CA2309753C - Appareil et procede de separation des phases liquide et solide pour des syntheses organiques en phase solide - Google Patents
Appareil et procede de separation des phases liquide et solide pour des syntheses organiques en phase solide Download PDFInfo
- Publication number
- CA2309753C CA2309753C CA002309753A CA2309753A CA2309753C CA 2309753 C CA2309753 C CA 2309753C CA 002309753 A CA002309753 A CA 002309753A CA 2309753 A CA2309753 A CA 2309753A CA 2309753 C CA2309753 C CA 2309753C
- Authority
- CA
- Canada
- Prior art keywords
- vessels
- solid phase
- liquid
- centrifuge
- rotor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
- C07K1/045—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers using devices to improve synthesis, e.g. reactors, special vessels
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
- B04B—CENTRIFUGES
- B04B5/00—Other centrifuges
- B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
- B04B5/0407—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers for liquids contained in receptacles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00279—Features relating to reactor vessels
- B01J2219/00306—Reactor vessels in a multiple arrangement
- B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
- B01J2219/00315—Microtiter plates
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/00421—Means for dispensing and evacuation of reagents using centrifugation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00457—Dispensing or evacuation of the solid phase support
- B01J2219/00459—Beads
- B01J2219/00461—Beads and reaction vessel together
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00479—Means for mixing reactants or products in the reaction vessels
- B01J2219/00488—Means for mixing reactants or products in the reaction vessels by rotation of the reaction vessels
- B01J2219/0049—Means for mixing reactants or products in the reaction vessels by rotation of the reaction vessels by centrifugation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00497—Features relating to the solid phase supports
- B01J2219/005—Beads
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00585—Parallel processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00596—Solid-phase processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
- C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00465—Separating and mixing arrangements
- G01N2035/00495—Centrifuges
- G01N2035/00504—Centrifuges combined with carousels
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/028—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having reaction cells in the form of microtitration plates
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/11—Automated chemical analysis
- Y10T436/111666—Utilizing a centrifuge or compartmented rotor
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/25125—Digestion or removing interfering materials
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Centrifugal Separators (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
L'invention concerne un appareil et un procédé à la fois simples et efficaces de séparation des phases solide et liquide convenant particulièrement pour la synthèse organique combinatoire à fort rendement de collections importantes ou de méga-séries de composés organiques. Ce procédé consiste à: (1) placer une cuve à réaction, voire une série ou plusieurs séries de cuves à réaction (constituées par exemple par des plaques de microtitrage) renfermant une boue de particules en phase solide ou des billes dans un liquide, à la périphérie d'une centrifugeuse, en position inclinée ou non; et (2) faire tourner la centrifugeuse à une vitesse telle que les particules en phase solide se déposent dans une "poche" des récipients et que la phase liquide soit expulsée hors desdits récipients. Cet appareil et ce procédé sont utiles, que la méthode utilisée pour la synthèse combinatoire organique soit automatique, robotisée ou manuelle. Dans une réalisation préférée, l'invention concerne un appareil et un procédé permettant de séparer la phase liquide de la phase solide et qui sont compatibles avec une ou plusieurs séries de plaques de microtitration de cuves de réaction.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/974,090 US6121054A (en) | 1997-11-19 | 1997-11-19 | Method for separation of liquid and solid phases for solid phase organic syntheses |
US08/974,090 | 1997-11-19 | ||
PCT/US1998/024519 WO1999025470A1 (fr) | 1997-11-19 | 1998-11-17 | Appareil et procede de separation des phases liquide et solide pour des syntheses organiques en phase solide |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2309753A1 CA2309753A1 (fr) | 1999-05-27 |
CA2309753C true CA2309753C (fr) | 2007-07-03 |
Family
ID=25521582
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002309753A Expired - Fee Related CA2309753C (fr) | 1997-11-19 | 1998-11-17 | Appareil et procede de separation des phases liquide et solide pour des syntheses organiques en phase solide |
Country Status (9)
Country | Link |
---|---|
US (1) | US6121054A (fr) |
EP (1) | EP1032469B1 (fr) |
JP (1) | JP2001523550A (fr) |
AT (1) | ATE234149T1 (fr) |
AU (1) | AU751424B2 (fr) |
CA (1) | CA2309753C (fr) |
CZ (1) | CZ295859B6 (fr) |
DE (1) | DE69812154T2 (fr) |
WO (1) | WO1999025470A1 (fr) |
Families Citing this family (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5976896A (en) * | 1994-06-06 | 1999-11-02 | Idexx Laboratories, Inc. | Immunoassays in capillary tubes |
US6274088B1 (en) * | 1998-04-06 | 2001-08-14 | Pharmacopeia, Inc. | Methods and apparatus for high throughput plate to plate or plate to membrane transfer |
US8337753B2 (en) | 1998-05-01 | 2012-12-25 | Gen-Probe Incorporated | Temperature-controlled incubator having a receptacle mixing mechanism |
DE69940490D1 (de) * | 1998-05-01 | 2009-04-09 | Gen Probe Inc | Automatisches Isolierungs- und Amplifizierungsverfahren für eine Zielnukleinsäuresequenz |
WO2000044491A2 (fr) * | 1999-01-29 | 2000-08-03 | Illumina, Inc. | Appareil et procede destines a la separation de phases liquides de differentes densites et a la synthese organique en phase fluoree |
US6846460B1 (en) | 1999-01-29 | 2005-01-25 | Illumina, Inc. | Apparatus and method for separation of liquid phases of different density and for fluorous phase organic syntheses |
US7932213B2 (en) | 1999-05-11 | 2011-04-26 | President And Fellows Of Harvard College | Small molecule printing |
US7390459B2 (en) * | 1999-12-13 | 2008-06-24 | Illumina, Inc. | Oligonucleotide synthesizer |
AU779983B2 (en) * | 1999-12-13 | 2005-02-24 | Illumina, Inc. | Oligonucleotide synthesizer using centrifugal force |
AU2001247971A1 (en) * | 2000-02-14 | 2001-08-27 | Orchid Biosciences, Inc. | Well plate holder |
US6432365B1 (en) * | 2000-04-14 | 2002-08-13 | Discovery Partners International, Inc. | System and method for dispensing solution to a multi-well container |
US6824738B1 (en) | 2000-04-14 | 2004-11-30 | Discovery Partners International, Inc. | System and method for treatment of samples on solid supports |
US6720187B2 (en) * | 2000-06-28 | 2004-04-13 | 3M Innovative Properties Company | Multi-format sample processing devices |
US6899810B1 (en) | 2000-08-11 | 2005-05-31 | Millipore Corporation | Fluid filtering device |
US6855553B1 (en) | 2000-10-02 | 2005-02-15 | 3M Innovative Properties Company | Sample processing apparatus, methods and systems |
US20030072689A1 (en) * | 2001-08-15 | 2003-04-17 | Third Wave Technologies, Inc. | Polymer synthesizer |
AU2002239520A1 (en) | 2000-12-06 | 2002-06-18 | Pharmacore, Inc. | Quaternary amino acids on solid supports |
US6890740B2 (en) * | 2001-02-12 | 2005-05-10 | The Regents Of The University Of California | Method and apparatus for biological material separation |
AU2003247689A1 (en) * | 2002-07-05 | 2004-01-23 | Aventis Pharmaceuticals Inc. | Apparatus and method for use in solid phase chemical synthesis |
GB0225631D0 (en) * | 2002-07-05 | 2002-12-11 | Aventis Pharma Inc | Apparatus and method for use in solid phase chemical synthesis |
US7887752B2 (en) | 2003-01-21 | 2011-02-15 | Illumina, Inc. | Chemical reaction monitor |
CA2527338A1 (fr) * | 2003-06-05 | 2004-12-16 | Bioprocessors Corp. | Appareil et procede de manipulation de substrats |
DE10338136A1 (de) * | 2003-08-15 | 2005-03-24 | European Molecular Biology Laboratory | Zentrifuge und ein Träger zur Verwendung in einer Zentrifuge |
US8022013B2 (en) | 2003-08-29 | 2011-09-20 | Illumina, Inc. | Method of forming and using solid-phase support |
US20050266432A1 (en) * | 2004-02-26 | 2005-12-01 | Illumina, Inc. | Haplotype markers for diagnosing susceptibility to immunological conditions |
DE102004012025C5 (de) * | 2004-03-10 | 2012-04-05 | Eppendorf Ag | Laborzentrifuge mit Ausschwingbehältern |
US20070027879A1 (en) * | 2005-07-27 | 2007-02-01 | Lexmark International, Inc. | Systems and methods for managing multi-function device operation using containers and workflow objects |
WO2007033176A2 (fr) * | 2005-09-14 | 2007-03-22 | Illumina, Inc. | Dispositif de synthese en continu de polymere |
US8315817B2 (en) * | 2007-01-26 | 2012-11-20 | Illumina, Inc. | Independently removable nucleic acid sequencing system and method |
US7835871B2 (en) * | 2007-01-26 | 2010-11-16 | Illumina, Inc. | Nucleic acid sequencing system and method |
MX2010003578A (es) * | 2007-10-02 | 2010-06-09 | Theranos Inc | Dispositivos modulares de punto de cuidado y usos de los mismos. |
EP2189218A1 (fr) * | 2008-11-12 | 2010-05-26 | F. Hoffmann-Roche AG | Séparation utilisant un couvercle de plaque multipuits |
WO2011026128A2 (fr) * | 2009-08-31 | 2011-03-03 | Life Technologies Corporation | Cuves à circulation et leurs procédés de remplissage et d'utilisation |
WO2011090949A2 (fr) | 2010-01-19 | 2011-07-28 | Illumina, Inc. | Procédés et compositions pour le traitement de réactions chimiques |
CN102135542A (zh) * | 2010-01-21 | 2011-07-27 | 北京大学 | 用于检测可溶性pdcd5蛋白的elisa方法和试剂盒 |
TWI690594B (zh) | 2011-01-21 | 2020-04-11 | 美商賽瑞諾斯Ip有限責任公司 | 樣本使用最大化之系統及方法 |
US9619627B2 (en) | 2011-09-25 | 2017-04-11 | Theranos, Inc. | Systems and methods for collecting and transmitting assay results |
US9268915B2 (en) | 2011-09-25 | 2016-02-23 | Theranos, Inc. | Systems and methods for diagnosis or treatment |
US8840838B2 (en) | 2011-09-25 | 2014-09-23 | Theranos, Inc. | Centrifuge configurations |
US8475739B2 (en) | 2011-09-25 | 2013-07-02 | Theranos, Inc. | Systems and methods for fluid handling |
US9632102B2 (en) | 2011-09-25 | 2017-04-25 | Theranos, Inc. | Systems and methods for multi-purpose analysis |
US9664702B2 (en) | 2011-09-25 | 2017-05-30 | Theranos, Inc. | Fluid handling apparatus and configurations |
US20140170735A1 (en) | 2011-09-25 | 2014-06-19 | Elizabeth A. Holmes | Systems and methods for multi-analysis |
US9810704B2 (en) | 2013-02-18 | 2017-11-07 | Theranos, Inc. | Systems and methods for multi-analysis |
US10012664B2 (en) | 2011-09-25 | 2018-07-03 | Theranos Ip Company, Llc | Systems and methods for fluid and component handling |
US9250229B2 (en) | 2011-09-25 | 2016-02-02 | Theranos, Inc. | Systems and methods for multi-analysis |
US10422806B1 (en) | 2013-07-25 | 2019-09-24 | Theranos Ip Company, Llc | Methods for improving assays of biological samples |
US11545241B1 (en) | 2013-09-07 | 2023-01-03 | Labrador Diagnostics Llc | Systems and methods for analyte testing and data management |
EP3175022B1 (fr) | 2014-07-28 | 2020-09-16 | Sanofi Pasteur VaxDesign Corporation | Imagerie et analyse automatiques de l'essai d'inhibition de l'hémagglutination (iha) |
US10040048B1 (en) | 2014-09-25 | 2018-08-07 | Synthego Corporation | Automated modular system and method for production of biopolymers |
IT201700105911A1 (it) * | 2017-09-21 | 2019-03-21 | Menarini Silicon Biosystems Spa | Metodo ed apparato per la riduzione del volume di un campione |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3586484A (en) * | 1969-05-23 | 1971-06-22 | Atomic Energy Commission | Multistation analytical photometer and method of use |
AT308712B (de) * | 1971-10-08 | 1973-07-25 | Immuno Ag | Tischzentrifuge |
US4244694A (en) * | 1978-03-31 | 1981-01-13 | Union Carbide Corporation | Reactor/separator device for use in automated solid phase immunoassay |
FR2496268A1 (fr) * | 1980-12-15 | 1982-06-18 | Guigan Jean | Dispositif autonome d'analyse simultanee et procede de mise en oeuvre |
CZ280777B6 (cs) * | 1990-02-02 | 1996-04-17 | Ústav Organické Chemie A Biochemie Avčr | Mnohonásobná automatizovaná syntéza peptidů na planárních nosičích |
WO1993010455A1 (fr) * | 1991-11-21 | 1993-05-27 | Cirrus Diagnostics, Inc. | Cuve centrifuge amelioree pour dosage immunologique automatique en phase solide |
EP0569115A3 (fr) * | 1992-05-05 | 1994-01-05 | General Atomics | Système d'élaboration d'ADN à grand débit |
US5472672A (en) * | 1993-10-22 | 1995-12-05 | The Board Of Trustees Of The Leland Stanford Junior University | Apparatus and method for polymer synthesis using arrays |
US5605616A (en) * | 1995-11-06 | 1997-02-25 | Versicor, Inc. | Reversible charge-based sequestration on solid support |
-
1997
- 1997-11-19 US US08/974,090 patent/US6121054A/en not_active Expired - Fee Related
-
1998
- 1998-11-17 WO PCT/US1998/024519 patent/WO1999025470A1/fr active IP Right Grant
- 1998-11-17 DE DE69812154T patent/DE69812154T2/de not_active Expired - Lifetime
- 1998-11-17 AT AT98958035T patent/ATE234149T1/de not_active IP Right Cessation
- 1998-11-17 JP JP2000520898A patent/JP2001523550A/ja active Pending
- 1998-11-17 CZ CZ20001875A patent/CZ295859B6/cs not_active IP Right Cessation
- 1998-11-17 AU AU14154/99A patent/AU751424B2/en not_active Ceased
- 1998-11-17 CA CA002309753A patent/CA2309753C/fr not_active Expired - Fee Related
- 1998-11-17 EP EP98958035A patent/EP1032469B1/fr not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US6121054A (en) | 2000-09-19 |
JP2001523550A (ja) | 2001-11-27 |
WO1999025470A1 (fr) | 1999-05-27 |
CZ295859B6 (cs) | 2005-11-16 |
DE69812154T2 (de) | 2004-01-08 |
DE69812154D1 (de) | 2003-04-17 |
CA2309753A1 (fr) | 1999-05-27 |
EP1032469A1 (fr) | 2000-09-06 |
EP1032469B1 (fr) | 2003-03-12 |
AU751424B2 (en) | 2002-08-15 |
AU1415499A (en) | 1999-06-07 |
CZ20001875A3 (cs) | 2000-12-13 |
ATE234149T1 (de) | 2003-03-15 |
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