) to where Rl is a linear or branched alkyl and/or alkenyl radical having 6 to 22, preferably 12 to 18, carbon atoms and nl is numbers from 1 to 5.
Said substances are known commercial products. Typical examples are adducts of on average 2 or 4 mol of ethylene oxide onto technical-grade C12~14 coconut fatty alcohol (Dehydol~ LS-2 and LS-4, respectively, from Henkel KGaA) or adducts of on average 4 mol of ethylene oxide onto C14/ls oxo alcohols (Dobanol~ 45-4, from Shell) . The products may have a conventional or else a narrowed homolog distribution.
Fatty alcohol polyethylene/polypropylene glycol ethers are nonionic surfactants of the formula (II) R'O-(CH2CH20)~2(CHZCHO)r,,iH (II) where R4 is a linear or branched alkyl and/or alkenyl radical having 6 to 22, preferably 12 to 18, carbon atoms, n2 is numbers from 1 to 5 and m2 is numbers from 1 to 4.
These substances are also known commercial products. A
typical example is an adduct of on average 5 mol of ethylene oxide and 4 mol of propylene oxide anto technical-grade C~z/14 coconut fatty alcohol (Dehydol~ LS-54, from Henkel KGaA).
Mixed ethers are endgroup-capped fatty alcohol polyglycol ethers with the formula (III) R50-(CHZCH20~,3(CIiZCHO)",3-R6 (III) where RS is a linear or branched alkyl and/or alkenyl radical having 6 to 22, preferably 12 to 18 carbon atoms, n3 is numbers from 1 to 10, m3 is 0 or numbers from 1 to 4, and R6 is an alkyl radical having 1 to 4 carbon atoms, or a benzyl radical.
Typical examples are mixed ethers of the formula (III) in which RS is a technical-grade C12/14 cocoalkyl radical, n3 is 5 or 10, m3 is 0, and R6 is a butyl group (Dehypon~ LS-54 and LS-104, respectively, from Henkel KGaA). The use of butyl- and/or benzyl-capped mixed ethers is particularly preferable on performance grounds.
Hydroxyalkyl polyethylene glycol ethers are compounds with the general formula (IV) RS -CH-CH-(OCH2CH20)"4-OR2 (IV) where RS is hydrogen or a straight-chain alkyl radical having 1 to 16 carbon atoms, R3 is a straight-chain or branched alkyl radical having 4 to 8 carbon atoms, RZ is hydrogen or an alkyl radical having 1 to 16 carbon atoms, and n4 is a number from 7 to 30, with the proviso that the total number of carbon atoms in RS and R2 is from 6 to 16.
Examples of textile treatment compositions are, in particular, cationic surfactants. Suitable cationic surfactants are all customary surface-active sub-stances, distinct preference being given to cationic surfactants having a textile-softening action.
Such cationic active substances with a textile-softening action are selected with particular preference from those which may be described by one or more of the formulae V, VI or VII:
R' R ~ -N~+~-(CH2)n-T-R2 ( V ) (CHz)~ T-Rz R' R'-N~+~-(CH2)"-CH-CH2 (VI) R' T T
R' R3-N~+'-(CH2)n-T-R' (VU) R°
in which each group Rl independently of the others is selected from C1_6 alkyl, alkenyl or hydroxyalkyl groups; each group R2 independently of the others is selected from Ce_28 alkyl or alkenyl groups; R3 - R1 or (CHz) "-T-R2; R4 - Rl Or Rz Or (CHZ) n-T-R2; T = -CHZ-, -O-CO- or -CO-O-, and n is an integer from 0 to 5.
Enzymes may be incorporated in the form of liquid or solid enzyme preparations into the capsules. Suitable enzymes in this context include in particular those from the classes of the hydrolases such as the proteases, esterases, lipases or lipolytic enzymes, amylases, cellulases, and other glycosyl hydrolases, and mixtures of said enzymes. All of these hydrolases contribute in the wash to removing stains such as proteinaceous, fatty or starchy stains, and instances of graying. Cellulases and other glycosyl hydrolases may, furthermore, by removing pilling and microfibrils, contribute to color retention and to increasing the softness of the textile. For bleaching, and/or for inhibiting color transfer, it is also possible to use oxidoreductases. Especially suitable enzymatic active substances are those obtained from bacterial strains or fungi such as Bacillus subtilis, Bacillus licheni-formis, Streptomyces griseus, Coprinus cinereus, and Humicola insolens, and also from genetically modified variants thereof. Preference is given to the use of proteases of the subtilisin type, and especially to proteases obtained from Bacillus lentus. Of particular interest in this context are enzyme mixtures, examples being those of protease and amylase or protease and lipase or lipolytic enzymes, or of protease and cellulase or of cellulase and lipase or lipolytic enzymes, or of protease, amylase and lipase or lipolytic enzymes, or of protease, lipase or lipolytic enzymes and cellulase, but especially protease and/or lipase-containing mixtures or mixtures with lipolytic enzymes. Examples of such lipolytic enzymes are the known cutinases. Peroxidases or oxidases have also proven suitable in some cases. The suitable amylases include, in particular, alpha-amylases, iso-amylases, pullulanases, and pectinases. Cellulases used are preferably cellobiohydrolases, endoglucanases and -glucosidases, which are also called cellobiases, and mixtures of these. Since different types of cellulase differ in their CMCase and Avicelase activities, the desired activities may be established by means of specific mixtures of the cellulases.
In capsules intended for use in detergents for machine dishwashing, of course, different enzymes are used in order to take account of the different substrates treated and different types of soiling. Suitable enzymes in this context include in particular those from the classes of the hydrolases such as the proteases, esterases, lipases or lipolytic enzymes, amylases, glycosyl hydrolases, and mixtures of said enzymes. All of these hydrolases contribute to removing stains such as proteinaceous, fatty or starchy stains.
For bleaching, it is also possible to use oxidoreductases. Especially suitable enzymatic active substances are those obtained from bacterial strains or fungi such as Bacillus subtilis, Bacillus licheniformis, Streptomyces griseus, Coprinus cinereus, and Humicola insolens, and also from genetically modified variants thereof. Preference is given to the use of proteases of the subtilisin type, and especially to proteases obtained from Bacillus lentus. Of particular interest in this context are enzyme mixtures, examples being those of protease and amylase or protease and lipase or lipolytic enzymes, or of protease, amylase and lipase or lipolytic enzymes, or of protease, lipase or lipolytic enzymes, but especially protease and/or lipase-containing mixtures or mixtures with lipolytic enzymes. Examples of such lipolytic enzymes are the known cutinases. Peroxidases or oxidases have also proven suitable in some cases.
The suitable amylases include, in particular, alpha-amylases, iso-amylases, pullulanases, and pectinases.
The. enzymes may be adsorbed on carrier substances or embedded in coating substances in order to protect them against premature decomposition.
The enzymes are usually prepared in a granulated and encapsulated form and added in that form to the laundry detergent and cleaning product. In liquid cleaning products containing water, these granulated and encapsulated enzymes would dissolve, and so in that case the use of liquid enzyme concentrates is generally preferred. Such liquid enzyme concentrates are based either, homogeneously, on a propylene glycol/water base or, heterogeneously, as slurry, or are present in a microencapsulated structure. The use of liquid enzyme products is likewise possible in the capsules of the invention.
Preferred liquid proteases are, for example, Savinase~ L, Durazyrri L, Esperase~ L, and Everlase~ from Novo Nordisk, Optimase~ L, Purafect~ L, Purafect~ OX L, Properase~ L from Genencor International, and BLAP~ L
from Biozym Ges.m.b.H.
Preferred amylases are Termamyl~ L, Duramyl~ L, and BAN
from Novo Nordisk, Maxamyl~ WL and Purafect~ HPAm L from Genencor International.
Preferred lipases are Lipolase~ L, Lipolase~ ultra L and Lipoprime~ L from Novo Nordisk and Lipomax~ L from Genencor International.
Slurries or microencapsulated liquid products that may be used are, for example, products such as those designated by SL or, respectively, LCC from Novo Nordisk. Said commercial liquid enzyme preparations contain, for example, from 20 to 90% by weight of propylene glycol or of mixtures of propylene glycol and water. Capsules preferred in the context of the present invention are those comprising one or more liquid amylase preparations and/or one or more liquid protease preparations.
Substances from the groups of the bleaches and bleach activators or bleaching catalysts are also suitable as ingredients for the capsules of the invention. Among the compounds used as bleaches which yield H202 in water, particular importance is possessed by sodium percarbonate. Examples of further bleaches which may be used are sodium perborate tetrahydrate and sodium perborate monohydrate, peroxypyrophosphates, citrate perhydrates, and H202-donating peracidic salts or peracids, such as perbenzoates, peroxophthalates, diperazelaic acid, phthaloimino peracid, or diperdo-decanedioic acid. Capsules of the invention for use in cleaning products may also comprise bleaches from the group of the organic bleaches. Typical organic bleaches are the diacyl peroxides, such as dibenzoyl peroxide for example. Further typical organic bleaches are the peroxy acids, particular examples being the alkyl peroxy acids and the aryl peroxy acids. Preferred representatives are (a) peroxybenzoic acid and its ring-substituted derivatives, such as alkylperoxy-benzoic acids, and also peroxy-a-naphthoic acid and magnesium monoperphthalate, (b) aliphatic or sub-stituted aliphatic peroxy acids, such as peroxylauric acid, peroxystearic acid, s-phthalimidoperoxycaproic acid [phthaloiminoperoxyhexanoic acid (PAP)], o-carboxy-benzamidoperoxycaproic acid, N-nonenylamidoperadipic acid, and N-nonenylamidopersuccinates, and (c) aliphatic and araliphatic peroxy dicarboxylic acids, such as 1,12-diperoxycarboxylic acid, 1,9-diperoxyazelaic acid, diperoxysebacic acid, diperoxybrassylic acid, the diperoxyphthalic acids, 2-decyldiperoxybutane-1,4-dioic acid, and N,N-terephthaloyldi(6-aminopercaproic acid) may be used.
Bleaches in the capsules of the invention used in detergents for machine dishwashing may also be substances which release chlorine or bromine. Among the suitable chlorine- or bromine-releasing materials, examples include heterocyclic N-bromoamides and N-chloroamides, examples being trichloroisocyanuric acid, tribromoisocyanuric acid, dibromoisocyanuric acid, and/or dichloroisocyanuric acid (DICA) and/or salts thereof with cations such as potassium and sodium. Hydantoin compounds, such as 1,3-dichloro-5,5-dimethylhydantoin, are likewise suitable.
Bleach activators, which boost the action of the bleaches, may likewise be ingredients in the capsules of the invention. Known bleach activators are compounds containing one or more N-acyl and/or O-acyl groups, such as substances from the class of the anhydrides, esters, imides and acylated imidazoles or oximes.
Examples are tetraacetylethylenediamine TAED, tetra-acetylmethylenediamine TAMD, and tetraacetylhexylene-diamine TAHD, and also pentaacetylglucose PAG, 1,5-diacetyl-2,2-dioxohexahydro-1,3,5-triazine DADHT, and isatoic anhydride ISA.
Bleach activators which may be used are compounds which under perhydrolysis conditions give rise to aliphatic peroxo carboxylic acids having preferably 1 to 10 carbon atoms, in particular 2 to 4 carbon atoms, and/or substituted or unsubstituted perbenzoic acid.
Suitable substances are those which carry O-acyl and/or N-acyl groups of the stated number of carbon atoms, and/or substituted or unsubstituted benzoyl groups.
Preference is given to polyacylated alkylenediamines, especially tetraacetylethylenediamine (TAED), acylated triazine derivatives, especially 1,5-diacetyl-2,4-dioxohexahydro-1,3,5-triazine (DADHT), acylated glycolurils, especially tetraacetyl glycoluril (TAGU), N-acylimides, especially N-nonanoylsuccinimide (NOSI), acylated phenolsulfonates, especially n-nonanoyl- or isononanoyloxybenzenesulfonate (n- or iso-NOBS), carboxylic anhydrides, especially phthalic anhydride, acylated polyhydric alcohols, especially triacetin, ethylene glycol diacetate, 2,5-diacetoxy-2,5-dihydrofuran, N-methylmorpholiniumacetonitrile methyl sulfate (MMA), and the enol esters known from German Patent Applications DE 196 16 693 and DE 196 16 767, and also acetylated sorbitol and mannitol and/or mixtures thereof (SORMAN), acylated sugar derivatives, especially pentaacetylglucose (PAG), pentaacetylfructose, tetraacetylxylose and octaacetyl-lactose, and also acetylated, optionally N-alkylated glucamine and gluconolactone, and/or N-acylated lactams, for example, N-benzoylcaprolactam. Hydro-philically substituted acyl acetals and acyllactams are likewise used with preference. Combinations of conventional bleach activators may also be used. In capsules for machine dishwashing compositions, the bleach activators are usually used in amounts from 0.1 to 20% by weight, preferably from 0.25 to 15% by weight, and in particular from 1 to 10% by weight, based in each case on the total composition.
In addition to the conventional bleach activators, or instead of them, it is also possible to incorporate what are known as bleaching catalysts into the capsules. These substances are bleach-boosting transition metal salts or transition metal complexes such as, for example, Mn-, Fe-, Co-, Ru- or Mo-salen complexes or -carbonyl complexes. Other bleaching catalysts which may be used include Mn, Fe, Co, Ru, Mo, Ti, V and Cu complexes with N-containing tripod ligands, and also Co-, Fe-, Cu- and Ru-ammine complexes.
Preference is given to the use of bleach activators from the group of the polyacylated alkylenediamines, especially tetraacetylethylenediamine (TAED), N-acyl imides, especially N-nonanoylsuccinimide (NOSI), acylated phenolsulfonates, especially n-nonanoyl- or isononanoyloxybenzenesulfonate (n- or iso-NOBS), N-methylmorpholiniumacetonitrile methyl sulfate (MMA), preferably in amounts of up to 10% by weight, in particular from 0.1% by weight to 8% by weight, especially from 2 to 8 % by weight, and with particular preference from 2 to 6% by weight, based on the total composition.
Bleach-boosting transition metal complexes, especially those with the central atoms Mn, Fe, Co, Cu, Mo, V, Ti and/or Ru, preferably selected from the group of manganese and/or cobalt salts and/or complexes, with particular preference cobalt ammine complexes, cobalt acetato complexes, cobalt carbonyl complexes, the chlorides of cobalt or of manganese, and manganese sulfate, are used in customary amounts, preferably in an amount of un to 5% by weicrht. in particular from 0.0025% by weight to 1% by weight, and with particular preference from 0.01% by weight to 0.25% by weight, based in each case on the total composition. In specific cases, however, it is also possible to use a greater amount of bleach activator.
When used in laundry detergents and cleaning products, the capsules of the invention may include corrosion inhibitors for protecting the ware or the machine, with special importance in the field of machine dishwashing being possessed, in particular, by silver protectants.
The known substances of the prior art may be used. In general it is possible to use, in particular, silver protectants selected from the group of the triazoles, benzotriazoles, bisbenzotriazoles, aminotriazoles, alkylaminotriazoles, and transition metal salts or transition metal complexes. Particular preference is given to the use of benzotriazole and/or alkylamino-triazole. Frequently encountered in cleaner formula-tions, furthermore, are agents containing active chlorine, which may significantly reduce corrosion of the silver surface. In chlorine-free cleaners, use is made in particular of oxygen-containing and nitrogen-containing organic redox-active compounds, such as difunctional and trifunctional phenols, e.g., hydroquinone, pyrocatechol, hydroxyhydroquinone, gallic acid, phloroglucinol, pyrogallol and derivatives of these classes of compound. Inorganic compounds in the form of salts and complexes, such as salts of the metals Mn, Ti, Zr, Hf, V, Co and Ce, also find frequent application. Preference is given here to the transition metal salts selected from the group of the manganese and/or cobalt salts and/or complexes, with particular preference cobalt ammine complexes, cobalt acetato complexes, cobalt carbonyl complexes, the chlorides of cobalt or of manganese, and manganese sulfate.
Similarly, zinc compounds may be used to prevent corrosion on the ware.
In shaped laundry detergent and cleaning product bodies which are preferred in the context of the present invention, the capsule comprises silver protectants from the group of the triazoles, benzotriazoles, bisbenzotriazoles, aminotriazoles, alkylaminotriazoles, and transition metal salts or transition metal complexes, with particular preference benzotriazole and/or alkylaminotriazole, in amounts of from 0.01 to 5% by weight, preferably from 0.05 to 4% by weight, and in particular from 0.5 to 3% by weight, based in each case on the weight of the total composition that comprises the capsules.
In order to enhance the esthetic appeal of the capsules or of the compositions that comprise the capsules, the capsules may in whole or in part be colored with appropriate dyes or comprise dyes. Preferred dyes, whose selection presents no difficulties whatsoever to the skilled worker, possess a high level of storage stability and insensitivity to the other ingredients of the compositions, and to light, and possess no pronounced affinity for the substrates treated, such as textile fibers or kitchen- or tableware items, for example, so as not to stain them.
Preference for use in capsules of the invention for textile laundering or for incorporation into textile detergents is given to all colorants which can be oxidatively destroyed in the washing process, and to mixes thereof with suitable blue dyes, known as bluing agents. It has proven advantageous to use colorants which are soluble in water or at room temperature in liquid organic substances. Examples of suitable colorants are anionic colorants, e.g., anionic nitroso dyes. One possible colorant is, for example, naphthol green (Colour Index (CI) Part 1: Acid Green 1; Part 2:
10020) which as a commercial product is available, for example, as Basacid~ Green 970 from BASF, Ludwigshafen, Germany, and also mixtures thereof with suitable blue dyes. Further suitable colorants used include Pigmosol~
Blue 6900 (CI 74160), Pigmosol~ Green 8730 (CI 74260), Basonyl~ Red 545 FL (CI 45170), Sandolan~ Rhodamine EB400 (CI 45100), Basacid~ Yellow 094 (CI 47005), Sicovit~ Patent Blue 85 E 131 (CI 42051), Acid Blue 183 (CAS 12217-22-0, CI Acid Blue 183), Pigment Blue 15 (CI 74160), Supranol~ Blue GLW (CAS 12219-32-8, CI Acid Blue 221), Nylosan~ Yellow N-7GL SGR (CAS 61814-57-1, CI Acid Yellow 218) and/or Sandolan~ Blue (CI Acid Blue 182, CAS 12219-26-0).
In the context of the choice of colorant it must be ensured that the colorants do not have too great an affinity for the textile surfaces, and especially for synthetic fibers. At the same time, it should also be borne in mind when choosing suitable colorants that colorants possess different stabilities with respect to oxidation. The general rule is that water-insoluble colorants are more stable to oxidation than water-soluble colorants. Depending on the solubility and hence also on the oxidation sensitivity, the concentration of the colorant in the laundry detergents or cleaning products varies. With readily water-soluble colorants, e.g., the abovementioned Basacid~ Green, or the likewise abovementioned Sandolan~ Blue, colorant concentrations chosen are typically in the range from a few 10-2 to 10-3 o by weight . In the case of the pigment dyes, which are particularly preferred owing to their brightness but are less readily soluble in water, examples being the abovementioned Pigmosol~ dyes, the appropriate concentration of the colorant in laundry detergents or cleaning products, in contrast, is typically from a few 10-3 to 10-4% by weight.
The capsules of the invention may comprise one or more optical brighteners. These substances, which are also called whiteners, are used in modern laundry detergents because even freshly washed and bleached white laundry has a slight yellow cast. Optical brighteners are organic dyes which convert a part of the invisible W radiation of sunlight into longer-wave blue light.
The emission of this blue light closes the "loophole"
in the light reflected by the textile, so that a textile treated with an optical brightener appears whiter and lighter to the eye. Since the mechanism of action of brighteners necessitates that they attach to the fibers, a distinction is made in accordance with the fibers to be "dyed" between, for example, brighteners for cotton, nylon or polyester fibers. The commercially customary brighteners suitable for incorporation into laundry detergents belong essentially to five structural groups: the stilbene group, the diphenylstilbene group, the coumarin-quinoline group, the diphenylpyrazoline group, and the group involving combination of benzoxazole or benzimidazole with conjugated systems. An overview of current brighteners may be found, for example, in G. Jakobi, A. Ldhr "Detergents and Textile Washing", VCH-Verlag, Weinheim, 1987, pages 94 to 100. Examples of suitable brighteners are salts of 4,4'-bis[(4-anilino-6-morpholino-s-triazin-2-yl)amino]stilbene-2,2'-disulfonic acid or compounds of similar structure which instead of the morpholino group carry a diethanolamino group, a methylamino group, an anilino group, or a 2-methoxyethylamino group. Furthermore, brighteners of the substituted diphenylstyryl type may be present, examples being the alkali metal salts of 4,4'-bis(2-sulfostyryl)biphenyl, 4,4'-bis(4-chloro-3-sulfostyryl)biphenyl, or 4-(4-chlorostyryl)-4'-(2-sulfostyryl)biphenyl. Mixtures of the abovementioned brighteners may also be used.
Fragrances are added to the capsules of the invention in order to enhance the esthetic appeal of the products and to provide the consumer with not only the performance of the product but also a visually and sensorially "typical and unmistakeable" product. Also of importance here is the aspect of the long-lasting fragrancing of textiles or of the delayed release of fragrance, which masks the unpleasant alkali odor when dishwashers are opened. As perfume oils and/or fragrances it is possible to use individual odorant compounds, examples being the synthetic products of the ester, ether, aldehyde, ketone, alcohol, and hydrocarbon types. Odorant compounds of the ester type are, for example, benzyl acetate, phenoxyethyl isobutyrate, p-tert-butylcyclohexyl acetate, linalyl acetate, dimethylbenzylcarbinyl acetate, phenylethyl acetate, linalyl benzoate, benzyl formate, ethyl methylphenylglycinate, allyl cyclohexylpropionate, styrallyl propionate, and benzyl salicylate. The ethers include, for example, benzyl ethyl ether; the aldehydes include, for example, the linear alkanals having 8-18 carbon atoms, citral, citronellal, citronellyloxy-acetaldehyde, cyclamen aldehyde, hydroxycitronellal, lilial and bourgeonal; the ketones include, for example, the ionones, a-isomethylionone and methyl cedryl ketone; the alcohols include anethole, citronellol, eugenol, geraniol, linalool, phenylethyl alcohol, and terpineol; the hydrocarbons include primarily the terpenes such as limonene and pinene.
Preference, however, is given to the use of mixtures of different odorants, which together produce an appealing fragrance note. Such perfume oils may also contain natural odorant mixtures, as obtainable from plant sources, examples being pine oil, citrus oil, jasmine oil, patchouli oil, rose oil or ylang-ylang oil.
Likewise suitable are clary sage oil, camomile oil, clove oil, balm oil, mint oil, cinnamon leaf oil, lime blossom oil, juniperberry oil, vetiver oil, olibanum oil, galbanum oil and labdanum oil, and also orange blossom oil, neroliol, orange peel oil, and sandalwood oil.
The fragrance content of the capsules of the invention or of the compositions comprising the capsules is usually up to 2% by weight of the overall formulation.
The fragrances may be incorporated directly into the capsules or compositions of the invention;
alternatively, it may be advantageous to apply the fragrances to carriers which intensify the adhesion of the perfume on the laundry and, by means of slower fragrance release, ensure long-lasting fragrance of the textiles. Materials which have become established as such carriers are, for example, cyclodextrins, it being possible for the cyclodextrin-perfume complexes to be additionally coated with further auxiliaries.
In addition, the capsules may also comprise components which have a positive influence on the ease with which oil and grease are washed off from textiles (these components being known as soil repellents). This effect becomes particularly marked when a textile is soiled that has already been laundered previously a number of times with a detergent of the invention comprising this oil- and fat-dissolving component. The preferred oil-and fat-dissolving components include, for example, nonionic cellulose ethers such as methylcellulose and methylhydroxypropylcellulose having a methoxy group content of from 15 to 30% by weight and a hydroxypropyl group content of from 1 to 15% by weight, based in each case on the nonionic cellulose ether, and also the prior art polymers of phthalic acid and/or terephthalic acid, and/or derivatives thereof, especially polymers of ethylene terephthalates and/or polyethylene glycol terephthalates or anionically and/or nonionically modified derivatives thereof. Of these, particular preference is given to the sulfonated derivatives of phthalic acid polymers and of terephthalic acid polymers.
Foam inhibitors which may be present in the capsules of the invention are suitably, for example, soaps, paraffins or silicone oils, which may if desired have been applied to carrier materials.
Graying inhibitors have the function of keeping the dirt detached from the fiber in suspension in the liquor and so preventing the redeposition of the dirt.
Suitable for this purpose are water-soluble colloids, usually organic in nature, examples being the water-soluble salts of polymeric carboxylic acids, glue, gelatin, salts of ethersulfonic acids of starch or of cellulose, or salts of acidic sulfuric esters of cellulose or of starch. Water-soluble polyamides containing acidic groups are also suitable for this purpose. Furthermore, soluble starch preparations and starch products other than those mentioned above may be used, examples being degraded starch, aldehyde starches, etc. Polyvinylpyrrolidone may also be used.
Preference, however, is given to the use of cellulose ethers such as carboxymethylcellulose (Na salt), methylcellulose, hydroxyalkylcellulose, and mixed ethers such as methylhydroxyethylcellulose, methyl-hydroxypropylcellulose, methylcarboxymethylcellulose and mixtures thereof in amounts of from 0.1 to 5% by weight, based on the compositions.
Since sheetlike textile structures, especially those of filament rayon, viscose rayon, cotton and blends thereof, may tend to crease because the individual fibers are susceptible to bending, buckling, compressing and pinching transverse to the fiber direction, the capsules may comprise synthetic crease control agents. These include, for example, synthetic products based on fatty acids, fatty acid esters, fatty acid amides, fatty acid alkylol esters, fatty acid alkylolamides, or fatty alcohols, which are usually reacted with ethylene oxide, or else products based on lecithin or on modified phosphoric esters.
In order to combat microorganisms, the capsules of the invention may comprise antimicrobial active substances.
In this context a distinction is made, depending on antimicrobial spectrum and mechanism of action, between bacteriostats and bactericides, fungiostats and fungicides, etc. Examples of important substances from these groups are benzalkonium chlorides, alkylaryl-sulfonates, halophenols, and phenylmercuric acetate, it also being possible to do without these compounds entirely.
In order to prevent unwanted changes to the compositions and/or the treated textiles or substrates as a result of oxygen exposure and other oxidative processes, the capsules may comprise antioxidants. This class of compound includes, for example, substituted phenols, hydroquinones, pyrocatechols and aromatic amines, and also organic sulfides, polysulfides, dithiocarbamates, phosphates, and phosphonates.
Increased wear comfort may result from the additional use of antistats which are further added to the capsules of the invention. Antistats increase the surface conductivity and thus enable better dissipation of charges that are formed. External antistats are generally substances having at least one hydrophilic molecule ligand, and provide a more or less hygroscopic film on the surfaces. These antistats, which are usually surface-active, may be subdivided into nitrogen-containing (amines, amides, quaternary ammonium compounds), phosphorus-containing (phosphoric esters), and sulfur-containing (alkylsulfonates, alkyl sulfates) antistats. External antistats are described, for example, in Patent Applications FR 1,156,513, GB
873 214 and GB 839 407. The lauryl- (or stearyl-)dimethylbenzylammonium chlorides disclosed here are suitable as antistats for textiles and as additives to laundry detergents, in which case, additionally, a hand effect is obtained.
In order to improve the water absorption capacity, the rewettability of the treated textiles, and to facilitate ironing of the treated textiles, silicone derivatives, for example, may be used in the capsules of the invention used to treat laundry. These derivatives additionally improve the rinse-out behavior of the compositions, by virtue of their foam-inhibiting properties. Examples of preferred silicone derivatives are polydialkylsiloxanes or alkylarylsiloxanes where the alkyl groups have one to five carbon atoms and are totally or partially fluorinated. Preferred silicones are polydimethylsiloxanes, which may if desired have been derivatized and in that case are amino-functional or quaternized, or have Si-OH, Si-H and/or Si-C1 bonds.
The viscosities of the preferred silicones at 25°C are in the range between 100 and 100,000 centistokes, it being possible to use the silicones in amounts of between 0.2 and 5% by weight, based on the overall composition.
Finally, the capsules of the invention for textile detergents may also comprise UV absorbers, which attach to the treated textiles and improve the light stability of the fibers. Compounds which have these desired properties are, for example, the compounds which are active via radiationless deactivation, and derivatives of benzophenone having substituents in positions) 2 and/or 4. Also suitable are substituted benzotriazoles, acrylates which are phenyl-substituted in position 3 (cinnamic acid derivatives), with or without cyano groups in position 2, salicylates, organic Ni com-plexes, and also natural substances such as umbelliferone and the endogenous urocanic acid.
It is of course also possible to incorporate further ingredients of laundry detergents and cleaning products, examples being builders, cobuilders, further surfactants, especially anionic surfactants, etc., into the capsules of the invention. The incorporation of any pharmaceutical or cosmetic active substance is also possible without problems, so that the advantages of the controlled release may be utilized in a very wide variety of fields of use with the aid of the capsules of the invention.
As component B it is possible to use any desired gas compatible with the other components in the capsule.
Examples are air, NZ, O2, noble gases and noble gas mixtures, and C02.
The capsules of the invention may be produced in various ways. One possibility is to fill prefabricated capsule parts comprising the abovementioned materials with components A and C and then to fit the capsule parts together. Prefabricated capsule parts are available commercially in the form of so-called hard capsules. The amount of the gas component B is determined by the amount of components A and C
introduced. If the capsule parts are filled in air, then the gas component is air. Where a gas other than air is to be used as the gas component, filling generally takes place under the corresponding gas atmosphere.
After the capsule has been sealed, it is provided with the aperture, usually by means of a pointed article with the appropriate diameter. Alternatively, use may also be made of capsule shells which have already been perforated beforehand.
A further mode of production consists in the preparation of soft capsules. This takes place industrially by the so-called Scherer process. In this process, two strips of the capsule wall materials (e. g., gelatin strips) are combined in counter-rotating shaping rolls, with capsule shaping and capsule filling taking place simultaneously. The capsule aperture may in this case be made during the capsule shaping/filling process, or else in a downstream process step.
As already mentioned, in order to obtain the stated properties of the capsule wall it may be sensible or necessary to apply one or more layers of further wall materials to the capsules. This can be done, for example, by means of immersion processes, film coating, or in the fluidized bed process.
It is also possible to produce microcapsules of the invention which allow the release mechanism. In this case it is possible to have recourse to the common production processes, followed by the making of one or more microholes.
Appropriate capsule materials are, as already mentioned, polymers in particular. The materials mentioned earlier on above, such as carrageenan, guar, pectin, xanthan, cellulose and its derivatives, and gelatin, are described below.
Carrageenan is a formed extract, with a composition similar to that of agar, of North Atlantic red algae which belong to the Florideae, and is named for the Irish coastal town of Carragheen. The carrageenan, precipitated from the hot-water extract of the algae, is a colorless to sandy-colored powder having molecular masses of 100,000-800,000 and a sulfate content of approximately 25%, which is very readily soluble in warm water. In carrageenan, three principal con-stituents are distinguished: the gel-forming K fraction consists of D-galactose 4-sulfate and 3,6-anhydro-a-D-galactose, having alternate glycoside linkages in the 1,3 and 1,4 positions (agar, in contrast, contains 3,6-anhydro-a-L-galactose). The non-gelling ~, fraction is composed of D-galactose 2-sulfate with 1,3-glycoside linkages and of D-galactose 2,6-Bisulfate residues with 1,4 linkages, and is readily soluble in cold water.
1-Carrageenan, composed of D-galactose 4-sulfate in 1,3 linkage and 3,6-anhydro-a-D-galactose 2-sulfate in 1,4 linkage, is both water-soluble and gel-forming.
Further types of carrageenan are likewise labeled with Greek letters: a, Vii, y, ~, v, ~, ~, cu, x. The nature of cations present (K, NH4, Na, Mg, Ca) also influences the solubility of the carrageenans. Semisynthetic products which contain only one ionic type and are likewise possible for use in capsule materials in the context of the present invention are also called carrag(h)eenates.
The guar which may be used as a capsule material in the context of the present invention, also called guar gum, is a grayish white powder obtained by milling the endosperm of the guar bean (Cyamopsis tetragonobolus), which belongs to the family of the Leguminosae and was originally endemic in the Indian and Pakistani region but has since been cultivated in other countries as well, for example, in the southern USA. The principal constituent of guar, with up to about 85% by weight of the dry matter, is guaran (guar gum, Cyamopsis gum);
secondary constituents are proteins, lipids, and cellulose. Guaran itself is a polygalactomannan, i.e., a polysaccharide whose linear chain is composed of unsubstituted mannose units (see formula VIII) and mannose units substituted in the C6 position by a galactose residue (see formula IX) in (3-D-(1~4) linkage.
OH CHZOH
Galactose > O
HO
HO
CH20H O gCH2 OH
OH
SOHO ~~ .~- Mannose --~. ~ HO
g 2 1 VIII IX
The ratio of VIII:IX is approximately 2:1; the IX
units, in contrast to what was originally assumed, are not strictly alternating but are instead arranged in pairs or triplets in the polygalactomannan molecule.
Data on the molecular mass of guaran vary with values of approximately 2.2105-2.2106 g/mol, depending on the degree of purity of the polysaccharide - the high value was determined on a highly purified product -significantly and correspond to approximately 1350-13,500 sugar units/macromolecule. Guaran is insoluble in the majority of organic solvents.
The pectins, which are likewise suitable for use as capsule material, are high molecular mass glycosidic plant substances which are very widespread in fruits, roots, and leaves. Pectins consist essentially of chains of 1,4-a-glycosidically linked galacturonic acid units with 20-80% of their acid groups esterified with methanol, a distinction being made between high-esterification (>50%) and low-esterification (<50%) pectins. The pectins have a folded leaf structure which positions them in the center between starch and cellulose molecules. Their macromolecules also contain some glucose, galactose, xylose and arabinose, and have weakly acidic properties.
_O~O O O.
OH OH r OH OH
.O ~0 ~O
OH COOCH3 OH ~COOGH3 Fruit pectin contains 95%, beet pectin up to 85%
galacturonic acid. The molecular masses of the various pectins vary between 10,000 and 500,000. The structural properties as well are highly dependent on the degree of polymerization; for example, the fruit pectins in the dried state form asbestoslike fibers while the flax pectins form fine, granular powders.
The pectins are prepared by extraction with dilute acids predominantly from the inner portions of citrus fruit peels, fruit residues, or sugar beet chips.
Xanthan may also be used as a capsule material in accordance with the invention. Xanthan is a microbial anionic heteropolysaccharide produced by Xanthomonas campestris and certain other species under aerobic conditions, having a molecular mass of from 2 to 15 million daltons. Xanthan is formed of a chain comprising (3-1,4-linked glucose (cellulose) with side chains. The structure of the subgroups comprises glucose, mannose, glucuronic acid, acetate, and pyruvate, the viscosity of the xanthan being determined by the number of pyruvate units. Xanthan may be described by the following formula:
O O' n OH O v -O
~ n O
OH
HO
M'~ COO-O O
O OH
M'' - OOC O O
OH HO OH M+ = Na,K,ll2 Ca HsC O
Basic unit of xanthan The celluloses and their derivatives have already been described above as capsule ingredients. The capsules may of course also be produced from such materials. In addition to cellulose and cellulose derivatives, it is also possible to use (modified) dextrins, starch, and starch derivatives as capsule materials.
Suitable nonionic organic capsule materials are dextrins, examples being oligomers and polymers of carbohydrates obtainable by partial hydrolysis from starches. The hydrolysis may be conducted in accordance with customary processes - for example, acid- or enzyme-catalyzed processes. The products in question are preferably hydrolysis products having average molecular masses in the range from 400 to 500,000 g/mol. Preference is given to a polysaccharide having a dextrose equivalent (DE) in the range from 0.5 to 40, in particular from from 2 to 30, DE being a customary measure of the reducing action of a polysaccharide in comparison with dextrose, which possesses a DE of 100. Dextrins suitable for use include not only maltodextrins having a DE of between 3 and 20 and dry glucose syrups having a DE of between 20 and 37 but also what are known as yellow dextrins and white dextrins having higher molecular masses in the range from 2000 to 30,000 g/mol.
The oxidized derivatives of such dextrins comprise the reaction products with oxidizing agents capable of oxidizing at least one alcohol function of the saccharide ring to the carboxylic acid function.
Oxidized dextrins of this kind and processes for preparing them are known, for example, from European Patent Applications EP-A-0 232 202, EP-A-0 427 349, EP-A-0 472 042 and EP-A-0 542 496 and International Patent Applications WO 92/18542, WO 93/08251, WO 93/16110, WO 94/28030, WO 95/07303, WO 95/12619 and WO 95/20608. Likewise suitable is an oxidized oligosaccharide in accordance with German Patent Application DE-A-196 00 018. A product oxidized at C6 of the saccharide ring may be particularly advantageous.
Starch as well may be used as capsule material for the capsules of the invention. Starch is a homoglycan in which the glucose units are linked a-glycosidically.
Starch is composed of two components of different molecular weight: approximately 20-30% straight-chain amylose (MW approx. 50,000-150,000) and 70-80%
branched-chain amylopectin (MW approx. 300,000-2,000,000), with small amounts of lipids, phosphoric acids, and cations being present as well. Whereas amylose forms long, helical, interlooped chains comprising approximately 300-1200 glucose molecules, owing to the 1,4 linkage, in the case of amylopectin the chain branches by 1,6 linkage, after on average 25 glucose units, to form a treelike structure comprising approximately 1500-12,000 molecules of glucose. In addition to straight starch, starch derivatives obtainable by polymer-analogous reactions from starch are also suitable for preparing capsules in the context of present invention. Examples of such chemically modified starches include products of esterifications and etherifications in which hydroxy hydrogen atoms have been substituted. Alternatively, starches in which the hydroxy groups have been replaced by functional groups not attached via an oxygen atom may be used as starch derivatives. The group of the starch derivatives includes, for example, alkali metal starches, carboxymethylstarch (CMS), starch esters and ethers, and amino starches.
Among the proteins and modified proteins, gelatin is of outstanding significance as capsule material. Gelatin is a polypeptide (molecular mass: approx. 15,000->250,000 g/mol) obtained principally by hydrolysis under acidic or alkaline conditions of the collagen present in the skin and bones of animals. The amino acid composition of gelatin corresponds largely to that of the collagen from which it was obtained, and varies as a function of its provenance. The use of gelatin as a water-soluble envelope material is extremely wide-spread, especially in pharmacy, in the form of hard or soft gelatin capsules.
Further polymers suitable for use as capsule materials are synthetic polymers, which are preferably water-swellable and/or water-soluble. These polymers hail in particular from the following groups:
a) water-soluble nonionic polymers from the group of al) polyvinylpyrrolidones a2) vinylpyrrolidone-vinyl ester copolymers a3) cellulose ethers a4) (modified) polyvinyl alcohols b) water-soluble amphoteric polymers from the group of bl) alkylacrylamide-acrylic acid copolymers b2) alkylacrylamide-methacrylic acid copolymers b3) alkylacrylamide-methylmethacrylic acid copolymers b4) alkylacrylamide-acrylic acid-alkylaminoalkyl-(meth)acrylic acid copolymers b5) alkylacrylamide-methacrylic acid-alkylamino-alkyl(meth)acrylic acid copolymers b6) alkylacrylamide-methylmethacrylic acid-alkyl-aminoalkyl(meth)acrylic acid copolymers b7) alkylacrylamide-alkyl methacrylate-alkylamino-ethyl methacrylate-alkyl methacrylate copolymers b8) copolymers of b8i) unsaturated carboxylic acid b8ii) cationically derivatized unsaturated carboxylic acids b8iii) if desired, further ionic or nonionic monomers c) water-soluble zwitterionic polymers from the group of cl) acrylamidoalkyltrialkylammonium chloride-acrylic acid copolymers and their alkali metal and ammonium salts c2) acrylamidoalkyltrialkylammonium chloride-methacrylic acid copolymers and their alkali metal and ammonium salts c3) methacroylethyl betaine-methacrylate copolymers d) water-soluble anionic polymers from the group of dl) vinyl acetate-crotonic acid copolymers d2) vinylpyrrolidone-vinyl acrylate copolymers d3) acrylic acid-ethyl acrylate-N-tert-butylacryl-amide terpolymers d4) graft polymers of vinyl esters, esters of acrylic acid or methacrylic acid alone or in a mixture, copolymerized with crotonic acid, acrylic acid or methacrylic acid with poly-alkylene oxides and/or polyalkylene glycols d5) grafted and crosslinked copolymers from the copolymerization of d5i) at least one monomer of the nonionic tYPe, d5ii) at least one monomer of the ionic type, d5iii) polyethylene glycol, and d5iv) a crosslinker d6) copolymers obtained by copolymerizing at least one monomer from each of the three following groups:
d6i) esters of unsaturated alcohols and short-chain saturated carboxylic acids and/or esters of short-chain saturated alcohols and unsaturated carboxylic acids, d6ii) unsaturated carboxylic acids, d6iii) esters of long-chain carboxylic acids and unsaturated alcohols and/or esters of the carboxylic acids of group d6ii) with saturated or unsaturated, straight-chain or branched C$_la alcohol d7) terpolymers of crotonic acid, vinyl acetate and an allyl or methallyl ester d8) tetra- and pentapolymers of d8i) crotonic acid or allyloxyacetic acid d8ii) vinyl acetate or vinyl propionate d8iii) branched allyl or methallyl esters d8iv) vinyl ethers, vinyl esters or straight-chain allyl or methallyl esters d9) crotonic acid copolymers with one or more monomers from the group consisting of ethylene, vinylbenzene, vinyl methyl ether, acrylamide and water-soluble salts thereof d10) terpolymers of vinyl acetate, crotonic acid and vinyl esters of a saturated aliphatic a-branched monocarboxylic acid e) water-soluble cationic polymers from the group of el) quaternized cellulose derivatives e2) polysiloxanes with quaternary groups e3) cationic guar derivatives e4) polymeric dimethyldiallylammonium salts and their copolymers with esters and amides of acrylic acid and methacrylic acid e5) copolymers of vinylpyrrolidone with quater-nized derivatives of dialkylaminoacrylate and -methacrylate e6) vinylpyrrolidone-methoimidazolinium chloride copolymers e7) quaternized polyvinyl alcohol e8) polymers indicated under the INCI designations Polyquaternium 2, Polyquaternium 17, Poly-quaternium 18, and Polyquaternium 27.
Water-soluble polymers in the sense of the invention are those polymers which are soluble to the extent of more than 2.5% by weight at room temperature in water.
The capsules of the invention may be prepared from individual polymers of those mentioned above;
alternatively, mixtures or multi-layer laminar constructions of the polymers may be used. The polymers are described in more detail below.
Water-soluble polymers which are preferred in accordance of the invention are nonionic. Examples of suitable nonionic polymers are the following:
polyvinylpyrrolidones, as marketed, for example, under the designation Luviskol~ (BASF). Polyvinyl-pyrrolidones are preferred nonionic polymers in the context of the invention.
Polyvinylpyrrolidones [poly(1-vinyl-2-pyrrolidin-ones)], abbreviated PVP, are polymers of the general formula (X) CH ~ CH2 N
~O
prepared by free-radical addition polymerization of 1-vinylpyrrolidone by processes of solution or suspension polymerization using free-radical initiators (peroxides, azo compounds). The ionic polymerization of the monomer yields only products having low molecular masses. Commercially customary polyvinylpyrrolidones have molecular masses in the range from approx. 2500-750,000 g/mol, which are characterized by stating the K values and - depending on the K value - have glass transition temperatures of 130-175°. They are supplied as white, hygroscopic powders or as aqueous solutions.
Polyvinylpyrrolidones are readily soluble in water and a large number of organic solvents (alcholos, ketones, glacial acetic acid, chlorinated hydrocarbons, phenols, etc) .
- Vinylpyrrolidone-vinyl ester copolymers, as marketed for example under the trademark Luviskol~
(BASF). Luviskol~ VA 64 and Luviskol~ VA 73, each vinylpyrrolidone-vinyl acetate copolymers, are particularly preferred nonionic polymers.
The vinyl ester polymers are polymers obtainable from vinyl esters and featuring the grouping of the formula (XI) O' R
(XI) as the characteristic basic structural unit of the macromolecules. Of these, the vinyl acetate polymers (R = CH3) with polyvinyl acetates, as by far the most important representatives, have the greatest industrial significance .
The vinyl esters are polymerized free-radically by various processes (solution polymerization, suspension polymerization, emulsion polymerization, and bulk polymerization). Copolymers of vinyl acetate with vinylpyrrolidone comprise monomer units of the formulae (I) and (II) - Cellulose ethers, such as hydroxypropylcellulose, hydroxyethylcellulose and methylhydroxypropyl-cellulose, as marketed for example under the trademarks Culminal~ and Benecel~ (AQUALON).
Cellulose ethers may be described by the general formula (XII) RocH2 oR
_o o Ro o_ Ro o d (XII), where R is H or an alkyl, alkenyl, alkynyl, aryl, or alkylaryl radical. In preferred products, at least one R in formula (XII) is -CHZCH2CH2-OH or -CH2CH2-OH. Cellulose ethers are prepared industrially by etherifying alkali metal cellulose (e.g., with ethylene oxide). Cellulose ethers are characterized by way of the average degree of substitution, DS, and/or by the molar degree of substitution, MS, which indicate how many hydroxyl groups of an anhydroglucose unit of cellulose have reacted with the etherifying reagent or how many moles of the etherifying reagent have been added on, on average, to one anhydroglucose unit.
Hydroxyethylcelluloses are water-soluble above a DS
of approximately 0.6 and, respectively, an MS of approximately 1. Commercially customary hydroxyethyl- and hydroxypropylcelluloses have degrees of substitution in the range of 0.85-1.35 (DS) and 1.5-3 (MS), respectively. Hydroxyethyl-and -propylcelluloses are marketed as yellowish white, odorless and tasteless powders in greatly varying degrees of polymerization. Hydroxyethyl-and -propylcelluloses are soluble in cold and hot water and in some (water-containing) organic solvents, but insoluble in the majority of (anhydrous) organic solvents; their aqueous solutions are relatively insensitive to changes in pH or addition of electrolyte.
Polyvinyl alcohols, denoted PVAL for short, are polymers of the general structure (-CHZ-CH(OH)-J"
including small fractions of structural units of the [-CH2-CH(OH)-CH(OH}-CH2]
type. Since the corresponding monomer, the vinyl alcohol, is unstable in free form, polyvinyl alcohols are prepared by way of polymer-analogous reactions by hydrolysis, but industrially in particular by alkali-catalyzed transesterification of polyvinyl acetates with alcohols (preferably methanol) in solution. These industrial processes also make it possible to obtain PVALs having a predeterminable residual fraction of acetate groups.
Commercially customary PVAL (e. g., Mowiol~ grades from Hoechst) are commercialized as yellowish white powders or granules having degrees of polymerization in the range of approx. 500-2500 (corresponding to molecular masses of approximately 20,000-100,000 g/mol) and have different degrees of hydrolysis of 98-99 or 87-89 mol%.
They are, therefore, partially hydrolyzed polyvinyl acetates having a residual acetyl group content of approximately 1-2 or 11-13 mol%.
The water-solubility of PVAL may be reduced by after-treatment with aldehydes (acetalization), by complexing with Ni salts or Cu salts, or by treatment with dichromates, boric acid and/or borax, and so adjusted to desired levels.
Further polymers suitable in accordance with the invention are water-soluble amphopolymers. The generic term amphopolymers embraces amphoteric polymers, i.e., polymers whose molecule includes both free amino groups and free -COOH or S03H groups and are capable of forming inner salts; zwitterionic polymers whose molecule contains quaternary ammonium groups and -COO-OR -S03- groups, and polymers containing -COOH or S03H
groups and quaternary ammonium groups. An example of an amphopolymer which may be used in accordance with the invention is the acrylic resin obtainable under the designation Amphomer~, which constitutes a copolymer of tert-butylaminoethyl methacrylate, N-(1,1,3,3-tetra-methylbutyl)acrylamide, and two or more monomers from the group consisting of acrylic acid, methacrylic acid and their simple esters. Likewise preferred amphopolymers are composed of unsaturated carboxylic acids (e. g., acrylic and methacrylic acid), cationically derivatized unsaturated carboxylic acids, (e. g., acrylamidopropyltrimethylammonium chloride), and, if desired, further ionic or nonionic monomers, as evident, for example, from German Laid-Open Specification 39 29 973 and the prior art cited therein. Terpolymers of acrylic acid, methyl acrylate and methacrylamidopropyltrimonium chloride, as avail-able commercially under the designation Merquat~ 2001 N, are particularly preferred ampho-polymers in accordance with the invention. Further suitable amphoteric polymers are, for example, the octylacrylamide-methyl methacrylate-tert-butylamino-ethyl methacrylate-2-hydroxypropyl methacrylate copolymers available under the designations Amphomer~
and Amphomer~ LV-71 (DELFT NATIONAL).
Examples of suitable zwitterionic polymers are the addition polymers disclosed in German Patent Applications DE 39 29 973, DE 21 50 557, DE 28 17 369 and DE 37 08 451. Acrylamidopropyltrimethylammonium chloride-acrylic acid or -methacrylic acid copolymers and their alkali metal salts and ammonium salts are preferred zwitterionic polymers. Further suitable zwitterionic polymers are methacryloylethyl betaine-methacrylate copolymers, which are obtainable com-mercially under the designation Amersette~ (AMERCHOL).
Anionic polymers that are suitable in accordance with the invention include:
- vinyl acetate-crotonic acid copolymers, as in commercialized, for example, under the designation Resyn~ (NATIONAL STARCH), Luviset~ (BASF) and Gafset~ (GAF) .
' CA 02313587 2000-07-07 In addition to monomer units of the above formula (II), these polymers also have monomer units of the general formula (IV) [-CH(CH3)-CH(COOH)-]" (IV) - Vinylpyrrolidone-vinyl acrylate copolymers, obtain-able for example under the trademark Luviflex~
(BASF). A preferred polymer is the vinyl-pyrrolidone-acrylate terpolymer obtainable under the designation LuvifleX VBM-35 (BASF).
- Acrylic acid-ethyl acrylate-N-tert-butylacrylamide terpolymers, which are marketed for example under the designation Ultrahold~ strong (BASF).
- Graft polymers of vinyl esters, esters of acrylic acid or methacrylic acid alone or in a mixture, copolymerized with crotonic acid, acrylic acid or methacrylic acid with polyalkylene oxides and/or polyalkylene glycols Such grafted polymers of vinyl esters, esters of acrylic acid or methacrylic acid alone or in a mixture with other copolymerizable compounds onto polyalkylene glycols are obtained by polymerization under hot conditions in homogeneous phase, by stirring the polyalkylene glycols into the monomers of the vinyl esters, esters of acrylic acid or methacrylic acid, in the presence of free-radical initiators.
Vinyl esters which have been found suitable are, for example, vinyl acetate, vinyl propionate, vinyl butyrate, vinyl benzoate, and esters of acrylic acid or methacrylic acid which have been found suitable are those obtainable with low molecular weight aliphatic alcohols, i.e., in particular, ethanol, propanol, isopropanol, 1-butanol, 2-butanol, 2-methyl-1-propanol, 2-methyl-2-propanol, 1-pentanol, 2-pentanol, 3-pentanol, 2,2-dimethyl-1-propanol, 3-methyl-1-butanol; 3-methyl-2-butanol, 2-methyl-2-butanol, 2-methyl-1-butanol, and 1-hexanol.
Suitable polyalkylene glycols include in particular polyethylene glycols and polypropylene glycols.
Polyethylene glycols are polymers of ethylene glycol which satisfy the general formula XIII
H-(O-CHZ-CH2)~-OH (XIII) in which n may adopt values between 1 (ethylene glycol) and several thousand. For polyethylene glycols there exist various nomenclatures, which may lead to confusion. It is common in the art to state the average relative molecular weight after the letters "PEG", so that "PEG 200" characterizes a polyethylene glycol having a relative molecular mass of from about 190 to about 210. For cosmetic ingredients, a different nomenclature is used, in which the abbreviation PEG is provided with a hyphen and the hyphen is followed directly by a number which corresponds to the number n in the abovementioned formula XIII. According to this nomenclature (known as the INCI nomenclature, CTFA
International Cosmetic Ingredient Dictionary and Handbook, 5th Edition, The Cosmetic, Toiletry and Fragrance Association, Washington, 1997), for example, 3 0 PEG- 4 , PEG- 6 , PEG- 8 , PEG- 9 , PEG-10 , PEG-12 , PEG-14 , and PEG-16 may be used. Polyethylene glycols are available commercially, for example, under the trade names Carbowax~ PEG 200 (Union Carbide), Emkapol~ 200 (ICI
Americas), Lipoxol~ 200 MED (HtJLS America), Polyglycol~
E-200 (Dow Chemical), Alkapol~ PEG 300 (Rhone-Poulenc), Lutrol~ E300 (BASF), and the corresponding trade names with higher numbers.
' CA 02313587 2000-07-07 Polypropylene glycols (abbreviation PPGs) are polymers of propylene glycol which satisfy the general formula XIV
H-(O-CH-CH2)"OH (XIV) in which n may adopt values between 1 (propylene glycol) and several thousand. Industrially significant in this case are, in particular, di-, tri- and tetrapropylene glycol, i.e., the representatives where n = 2, 3 and 4 in formula VI.
In particular, it is possible to use the vinyl acetate copolymers grafted onto polyethylene glycols and the polymers of vinyl acetate and crotonic acid grafted onto polyethylene glycols.
- Grafted and crosslinked copolymers from the copolymerization of i) at least one monomer of the nonionic type, ii) at least one monomer of the ionic type, iii) polyethylene glycol, and iv) a crosslinker The polyethylene glycol used has a molecular weight of between 200 and several million, preferably between 300 and 30,000.
The nonionic monomers may be of very different types and include the following preferred monomers: vinyl acetate, vinyl stearate, vinyl laurate, vinyl propionate, allyl stearate, allyl laurate, diethyl maleate, allyl acetate, methyl methacrylate, cetyl vinyl ether, stearyl vinyl ether, and 1-hexene.
The nonionic monomers may equally be of very different types, among which particular preference is given to the presence in the graft polymers of crotonic acid, allyloxyacetic acid, vinylacetic acid, malefic acid, acrylic acid, and methacrylic acid.
Preferred crosslinkers are ethylene glycol dimeth-acrylate, diallyl phthalate, ortho-, meta- and para-divinylbenzene, tetraallyloxyethane, and polyallyl-saccharoses containing 2 to 5 allyl groups per molecule of saccharin.
The above-described grafted and crosslinked copolymers are formed preferably of:
i) from 5 to 85% by weight of at least one monomer of the nonionic type, ii) from 3 to 80% by weight of at least one monomer of the ionic type, iii) from 2 to 50% by weight, preferably from 5 to 30%
by weight, of polyethylene glycol, and iv) from 0.1 to 8% by weight of a crosslinker, the percentage of the crosslinker being shaped by the ratio of the overall weights of i), ii) and iii).
- Copolymers obtained by copolymerizing at least one monomer from each of the three following groups:
i) esters of unsaturated alcohols and short-chain saturated carboxylic acids and/or esters of short-chain saturated alcohols and unsaturated carboxylic acids, ii) unsaturated carboxylic acids, iii) esters of long-chain carboxylic acids and unsaturated alcohols and/or esters of the carboxylic acids of group ii) with saturated ' CA 02313587 2000-07-07 or unsaturated, straight-chain or branched C$_18 alcohols Short-chain carboxylic acids and alcohols here are those having 1 to 8 carbon atoms, it being possible for the carbon chains of these compounds to be interrupted, if desired, by divalent hetero-groups such as -O-, -NH-, and -S-.
- Terpolymers of crotonic acid, vinyl acetate, and an allyl or methallyl ester These terpolymers contain monomer units of the general formulae (II) to (IV) (see above) and also monomer units of one or more allyl or methallyl esters of the formula XV:
R' R3 RZ-C-C(O)-O-CHz-C=CHZ (XV) in which R3 is -H or -CH3, R2 is -CH3 or -CH (CH3) 2 and Rl is -CH3 or a saturated straight-chain or branched Cl_s alkyl radical and the sum of the carbon atoms in the radicals R1 and R2 is preferably 7, 6, 5, 4, 3 or 2.
The abovementioned terpolymers result preferably from the copolymerization of from 7 to 12% by weight of crotonic acid, from 65 to 86% by weight, preferably from 71 to 83 % by weight, of vinyl acetate and from 8 to 20% by weight, preferably from 10 to 17% by weight, of allyl or methallyl esters of the formula XV.
- Tetra- and pentapolymers of i) crotonic acid or allyloxyacetic acid ii) vinyl acetate or vinyl propionate iii) branched allyl or methallyl esters iv) vinyl ethers, vinyl esters or straight-chain allyl or methallyl esters - Crotonic acid copolymers with one or more monomers from the group consisting of ethylene, vinylbenzene, vinyl methyl ether, acrylamide and the water-soluble salts thereof - Terpolymers of vinyl acetate, crotonic acid and vinyl esters of a saturated aliphatic a-branched monocarboxylic acid.
Particularly appropriate capsule materials among the anionic polymers are polycarboxylates/polycarboxylic acids, polymeric polycarboxylates, polyaspartic acid, polyacetals, and dextrins, which are described below.
Examples of organic capsule materials which may be used are the polycarboxylic acids which may be used in the form of their sodium salts but also in free form.
Polymeric polycarboxylates are, for example, the alkali metal salts of polyacrylic acid or of polymethacrylic acid, examples being those having a relative molecular mass of from 500 to 70,000 g/mol.
The molecular masses reported for polymeric poly-carboxylates, for the purposes of this document, are weight-average molecular masses, MW, of the respective acid form, determined fundamentally by means of gel permeation chromatography (GPC) using a W detector.
Measurement was made against an external polyacrylic acid standard, which owing to its structural similarity to the polymers under investigation provides realistic molecular weight values. These figures differ markedly from the molecular weight values obtained using polystyrenesulfonic acids as the standard. The molecular masses measured against polystyrenesulfonic acids are generally much higher than the molecular masses reported in this document.
Suitable polymers are, in particular, polyacrylates, which preferably have a molecular mass of from 2000 to 20,000 g/mol. Owing to their superior solubility, preference in this group may be given in turn to the short-chain polyacrylates, which have molecular masses of from 2000 to 10,000 g/mol, and with particular preference from 3000 to 5000 g/mol.
Also suitable are copolymeric polycarboxylates, especially those of acrylic acid with methacrylic acid and of acrylic or methacrylic acid with malefic acid.
Copolymers which have been found particularly suitable are those of acrylic acid with malefic acid, containing from 50 to 90% by weight acrylic acid and from 50 to 10% by weight malefic acid. Their relative molecular mass, based on free acids, is generally from 2000 to 70,000 g/mol, preferably from 20,000 to 50,000 g/mol, and in particular from 30,000 to 40,000 g/mol.
In order to improve the solubility in water, the polymers may also contain allylsulfonic acids, such as allyloxybenzenesulfonic acid and methallylsulfonic acid, for example, as monomers.
Particular preference as capsule materials is also given to biodegradable polymers comprising more than two different monomer units, examples being those comprising, as monomers, salts of acrylic acid and of malefic acid, and also vinyl alcohol or vinyl alcohol derivatives, or those comprising, as monomers, salts of acrylic acid and of 2-alkylallylsulfonic acid, and also sugar derivatives.
Further preferred copolymeric capsule materials are those described in German Patent Applications DE-A-43 03 320 and DE-A-44 17 734, whose monomers are preferably acrolein and acrylic acid/acrylic salts, and, respectively, acrolein and vinyl acetate.
Similarly, further preferred capsule materials that may be mentioned include polymeric amino dicarboxylic acids, their salts or their precursor substances.
Particular preference is given to polyaspartic acids and their salts and derivatives.
Further suitable capsule materials are polyacetals, which may be obtained by reacting dialdehydes with polyol carboxylic acids having 5 to 7 carbon atoms and at least 3 hydroxyl groups. Preferred polyacetals are obtained from dialdehydes such as glyoxal, glutar aldehyde, terephthalaldehyde and mixtures thereof and from polyol carboxylic acids such as gluconic acid and/or glucoheptonic acid.
Further polymers which may be used with preference as capsule materials are cationic polymers. Among the cationic polymers, the permanently cationic polymers are preferred. "Permanently cationic" refers according to the invention to those polymers which independently of the pH of the composition (i.e., both of the capsule and of the remaining composition that may be present) have a cationic group. These are generally polymers which include a quaternary nitrogen atom, in the form of an ammonium group, for example.
Examples of preferred cationic polymers are the following:
Quaternized cellulose derivatives, as available commercially under the designations Celquat~ and Polymer JR~. The compounds Celquat~ H 100, Celquat~
' CA 02313587 2000-07-07 L 200 and Polymer JR 400 are preferred quaternized cellulose derivatives.
- Polysiloxanes with quaternary groups, such as, for example, the commercially available products Q2-7224 (manufacturer: Dow Corning; a stabilized trimethylsilylamodimethicone), Dow Corning~ 929 emulsion (comprising a hydroxyl-amino-modified silicone, also referred to as amodimethicone), SM-2059 (manufacturer: General Electric), SLM-55067 (manufacturer: blacker), and Abil~-Quat 3270 and 3272 (manufacturer: Th. Goldschmidt; diquaternary polydimethylsiloxanes, Quaternium-80), - Cationic guar derivatives, such as in particular the products marketed under the trade names Cosmedia~ Guar and Jaguar~, - Polymeric dimethyldiallylammonium salts and their copolymers with esters and amides of acrylic acid and methacrylic acid. The products available commercially under the designations Merquat~ 100 (poly(dimethyldiallylammonium chloride)) and Merquat~ 550 (dimethyldiallylammonium chloride-acrylamide copolymer) are examples of such cationic polymers.
- Copolymers of vinylpyrrolidone with quaternized derivatives of dialkylamino acrylate and methacrylate, such as, for example, with diethyl sulfate-quaternized vinylpyrrolidone-dimethylamino methacrylate copolymers. Such compounds are available commercially under the designations Gafquat~ 734 and Gafquat~ 755.
- Vinylpyrrolidone-methoimidazolinium chloride copolymers, as offered under the designation Luviquat~ .
- Quaternized polyvinyl alcohol and also polymers known under the designations - Polyquaternium 2 - Polyquaternium 17, - Polyquaternium 18, and ' CA 02313587 2000-07-07 - Polyquaternium 27, having quaternary nitrogen atoms in the polymer main chain. These polymers are designated in accordance with the INCI nomenclature; detailed information can be found in the CTFA International Cosmetic Ingredient Dictionary and Handbook, 5th Edition, The Cosmetic, Toiletry and Fragrance Association, Washington, 1997, which is expressly incorporated herein by reference.
Cationic polymers which are preferred in accordance with the invention are quaternized cellulose derivatives and also polymeric dimethyldiallylammonium salts and copolymers thereof. Cationic cellulose derivatives, especially the commercial product Polymer~
JR 400, are especially preferred cationic polymers.
The capsules of the invention may be used, for example, in pharmaceutical and cosmetic preparations, and in surfactant, laundry detergent, rinse, laundering aid, cleaning product, and textile aftertreatment compositions. It is possible, for example, to provide a laundry detergent and cleaning composition comprising only the capsules of the invention, which are dosed by the user into the washing machine or dishwasher. Of course, it is also possible to add the capsules to an otherwise completely formulated cosmetic composition or to a laundry detergent and cleaning composition in order to give said composition additional utility through the controlled release of certain active substances.
The compositions to which the capsules of the invention are added may be liquid, gellike, pasty, pulverulent or granular, or in the form of compact tablets, with hardly any limits imposed on formulation freedom.
By virtue of the temperature-controlled release mechanism from the capsules of the invention it is possible to attain controlled release of the capsule ingredients, which opens up new performance dimensions to the products.
For example, it is possible to add the capsules of the invention to a particulate detergent for machine dishwashing. In this case the capsules of the invention are designed so that the release of the ingredients is initiated only after cooling of the medium surrounding them (the detergent liquor). On cooling, the medium surrounding the capsule enters the capsule, where it triggers a reaction which at least partially destroys the capsule wall. The duration of this procedure, and thus the time between the cooling of the external medium and the release of the active substances from the capsule, may be varied by way of the thickness of the capsule wall, the physical and/or chemical stability of the capsule wall, the nature of the reaction destroying the capsule wall, and/or the aggressiveness of the ingredients toward the capsule wall following entry of the external medium. For instance, capsules of the invention may be produced which do not release their ingredients in the main wash cycle (and also in optional prewash cycles) in a domestic dishwasher. The main wash cycle is followed by intermediate wash cycles with cold water, so that the external medium enters into the capsule. Appropriate formulation of the capsule ensures that the active substances are not released until the rinse cycle, where they develop their action. Thus, for example, rinse surfactants, acidifying agents or scale inhibitors may be ingredients of the capsules, thereby bringing about a rinse-clean effect. In addition to this chemical formulation, a physical formulation may be necessary depending on the type of dishwasher, so that the capsules of the invention are not pumped off in the machine when the water is changed and hence are no longer available for the rinse cycle. Standard domestic dishwashers, upstream of the detergent-liquor pump, which pumps the water or cleaning solution from the machine after the individual cleaning cycles, comprise a sieve insert, intended to prevent clogging of the pump by food residues. If the user cleans heavily soiled kitchen- and tableware, then this sieve insert requires regular cleaning, which is a simple option owing to the ease of access and removeability.
The capsules of the invention, then, are preferably so designed in terms of their size and shape that they do no pass through the sieve insert of the dishwasher even after the cleaning cycle, i.e., after exposure to agitation in the machine and to the detergent solution.
This ensures that capsules of the invention are present in the dishwasher in the rinse cycle, these capsules releasing the active substances) under the action of the colder water after the main wash cycle, by at least partial destruction of the capsule wall, and so bringing the desired clean-rinse effect. Particulate machine dishwashing compositions that are preferred in the context of the present invention are those wherein the capsules of the invention they comprise have particle sizes of between 1 and 20 mm, preferably between 1.5 and 15 mm, and in particular between 2 and 12 mm.
In particulate dishwashing compositions of this kind, the capsules of the invention, having the sizes stated above, may project from the matrix of the other particulate ingredients; alternatively, the other particles may likewise have sizes within the stated range, so that, overall, a detergent composition is formulated that comprises large detergent particles and capsules. Especially if the capsules of the invention are colored, i.e., have a red, blue, green, or yellow color, for example, it is advantageous for the appearance of the product, i.e. of the overall detergent composition, if the capsules are visibly ' CA 02313587 2000-07-07 larger than the matrix comprising the particles of the other ingredients of the detergent composition. Here, preference is given to particulate machine dishwashing compositions which (not taking into account the capsules) have particle sizes between 200 and 3000 ~,m, preferably between 300 and 2500 ~.m, and in particular between 400 and 2000 ~,m.
If detergent compositions of this kind are formulated as a powder mixture, then - especially if there are large differences between the sizes of capsules and detergent matrix - on the one hand partial separation may occur when the pack is shaken, and on the other hand dosing may be different in two successive washing operations, since the user does not always automatically dose equal quantities of detergent and capsules. If it is desired technically to use an identical amount for each washing operation, this can be realized by the packaging - familiar to the skilled worker, of the compositions of the invention in water-soluble film bags. The present invention also provides particulate machine dishwashing compositions wherein one dose unit is welded in a water-soluble film bag. Of course, other cosmetic or pharmaceutical preparations or laundry detergent and cleaning compositions, such as textile detergents, for example, may also be provided in an entirely analogous manner.
By this means, the user need only insert a bag, containing for example a detergent powder and a plurality of visually distinctive capsules, into the dosing drawer of his or her dishwasher. This embodiment of the present invention is therefore a visually attractive alternative to conventional detergent tablets.
The detergent compositions of the invention may be prepared in conventional manner. A process for preparing pulverulent machine dishwashing compositions with a rinse-clean effect, in which a conventional pulverulent machine dishwashing composition is mixed with capsules of the invention comprising surfactants and/or acidifying agents and/or scale inhibitors, is therefore also provided with the present invention.
The above-described desired retention of the capsules in the machine, even when the water is changed, may be realized not only by the abovementioned enlargement of the capsules but also by a reduction in the size of the holes in the sieve insert . In this way, it is possible for formulate machine dishwashing compositions having a uniform average particle size of less than, for example, from 4 to 12 mm. For this purpose, the product of the invention, in which the capsules as well have relatively low particle sizes, is provided with a sieve insert which replaces or covers the insert present in the machine. The present invention additionally provides a kit of parts comprising a pulverulent machine dishwashing composition of the invention and a sieve insert for domestic dishwashers.
As already mentioned, the novel combination of composition and sieve insert permits the formulation of compositions in which the capsules as well have relatively low particle sizes. Kits of parts of the invention wherein the particle sizes of the machine dishwashing composition (taking into account the capsules) are in the range from 400 to 2500 Vim, preferably from 500 to 1600 ~,m, and in particular from 600 to 1200 ~.m, are preferred.
In order to prevent blockages of the added sieve insert by food residues, the mesh size or hole size chosen should not be too small. Here, preference is given to kits of parts of the invention wherein the mesh size or hole size of the sieve insert is from 1 to 4 mm and the rinse aid particles are larger than this mesh size or hole size of the sieve insert.
The kit of parts of the invention is not restricted to the particular form of the sieve insert in which said insert replaces or covers the insert present in the machine. In accordance with the invention it is also possible and preferred to provide the kit of parts with a sieve insert having the form of a basket which may be hung in a known manner in the dishwasher - on the cutlery basket, for example. In this way, a sieve insert of such design replaces the dispensing cup, i.e., the user doses the machine dishwashing composition of the invention directly into this sieve insert, which acts in the manner described above in the wash and rinse cycles.
The above example was based closely on conditions in standard domestic dishwashers. It is readily evident that, in an entirely analogous manner, pulverulent laundry detergents may be formulated which release, for example, fabric softener active substances only after the main wash cycle, from capsules of the invention comprising such active substances. In the fields of pharmacy, cosmetics, rinsing, and cleaning products in general, as well, in an entirely analogous manner, it is possible to formulate compositions which release the desired active substance from the capsules of the invention.
It is of course also possible to add the capsules of the invention to compact compositions or to incorporate them into them. For example, laundry detergent and cleaning product tablets may be produced which comprise one or more of the capsules of the invention. In this case, the capsules) may be attached either on or in the tablet. The first-mentioned embodiment may be realized, for example, by adhesively bonding one or ' CA 02313587 2000-07-07 more capsules onto a conventionally produced tablet.
The last-mentioned embodiment comprises, for example, the insertion of one or more capsules of the invention into the cavities of pre-produced tablets which have depressions or holes passing through them. Particularly attractive from a visual standpoint is the insertion of a capsule of the invention into a ring-shaped tablet.
Examples Production of capsules for use in machine dishwashing compositions Example 1 The bottom parts of hard gelatin capsules of size 000 (volume 1.37 ml) and those of size 0 (volume 0.68 ml) from the company WEPA were filled with the substances shown in Table 1. Subsequently, the capsules were put together and the top and bottom parts were firmly bonded. The capsules were coated with a basic polyacrylate (Eudragit° E from Rohm), giving a polymer coat with a thickness of between 0.2 and 0.3 mm. The aperture, with a diameter of 0.5 mm, was made in the bottom part of the capsule with the aid of a needle.
Subsequently, the capsule prepared in this way was placed in a glass beaker containing warm water at 20°C.
The water was heated to 65 ° C ( stage I ) ; of ter reaching this temperature, the capsule remained at this temperature for 10 minutes. The capsule was then placed for 5 minutes into water at 35°C (stage II) , which was subsequently heated again to 65°C (stage III). This experimental procedure simulates the temperature/time regime of a universal program at 65°C in a dishwasher.
The ingredients of the individual capsules, and the capsule weight during the procedure and at the end of the experiment, are shown in Table 1 below.
' CA 02313587 2000-07-07 Table 1 Capsule contents AmountCapsule weight fgl InitialStage Stage Stage I II III
Polytergent~1 1.4 1.72 1.65 1.10 -Polytergent~1 (70%);0.7 0.90 ? 0.55 -Citric anhydride/
soda (30%) Polytergent~1 (70%)0.7 0.95 0.80 0.4 -PEG 15502 (15%) citric anhydride/soda (15%) Citric anhydride and soda were used in a weight ratio of 1:1 5 1 Polytergent° SLF-18 B 45: ethylene oxide-propylene oxide block copolymer (alcohol alkoxylate from Olin Chemicals, softening point 25-45°C) Polyethylene glycol with a molecular weight of Example 2 In this example, hard gelatin capsules of size 000 (volume 1.37 ml) from 4AEPA were treated further as follows: the bottom part of the capsules was initially prepared with 80-100 mg of polyethylene glycol (PEG 3000), an inner coating being applied in the region of the capsule end. Subsequently, the bottom part of the capsule was filled with the following composition:
Ingredient Amount [% by weight]
Polytergent~ SLF18B45 74.8 Sulfamic acid 14.0 Cetylstearyl alcohol 11.2 ' CA 02313587 2000-07-07 The amount of contents in the capsules was 1.3 g.
Following the assembly of the capsule, the residual volume of air enclosed in the capsule was 10% of the total volume.
Various coatings were subsequently applied to the capsules, the composition of said coatings being indicated, in % by weight, in the table below.
Ingredient Formulation Formulation Formulation Eudragit~ E 100.0 73.0 -Vitacel~ P 290 - 27.0 53.0 Eudragit~ S 12.5 - - 47.0 P
The following capsules were produced:
Type l: 0.25 mm coat of formulation 2 Type 2: 0.04 mm coat of formulation 1, then 0.15 mm coat of formulation 3 The capsules were subsequently provided with a hole (diameter 0.5 mm) at the capsule end.
The capsules produced in this way were each used together with a tablet-form detergent in a 55°C and a 65°C program in standard commercial dishwashers (Bosch S 712, Miele G 590). The rinse aid tank of the machines was emptied prior to the tests, so that any rinse-clean effects arising are brought about by the capsules of the invention.
Observation over the running time of the different programs revealed no visual changes in the capsules of type 1 and of type 2 during the wash cycle and the intermittent rinsing. During the final rinse cycle, the capsules broke down and the contents were released.
In all of the tests, the rinse-clean effects on glasses, plates and pans were at least equivalent to those found in comparative tests with conventional rinse-aid dosing via the automatic mechanism of the machine.
The invention may be varied in any number of ways as would be apparent to a person skilled in the art and all obvious equivalents and the like are meant to fall within the scope of this description and claims. The description is meant to serve as a guide to interpret the claims and not to limit them unnecessarily.
In one preferred embodiment of the present invention, the component A is a solid acid and one material of the capsule wall is an acid-soluble polymer. Solid or crystalline acids used are preferably those which do not give off any water of crystallization at the process temperatures, examples being sulfamic acid, citric acid, and Na,KHS04. As acidifying agents it is also possible, for example, to use boric acid and also further alkali metal hydrogen sulfates, alkali metal dihydrogen phosphates, and other inorganic salts.
Preference, however, is given to the use of organic acidifying agents, with citric acid being a particularly preferred acidifying agent. The other solid mono-, oligo- and polycarboxylic acids, however, in particular may also be used. Preferred in turn from this group are tartaric acid, succinic acid, malonic acid, adipic acid, malefic acid, fumaric acid, oxalic acid, and polyacrylic acid. Organic sulfonic acids such as sulfamic acid may likewise be used. A commercially available acidifying agent which may likewise be used with preference in the context of the present invention is Sokalan~ DCS (trademark of BASF) , a mixture of succinic acid (max. 31% by weight), glutaric acid (max. 50% by weight), and adipic acid (max. 33% by weight ) .
In another embodiment, the component A is a substance which gives an alkaline reaction with water, and the material of the capsule wall is a polymer which is soluble in the alkaline range. Examples of solid substances which give alkaline reactions in aqueous solution are hydroxides, carbonates, hydrogen carbonates, and/or silicates, preference being given to alkali metal hydroxides, alkali metal carbonates, alkali metal hydrogen carbonates, alkali metal sesquicarbonates, alkali metal silicates, alkali metal metasilicates, and mixtures of the abovementioned substances. For the purposes of this invention, preference is given among the alkali metal salts to the potassium and in particular the sodium salts, especially sodium carbonate, sodium hydrogen carbonate, and sodium sesquicarbonate.
In a further embodiment of the present invention, the release takes place, as already mentioned above, by the formation of gas in the interior of the capsule and subsequent destruction as a result of the overpressure.
In this embodiment, the component A is a substance or a mixture of substances which reacts with the incoming water to form gas. Examples of possible substances are a combination of carbonates, such as alkali metal carbonates and alkali metal hydrogen carbonates, and a solid acid, e.g., citric acid, succinic acid, or one or more of the abovementioned acidifying agents, or cobalt ammine complexes in combination with resorcinol, an example which may be mentioned of an appropriate cobalt ammine complex being [Co (NH3) SCl] C12.
_ g _ A third possible release mechanism for the active substance C is the use of swelling agents as component A. As suitable swelling agents, mention may be made of cellulose and cellulose derivatives, which when water penetrates the capsule swell and lead to destruction and thus to the release of the active substance. Swelling agents, which because of their action are also referred to, inter alia, as disintegrants, increase in volume on ingress of water, with firstly an increase in their own volume (swelling) and secondly the possibility, by way of the release of gases, for the generation of a pressure which bursts the capsule and causes it to break down into relatively small particles. Examples of well-known swelling agents are synthetic polymers such as polyvinylpyrrolidone (PVP) or natural polymers and/or modified natural substances such as cellulose and starch and their derivatives, alginates, or casein derivatives.
Preferred swelling agents used in the context of the present invention are those based on cellulose. Pure cellulose has the formal empirical composition (C6HloOs) n and, considered formally, is a (3-1,4-polyacetal of cellobiose, which itself is constructed of two molecules of glucose. Suitable celluloses consist of from about 500 to 5000 glucose units and, accordingly, have average molecular masses of from 50,000 to 500,000. Cellulose-based swelling agents which may be used also include, in the context of the present invention, cellulose derivatives obtainable by polymer-analogous reactions from cellulose. Such chemically modified celluloses include, for example, products of esterifications and etherifications in which hydroxy hydrogen atoms have been substituted. However, celluloses in which the hydroxy groups have been replaced by functional groups not attached by an oxygen atom may also be used as cellulose derivatives. The group of cellulose derivatives embraces, for example, _ g _ alkali metal celluloses, carboxymethylcellulose (CMC), cellulose esters and cellulose ethers, and amino-celluloses. Said cellulose derivatives are preferably not used alone as cellulose-based disintegrants but instead are used in a mixture with cellulose. The cellulose derivative content of these mixtures is preferably less than 50% by weight, with particular preference less than 20% by weight, based on the cellulose-based swelling agent. The particularly preferred cellulose-based swelling agent used is pure cellulose, free from cellulose derivatives.
The cellulose used as the swelling agent is preferably not incorporated into the capsule in finely divided form but instead is converted before its introduction into a coarser form, by granulation or compaction, for example. The particle sizes of such disintegrants are usually above 200 Vim, preferably between 300 and 1600 ~m to the extent of at least 90% by weight, and~in particular between 400 and 1200 ~m to the extent of at least 90% by weight.
As a further cellulose-based swelling agent, or as a constituent of this component, it is possible to use microcrystalline cellulose. This microcrystalline cellulose is obtained by partial hydrolysis of celluloses under conditions which attack only the amorphous regions (approximately 30% of the total cellulose mass) of the celluloses and break them up completely but leave the crystalline regions (approximately 70%) intact. Subsequent deaggregation of the microfine celluloses resulting from the hydrolysis yields the microcrystalline celluloses, which have primary particle sizes of approximately 5 ~m and may be compacted, for example, to granules having an average particle size of 200 Vim.
One further possible release mechanism for the active substance C is the use of enzymes as component A. These enzymes may, for example, be coated in which case the coating dissolves after slight ingress of water into the capsule interior, after which the enzymes break down the capsule material and thus release the active substance C. Suitable enzymes for use, in dependence on the capsule material, are all common enzymes such as proteases, amylases, cellulases, etc., which may additionally possess a function in the wash or cleaning cycle. These enzymes are described at length later on below.
As active substance C it is possible to use any substances for which controlled release is desired. In the field of drugs, any desired active substances are suitable.
In the laundry detergents and cleaning products, the kind of substances incorporated in capsule form are in particular those which under normal conditions are not stable and/or are intended for use in a later stage of the washing process. Examples of active substances incorporated in the form of capsules into laundry detergents and cleaning products are rinse-aid surfactants, textile treatment compositions (fabric softeners), enzymes, bleaches, bleaching catalysts, bleach activators, optical brighteners, dyes, fragrances, corrosion inhibitors, etc.
The abovementioned rinse-aid surfactants, which are used in particular in the machine washing of kitchen-and tableware, and the textile treatment compositions, such as fabric softener components, which find applica-tion in the laundering of textiles, are components which in machine washing and cleaning processes are not added until a process stage which follows the actual washing operation. Suitable rinse-aid surfactants are all nonionic surfactants, but especially fatty alcohol polyethylene glycol ethers, fatty alcohol polyethylene/polypropylene glycol ethers, mixed ethers and/or hydroxyalkyl polyethylene glycol ethers.
Examples of fatty alcohol polyethylene glycol ethers are those with the formula (I) RIO-{CH2CHZO~,,H (I) to where Rl is a linear or branched alkyl and/or alkenyl radical having 6 to 22, preferably 12 to 18, carbon atoms and nl is numbers from 1 to 5.
Said substances are known commercial products. Typical examples are adducts of on average 2 or 4 mol of ethylene oxide onto technical-grade C12~14 coconut fatty alcohol (Dehydol~ LS-2 and LS-4, respectively, from Henkel KGaA) or adducts of on average 4 mol of ethylene oxide onto C14/ls oxo alcohols (Dobanol~ 45-4, from Shell) . The products may have a conventional or else a narrowed homolog distribution.
Fatty alcohol polyethylene/polypropylene glycol ethers are nonionic surfactants of the formula (II) R'O-(CH2CH20)~2(CHZCHO)r,,iH (II) where R4 is a linear or branched alkyl and/or alkenyl radical having 6 to 22, preferably 12 to 18, carbon atoms, n2 is numbers from 1 to 5 and m2 is numbers from 1 to 4.
These substances are also known commercial products. A
typical example is an adduct of on average 5 mol of ethylene oxide and 4 mol of propylene oxide anto technical-grade C~z/14 coconut fatty alcohol (Dehydol~ LS-54, from Henkel KGaA).
Mixed ethers are endgroup-capped fatty alcohol polyglycol ethers with the formula (III) R50-(CHZCH20~,3(CIiZCHO)",3-R6 (III) where RS is a linear or branched alkyl and/or alkenyl radical having 6 to 22, preferably 12 to 18 carbon atoms, n3 is numbers from 1 to 10, m3 is 0 or numbers from 1 to 4, and R6 is an alkyl radical having 1 to 4 carbon atoms, or a benzyl radical.
Typical examples are mixed ethers of the formula (III) in which RS is a technical-grade C12/14 cocoalkyl radical, n3 is 5 or 10, m3 is 0, and R6 is a butyl group (Dehypon~ LS-54 and LS-104, respectively, from Henkel KGaA). The use of butyl- and/or benzyl-capped mixed ethers is particularly preferable on performance grounds.
Hydroxyalkyl polyethylene glycol ethers are compounds with the general formula (IV) RS -CH-CH-(OCH2CH20)"4-OR2 (IV) where RS is hydrogen or a straight-chain alkyl radical having 1 to 16 carbon atoms, R3 is a straight-chain or branched alkyl radical having 4 to 8 carbon atoms, RZ is hydrogen or an alkyl radical having 1 to 16 carbon atoms, and n4 is a number from 7 to 30, with the proviso that the total number of carbon atoms in RS and R2 is from 6 to 16.
Examples of textile treatment compositions are, in particular, cationic surfactants. Suitable cationic surfactants are all customary surface-active sub-stances, distinct preference being given to cationic surfactants having a textile-softening action.
Such cationic active substances with a textile-softening action are selected with particular preference from those which may be described by one or more of the formulae V, VI or VII:
R' R ~ -N~+~-(CH2)n-T-R2 ( V ) (CHz)~ T-Rz R' R'-N~+~-(CH2)"-CH-CH2 (VI) R' T T
R' R3-N~+'-(CH2)n-T-R' (VU) R°
in which each group Rl independently of the others is selected from C1_6 alkyl, alkenyl or hydroxyalkyl groups; each group R2 independently of the others is selected from Ce_28 alkyl or alkenyl groups; R3 - R1 or (CHz) "-T-R2; R4 - Rl Or Rz Or (CHZ) n-T-R2; T = -CHZ-, -O-CO- or -CO-O-, and n is an integer from 0 to 5.
Enzymes may be incorporated in the form of liquid or solid enzyme preparations into the capsules. Suitable enzymes in this context include in particular those from the classes of the hydrolases such as the proteases, esterases, lipases or lipolytic enzymes, amylases, cellulases, and other glycosyl hydrolases, and mixtures of said enzymes. All of these hydrolases contribute in the wash to removing stains such as proteinaceous, fatty or starchy stains, and instances of graying. Cellulases and other glycosyl hydrolases may, furthermore, by removing pilling and microfibrils, contribute to color retention and to increasing the softness of the textile. For bleaching, and/or for inhibiting color transfer, it is also possible to use oxidoreductases. Especially suitable enzymatic active substances are those obtained from bacterial strains or fungi such as Bacillus subtilis, Bacillus licheni-formis, Streptomyces griseus, Coprinus cinereus, and Humicola insolens, and also from genetically modified variants thereof. Preference is given to the use of proteases of the subtilisin type, and especially to proteases obtained from Bacillus lentus. Of particular interest in this context are enzyme mixtures, examples being those of protease and amylase or protease and lipase or lipolytic enzymes, or of protease and cellulase or of cellulase and lipase or lipolytic enzymes, or of protease, amylase and lipase or lipolytic enzymes, or of protease, lipase or lipolytic enzymes and cellulase, but especially protease and/or lipase-containing mixtures or mixtures with lipolytic enzymes. Examples of such lipolytic enzymes are the known cutinases. Peroxidases or oxidases have also proven suitable in some cases. The suitable amylases include, in particular, alpha-amylases, iso-amylases, pullulanases, and pectinases. Cellulases used are preferably cellobiohydrolases, endoglucanases and -glucosidases, which are also called cellobiases, and mixtures of these. Since different types of cellulase differ in their CMCase and Avicelase activities, the desired activities may be established by means of specific mixtures of the cellulases.
In capsules intended for use in detergents for machine dishwashing, of course, different enzymes are used in order to take account of the different substrates treated and different types of soiling. Suitable enzymes in this context include in particular those from the classes of the hydrolases such as the proteases, esterases, lipases or lipolytic enzymes, amylases, glycosyl hydrolases, and mixtures of said enzymes. All of these hydrolases contribute to removing stains such as proteinaceous, fatty or starchy stains.
For bleaching, it is also possible to use oxidoreductases. Especially suitable enzymatic active substances are those obtained from bacterial strains or fungi such as Bacillus subtilis, Bacillus licheniformis, Streptomyces griseus, Coprinus cinereus, and Humicola insolens, and also from genetically modified variants thereof. Preference is given to the use of proteases of the subtilisin type, and especially to proteases obtained from Bacillus lentus. Of particular interest in this context are enzyme mixtures, examples being those of protease and amylase or protease and lipase or lipolytic enzymes, or of protease, amylase and lipase or lipolytic enzymes, or of protease, lipase or lipolytic enzymes, but especially protease and/or lipase-containing mixtures or mixtures with lipolytic enzymes. Examples of such lipolytic enzymes are the known cutinases. Peroxidases or oxidases have also proven suitable in some cases.
The suitable amylases include, in particular, alpha-amylases, iso-amylases, pullulanases, and pectinases.
The. enzymes may be adsorbed on carrier substances or embedded in coating substances in order to protect them against premature decomposition.
The enzymes are usually prepared in a granulated and encapsulated form and added in that form to the laundry detergent and cleaning product. In liquid cleaning products containing water, these granulated and encapsulated enzymes would dissolve, and so in that case the use of liquid enzyme concentrates is generally preferred. Such liquid enzyme concentrates are based either, homogeneously, on a propylene glycol/water base or, heterogeneously, as slurry, or are present in a microencapsulated structure. The use of liquid enzyme products is likewise possible in the capsules of the invention.
Preferred liquid proteases are, for example, Savinase~ L, Durazyrri L, Esperase~ L, and Everlase~ from Novo Nordisk, Optimase~ L, Purafect~ L, Purafect~ OX L, Properase~ L from Genencor International, and BLAP~ L
from Biozym Ges.m.b.H.
Preferred amylases are Termamyl~ L, Duramyl~ L, and BAN
from Novo Nordisk, Maxamyl~ WL and Purafect~ HPAm L from Genencor International.
Preferred lipases are Lipolase~ L, Lipolase~ ultra L and Lipoprime~ L from Novo Nordisk and Lipomax~ L from Genencor International.
Slurries or microencapsulated liquid products that may be used are, for example, products such as those designated by SL or, respectively, LCC from Novo Nordisk. Said commercial liquid enzyme preparations contain, for example, from 20 to 90% by weight of propylene glycol or of mixtures of propylene glycol and water. Capsules preferred in the context of the present invention are those comprising one or more liquid amylase preparations and/or one or more liquid protease preparations.
Substances from the groups of the bleaches and bleach activators or bleaching catalysts are also suitable as ingredients for the capsules of the invention. Among the compounds used as bleaches which yield H202 in water, particular importance is possessed by sodium percarbonate. Examples of further bleaches which may be used are sodium perborate tetrahydrate and sodium perborate monohydrate, peroxypyrophosphates, citrate perhydrates, and H202-donating peracidic salts or peracids, such as perbenzoates, peroxophthalates, diperazelaic acid, phthaloimino peracid, or diperdo-decanedioic acid. Capsules of the invention for use in cleaning products may also comprise bleaches from the group of the organic bleaches. Typical organic bleaches are the diacyl peroxides, such as dibenzoyl peroxide for example. Further typical organic bleaches are the peroxy acids, particular examples being the alkyl peroxy acids and the aryl peroxy acids. Preferred representatives are (a) peroxybenzoic acid and its ring-substituted derivatives, such as alkylperoxy-benzoic acids, and also peroxy-a-naphthoic acid and magnesium monoperphthalate, (b) aliphatic or sub-stituted aliphatic peroxy acids, such as peroxylauric acid, peroxystearic acid, s-phthalimidoperoxycaproic acid [phthaloiminoperoxyhexanoic acid (PAP)], o-carboxy-benzamidoperoxycaproic acid, N-nonenylamidoperadipic acid, and N-nonenylamidopersuccinates, and (c) aliphatic and araliphatic peroxy dicarboxylic acids, such as 1,12-diperoxycarboxylic acid, 1,9-diperoxyazelaic acid, diperoxysebacic acid, diperoxybrassylic acid, the diperoxyphthalic acids, 2-decyldiperoxybutane-1,4-dioic acid, and N,N-terephthaloyldi(6-aminopercaproic acid) may be used.
Bleaches in the capsules of the invention used in detergents for machine dishwashing may also be substances which release chlorine or bromine. Among the suitable chlorine- or bromine-releasing materials, examples include heterocyclic N-bromoamides and N-chloroamides, examples being trichloroisocyanuric acid, tribromoisocyanuric acid, dibromoisocyanuric acid, and/or dichloroisocyanuric acid (DICA) and/or salts thereof with cations such as potassium and sodium. Hydantoin compounds, such as 1,3-dichloro-5,5-dimethylhydantoin, are likewise suitable.
Bleach activators, which boost the action of the bleaches, may likewise be ingredients in the capsules of the invention. Known bleach activators are compounds containing one or more N-acyl and/or O-acyl groups, such as substances from the class of the anhydrides, esters, imides and acylated imidazoles or oximes.
Examples are tetraacetylethylenediamine TAED, tetra-acetylmethylenediamine TAMD, and tetraacetylhexylene-diamine TAHD, and also pentaacetylglucose PAG, 1,5-diacetyl-2,2-dioxohexahydro-1,3,5-triazine DADHT, and isatoic anhydride ISA.
Bleach activators which may be used are compounds which under perhydrolysis conditions give rise to aliphatic peroxo carboxylic acids having preferably 1 to 10 carbon atoms, in particular 2 to 4 carbon atoms, and/or substituted or unsubstituted perbenzoic acid.
Suitable substances are those which carry O-acyl and/or N-acyl groups of the stated number of carbon atoms, and/or substituted or unsubstituted benzoyl groups.
Preference is given to polyacylated alkylenediamines, especially tetraacetylethylenediamine (TAED), acylated triazine derivatives, especially 1,5-diacetyl-2,4-dioxohexahydro-1,3,5-triazine (DADHT), acylated glycolurils, especially tetraacetyl glycoluril (TAGU), N-acylimides, especially N-nonanoylsuccinimide (NOSI), acylated phenolsulfonates, especially n-nonanoyl- or isononanoyloxybenzenesulfonate (n- or iso-NOBS), carboxylic anhydrides, especially phthalic anhydride, acylated polyhydric alcohols, especially triacetin, ethylene glycol diacetate, 2,5-diacetoxy-2,5-dihydrofuran, N-methylmorpholiniumacetonitrile methyl sulfate (MMA), and the enol esters known from German Patent Applications DE 196 16 693 and DE 196 16 767, and also acetylated sorbitol and mannitol and/or mixtures thereof (SORMAN), acylated sugar derivatives, especially pentaacetylglucose (PAG), pentaacetylfructose, tetraacetylxylose and octaacetyl-lactose, and also acetylated, optionally N-alkylated glucamine and gluconolactone, and/or N-acylated lactams, for example, N-benzoylcaprolactam. Hydro-philically substituted acyl acetals and acyllactams are likewise used with preference. Combinations of conventional bleach activators may also be used. In capsules for machine dishwashing compositions, the bleach activators are usually used in amounts from 0.1 to 20% by weight, preferably from 0.25 to 15% by weight, and in particular from 1 to 10% by weight, based in each case on the total composition.
In addition to the conventional bleach activators, or instead of them, it is also possible to incorporate what are known as bleaching catalysts into the capsules. These substances are bleach-boosting transition metal salts or transition metal complexes such as, for example, Mn-, Fe-, Co-, Ru- or Mo-salen complexes or -carbonyl complexes. Other bleaching catalysts which may be used include Mn, Fe, Co, Ru, Mo, Ti, V and Cu complexes with N-containing tripod ligands, and also Co-, Fe-, Cu- and Ru-ammine complexes.
Preference is given to the use of bleach activators from the group of the polyacylated alkylenediamines, especially tetraacetylethylenediamine (TAED), N-acyl imides, especially N-nonanoylsuccinimide (NOSI), acylated phenolsulfonates, especially n-nonanoyl- or isononanoyloxybenzenesulfonate (n- or iso-NOBS), N-methylmorpholiniumacetonitrile methyl sulfate (MMA), preferably in amounts of up to 10% by weight, in particular from 0.1% by weight to 8% by weight, especially from 2 to 8 % by weight, and with particular preference from 2 to 6% by weight, based on the total composition.
Bleach-boosting transition metal complexes, especially those with the central atoms Mn, Fe, Co, Cu, Mo, V, Ti and/or Ru, preferably selected from the group of manganese and/or cobalt salts and/or complexes, with particular preference cobalt ammine complexes, cobalt acetato complexes, cobalt carbonyl complexes, the chlorides of cobalt or of manganese, and manganese sulfate, are used in customary amounts, preferably in an amount of un to 5% by weicrht. in particular from 0.0025% by weight to 1% by weight, and with particular preference from 0.01% by weight to 0.25% by weight, based in each case on the total composition. In specific cases, however, it is also possible to use a greater amount of bleach activator.
When used in laundry detergents and cleaning products, the capsules of the invention may include corrosion inhibitors for protecting the ware or the machine, with special importance in the field of machine dishwashing being possessed, in particular, by silver protectants.
The known substances of the prior art may be used. In general it is possible to use, in particular, silver protectants selected from the group of the triazoles, benzotriazoles, bisbenzotriazoles, aminotriazoles, alkylaminotriazoles, and transition metal salts or transition metal complexes. Particular preference is given to the use of benzotriazole and/or alkylamino-triazole. Frequently encountered in cleaner formula-tions, furthermore, are agents containing active chlorine, which may significantly reduce corrosion of the silver surface. In chlorine-free cleaners, use is made in particular of oxygen-containing and nitrogen-containing organic redox-active compounds, such as difunctional and trifunctional phenols, e.g., hydroquinone, pyrocatechol, hydroxyhydroquinone, gallic acid, phloroglucinol, pyrogallol and derivatives of these classes of compound. Inorganic compounds in the form of salts and complexes, such as salts of the metals Mn, Ti, Zr, Hf, V, Co and Ce, also find frequent application. Preference is given here to the transition metal salts selected from the group of the manganese and/or cobalt salts and/or complexes, with particular preference cobalt ammine complexes, cobalt acetato complexes, cobalt carbonyl complexes, the chlorides of cobalt or of manganese, and manganese sulfate.
Similarly, zinc compounds may be used to prevent corrosion on the ware.
In shaped laundry detergent and cleaning product bodies which are preferred in the context of the present invention, the capsule comprises silver protectants from the group of the triazoles, benzotriazoles, bisbenzotriazoles, aminotriazoles, alkylaminotriazoles, and transition metal salts or transition metal complexes, with particular preference benzotriazole and/or alkylaminotriazole, in amounts of from 0.01 to 5% by weight, preferably from 0.05 to 4% by weight, and in particular from 0.5 to 3% by weight, based in each case on the weight of the total composition that comprises the capsules.
In order to enhance the esthetic appeal of the capsules or of the compositions that comprise the capsules, the capsules may in whole or in part be colored with appropriate dyes or comprise dyes. Preferred dyes, whose selection presents no difficulties whatsoever to the skilled worker, possess a high level of storage stability and insensitivity to the other ingredients of the compositions, and to light, and possess no pronounced affinity for the substrates treated, such as textile fibers or kitchen- or tableware items, for example, so as not to stain them.
Preference for use in capsules of the invention for textile laundering or for incorporation into textile detergents is given to all colorants which can be oxidatively destroyed in the washing process, and to mixes thereof with suitable blue dyes, known as bluing agents. It has proven advantageous to use colorants which are soluble in water or at room temperature in liquid organic substances. Examples of suitable colorants are anionic colorants, e.g., anionic nitroso dyes. One possible colorant is, for example, naphthol green (Colour Index (CI) Part 1: Acid Green 1; Part 2:
10020) which as a commercial product is available, for example, as Basacid~ Green 970 from BASF, Ludwigshafen, Germany, and also mixtures thereof with suitable blue dyes. Further suitable colorants used include Pigmosol~
Blue 6900 (CI 74160), Pigmosol~ Green 8730 (CI 74260), Basonyl~ Red 545 FL (CI 45170), Sandolan~ Rhodamine EB400 (CI 45100), Basacid~ Yellow 094 (CI 47005), Sicovit~ Patent Blue 85 E 131 (CI 42051), Acid Blue 183 (CAS 12217-22-0, CI Acid Blue 183), Pigment Blue 15 (CI 74160), Supranol~ Blue GLW (CAS 12219-32-8, CI Acid Blue 221), Nylosan~ Yellow N-7GL SGR (CAS 61814-57-1, CI Acid Yellow 218) and/or Sandolan~ Blue (CI Acid Blue 182, CAS 12219-26-0).
In the context of the choice of colorant it must be ensured that the colorants do not have too great an affinity for the textile surfaces, and especially for synthetic fibers. At the same time, it should also be borne in mind when choosing suitable colorants that colorants possess different stabilities with respect to oxidation. The general rule is that water-insoluble colorants are more stable to oxidation than water-soluble colorants. Depending on the solubility and hence also on the oxidation sensitivity, the concentration of the colorant in the laundry detergents or cleaning products varies. With readily water-soluble colorants, e.g., the abovementioned Basacid~ Green, or the likewise abovementioned Sandolan~ Blue, colorant concentrations chosen are typically in the range from a few 10-2 to 10-3 o by weight . In the case of the pigment dyes, which are particularly preferred owing to their brightness but are less readily soluble in water, examples being the abovementioned Pigmosol~ dyes, the appropriate concentration of the colorant in laundry detergents or cleaning products, in contrast, is typically from a few 10-3 to 10-4% by weight.
The capsules of the invention may comprise one or more optical brighteners. These substances, which are also called whiteners, are used in modern laundry detergents because even freshly washed and bleached white laundry has a slight yellow cast. Optical brighteners are organic dyes which convert a part of the invisible W radiation of sunlight into longer-wave blue light.
The emission of this blue light closes the "loophole"
in the light reflected by the textile, so that a textile treated with an optical brightener appears whiter and lighter to the eye. Since the mechanism of action of brighteners necessitates that they attach to the fibers, a distinction is made in accordance with the fibers to be "dyed" between, for example, brighteners for cotton, nylon or polyester fibers. The commercially customary brighteners suitable for incorporation into laundry detergents belong essentially to five structural groups: the stilbene group, the diphenylstilbene group, the coumarin-quinoline group, the diphenylpyrazoline group, and the group involving combination of benzoxazole or benzimidazole with conjugated systems. An overview of current brighteners may be found, for example, in G. Jakobi, A. Ldhr "Detergents and Textile Washing", VCH-Verlag, Weinheim, 1987, pages 94 to 100. Examples of suitable brighteners are salts of 4,4'-bis[(4-anilino-6-morpholino-s-triazin-2-yl)amino]stilbene-2,2'-disulfonic acid or compounds of similar structure which instead of the morpholino group carry a diethanolamino group, a methylamino group, an anilino group, or a 2-methoxyethylamino group. Furthermore, brighteners of the substituted diphenylstyryl type may be present, examples being the alkali metal salts of 4,4'-bis(2-sulfostyryl)biphenyl, 4,4'-bis(4-chloro-3-sulfostyryl)biphenyl, or 4-(4-chlorostyryl)-4'-(2-sulfostyryl)biphenyl. Mixtures of the abovementioned brighteners may also be used.
Fragrances are added to the capsules of the invention in order to enhance the esthetic appeal of the products and to provide the consumer with not only the performance of the product but also a visually and sensorially "typical and unmistakeable" product. Also of importance here is the aspect of the long-lasting fragrancing of textiles or of the delayed release of fragrance, which masks the unpleasant alkali odor when dishwashers are opened. As perfume oils and/or fragrances it is possible to use individual odorant compounds, examples being the synthetic products of the ester, ether, aldehyde, ketone, alcohol, and hydrocarbon types. Odorant compounds of the ester type are, for example, benzyl acetate, phenoxyethyl isobutyrate, p-tert-butylcyclohexyl acetate, linalyl acetate, dimethylbenzylcarbinyl acetate, phenylethyl acetate, linalyl benzoate, benzyl formate, ethyl methylphenylglycinate, allyl cyclohexylpropionate, styrallyl propionate, and benzyl salicylate. The ethers include, for example, benzyl ethyl ether; the aldehydes include, for example, the linear alkanals having 8-18 carbon atoms, citral, citronellal, citronellyloxy-acetaldehyde, cyclamen aldehyde, hydroxycitronellal, lilial and bourgeonal; the ketones include, for example, the ionones, a-isomethylionone and methyl cedryl ketone; the alcohols include anethole, citronellol, eugenol, geraniol, linalool, phenylethyl alcohol, and terpineol; the hydrocarbons include primarily the terpenes such as limonene and pinene.
Preference, however, is given to the use of mixtures of different odorants, which together produce an appealing fragrance note. Such perfume oils may also contain natural odorant mixtures, as obtainable from plant sources, examples being pine oil, citrus oil, jasmine oil, patchouli oil, rose oil or ylang-ylang oil.
Likewise suitable are clary sage oil, camomile oil, clove oil, balm oil, mint oil, cinnamon leaf oil, lime blossom oil, juniperberry oil, vetiver oil, olibanum oil, galbanum oil and labdanum oil, and also orange blossom oil, neroliol, orange peel oil, and sandalwood oil.
The fragrance content of the capsules of the invention or of the compositions comprising the capsules is usually up to 2% by weight of the overall formulation.
The fragrances may be incorporated directly into the capsules or compositions of the invention;
alternatively, it may be advantageous to apply the fragrances to carriers which intensify the adhesion of the perfume on the laundry and, by means of slower fragrance release, ensure long-lasting fragrance of the textiles. Materials which have become established as such carriers are, for example, cyclodextrins, it being possible for the cyclodextrin-perfume complexes to be additionally coated with further auxiliaries.
In addition, the capsules may also comprise components which have a positive influence on the ease with which oil and grease are washed off from textiles (these components being known as soil repellents). This effect becomes particularly marked when a textile is soiled that has already been laundered previously a number of times with a detergent of the invention comprising this oil- and fat-dissolving component. The preferred oil-and fat-dissolving components include, for example, nonionic cellulose ethers such as methylcellulose and methylhydroxypropylcellulose having a methoxy group content of from 15 to 30% by weight and a hydroxypropyl group content of from 1 to 15% by weight, based in each case on the nonionic cellulose ether, and also the prior art polymers of phthalic acid and/or terephthalic acid, and/or derivatives thereof, especially polymers of ethylene terephthalates and/or polyethylene glycol terephthalates or anionically and/or nonionically modified derivatives thereof. Of these, particular preference is given to the sulfonated derivatives of phthalic acid polymers and of terephthalic acid polymers.
Foam inhibitors which may be present in the capsules of the invention are suitably, for example, soaps, paraffins or silicone oils, which may if desired have been applied to carrier materials.
Graying inhibitors have the function of keeping the dirt detached from the fiber in suspension in the liquor and so preventing the redeposition of the dirt.
Suitable for this purpose are water-soluble colloids, usually organic in nature, examples being the water-soluble salts of polymeric carboxylic acids, glue, gelatin, salts of ethersulfonic acids of starch or of cellulose, or salts of acidic sulfuric esters of cellulose or of starch. Water-soluble polyamides containing acidic groups are also suitable for this purpose. Furthermore, soluble starch preparations and starch products other than those mentioned above may be used, examples being degraded starch, aldehyde starches, etc. Polyvinylpyrrolidone may also be used.
Preference, however, is given to the use of cellulose ethers such as carboxymethylcellulose (Na salt), methylcellulose, hydroxyalkylcellulose, and mixed ethers such as methylhydroxyethylcellulose, methyl-hydroxypropylcellulose, methylcarboxymethylcellulose and mixtures thereof in amounts of from 0.1 to 5% by weight, based on the compositions.
Since sheetlike textile structures, especially those of filament rayon, viscose rayon, cotton and blends thereof, may tend to crease because the individual fibers are susceptible to bending, buckling, compressing and pinching transverse to the fiber direction, the capsules may comprise synthetic crease control agents. These include, for example, synthetic products based on fatty acids, fatty acid esters, fatty acid amides, fatty acid alkylol esters, fatty acid alkylolamides, or fatty alcohols, which are usually reacted with ethylene oxide, or else products based on lecithin or on modified phosphoric esters.
In order to combat microorganisms, the capsules of the invention may comprise antimicrobial active substances.
In this context a distinction is made, depending on antimicrobial spectrum and mechanism of action, between bacteriostats and bactericides, fungiostats and fungicides, etc. Examples of important substances from these groups are benzalkonium chlorides, alkylaryl-sulfonates, halophenols, and phenylmercuric acetate, it also being possible to do without these compounds entirely.
In order to prevent unwanted changes to the compositions and/or the treated textiles or substrates as a result of oxygen exposure and other oxidative processes, the capsules may comprise antioxidants. This class of compound includes, for example, substituted phenols, hydroquinones, pyrocatechols and aromatic amines, and also organic sulfides, polysulfides, dithiocarbamates, phosphates, and phosphonates.
Increased wear comfort may result from the additional use of antistats which are further added to the capsules of the invention. Antistats increase the surface conductivity and thus enable better dissipation of charges that are formed. External antistats are generally substances having at least one hydrophilic molecule ligand, and provide a more or less hygroscopic film on the surfaces. These antistats, which are usually surface-active, may be subdivided into nitrogen-containing (amines, amides, quaternary ammonium compounds), phosphorus-containing (phosphoric esters), and sulfur-containing (alkylsulfonates, alkyl sulfates) antistats. External antistats are described, for example, in Patent Applications FR 1,156,513, GB
873 214 and GB 839 407. The lauryl- (or stearyl-)dimethylbenzylammonium chlorides disclosed here are suitable as antistats for textiles and as additives to laundry detergents, in which case, additionally, a hand effect is obtained.
In order to improve the water absorption capacity, the rewettability of the treated textiles, and to facilitate ironing of the treated textiles, silicone derivatives, for example, may be used in the capsules of the invention used to treat laundry. These derivatives additionally improve the rinse-out behavior of the compositions, by virtue of their foam-inhibiting properties. Examples of preferred silicone derivatives are polydialkylsiloxanes or alkylarylsiloxanes where the alkyl groups have one to five carbon atoms and are totally or partially fluorinated. Preferred silicones are polydimethylsiloxanes, which may if desired have been derivatized and in that case are amino-functional or quaternized, or have Si-OH, Si-H and/or Si-C1 bonds.
The viscosities of the preferred silicones at 25°C are in the range between 100 and 100,000 centistokes, it being possible to use the silicones in amounts of between 0.2 and 5% by weight, based on the overall composition.
Finally, the capsules of the invention for textile detergents may also comprise UV absorbers, which attach to the treated textiles and improve the light stability of the fibers. Compounds which have these desired properties are, for example, the compounds which are active via radiationless deactivation, and derivatives of benzophenone having substituents in positions) 2 and/or 4. Also suitable are substituted benzotriazoles, acrylates which are phenyl-substituted in position 3 (cinnamic acid derivatives), with or without cyano groups in position 2, salicylates, organic Ni com-plexes, and also natural substances such as umbelliferone and the endogenous urocanic acid.
It is of course also possible to incorporate further ingredients of laundry detergents and cleaning products, examples being builders, cobuilders, further surfactants, especially anionic surfactants, etc., into the capsules of the invention. The incorporation of any pharmaceutical or cosmetic active substance is also possible without problems, so that the advantages of the controlled release may be utilized in a very wide variety of fields of use with the aid of the capsules of the invention.
As component B it is possible to use any desired gas compatible with the other components in the capsule.
Examples are air, NZ, O2, noble gases and noble gas mixtures, and C02.
The capsules of the invention may be produced in various ways. One possibility is to fill prefabricated capsule parts comprising the abovementioned materials with components A and C and then to fit the capsule parts together. Prefabricated capsule parts are available commercially in the form of so-called hard capsules. The amount of the gas component B is determined by the amount of components A and C
introduced. If the capsule parts are filled in air, then the gas component is air. Where a gas other than air is to be used as the gas component, filling generally takes place under the corresponding gas atmosphere.
After the capsule has been sealed, it is provided with the aperture, usually by means of a pointed article with the appropriate diameter. Alternatively, use may also be made of capsule shells which have already been perforated beforehand.
A further mode of production consists in the preparation of soft capsules. This takes place industrially by the so-called Scherer process. In this process, two strips of the capsule wall materials (e. g., gelatin strips) are combined in counter-rotating shaping rolls, with capsule shaping and capsule filling taking place simultaneously. The capsule aperture may in this case be made during the capsule shaping/filling process, or else in a downstream process step.
As already mentioned, in order to obtain the stated properties of the capsule wall it may be sensible or necessary to apply one or more layers of further wall materials to the capsules. This can be done, for example, by means of immersion processes, film coating, or in the fluidized bed process.
It is also possible to produce microcapsules of the invention which allow the release mechanism. In this case it is possible to have recourse to the common production processes, followed by the making of one or more microholes.
Appropriate capsule materials are, as already mentioned, polymers in particular. The materials mentioned earlier on above, such as carrageenan, guar, pectin, xanthan, cellulose and its derivatives, and gelatin, are described below.
Carrageenan is a formed extract, with a composition similar to that of agar, of North Atlantic red algae which belong to the Florideae, and is named for the Irish coastal town of Carragheen. The carrageenan, precipitated from the hot-water extract of the algae, is a colorless to sandy-colored powder having molecular masses of 100,000-800,000 and a sulfate content of approximately 25%, which is very readily soluble in warm water. In carrageenan, three principal con-stituents are distinguished: the gel-forming K fraction consists of D-galactose 4-sulfate and 3,6-anhydro-a-D-galactose, having alternate glycoside linkages in the 1,3 and 1,4 positions (agar, in contrast, contains 3,6-anhydro-a-L-galactose). The non-gelling ~, fraction is composed of D-galactose 2-sulfate with 1,3-glycoside linkages and of D-galactose 2,6-Bisulfate residues with 1,4 linkages, and is readily soluble in cold water.
1-Carrageenan, composed of D-galactose 4-sulfate in 1,3 linkage and 3,6-anhydro-a-D-galactose 2-sulfate in 1,4 linkage, is both water-soluble and gel-forming.
Further types of carrageenan are likewise labeled with Greek letters: a, Vii, y, ~, v, ~, ~, cu, x. The nature of cations present (K, NH4, Na, Mg, Ca) also influences the solubility of the carrageenans. Semisynthetic products which contain only one ionic type and are likewise possible for use in capsule materials in the context of the present invention are also called carrag(h)eenates.
The guar which may be used as a capsule material in the context of the present invention, also called guar gum, is a grayish white powder obtained by milling the endosperm of the guar bean (Cyamopsis tetragonobolus), which belongs to the family of the Leguminosae and was originally endemic in the Indian and Pakistani region but has since been cultivated in other countries as well, for example, in the southern USA. The principal constituent of guar, with up to about 85% by weight of the dry matter, is guaran (guar gum, Cyamopsis gum);
secondary constituents are proteins, lipids, and cellulose. Guaran itself is a polygalactomannan, i.e., a polysaccharide whose linear chain is composed of unsubstituted mannose units (see formula VIII) and mannose units substituted in the C6 position by a galactose residue (see formula IX) in (3-D-(1~4) linkage.
OH CHZOH
Galactose > O
HO
HO
CH20H O gCH2 OH
OH
SOHO ~~ .~- Mannose --~. ~ HO
g 2 1 VIII IX
The ratio of VIII:IX is approximately 2:1; the IX
units, in contrast to what was originally assumed, are not strictly alternating but are instead arranged in pairs or triplets in the polygalactomannan molecule.
Data on the molecular mass of guaran vary with values of approximately 2.2105-2.2106 g/mol, depending on the degree of purity of the polysaccharide - the high value was determined on a highly purified product -significantly and correspond to approximately 1350-13,500 sugar units/macromolecule. Guaran is insoluble in the majority of organic solvents.
The pectins, which are likewise suitable for use as capsule material, are high molecular mass glycosidic plant substances which are very widespread in fruits, roots, and leaves. Pectins consist essentially of chains of 1,4-a-glycosidically linked galacturonic acid units with 20-80% of their acid groups esterified with methanol, a distinction being made between high-esterification (>50%) and low-esterification (<50%) pectins. The pectins have a folded leaf structure which positions them in the center between starch and cellulose molecules. Their macromolecules also contain some glucose, galactose, xylose and arabinose, and have weakly acidic properties.
_O~O O O.
OH OH r OH OH
.O ~0 ~O
OH COOCH3 OH ~COOGH3 Fruit pectin contains 95%, beet pectin up to 85%
galacturonic acid. The molecular masses of the various pectins vary between 10,000 and 500,000. The structural properties as well are highly dependent on the degree of polymerization; for example, the fruit pectins in the dried state form asbestoslike fibers while the flax pectins form fine, granular powders.
The pectins are prepared by extraction with dilute acids predominantly from the inner portions of citrus fruit peels, fruit residues, or sugar beet chips.
Xanthan may also be used as a capsule material in accordance with the invention. Xanthan is a microbial anionic heteropolysaccharide produced by Xanthomonas campestris and certain other species under aerobic conditions, having a molecular mass of from 2 to 15 million daltons. Xanthan is formed of a chain comprising (3-1,4-linked glucose (cellulose) with side chains. The structure of the subgroups comprises glucose, mannose, glucuronic acid, acetate, and pyruvate, the viscosity of the xanthan being determined by the number of pyruvate units. Xanthan may be described by the following formula:
O O' n OH O v -O
~ n O
OH
HO
M'~ COO-O O
O OH
M'' - OOC O O
OH HO OH M+ = Na,K,ll2 Ca HsC O
Basic unit of xanthan The celluloses and their derivatives have already been described above as capsule ingredients. The capsules may of course also be produced from such materials. In addition to cellulose and cellulose derivatives, it is also possible to use (modified) dextrins, starch, and starch derivatives as capsule materials.
Suitable nonionic organic capsule materials are dextrins, examples being oligomers and polymers of carbohydrates obtainable by partial hydrolysis from starches. The hydrolysis may be conducted in accordance with customary processes - for example, acid- or enzyme-catalyzed processes. The products in question are preferably hydrolysis products having average molecular masses in the range from 400 to 500,000 g/mol. Preference is given to a polysaccharide having a dextrose equivalent (DE) in the range from 0.5 to 40, in particular from from 2 to 30, DE being a customary measure of the reducing action of a polysaccharide in comparison with dextrose, which possesses a DE of 100. Dextrins suitable for use include not only maltodextrins having a DE of between 3 and 20 and dry glucose syrups having a DE of between 20 and 37 but also what are known as yellow dextrins and white dextrins having higher molecular masses in the range from 2000 to 30,000 g/mol.
The oxidized derivatives of such dextrins comprise the reaction products with oxidizing agents capable of oxidizing at least one alcohol function of the saccharide ring to the carboxylic acid function.
Oxidized dextrins of this kind and processes for preparing them are known, for example, from European Patent Applications EP-A-0 232 202, EP-A-0 427 349, EP-A-0 472 042 and EP-A-0 542 496 and International Patent Applications WO 92/18542, WO 93/08251, WO 93/16110, WO 94/28030, WO 95/07303, WO 95/12619 and WO 95/20608. Likewise suitable is an oxidized oligosaccharide in accordance with German Patent Application DE-A-196 00 018. A product oxidized at C6 of the saccharide ring may be particularly advantageous.
Starch as well may be used as capsule material for the capsules of the invention. Starch is a homoglycan in which the glucose units are linked a-glycosidically.
Starch is composed of two components of different molecular weight: approximately 20-30% straight-chain amylose (MW approx. 50,000-150,000) and 70-80%
branched-chain amylopectin (MW approx. 300,000-2,000,000), with small amounts of lipids, phosphoric acids, and cations being present as well. Whereas amylose forms long, helical, interlooped chains comprising approximately 300-1200 glucose molecules, owing to the 1,4 linkage, in the case of amylopectin the chain branches by 1,6 linkage, after on average 25 glucose units, to form a treelike structure comprising approximately 1500-12,000 molecules of glucose. In addition to straight starch, starch derivatives obtainable by polymer-analogous reactions from starch are also suitable for preparing capsules in the context of present invention. Examples of such chemically modified starches include products of esterifications and etherifications in which hydroxy hydrogen atoms have been substituted. Alternatively, starches in which the hydroxy groups have been replaced by functional groups not attached via an oxygen atom may be used as starch derivatives. The group of the starch derivatives includes, for example, alkali metal starches, carboxymethylstarch (CMS), starch esters and ethers, and amino starches.
Among the proteins and modified proteins, gelatin is of outstanding significance as capsule material. Gelatin is a polypeptide (molecular mass: approx. 15,000->250,000 g/mol) obtained principally by hydrolysis under acidic or alkaline conditions of the collagen present in the skin and bones of animals. The amino acid composition of gelatin corresponds largely to that of the collagen from which it was obtained, and varies as a function of its provenance. The use of gelatin as a water-soluble envelope material is extremely wide-spread, especially in pharmacy, in the form of hard or soft gelatin capsules.
Further polymers suitable for use as capsule materials are synthetic polymers, which are preferably water-swellable and/or water-soluble. These polymers hail in particular from the following groups:
a) water-soluble nonionic polymers from the group of al) polyvinylpyrrolidones a2) vinylpyrrolidone-vinyl ester copolymers a3) cellulose ethers a4) (modified) polyvinyl alcohols b) water-soluble amphoteric polymers from the group of bl) alkylacrylamide-acrylic acid copolymers b2) alkylacrylamide-methacrylic acid copolymers b3) alkylacrylamide-methylmethacrylic acid copolymers b4) alkylacrylamide-acrylic acid-alkylaminoalkyl-(meth)acrylic acid copolymers b5) alkylacrylamide-methacrylic acid-alkylamino-alkyl(meth)acrylic acid copolymers b6) alkylacrylamide-methylmethacrylic acid-alkyl-aminoalkyl(meth)acrylic acid copolymers b7) alkylacrylamide-alkyl methacrylate-alkylamino-ethyl methacrylate-alkyl methacrylate copolymers b8) copolymers of b8i) unsaturated carboxylic acid b8ii) cationically derivatized unsaturated carboxylic acids b8iii) if desired, further ionic or nonionic monomers c) water-soluble zwitterionic polymers from the group of cl) acrylamidoalkyltrialkylammonium chloride-acrylic acid copolymers and their alkali metal and ammonium salts c2) acrylamidoalkyltrialkylammonium chloride-methacrylic acid copolymers and their alkali metal and ammonium salts c3) methacroylethyl betaine-methacrylate copolymers d) water-soluble anionic polymers from the group of dl) vinyl acetate-crotonic acid copolymers d2) vinylpyrrolidone-vinyl acrylate copolymers d3) acrylic acid-ethyl acrylate-N-tert-butylacryl-amide terpolymers d4) graft polymers of vinyl esters, esters of acrylic acid or methacrylic acid alone or in a mixture, copolymerized with crotonic acid, acrylic acid or methacrylic acid with poly-alkylene oxides and/or polyalkylene glycols d5) grafted and crosslinked copolymers from the copolymerization of d5i) at least one monomer of the nonionic tYPe, d5ii) at least one monomer of the ionic type, d5iii) polyethylene glycol, and d5iv) a crosslinker d6) copolymers obtained by copolymerizing at least one monomer from each of the three following groups:
d6i) esters of unsaturated alcohols and short-chain saturated carboxylic acids and/or esters of short-chain saturated alcohols and unsaturated carboxylic acids, d6ii) unsaturated carboxylic acids, d6iii) esters of long-chain carboxylic acids and unsaturated alcohols and/or esters of the carboxylic acids of group d6ii) with saturated or unsaturated, straight-chain or branched C$_la alcohol d7) terpolymers of crotonic acid, vinyl acetate and an allyl or methallyl ester d8) tetra- and pentapolymers of d8i) crotonic acid or allyloxyacetic acid d8ii) vinyl acetate or vinyl propionate d8iii) branched allyl or methallyl esters d8iv) vinyl ethers, vinyl esters or straight-chain allyl or methallyl esters d9) crotonic acid copolymers with one or more monomers from the group consisting of ethylene, vinylbenzene, vinyl methyl ether, acrylamide and water-soluble salts thereof d10) terpolymers of vinyl acetate, crotonic acid and vinyl esters of a saturated aliphatic a-branched monocarboxylic acid e) water-soluble cationic polymers from the group of el) quaternized cellulose derivatives e2) polysiloxanes with quaternary groups e3) cationic guar derivatives e4) polymeric dimethyldiallylammonium salts and their copolymers with esters and amides of acrylic acid and methacrylic acid e5) copolymers of vinylpyrrolidone with quater-nized derivatives of dialkylaminoacrylate and -methacrylate e6) vinylpyrrolidone-methoimidazolinium chloride copolymers e7) quaternized polyvinyl alcohol e8) polymers indicated under the INCI designations Polyquaternium 2, Polyquaternium 17, Poly-quaternium 18, and Polyquaternium 27.
Water-soluble polymers in the sense of the invention are those polymers which are soluble to the extent of more than 2.5% by weight at room temperature in water.
The capsules of the invention may be prepared from individual polymers of those mentioned above;
alternatively, mixtures or multi-layer laminar constructions of the polymers may be used. The polymers are described in more detail below.
Water-soluble polymers which are preferred in accordance of the invention are nonionic. Examples of suitable nonionic polymers are the following:
polyvinylpyrrolidones, as marketed, for example, under the designation Luviskol~ (BASF). Polyvinyl-pyrrolidones are preferred nonionic polymers in the context of the invention.
Polyvinylpyrrolidones [poly(1-vinyl-2-pyrrolidin-ones)], abbreviated PVP, are polymers of the general formula (X) CH ~ CH2 N
~O
prepared by free-radical addition polymerization of 1-vinylpyrrolidone by processes of solution or suspension polymerization using free-radical initiators (peroxides, azo compounds). The ionic polymerization of the monomer yields only products having low molecular masses. Commercially customary polyvinylpyrrolidones have molecular masses in the range from approx. 2500-750,000 g/mol, which are characterized by stating the K values and - depending on the K value - have glass transition temperatures of 130-175°. They are supplied as white, hygroscopic powders or as aqueous solutions.
Polyvinylpyrrolidones are readily soluble in water and a large number of organic solvents (alcholos, ketones, glacial acetic acid, chlorinated hydrocarbons, phenols, etc) .
- Vinylpyrrolidone-vinyl ester copolymers, as marketed for example under the trademark Luviskol~
(BASF). Luviskol~ VA 64 and Luviskol~ VA 73, each vinylpyrrolidone-vinyl acetate copolymers, are particularly preferred nonionic polymers.
The vinyl ester polymers are polymers obtainable from vinyl esters and featuring the grouping of the formula (XI) O' R
(XI) as the characteristic basic structural unit of the macromolecules. Of these, the vinyl acetate polymers (R = CH3) with polyvinyl acetates, as by far the most important representatives, have the greatest industrial significance .
The vinyl esters are polymerized free-radically by various processes (solution polymerization, suspension polymerization, emulsion polymerization, and bulk polymerization). Copolymers of vinyl acetate with vinylpyrrolidone comprise monomer units of the formulae (I) and (II) - Cellulose ethers, such as hydroxypropylcellulose, hydroxyethylcellulose and methylhydroxypropyl-cellulose, as marketed for example under the trademarks Culminal~ and Benecel~ (AQUALON).
Cellulose ethers may be described by the general formula (XII) RocH2 oR
_o o Ro o_ Ro o d (XII), where R is H or an alkyl, alkenyl, alkynyl, aryl, or alkylaryl radical. In preferred products, at least one R in formula (XII) is -CHZCH2CH2-OH or -CH2CH2-OH. Cellulose ethers are prepared industrially by etherifying alkali metal cellulose (e.g., with ethylene oxide). Cellulose ethers are characterized by way of the average degree of substitution, DS, and/or by the molar degree of substitution, MS, which indicate how many hydroxyl groups of an anhydroglucose unit of cellulose have reacted with the etherifying reagent or how many moles of the etherifying reagent have been added on, on average, to one anhydroglucose unit.
Hydroxyethylcelluloses are water-soluble above a DS
of approximately 0.6 and, respectively, an MS of approximately 1. Commercially customary hydroxyethyl- and hydroxypropylcelluloses have degrees of substitution in the range of 0.85-1.35 (DS) and 1.5-3 (MS), respectively. Hydroxyethyl-and -propylcelluloses are marketed as yellowish white, odorless and tasteless powders in greatly varying degrees of polymerization. Hydroxyethyl-and -propylcelluloses are soluble in cold and hot water and in some (water-containing) organic solvents, but insoluble in the majority of (anhydrous) organic solvents; their aqueous solutions are relatively insensitive to changes in pH or addition of electrolyte.
Polyvinyl alcohols, denoted PVAL for short, are polymers of the general structure (-CHZ-CH(OH)-J"
including small fractions of structural units of the [-CH2-CH(OH)-CH(OH}-CH2]
type. Since the corresponding monomer, the vinyl alcohol, is unstable in free form, polyvinyl alcohols are prepared by way of polymer-analogous reactions by hydrolysis, but industrially in particular by alkali-catalyzed transesterification of polyvinyl acetates with alcohols (preferably methanol) in solution. These industrial processes also make it possible to obtain PVALs having a predeterminable residual fraction of acetate groups.
Commercially customary PVAL (e. g., Mowiol~ grades from Hoechst) are commercialized as yellowish white powders or granules having degrees of polymerization in the range of approx. 500-2500 (corresponding to molecular masses of approximately 20,000-100,000 g/mol) and have different degrees of hydrolysis of 98-99 or 87-89 mol%.
They are, therefore, partially hydrolyzed polyvinyl acetates having a residual acetyl group content of approximately 1-2 or 11-13 mol%.
The water-solubility of PVAL may be reduced by after-treatment with aldehydes (acetalization), by complexing with Ni salts or Cu salts, or by treatment with dichromates, boric acid and/or borax, and so adjusted to desired levels.
Further polymers suitable in accordance with the invention are water-soluble amphopolymers. The generic term amphopolymers embraces amphoteric polymers, i.e., polymers whose molecule includes both free amino groups and free -COOH or S03H groups and are capable of forming inner salts; zwitterionic polymers whose molecule contains quaternary ammonium groups and -COO-OR -S03- groups, and polymers containing -COOH or S03H
groups and quaternary ammonium groups. An example of an amphopolymer which may be used in accordance with the invention is the acrylic resin obtainable under the designation Amphomer~, which constitutes a copolymer of tert-butylaminoethyl methacrylate, N-(1,1,3,3-tetra-methylbutyl)acrylamide, and two or more monomers from the group consisting of acrylic acid, methacrylic acid and their simple esters. Likewise preferred amphopolymers are composed of unsaturated carboxylic acids (e. g., acrylic and methacrylic acid), cationically derivatized unsaturated carboxylic acids, (e. g., acrylamidopropyltrimethylammonium chloride), and, if desired, further ionic or nonionic monomers, as evident, for example, from German Laid-Open Specification 39 29 973 and the prior art cited therein. Terpolymers of acrylic acid, methyl acrylate and methacrylamidopropyltrimonium chloride, as avail-able commercially under the designation Merquat~ 2001 N, are particularly preferred ampho-polymers in accordance with the invention. Further suitable amphoteric polymers are, for example, the octylacrylamide-methyl methacrylate-tert-butylamino-ethyl methacrylate-2-hydroxypropyl methacrylate copolymers available under the designations Amphomer~
and Amphomer~ LV-71 (DELFT NATIONAL).
Examples of suitable zwitterionic polymers are the addition polymers disclosed in German Patent Applications DE 39 29 973, DE 21 50 557, DE 28 17 369 and DE 37 08 451. Acrylamidopropyltrimethylammonium chloride-acrylic acid or -methacrylic acid copolymers and their alkali metal salts and ammonium salts are preferred zwitterionic polymers. Further suitable zwitterionic polymers are methacryloylethyl betaine-methacrylate copolymers, which are obtainable com-mercially under the designation Amersette~ (AMERCHOL).
Anionic polymers that are suitable in accordance with the invention include:
- vinyl acetate-crotonic acid copolymers, as in commercialized, for example, under the designation Resyn~ (NATIONAL STARCH), Luviset~ (BASF) and Gafset~ (GAF) .
' CA 02313587 2000-07-07 In addition to monomer units of the above formula (II), these polymers also have monomer units of the general formula (IV) [-CH(CH3)-CH(COOH)-]" (IV) - Vinylpyrrolidone-vinyl acrylate copolymers, obtain-able for example under the trademark Luviflex~
(BASF). A preferred polymer is the vinyl-pyrrolidone-acrylate terpolymer obtainable under the designation LuvifleX VBM-35 (BASF).
- Acrylic acid-ethyl acrylate-N-tert-butylacrylamide terpolymers, which are marketed for example under the designation Ultrahold~ strong (BASF).
- Graft polymers of vinyl esters, esters of acrylic acid or methacrylic acid alone or in a mixture, copolymerized with crotonic acid, acrylic acid or methacrylic acid with polyalkylene oxides and/or polyalkylene glycols Such grafted polymers of vinyl esters, esters of acrylic acid or methacrylic acid alone or in a mixture with other copolymerizable compounds onto polyalkylene glycols are obtained by polymerization under hot conditions in homogeneous phase, by stirring the polyalkylene glycols into the monomers of the vinyl esters, esters of acrylic acid or methacrylic acid, in the presence of free-radical initiators.
Vinyl esters which have been found suitable are, for example, vinyl acetate, vinyl propionate, vinyl butyrate, vinyl benzoate, and esters of acrylic acid or methacrylic acid which have been found suitable are those obtainable with low molecular weight aliphatic alcohols, i.e., in particular, ethanol, propanol, isopropanol, 1-butanol, 2-butanol, 2-methyl-1-propanol, 2-methyl-2-propanol, 1-pentanol, 2-pentanol, 3-pentanol, 2,2-dimethyl-1-propanol, 3-methyl-1-butanol; 3-methyl-2-butanol, 2-methyl-2-butanol, 2-methyl-1-butanol, and 1-hexanol.
Suitable polyalkylene glycols include in particular polyethylene glycols and polypropylene glycols.
Polyethylene glycols are polymers of ethylene glycol which satisfy the general formula XIII
H-(O-CHZ-CH2)~-OH (XIII) in which n may adopt values between 1 (ethylene glycol) and several thousand. For polyethylene glycols there exist various nomenclatures, which may lead to confusion. It is common in the art to state the average relative molecular weight after the letters "PEG", so that "PEG 200" characterizes a polyethylene glycol having a relative molecular mass of from about 190 to about 210. For cosmetic ingredients, a different nomenclature is used, in which the abbreviation PEG is provided with a hyphen and the hyphen is followed directly by a number which corresponds to the number n in the abovementioned formula XIII. According to this nomenclature (known as the INCI nomenclature, CTFA
International Cosmetic Ingredient Dictionary and Handbook, 5th Edition, The Cosmetic, Toiletry and Fragrance Association, Washington, 1997), for example, 3 0 PEG- 4 , PEG- 6 , PEG- 8 , PEG- 9 , PEG-10 , PEG-12 , PEG-14 , and PEG-16 may be used. Polyethylene glycols are available commercially, for example, under the trade names Carbowax~ PEG 200 (Union Carbide), Emkapol~ 200 (ICI
Americas), Lipoxol~ 200 MED (HtJLS America), Polyglycol~
E-200 (Dow Chemical), Alkapol~ PEG 300 (Rhone-Poulenc), Lutrol~ E300 (BASF), and the corresponding trade names with higher numbers.
' CA 02313587 2000-07-07 Polypropylene glycols (abbreviation PPGs) are polymers of propylene glycol which satisfy the general formula XIV
H-(O-CH-CH2)"OH (XIV) in which n may adopt values between 1 (propylene glycol) and several thousand. Industrially significant in this case are, in particular, di-, tri- and tetrapropylene glycol, i.e., the representatives where n = 2, 3 and 4 in formula VI.
In particular, it is possible to use the vinyl acetate copolymers grafted onto polyethylene glycols and the polymers of vinyl acetate and crotonic acid grafted onto polyethylene glycols.
- Grafted and crosslinked copolymers from the copolymerization of i) at least one monomer of the nonionic type, ii) at least one monomer of the ionic type, iii) polyethylene glycol, and iv) a crosslinker The polyethylene glycol used has a molecular weight of between 200 and several million, preferably between 300 and 30,000.
The nonionic monomers may be of very different types and include the following preferred monomers: vinyl acetate, vinyl stearate, vinyl laurate, vinyl propionate, allyl stearate, allyl laurate, diethyl maleate, allyl acetate, methyl methacrylate, cetyl vinyl ether, stearyl vinyl ether, and 1-hexene.
The nonionic monomers may equally be of very different types, among which particular preference is given to the presence in the graft polymers of crotonic acid, allyloxyacetic acid, vinylacetic acid, malefic acid, acrylic acid, and methacrylic acid.
Preferred crosslinkers are ethylene glycol dimeth-acrylate, diallyl phthalate, ortho-, meta- and para-divinylbenzene, tetraallyloxyethane, and polyallyl-saccharoses containing 2 to 5 allyl groups per molecule of saccharin.
The above-described grafted and crosslinked copolymers are formed preferably of:
i) from 5 to 85% by weight of at least one monomer of the nonionic type, ii) from 3 to 80% by weight of at least one monomer of the ionic type, iii) from 2 to 50% by weight, preferably from 5 to 30%
by weight, of polyethylene glycol, and iv) from 0.1 to 8% by weight of a crosslinker, the percentage of the crosslinker being shaped by the ratio of the overall weights of i), ii) and iii).
- Copolymers obtained by copolymerizing at least one monomer from each of the three following groups:
i) esters of unsaturated alcohols and short-chain saturated carboxylic acids and/or esters of short-chain saturated alcohols and unsaturated carboxylic acids, ii) unsaturated carboxylic acids, iii) esters of long-chain carboxylic acids and unsaturated alcohols and/or esters of the carboxylic acids of group ii) with saturated ' CA 02313587 2000-07-07 or unsaturated, straight-chain or branched C$_18 alcohols Short-chain carboxylic acids and alcohols here are those having 1 to 8 carbon atoms, it being possible for the carbon chains of these compounds to be interrupted, if desired, by divalent hetero-groups such as -O-, -NH-, and -S-.
- Terpolymers of crotonic acid, vinyl acetate, and an allyl or methallyl ester These terpolymers contain monomer units of the general formulae (II) to (IV) (see above) and also monomer units of one or more allyl or methallyl esters of the formula XV:
R' R3 RZ-C-C(O)-O-CHz-C=CHZ (XV) in which R3 is -H or -CH3, R2 is -CH3 or -CH (CH3) 2 and Rl is -CH3 or a saturated straight-chain or branched Cl_s alkyl radical and the sum of the carbon atoms in the radicals R1 and R2 is preferably 7, 6, 5, 4, 3 or 2.
The abovementioned terpolymers result preferably from the copolymerization of from 7 to 12% by weight of crotonic acid, from 65 to 86% by weight, preferably from 71 to 83 % by weight, of vinyl acetate and from 8 to 20% by weight, preferably from 10 to 17% by weight, of allyl or methallyl esters of the formula XV.
- Tetra- and pentapolymers of i) crotonic acid or allyloxyacetic acid ii) vinyl acetate or vinyl propionate iii) branched allyl or methallyl esters iv) vinyl ethers, vinyl esters or straight-chain allyl or methallyl esters - Crotonic acid copolymers with one or more monomers from the group consisting of ethylene, vinylbenzene, vinyl methyl ether, acrylamide and the water-soluble salts thereof - Terpolymers of vinyl acetate, crotonic acid and vinyl esters of a saturated aliphatic a-branched monocarboxylic acid.
Particularly appropriate capsule materials among the anionic polymers are polycarboxylates/polycarboxylic acids, polymeric polycarboxylates, polyaspartic acid, polyacetals, and dextrins, which are described below.
Examples of organic capsule materials which may be used are the polycarboxylic acids which may be used in the form of their sodium salts but also in free form.
Polymeric polycarboxylates are, for example, the alkali metal salts of polyacrylic acid or of polymethacrylic acid, examples being those having a relative molecular mass of from 500 to 70,000 g/mol.
The molecular masses reported for polymeric poly-carboxylates, for the purposes of this document, are weight-average molecular masses, MW, of the respective acid form, determined fundamentally by means of gel permeation chromatography (GPC) using a W detector.
Measurement was made against an external polyacrylic acid standard, which owing to its structural similarity to the polymers under investigation provides realistic molecular weight values. These figures differ markedly from the molecular weight values obtained using polystyrenesulfonic acids as the standard. The molecular masses measured against polystyrenesulfonic acids are generally much higher than the molecular masses reported in this document.
Suitable polymers are, in particular, polyacrylates, which preferably have a molecular mass of from 2000 to 20,000 g/mol. Owing to their superior solubility, preference in this group may be given in turn to the short-chain polyacrylates, which have molecular masses of from 2000 to 10,000 g/mol, and with particular preference from 3000 to 5000 g/mol.
Also suitable are copolymeric polycarboxylates, especially those of acrylic acid with methacrylic acid and of acrylic or methacrylic acid with malefic acid.
Copolymers which have been found particularly suitable are those of acrylic acid with malefic acid, containing from 50 to 90% by weight acrylic acid and from 50 to 10% by weight malefic acid. Their relative molecular mass, based on free acids, is generally from 2000 to 70,000 g/mol, preferably from 20,000 to 50,000 g/mol, and in particular from 30,000 to 40,000 g/mol.
In order to improve the solubility in water, the polymers may also contain allylsulfonic acids, such as allyloxybenzenesulfonic acid and methallylsulfonic acid, for example, as monomers.
Particular preference as capsule materials is also given to biodegradable polymers comprising more than two different monomer units, examples being those comprising, as monomers, salts of acrylic acid and of malefic acid, and also vinyl alcohol or vinyl alcohol derivatives, or those comprising, as monomers, salts of acrylic acid and of 2-alkylallylsulfonic acid, and also sugar derivatives.
Further preferred copolymeric capsule materials are those described in German Patent Applications DE-A-43 03 320 and DE-A-44 17 734, whose monomers are preferably acrolein and acrylic acid/acrylic salts, and, respectively, acrolein and vinyl acetate.
Similarly, further preferred capsule materials that may be mentioned include polymeric amino dicarboxylic acids, their salts or their precursor substances.
Particular preference is given to polyaspartic acids and their salts and derivatives.
Further suitable capsule materials are polyacetals, which may be obtained by reacting dialdehydes with polyol carboxylic acids having 5 to 7 carbon atoms and at least 3 hydroxyl groups. Preferred polyacetals are obtained from dialdehydes such as glyoxal, glutar aldehyde, terephthalaldehyde and mixtures thereof and from polyol carboxylic acids such as gluconic acid and/or glucoheptonic acid.
Further polymers which may be used with preference as capsule materials are cationic polymers. Among the cationic polymers, the permanently cationic polymers are preferred. "Permanently cationic" refers according to the invention to those polymers which independently of the pH of the composition (i.e., both of the capsule and of the remaining composition that may be present) have a cationic group. These are generally polymers which include a quaternary nitrogen atom, in the form of an ammonium group, for example.
Examples of preferred cationic polymers are the following:
Quaternized cellulose derivatives, as available commercially under the designations Celquat~ and Polymer JR~. The compounds Celquat~ H 100, Celquat~
' CA 02313587 2000-07-07 L 200 and Polymer JR 400 are preferred quaternized cellulose derivatives.
- Polysiloxanes with quaternary groups, such as, for example, the commercially available products Q2-7224 (manufacturer: Dow Corning; a stabilized trimethylsilylamodimethicone), Dow Corning~ 929 emulsion (comprising a hydroxyl-amino-modified silicone, also referred to as amodimethicone), SM-2059 (manufacturer: General Electric), SLM-55067 (manufacturer: blacker), and Abil~-Quat 3270 and 3272 (manufacturer: Th. Goldschmidt; diquaternary polydimethylsiloxanes, Quaternium-80), - Cationic guar derivatives, such as in particular the products marketed under the trade names Cosmedia~ Guar and Jaguar~, - Polymeric dimethyldiallylammonium salts and their copolymers with esters and amides of acrylic acid and methacrylic acid. The products available commercially under the designations Merquat~ 100 (poly(dimethyldiallylammonium chloride)) and Merquat~ 550 (dimethyldiallylammonium chloride-acrylamide copolymer) are examples of such cationic polymers.
- Copolymers of vinylpyrrolidone with quaternized derivatives of dialkylamino acrylate and methacrylate, such as, for example, with diethyl sulfate-quaternized vinylpyrrolidone-dimethylamino methacrylate copolymers. Such compounds are available commercially under the designations Gafquat~ 734 and Gafquat~ 755.
- Vinylpyrrolidone-methoimidazolinium chloride copolymers, as offered under the designation Luviquat~ .
- Quaternized polyvinyl alcohol and also polymers known under the designations - Polyquaternium 2 - Polyquaternium 17, - Polyquaternium 18, and ' CA 02313587 2000-07-07 - Polyquaternium 27, having quaternary nitrogen atoms in the polymer main chain. These polymers are designated in accordance with the INCI nomenclature; detailed information can be found in the CTFA International Cosmetic Ingredient Dictionary and Handbook, 5th Edition, The Cosmetic, Toiletry and Fragrance Association, Washington, 1997, which is expressly incorporated herein by reference.
Cationic polymers which are preferred in accordance with the invention are quaternized cellulose derivatives and also polymeric dimethyldiallylammonium salts and copolymers thereof. Cationic cellulose derivatives, especially the commercial product Polymer~
JR 400, are especially preferred cationic polymers.
The capsules of the invention may be used, for example, in pharmaceutical and cosmetic preparations, and in surfactant, laundry detergent, rinse, laundering aid, cleaning product, and textile aftertreatment compositions. It is possible, for example, to provide a laundry detergent and cleaning composition comprising only the capsules of the invention, which are dosed by the user into the washing machine or dishwasher. Of course, it is also possible to add the capsules to an otherwise completely formulated cosmetic composition or to a laundry detergent and cleaning composition in order to give said composition additional utility through the controlled release of certain active substances.
The compositions to which the capsules of the invention are added may be liquid, gellike, pasty, pulverulent or granular, or in the form of compact tablets, with hardly any limits imposed on formulation freedom.
By virtue of the temperature-controlled release mechanism from the capsules of the invention it is possible to attain controlled release of the capsule ingredients, which opens up new performance dimensions to the products.
For example, it is possible to add the capsules of the invention to a particulate detergent for machine dishwashing. In this case the capsules of the invention are designed so that the release of the ingredients is initiated only after cooling of the medium surrounding them (the detergent liquor). On cooling, the medium surrounding the capsule enters the capsule, where it triggers a reaction which at least partially destroys the capsule wall. The duration of this procedure, and thus the time between the cooling of the external medium and the release of the active substances from the capsule, may be varied by way of the thickness of the capsule wall, the physical and/or chemical stability of the capsule wall, the nature of the reaction destroying the capsule wall, and/or the aggressiveness of the ingredients toward the capsule wall following entry of the external medium. For instance, capsules of the invention may be produced which do not release their ingredients in the main wash cycle (and also in optional prewash cycles) in a domestic dishwasher. The main wash cycle is followed by intermediate wash cycles with cold water, so that the external medium enters into the capsule. Appropriate formulation of the capsule ensures that the active substances are not released until the rinse cycle, where they develop their action. Thus, for example, rinse surfactants, acidifying agents or scale inhibitors may be ingredients of the capsules, thereby bringing about a rinse-clean effect. In addition to this chemical formulation, a physical formulation may be necessary depending on the type of dishwasher, so that the capsules of the invention are not pumped off in the machine when the water is changed and hence are no longer available for the rinse cycle. Standard domestic dishwashers, upstream of the detergent-liquor pump, which pumps the water or cleaning solution from the machine after the individual cleaning cycles, comprise a sieve insert, intended to prevent clogging of the pump by food residues. If the user cleans heavily soiled kitchen- and tableware, then this sieve insert requires regular cleaning, which is a simple option owing to the ease of access and removeability.
The capsules of the invention, then, are preferably so designed in terms of their size and shape that they do no pass through the sieve insert of the dishwasher even after the cleaning cycle, i.e., after exposure to agitation in the machine and to the detergent solution.
This ensures that capsules of the invention are present in the dishwasher in the rinse cycle, these capsules releasing the active substances) under the action of the colder water after the main wash cycle, by at least partial destruction of the capsule wall, and so bringing the desired clean-rinse effect. Particulate machine dishwashing compositions that are preferred in the context of the present invention are those wherein the capsules of the invention they comprise have particle sizes of between 1 and 20 mm, preferably between 1.5 and 15 mm, and in particular between 2 and 12 mm.
In particulate dishwashing compositions of this kind, the capsules of the invention, having the sizes stated above, may project from the matrix of the other particulate ingredients; alternatively, the other particles may likewise have sizes within the stated range, so that, overall, a detergent composition is formulated that comprises large detergent particles and capsules. Especially if the capsules of the invention are colored, i.e., have a red, blue, green, or yellow color, for example, it is advantageous for the appearance of the product, i.e. of the overall detergent composition, if the capsules are visibly ' CA 02313587 2000-07-07 larger than the matrix comprising the particles of the other ingredients of the detergent composition. Here, preference is given to particulate machine dishwashing compositions which (not taking into account the capsules) have particle sizes between 200 and 3000 ~,m, preferably between 300 and 2500 ~.m, and in particular between 400 and 2000 ~,m.
If detergent compositions of this kind are formulated as a powder mixture, then - especially if there are large differences between the sizes of capsules and detergent matrix - on the one hand partial separation may occur when the pack is shaken, and on the other hand dosing may be different in two successive washing operations, since the user does not always automatically dose equal quantities of detergent and capsules. If it is desired technically to use an identical amount for each washing operation, this can be realized by the packaging - familiar to the skilled worker, of the compositions of the invention in water-soluble film bags. The present invention also provides particulate machine dishwashing compositions wherein one dose unit is welded in a water-soluble film bag. Of course, other cosmetic or pharmaceutical preparations or laundry detergent and cleaning compositions, such as textile detergents, for example, may also be provided in an entirely analogous manner.
By this means, the user need only insert a bag, containing for example a detergent powder and a plurality of visually distinctive capsules, into the dosing drawer of his or her dishwasher. This embodiment of the present invention is therefore a visually attractive alternative to conventional detergent tablets.
The detergent compositions of the invention may be prepared in conventional manner. A process for preparing pulverulent machine dishwashing compositions with a rinse-clean effect, in which a conventional pulverulent machine dishwashing composition is mixed with capsules of the invention comprising surfactants and/or acidifying agents and/or scale inhibitors, is therefore also provided with the present invention.
The above-described desired retention of the capsules in the machine, even when the water is changed, may be realized not only by the abovementioned enlargement of the capsules but also by a reduction in the size of the holes in the sieve insert . In this way, it is possible for formulate machine dishwashing compositions having a uniform average particle size of less than, for example, from 4 to 12 mm. For this purpose, the product of the invention, in which the capsules as well have relatively low particle sizes, is provided with a sieve insert which replaces or covers the insert present in the machine. The present invention additionally provides a kit of parts comprising a pulverulent machine dishwashing composition of the invention and a sieve insert for domestic dishwashers.
As already mentioned, the novel combination of composition and sieve insert permits the formulation of compositions in which the capsules as well have relatively low particle sizes. Kits of parts of the invention wherein the particle sizes of the machine dishwashing composition (taking into account the capsules) are in the range from 400 to 2500 Vim, preferably from 500 to 1600 ~,m, and in particular from 600 to 1200 ~.m, are preferred.
In order to prevent blockages of the added sieve insert by food residues, the mesh size or hole size chosen should not be too small. Here, preference is given to kits of parts of the invention wherein the mesh size or hole size of the sieve insert is from 1 to 4 mm and the rinse aid particles are larger than this mesh size or hole size of the sieve insert.
The kit of parts of the invention is not restricted to the particular form of the sieve insert in which said insert replaces or covers the insert present in the machine. In accordance with the invention it is also possible and preferred to provide the kit of parts with a sieve insert having the form of a basket which may be hung in a known manner in the dishwasher - on the cutlery basket, for example. In this way, a sieve insert of such design replaces the dispensing cup, i.e., the user doses the machine dishwashing composition of the invention directly into this sieve insert, which acts in the manner described above in the wash and rinse cycles.
The above example was based closely on conditions in standard domestic dishwashers. It is readily evident that, in an entirely analogous manner, pulverulent laundry detergents may be formulated which release, for example, fabric softener active substances only after the main wash cycle, from capsules of the invention comprising such active substances. In the fields of pharmacy, cosmetics, rinsing, and cleaning products in general, as well, in an entirely analogous manner, it is possible to formulate compositions which release the desired active substance from the capsules of the invention.
It is of course also possible to add the capsules of the invention to compact compositions or to incorporate them into them. For example, laundry detergent and cleaning product tablets may be produced which comprise one or more of the capsules of the invention. In this case, the capsules) may be attached either on or in the tablet. The first-mentioned embodiment may be realized, for example, by adhesively bonding one or ' CA 02313587 2000-07-07 more capsules onto a conventionally produced tablet.
The last-mentioned embodiment comprises, for example, the insertion of one or more capsules of the invention into the cavities of pre-produced tablets which have depressions or holes passing through them. Particularly attractive from a visual standpoint is the insertion of a capsule of the invention into a ring-shaped tablet.
Examples Production of capsules for use in machine dishwashing compositions Example 1 The bottom parts of hard gelatin capsules of size 000 (volume 1.37 ml) and those of size 0 (volume 0.68 ml) from the company WEPA were filled with the substances shown in Table 1. Subsequently, the capsules were put together and the top and bottom parts were firmly bonded. The capsules were coated with a basic polyacrylate (Eudragit° E from Rohm), giving a polymer coat with a thickness of between 0.2 and 0.3 mm. The aperture, with a diameter of 0.5 mm, was made in the bottom part of the capsule with the aid of a needle.
Subsequently, the capsule prepared in this way was placed in a glass beaker containing warm water at 20°C.
The water was heated to 65 ° C ( stage I ) ; of ter reaching this temperature, the capsule remained at this temperature for 10 minutes. The capsule was then placed for 5 minutes into water at 35°C (stage II) , which was subsequently heated again to 65°C (stage III). This experimental procedure simulates the temperature/time regime of a universal program at 65°C in a dishwasher.
The ingredients of the individual capsules, and the capsule weight during the procedure and at the end of the experiment, are shown in Table 1 below.
' CA 02313587 2000-07-07 Table 1 Capsule contents AmountCapsule weight fgl InitialStage Stage Stage I II III
Polytergent~1 1.4 1.72 1.65 1.10 -Polytergent~1 (70%);0.7 0.90 ? 0.55 -Citric anhydride/
soda (30%) Polytergent~1 (70%)0.7 0.95 0.80 0.4 -PEG 15502 (15%) citric anhydride/soda (15%) Citric anhydride and soda were used in a weight ratio of 1:1 5 1 Polytergent° SLF-18 B 45: ethylene oxide-propylene oxide block copolymer (alcohol alkoxylate from Olin Chemicals, softening point 25-45°C) Polyethylene glycol with a molecular weight of Example 2 In this example, hard gelatin capsules of size 000 (volume 1.37 ml) from 4AEPA were treated further as follows: the bottom part of the capsules was initially prepared with 80-100 mg of polyethylene glycol (PEG 3000), an inner coating being applied in the region of the capsule end. Subsequently, the bottom part of the capsule was filled with the following composition:
Ingredient Amount [% by weight]
Polytergent~ SLF18B45 74.8 Sulfamic acid 14.0 Cetylstearyl alcohol 11.2 ' CA 02313587 2000-07-07 The amount of contents in the capsules was 1.3 g.
Following the assembly of the capsule, the residual volume of air enclosed in the capsule was 10% of the total volume.
Various coatings were subsequently applied to the capsules, the composition of said coatings being indicated, in % by weight, in the table below.
Ingredient Formulation Formulation Formulation Eudragit~ E 100.0 73.0 -Vitacel~ P 290 - 27.0 53.0 Eudragit~ S 12.5 - - 47.0 P
The following capsules were produced:
Type l: 0.25 mm coat of formulation 2 Type 2: 0.04 mm coat of formulation 1, then 0.15 mm coat of formulation 3 The capsules were subsequently provided with a hole (diameter 0.5 mm) at the capsule end.
The capsules produced in this way were each used together with a tablet-form detergent in a 55°C and a 65°C program in standard commercial dishwashers (Bosch S 712, Miele G 590). The rinse aid tank of the machines was emptied prior to the tests, so that any rinse-clean effects arising are brought about by the capsules of the invention.
Observation over the running time of the different programs revealed no visual changes in the capsules of type 1 and of type 2 during the wash cycle and the intermittent rinsing. During the final rinse cycle, the capsules broke down and the contents were released.
In all of the tests, the rinse-clean effects on glasses, plates and pans were at least equivalent to those found in comparative tests with conventional rinse-aid dosing via the automatic mechanism of the machine.
The invention may be varied in any number of ways as would be apparent to a person skilled in the art and all obvious equivalents and the like are meant to fall within the scope of this description and claims. The description is meant to serve as a guide to interpret the claims and not to limit them unnecessarily.
Claims (10)
1. A capsule for the controlled release of an active substance, comprising (A) a substance apt to destroy the capsule wall by means of reaction with the capsule material and/or with a further substance, (B) a gas which under storage conditions does not react with the contents of the capsule, and (C) the active substance, the capsule wall having an aperture for the emergence of the components present therein.
2. The capsule as claimed in claim 1, wherein the material used for the capsule wall is an acid-soluble, alkali-soluble or water-soluble polymer or a polymer which softens at relatively high temperatures.
3. The capsule as claimed in claim 1 or 2, wherein the aperture in the capsule wall has a size of up to 1 mm.
4. The capsule as claimed in any of claims 1 to 3, wherein component A is selected from crystalline acids and/or bases, from components or mixtures which in reaction with water form a gas, and/or from substances which are swellable in water.
5. The capsule as claimed in any of claims 1 to 4, wherein said gas is selected from air, N2, O2, and CO2.
6. The use of the capsule as claimed in any of claims 1 to 5 in machine cleaning compositions for cleaning textiles and hard surfaces.
7. The use as claimed in claim 6, wherein the active substance is selected from rinse-aid surfactants, textile treatment compositions (fabric softeners), enzymes, bleaches, bleaching catalysts, bleach activators, and/or optical brighteners.
8. The use as claimed in claim 7, wherein said rinse-aid surfactants are selected from nonionic surfactants, preferably selected from the group of fatty alcohol polyethylene glycol ethers, fatty alcohol polyethylene/polypropylene glycol ethers, mixed ethers and/or hydroxyalkyl polyethylene glycol ethers.
9. The use of the capsule as claimed in any of claims 1 to 5 for delivering cosmetic or pharmaceutical active substances.
10. The use as claimed in claim 6, wherein kitchenware and tableware are cleaned.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19931399.7 | 1999-07-07 | ||
DE1999131399 DE19931399A1 (en) | 1999-07-07 | 1999-07-07 | Capsule for the controlled release of active substances |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2313587A1 true CA2313587A1 (en) | 2001-01-07 |
Family
ID=7913969
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA 2313587 Abandoned CA2313587A1 (en) | 1999-07-07 | 2000-07-07 | Capsule for controlled release of active substances |
Country Status (4)
Country | Link |
---|---|
AU (1) | AU5820900A (en) |
CA (1) | CA2313587A1 (en) |
DE (1) | DE19931399A1 (en) |
WO (1) | WO2001004255A1 (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015054067A1 (en) * | 2013-10-07 | 2015-04-16 | Monosol Llc | Water-soluble delayed release capsules, related methods, and related articles |
JP2017500376A (en) * | 2013-10-07 | 2017-01-05 | モノソル リミテッド ライアビリティ カンパニー | Water soluble delayed release capsules, related methods and related articles |
CN109777634A (en) * | 2019-01-25 | 2019-05-21 | 关汉杰 | A kind of chance Water blown capsule and preparation method thereof |
WO2023126913A1 (en) * | 2021-12-29 | 2023-07-06 | Sterokem Ltd | A soluble detergent unit |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10019344A1 (en) | 2000-04-18 | 2001-11-08 | Cognis Deutschland Gmbh | Detergents and cleaning agents |
CA2406174A1 (en) * | 2000-04-26 | 2001-11-01 | Colgate-Palmolive Company | Wash cycle unit dose softener |
EP1149893B1 (en) * | 2000-04-26 | 2010-12-15 | Colgate-Palmolive Company | Wash cycle unit dose softener |
DE60129427T3 (en) | 2000-05-11 | 2014-07-24 | The Procter & Gamble Company | HIGHLY CONCENTRATED LAUNDRY SPRAY COMPOSITIONS AND COMPOUNDS CONTAINING THEM |
US6946501B2 (en) | 2001-01-31 | 2005-09-20 | The Procter & Gamble Company | Rapidly dissolvable polymer films and articles made therefrom |
GB2375768B (en) * | 2001-05-25 | 2004-02-18 | Reckitt Benckiser Nv | Encapsulated liquid detergent compositions |
DE102004062704B4 (en) * | 2004-12-21 | 2007-09-13 | Henkel Kgaa | Process for the preparation of a portioned washing or cleaning agent |
KR20150054910A (en) | 2012-09-07 | 2015-05-20 | 레킷트 벵키저 엔.브이. | Packaged detergent composition |
FR3123330A1 (en) * | 2021-05-25 | 2022-12-02 | Unilever Ip Holdings B.V. | Packaging containing water-soluble capsules |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT862247A (en) * | 1968-03-29 | |||
US4675174A (en) * | 1985-08-16 | 1987-06-23 | Alza Corporation | Veterinary dispenser delivering beneficial agent by gas power generated in situ |
US5429822A (en) * | 1992-03-13 | 1995-07-04 | Cambridge Scientific, Inc. | Biodegradable bursting release system |
US5441660A (en) * | 1993-11-12 | 1995-08-15 | Lever Brothers Company | Compositions comprising capsule comprising oil surrounding hydrophobic or hydrophilic active and polymeric shell surrounding oil |
-
1999
- 1999-07-07 DE DE1999131399 patent/DE19931399A1/en not_active Withdrawn
-
2000
- 2000-06-28 WO PCT/EP2000/005996 patent/WO2001004255A1/en active Application Filing
- 2000-06-28 AU AU58209/00A patent/AU5820900A/en not_active Abandoned
- 2000-07-07 CA CA 2313587 patent/CA2313587A1/en not_active Abandoned
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015054067A1 (en) * | 2013-10-07 | 2015-04-16 | Monosol Llc | Water-soluble delayed release capsules, related methods, and related articles |
JP2016540836A (en) * | 2013-10-07 | 2016-12-28 | モノソル リミテッド ライアビリティ カンパニー | Water soluble delayed release capsules, related methods and related articles |
JP2017500376A (en) * | 2013-10-07 | 2017-01-05 | モノソル リミテッド ライアビリティ カンパニー | Water soluble delayed release capsules, related methods and related articles |
US9670437B2 (en) | 2013-10-07 | 2017-06-06 | Monosol, Llc | Water-soluble delayed release capsules, related methods, and related articles |
US9670440B2 (en) | 2013-10-07 | 2017-06-06 | Monosol, Llc | Water-soluble delayed release capsules, related methods, and related articles |
CN109777634A (en) * | 2019-01-25 | 2019-05-21 | 关汉杰 | A kind of chance Water blown capsule and preparation method thereof |
WO2023126913A1 (en) * | 2021-12-29 | 2023-07-06 | Sterokem Ltd | A soluble detergent unit |
Also Published As
Publication number | Publication date |
---|---|
WO2001004255A1 (en) | 2001-01-18 |
DE19931399A1 (en) | 2001-01-11 |
AU5820900A (en) | 2001-01-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US7786027B2 (en) | Functionalized substrates comprising perfume microcapsules | |
ES2279467T3 (en) | COMPARTMENT DROPPED SOLID CONTAINING A PORTION OF DETERGENT, CLEANING PRODUCT OR CLEANER. | |
EP1299517B2 (en) | Dishwasher agent with additional uses | |
US20080064623A1 (en) | Multiphase laundry detergent and cleaning product shaped bodies having noncompressed parts | |
US20020010123A1 (en) | Laundry detergents and cleaning products | |
JP2007534808A (en) | Process for producing cleaning products or products for cleaning | |
JP2003504491A (en) | Packaging of laundry detergent / dishwasher detergent | |
CA2313587A1 (en) | Capsule for controlled release of active substances | |
CN102695491A (en) | Perfumes and perfume encapsulates | |
AU779119B2 (en) | Composition for use in a dishwasher | |
WO2003099985A2 (en) | Tablet portions which can be dosed in a rinsing chamber | |
DE10062582A1 (en) | Compacted particulate detergent for use in dishwasher or textile washing machines has active substance-containing cavity lined with a polymeric film | |
WO2001005929A1 (en) | Detergent moulded bodies and lined cleansing agents | |
ES2277865T5 (en) | Portions of laundry agent, rinse agent or cleaning agent with enzyme-controlled active ingredient release | |
WO2006114184A1 (en) | Detergent and cleanser dosing unit | |
DE19941266B4 (en) | Molded body with specially shaped cavity, process for its preparation and washing and cleaning process using this molding | |
DE19939992A1 (en) | Detergent tablets, useful in domestic washing machine or automatic dishwasher, have pressed part with cavity (partly) enclosing solid part and also (partly) filled with active substance | |
DE20022229U1 (en) | Dishwasher detergent with additional benefits | |
DE10233832A1 (en) | Detergent tablets useful in dishwashing machines include a cationic nitrile contained in a cavity sealed with a film | |
EP1081218A2 (en) | Shaped body with a specially shaped cavity filler | |
DE10314441A1 (en) | Bleach activator compounds | |
CA2327453A1 (en) | Laundry detergents and cleaning products | |
DE10314442A1 (en) | Detergent portions, especially for automatic dishwasher, contain cationic, quaternized aminoacetonitrile in deep-drawn, cast or injection molded, water-soluble or water-dispersible container, | |
DE10243819A1 (en) | Detergent portions, especially for automatic dishwasher, contain cationic, quaternized aminoacetonitrile in deep-drawn, cast or injection molded, water-soluble or water-dispersible container, | |
WO2004029187A1 (en) | Dishwasher compositions (mgsm) provided with specially formulated bleach activators (iii) |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Dead |