CA2308639A1 - Method of using cyclooxygenase-2 inhibitors in maintaining the fetal ductus ateriosus during treatment and prevention of preterm labor - Google Patents

Method of using cyclooxygenase-2 inhibitors in maintaining the fetal ductus ateriosus during treatment and prevention of preterm labor Download PDF

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Publication number
CA2308639A1
CA2308639A1 CA002308639A CA2308639A CA2308639A1 CA 2308639 A1 CA2308639 A1 CA 2308639A1 CA 002308639 A CA002308639 A CA 002308639A CA 2308639 A CA2308639 A CA 2308639A CA 2308639 A1 CA2308639 A1 CA 2308639A1
Authority
CA
Canada
Prior art keywords
benzenesulfonamide
pyrazol
trifluoromethyl
alkyl
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002308639A
Other languages
English (en)
French (fr)
Inventor
Philip Needleman
Jaime Masferrer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2308639A1 publication Critical patent/CA2308639A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/06Anti-spasmodics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA002308639A 1997-10-31 1998-10-27 Method of using cyclooxygenase-2 inhibitors in maintaining the fetal ductus ateriosus during treatment and prevention of preterm labor Abandoned CA2308639A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6388997P 1997-10-31 1997-10-31
US60/063,889 1997-10-31
PCT/US1998/022246 WO1999022720A2 (en) 1997-10-31 1998-10-27 Selective cyclooxygenase-2 inhibitors against premature labor

Publications (1)

Publication Number Publication Date
CA2308639A1 true CA2308639A1 (en) 1999-05-14

Family

ID=22052179

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002308639A Abandoned CA2308639A1 (en) 1997-10-31 1998-10-27 Method of using cyclooxygenase-2 inhibitors in maintaining the fetal ductus ateriosus during treatment and prevention of preterm labor

Country Status (9)

Country Link
EP (1) EP1027048A2 (US06815460-20041109-C00023.png)
JP (1) JP2001521889A (US06815460-20041109-C00023.png)
AR (1) AR014000A1 (US06815460-20041109-C00023.png)
AU (1) AU758566B2 (US06815460-20041109-C00023.png)
BR (1) BR9813164A (US06815460-20041109-C00023.png)
CA (1) CA2308639A1 (US06815460-20041109-C00023.png)
TW (2) TW577739B (US06815460-20041109-C00023.png)
WO (1) WO1999022720A2 (US06815460-20041109-C00023.png)
ZA (1) ZA989876B (US06815460-20041109-C00023.png)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1353664A2 (en) * 2000-06-08 2003-10-22 The Board Of Regents, The University Of Texas System Heterocycle derivatives and methods of use for treating anthrax infection
PL1534305T3 (pl) 2003-05-07 2007-03-30 Osteologix As Leczenie zaburzeń chrząstek i kości solami strontu rozpuszczalnymi w wodzie

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994026731A1 (en) * 1993-05-13 1994-11-24 Merck Frosst Canada Inc. 2-substituted-3,4-diarylthiophene derivatives as inhibitors of cyclooxygenase
US5474995A (en) * 1993-06-24 1995-12-12 Merck Frosst Canada, Inc. Phenyl heterocycles as cox-2 inhibitors
US5466823A (en) * 1993-11-30 1995-11-14 G.D. Searle & Co. Substituted pyrazolyl benzenesulfonamides
EP0889724A1 (en) * 1996-02-27 1999-01-13 Rpms Technology Limited Cox-2 selective inhibitors for managing labour and uterine contractions
US5677318A (en) * 1996-07-11 1997-10-14 Merck Frosst Canada, Inc. Diphenyl-1,2-3-thiadiazoles as anti-inflammatory agents

Also Published As

Publication number Publication date
JP2001521889A (ja) 2001-11-13
AU1192699A (en) 1999-05-24
AR014000A1 (es) 2001-01-31
EP1027048A2 (en) 2000-08-16
TW200404535A (en) 2004-04-01
TW577739B (en) 2004-03-01
WO1999022720A2 (en) 1999-05-14
BR9813164A (pt) 2000-08-22
AU758566B2 (en) 2003-03-27
WO1999022720A3 (en) 1999-08-26
ZA989876B (en) 1999-10-29

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued
FZDE Discontinued

Effective date: 20080618