CA2308375A1 - Multispectral/hyperspectral medical instrument - Google Patents

Multispectral/hyperspectral medical instrument Download PDF

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Publication number
CA2308375A1
CA2308375A1 CA002308375A CA2308375A CA2308375A1 CA 2308375 A1 CA2308375 A1 CA 2308375A1 CA 002308375 A CA002308375 A CA 002308375A CA 2308375 A CA2308375 A CA 2308375A CA 2308375 A1 CA2308375 A1 CA 2308375A1
Authority
CA
Canada
Prior art keywords
medical instrument
general
diagnostic
filter
operative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002308375A
Other languages
French (fr)
Other versions
CA2308375C (en
Inventor
Edgar N. Lewis
Jenny E. Freeman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
US Department of Health and Human Services
Hypermed Imaging Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CA2805807A priority Critical patent/CA2805807A1/en
Publication of CA2308375A1 publication Critical patent/CA2308375A1/en
Application granted granted Critical
Publication of CA2308375C publication Critical patent/CA2308375C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
    • A61B1/05—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances characterised by the image sensor, e.g. camera, being in the distal end portion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00002—Operational features of endoscopes
    • A61B1/00039—Operational features of endoscopes provided with input arrangements for the user
    • A61B1/00042—Operational features of endoscopes provided with input arrangements for the user for mechanical operation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0088—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for oral or dental tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/36—Image-producing devices or illumination devices not otherwise provided for

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Medical Informatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Optics & Photonics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Mechanical Engineering (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Instruments For Viewing The Inside Of Hollow Bodies (AREA)
  • Endoscopes (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

A medical instrument that comprises: a first-stage optic (40) responsive to a tissue surface of a patient; a spectral separator (42) optically responsive to the first stage optic and having a control input; an imaging sensor (46) optically responsive to the spectral separator and having an image data output; and a diagnostic processor (38) having an image acquisition interface (50) with an input responsive to the imaging sensor and a filter control interface (52) having a control output provided to the control input of the spectral separator (42).

Claims (22)

1. A medical instrument, including:
a first-stage optic responsive to a tissue surface of a patient, a spectral separator optically responsive to the first stage optic and having a control input, an imaging sensor optically responsive to the spectral separator and having an image data output, and a diagnostic processor having an image acquisition interface with an input responsive to the imaging sensor and a filter control interface having a control output provided to the control input of the spectral separator.
2. The medical instrument of claim 1, wherein the spectral separator is a tunable filter.
3. The medical instrument of claim 2, wherein the spectral separator is a liquid crystal tunable filter.
4. The medical instrument of claim 1 wherein the imaging sensor is a two-dimensional imaging array.
5. The medical instrument of claim 1 wherein the imaging sensor includes a charge coupled device.
6. The medical instrument of claim 1 wherein the imaging sensor includes an infra-red sensitive focal plane array.
7. The medical instrument of claim 1 wherein the diagnostic processor includes a general-purpose processing module and a plurality of diagnostic protocol modules.
8. The medical instrument of claim 1 wherein the first-stage optic is a macro lens.
9. The medical instrument of claim 1 wherein the first stage optic is an adjustable lens.
10. The medical instrument of claim 9 further including a stand connected relative to the first-stage optic to position the first-stage optic relative to the patient.
11. The medical instrument of claim 1 wherein the first stage optic includes a probe that includes an imaging fiber optic cable.
12. The medical instrument of claim 1 further including a surgical implement attached to the probe.
13. The medical instrument of claim 1 wherein the control interface is operable to adjust the filter at least twenty times to acquire hyperspectral data for redisplay in real time
14. The medical instrument of claim 1 wherein the diagnostic processor includes a general-purpose processing module and a plurality of diagnostic protocol modules, wherein each of the diagnostic protocol modules includes a plurality of filter transfer functions and an image processing protocol, wherein the general-purpose processing module is operative to instruct the filter to successively apply the filter transfer functions to light collected from the patient, wherein the general-purpose processing module is operative to acquire from the imaging sensor a plurality of images of the collected light each obtained after one of the filter transfer functions is applied, and wherein the general-purpose processing module is operative to process the acquired images according to the image processing protocol to obtain a processed display image.
15. The medical instrument of claim 14 wherein the general-purpose processor is a real-time processor operative to generate a processed display image within a time period on the order of the persistence of human vision.
16. The medical instrument of claim 14 wherein the general-purpose processor is a real-time processor operative to generate a processed display image within about one minute.
17. The medical instrument of claim 16 wherein the general processor is operative to acquire some images more slowly depending on the number of wavelengths and complexity of diagnostic protocols.
18. The medical instrument of claim 1 wherein the diagnostic processor includes a general-purpose processing module and a diagnostic protocol module, wherein the diagnostic protocol module includes a plurality of filter transfer functions and an image processing protocol adapted to detect more than one condition, wherein the general-purpose processing module is operative to instruct the filter to successively apply the filter transfer functions to light collected from the patient, wherein the general-purpose processing module is operative to acquire from the imaging sensor a plurality of images of the collected light each obtained after one of the filter transfer functions is applied, and wherein the general-purpose processing module is operative to process the acquired images according to the image processing protocol to obtain a processed display image.
19. The medical instrument of claim 1 wherein the diagnostic processor includes a real-time processor operative to generate a processed display image within a time period on the order of the persistence of human vision.
20. The medical instrument of claim 1 wherein the diagnostic processor is operable to perform diagnostic processing for images acquired from a source that includes visible light.
21. The medical instrument of claim 1 wherein the filter and sensor are operable in the visible and far infra-red regions.
22. The medical instrument of claim 1 wherein the filter and sensor are operable in the ultra-violet, visible, and infra-red regions.
CA2308375A 1997-10-30 1998-10-30 Multispectral/hyperspectral medical instrument Expired - Lifetime CA2308375C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2805807A CA2805807A1 (en) 1997-10-30 1998-10-30 Multispectral/hyperspectral medical instrument

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US96129497A 1997-10-30 1997-10-30
US08/961,294 1997-10-30
US9304197P 1997-11-10 1997-11-10
US60/093,041 1997-11-10
PCT/US1998/022961 WO1999022640A2 (en) 1997-10-30 1998-10-30 Multispectral/hyperspectral medical instrument

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA2805807A Division CA2805807A1 (en) 1997-10-30 1998-10-30 Multispectral/hyperspectral medical instrument

Publications (2)

Publication Number Publication Date
CA2308375A1 true CA2308375A1 (en) 1999-05-14
CA2308375C CA2308375C (en) 2013-04-09

Family

ID=26786736

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2308375A Expired - Lifetime CA2308375C (en) 1997-10-30 1998-10-30 Multispectral/hyperspectral medical instrument

Country Status (5)

Country Link
EP (1) EP1026983A2 (en)
JP (2) JP2001521772A (en)
AU (1) AU751456B2 (en)
CA (1) CA2308375C (en)
WO (1) WO1999022640A2 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8024027B2 (en) 1998-09-03 2011-09-20 Hyperspectral Imaging, Inc. Infrared endoscopic balloon probes
AU5783900A (en) 1999-07-02 2001-01-22 Hypermed, Inc. Integrated imaging apparatus
AU5908000A (en) * 1999-07-02 2001-01-22 Hypermed Imaging, Inc. Imaging apparatus with means for fusing thermal and hyperspectral images
US6709387B1 (en) 2000-05-15 2004-03-23 Given Imaging Ltd. System and method for controlling in vivo camera capture and display rate
WO2005079661A1 (en) * 2004-02-24 2005-09-01 Waseda University Apparent chemical species measuring method and measuring system
US8548570B2 (en) * 2004-11-29 2013-10-01 Hypermed Imaging, Inc. Hyperspectral imaging of angiogenesis
EP1835845A4 (en) * 2004-12-28 2008-09-10 Hypermed Inc Hyperspectral/multispectral imaging in determination, assessment and monitoring of systemic physiology and shock
WO2006107947A2 (en) 2005-04-04 2006-10-12 Hypermed, Inc. Hyperspectral imaging in diabetes and peripheral vascular disease
JP4575474B2 (en) * 2008-06-11 2010-11-04 国立大学法人東京工業大学 Biological tissue identification apparatus and method
JP5649657B2 (en) 2009-11-20 2015-01-07 ギブン イメージング リミテッドＧｉｖｅｎ Ｉｍａｇｉｎｇ Ｌｔｄ． System and method for controlling power consumption of in-vivo devices
US8988680B2 (en) 2010-04-30 2015-03-24 Chemimage Technologies Llc Dual polarization with liquid crystal tunable filters
BR112014028811B1 (en) * 2013-03-19 2020-11-17 Koninklijke Philips N.V. imaging system, method for registering an image of an object in a spectral band of terahertz radiation through radiography and visualization of the image in visible light, and storage medium
JP2014220639A (en) 2013-05-08 2014-11-20 ソニー株式会社 Imaging apparatus and imaging method

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2068537B (en) * 1980-02-04 1984-11-14 Energy Conversion Devices Inc Examining biological materials
US4515165A (en) * 1980-02-04 1985-05-07 Energy Conversion Devices, Inc. Apparatus and method for detecting tumors
JPS585631A (en) * 1981-07-02 1983-01-13 Masaaki Motoi Spectrochemical analysis device
US4505583A (en) * 1981-04-10 1985-03-19 Masaaki Konomi Spectroscopic analyzer system for examining intravital tissue
JPS61107482A (en) * 1984-10-30 1986-05-26 Hiroaki Kumagai Photographing device of biological tissue
JP2802061B2 (en) * 1987-04-30 1998-09-21 オリンパス光学工業株式会社 Endoscope optical system
DE69231614T2 (en) * 1991-02-26 2001-05-03 Massachusetts Inst Technology MOLECULAR SPECTROSCOPY METHOD AND DEVICES FOR TISSUE DIAGNOSIS
IL108350A0 (en) * 1993-01-19 1994-04-12 Computer Aided Medical Inc Diagnostic imaging method and device
JP2756632B2 (en) * 1993-03-01 1998-05-25 日本電信電話株式会社 Tunable mode-locked laser device
US5599717A (en) * 1994-09-02 1997-02-04 Martin Marietta Energy Systems, Inc. Advanced synchronous luminescence system
US5863504A (en) * 1995-03-16 1999-01-26 Bio-Rad Laboratories, Inc. Fluorescence imaging instrument utilizing fish
IL113333A (en) * 1995-04-11 2001-01-28 Yoav Paltieli Optical-fiber type endoscope
ZA967500B (en) * 1995-12-21 1998-03-05 Unilever Plc Device for the identification of acne, microcomedones, and bacteria on human skin.

Also Published As

Publication number Publication date
JP2001521772A (en) 2001-11-13
WO1999022640A3 (en) 1999-08-19
AU1287499A (en) 1999-05-24
CA2308375C (en) 2013-04-09
JP5174877B2 (en) 2013-04-03
WO1999022640A2 (en) 1999-05-14
AU751456B2 (en) 2002-08-15
JP2011036695A (en) 2011-02-24
EP1026983A2 (en) 2000-08-16

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Effective date: 20181030