CA2309763A1 - Peptides de fusion de region variable qui forment des complexes effecteurs en presence d'antigenes - Google Patents
Peptides de fusion de region variable qui forment des complexes effecteurs en presence d'antigenes Download PDFInfo
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- CA2309763A1 CA2309763A1 CA002309763A CA2309763A CA2309763A1 CA 2309763 A1 CA2309763 A1 CA 2309763A1 CA 002309763 A CA002309763 A CA 002309763A CA 2309763 A CA2309763 A CA 2309763A CA 2309763 A1 CA2309763 A1 CA 2309763A1
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- antigen
- effector
- pair
- fusion polypeptides
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- 238000011144 upstream manufacturing Methods 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
Les polypeptides de fusion faisant l'objet de cette invention contiennent une séquence de région variable liée à une séquence effectrice. Ces polypeptides ne forment pas de complexes stables en solution, sauf en présence d'un antigène. Lors du contact avec l'antigène, les séquences de région variable se fixent l'une à l'autre, ce qui a pour conséquence de mettre en juxtaposition les séquences effectrices. L'association d'une séquence effectrice avec l'autre fournit une fonction effectrice, par exemple une activation enzymatique, qui peut servir à un grand nombre d'applications thérapeutiques ou diagnostiques.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6571997P | 1997-11-14 | 1997-11-14 | |
| US60/065,719 | 1997-11-14 | ||
| PCT/US1998/020017 WO1999025739A1 (fr) | 1997-11-14 | 1998-09-24 | Peptides de fusion de region variable qui forment des complexes effecteurs en presence d'antigenes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2309763A1 true CA2309763A1 (fr) | 1999-05-27 |
Family
ID=22064634
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002309763A Abandoned CA2309763A1 (fr) | 1997-11-14 | 1998-09-24 | Peptides de fusion de region variable qui forment des complexes effecteurs en presence d'antigenes |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP1028979A1 (fr) |
| JP (1) | JP2002502585A (fr) |
| CA (1) | CA2309763A1 (fr) |
| WO (1) | WO1999025739A1 (fr) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9487592B2 (en) | 2008-10-24 | 2016-11-08 | Fujifilm Corporation | Immobilization substrate and method for producing the same |
| JP5518450B2 (ja) * | 2008-12-04 | 2014-06-11 | 富士フイルム株式会社 | 断片化抗体固定化担体及びその製造方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5989808A (en) * | 1994-06-14 | 1999-11-23 | American Cyanamid Company | Identification of compounds affecting specific interaction of peptide binding pairs |
| US6342345B1 (en) * | 1997-04-02 | 2002-01-29 | The Board Of Trustees Of The Leland Stanford Junior University | Detection of molecular interactions by reporter subunit complementation |
-
1998
- 1998-09-24 EP EP98948515A patent/EP1028979A1/fr not_active Withdrawn
- 1998-09-24 JP JP2000521118A patent/JP2002502585A/ja not_active Withdrawn
- 1998-09-24 CA CA002309763A patent/CA2309763A1/fr not_active Abandoned
- 1998-09-24 WO PCT/US1998/020017 patent/WO1999025739A1/fr not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1028979A1 (fr) | 2000-08-23 |
| JP2002502585A (ja) | 2002-01-29 |
| WO1999025739A1 (fr) | 1999-05-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |