CA2312808A1 - A device for examining respiratory diseases, and diagnostic agents - Google Patents

A device for examining respiratory diseases, and diagnostic agents Download PDF

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Publication number
CA2312808A1
CA2312808A1 CA002312808A CA2312808A CA2312808A1 CA 2312808 A1 CA2312808 A1 CA 2312808A1 CA 002312808 A CA002312808 A CA 002312808A CA 2312808 A CA2312808 A CA 2312808A CA 2312808 A1 CA2312808 A1 CA 2312808A1
Authority
CA
Canada
Prior art keywords
diagnostic agents
metabolic capacity
conjunction
present
determining
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002312808A
Other languages
French (fr)
Other versions
CA2312808C (en
Inventor
Peter Krumbiegel
Rainer Kobrich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Helmholtz Zentrum fuer Umweltforschung GmbH UFZ
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2312808A1 publication Critical patent/CA2312808A1/en
Application granted granted Critical
Publication of CA2312808C publication Critical patent/CA2312808C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/497—Physical analysis of biological material of gaseous biological material, e.g. breath

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Food Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)

Abstract

The invention relates to a device which can be used in conjunction with a conventional analysis system for diagnosing the metabolic capacity of the respiratory tracts. The device enables specific quantities of suitable diagnostic agents to be added to the inspired air and after a certain time span, can be used to collect metabolites of the diagnostic agents present in the expired air and/or the diagnostic agent itself if still present. Conventional analysis systems are then used to identify the substances which have been expired and collected and determine the quantities present (e.g. using mass spectrometry, gas chromatography, GC-MS-MS, HPL-MS, isotope analysis). Conclusions can then be drawn as to the state of health of the respiratory tract organs. The invention also relates to diagnostic agents which can be used for determining the metabolic capacity of the respiratory tract epithelium, and which are used especially advantageously in conjunction with the inventive device, and to an analytical chemical method for determining the metabolic capacity of the bronchial epithelium.
CA002312808A 1997-12-03 1998-11-19 A device for examining respiratory diseases, and diagnostic agents Expired - Fee Related CA2312808C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19755471A DE19755471A1 (en) 1997-12-03 1997-12-03 Device for examining respiratory diseases and diagnostic means
DE19755471.7 1997-12-03
PCT/EP1998/007549 WO1999028743A1 (en) 1997-12-03 1998-11-19 Device for investigating respiratory tract diseases and diagnostic agents

Publications (2)

Publication Number Publication Date
CA2312808A1 true CA2312808A1 (en) 1999-06-10
CA2312808C CA2312808C (en) 2008-01-15

Family

ID=7851811

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002312808A Expired - Fee Related CA2312808C (en) 1997-12-03 1998-11-19 A device for examining respiratory diseases, and diagnostic agents

Country Status (5)

Country Link
EP (1) EP1036322B1 (en)
AT (1) ATE237805T1 (en)
CA (1) CA2312808C (en)
DE (2) DE19755471A1 (en)
WO (1) WO1999028743A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2451249A (en) * 2007-07-24 2009-01-28 Equine Healthcare Ltd A breath condensate collector

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10125415A1 (en) * 2001-05-25 2002-11-28 Fischer Analysen Instr Gmbh Apparatus for the measurement of respiratory gases converts exhaled air into the correct composition of breathing air using a non-dispersive infra red spectroscope
DE10137564A1 (en) * 2001-07-30 2003-02-27 Filt Lungen Und Thoraxdiagnost Screening for drugs in a human or animal, comprises taking the condensation from exhaled breath, to be prepared for quantitative and qualitative analysis on site or to give a sample for a laboratory
DE10137566B4 (en) * 2001-07-30 2006-11-30 Filt Lungen- Und Thoraxdiagnostik Gmbh Method for quantifying the exchange processes in the respiratory tract
DE10232849A1 (en) * 2002-07-19 2004-02-12 Abb Patent Gmbh Gas analyzer, e.g. for field detection of odorless, invisible toxic agents and pollutants, has self-contained sampling and detector, and sample is transferred to detector under action of force field
DE10232850A1 (en) * 2002-07-19 2004-02-12 Abb Patent Gmbh Mobile analysis facility
DE102009048644A1 (en) 2009-09-30 2011-04-07 Filt Lungen- Und Thoraxdiagnostik Gmbh Device for fractioned extraction of substance of exhalation air, has collecting device aligned downstream-side to nozzle and accommodating fluid and/or frozen particles that are carried along exhalation air stream
WO2011038726A1 (en) 2009-09-30 2011-04-07 Mti Medtech Innovation Gmbh Device and method for fractionally collecting contents of exhaled air
DE202009013577U1 (en) 2009-09-30 2010-02-11 Filt Lungen- Und Thoraxdiagnostik Gmbh Apparatus for the fractionated recovery of ingredients of the exhaled air

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4803977A (en) * 1982-03-25 1989-02-14 Mallinckrodt, Inc. Method and apparatus for the diagnosis of respiratory diseases and allergies
US4622976A (en) * 1985-04-15 1986-11-18 Enhancer R & D Method and apparatus for conducting xenon inhalation studies
DE3932784C3 (en) * 1989-09-30 2002-08-01 Nmi Univ Tuebingen Process for the extraction of non-volatile substances as analytical sample material from the human breath
US5386832A (en) * 1993-06-11 1995-02-07 New England Deaconess Hospital Liver function breath test using aromatic amino acids
DE19505504A1 (en) * 1994-05-13 1995-11-16 Filt Forschungsgesellschaft Fu Collection of exhaled breath sample
DE19528158A1 (en) * 1995-07-24 1997-01-30 Medium Sensor Gmbh Device for extracting the contents of the exhaled air
DE19606470C2 (en) * 1996-02-21 2001-03-15 Mpo Ges Fuer Medizintechnische Procedure for determining the functional residual capacity (FRC)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2451249A (en) * 2007-07-24 2009-01-28 Equine Healthcare Ltd A breath condensate collector
US9968281B2 (en) 2007-07-24 2018-05-15 Exhalation Technology Ltd Breath condensate collector

Also Published As

Publication number Publication date
EP1036322B1 (en) 2003-04-16
DE59807995D1 (en) 2003-05-22
DE19755471A1 (en) 1999-06-17
ATE237805T1 (en) 2003-05-15
WO1999028743A1 (en) 1999-06-10
EP1036322A1 (en) 2000-09-20
CA2312808C (en) 2008-01-15

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