CA2306795C - Acetic acid as contrast agent in fluorescence spectroscopy - Google Patents
Acetic acid as contrast agent in fluorescence spectroscopy Download PDFInfo
- Publication number
- CA2306795C CA2306795C CA002306795A CA2306795A CA2306795C CA 2306795 C CA2306795 C CA 2306795C CA 002306795 A CA002306795 A CA 002306795A CA 2306795 A CA2306795 A CA 2306795A CA 2306795 C CA2306795 C CA 2306795C
- Authority
- CA
- Canada
- Prior art keywords
- tissue
- diagnostic
- diagnostic tissue
- fluorescence
- acetic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 title claims abstract description 120
- 238000001506 fluorescence spectroscopy Methods 0.000 title abstract description 14
- 239000002872 contrast media Substances 0.000 title abstract description 7
- 238000000034 method Methods 0.000 claims abstract description 36
- 238000001228 spectrum Methods 0.000 claims abstract description 36
- 230000002159 abnormal effect Effects 0.000 claims abstract description 24
- 230000005670 electromagnetic radiation Effects 0.000 claims abstract description 11
- 230000005856 abnormality Effects 0.000 claims abstract description 8
- 230000008859 change Effects 0.000 claims abstract description 6
- 230000004044 response Effects 0.000 claims abstract description 5
- 230000005284 excitation Effects 0.000 claims description 10
- 238000001727 in vivo Methods 0.000 claims description 6
- 238000005259 measurement Methods 0.000 claims description 3
- 230000009467 reduction Effects 0.000 claims description 3
- 102000001554 Hemoglobins Human genes 0.000 claims description 2
- 108010054147 Hemoglobins Proteins 0.000 claims description 2
- 238000010521 absorption reaction Methods 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 abstract description 54
- 210000000981 epithelium Anatomy 0.000 abstract description 13
- 230000002708 enhancing effect Effects 0.000 abstract description 5
- 230000001613 neoplastic effect Effects 0.000 abstract description 5
- 239000000523 sample Substances 0.000 description 22
- 230000003287 optical effect Effects 0.000 description 12
- 238000003745 diagnosis Methods 0.000 description 11
- 206010008342 Cervix carcinoma Diseases 0.000 description 10
- 206010028980 Neoplasm Diseases 0.000 description 10
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 description 10
- 201000010881 cervical cancer Diseases 0.000 description 10
- 210000003679 cervix uteri Anatomy 0.000 description 9
- 238000001514 detection method Methods 0.000 description 8
- 238000002189 fluorescence spectrum Methods 0.000 description 8
- 238000002573 colposcopy Methods 0.000 description 6
- 238000009595 pap smear Methods 0.000 description 6
- 238000000692 Student's t-test Methods 0.000 description 5
- 201000011510 cancer Diseases 0.000 description 5
- 238000001499 laser induced fluorescence spectroscopy Methods 0.000 description 5
- 230000003595 spectral effect Effects 0.000 description 5
- 238000012353 t test Methods 0.000 description 5
- 230000000694 effects Effects 0.000 description 4
- 238000013507 mapping Methods 0.000 description 4
- 230000009826 neoplastic cell growth Effects 0.000 description 4
- 238000012216 screening Methods 0.000 description 4
- 230000035945 sensitivity Effects 0.000 description 4
- 208000009458 Carcinoma in Situ Diseases 0.000 description 3
- 208000032124 Squamous Intraepithelial Lesions Diseases 0.000 description 3
- 238000003384 imaging method Methods 0.000 description 3
- 201000004933 in situ carcinoma Diseases 0.000 description 3
- 208000020077 squamous cell intraepithelial neoplasia Diseases 0.000 description 3
- 206010058314 Dysplasia Diseases 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 230000002596 correlated effect Effects 0.000 description 2
- 238000002405 diagnostic procedure Methods 0.000 description 2
- 238000012631 diagnostic technique Methods 0.000 description 2
- 238000007619 statistical method Methods 0.000 description 2
- ZGXJTSGNIOSYLO-UHFFFAOYSA-N 88755TAZ87 Chemical compound NCC(=O)CCC(O)=O ZGXJTSGNIOSYLO-UHFFFAOYSA-N 0.000 description 1
- 206010006187 Breast cancer Diseases 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- KSFOVUSSGSKXFI-GAQDCDSVSA-N CC1=C/2NC(\C=C3/N=C(/C=C4\N\C(=C/C5=N/C(=C\2)/C(C=C)=C5C)C(C=C)=C4C)C(C)=C3CCC(O)=O)=C1CCC(O)=O Chemical compound CC1=C/2NC(\C=C3/N=C(/C=C4\N\C(=C/C5=N/C(=C\2)/C(C=C)=C5C)C(C=C)=C4C)C(C)=C3CCC(O)=O)=C1CCC(O)=O KSFOVUSSGSKXFI-GAQDCDSVSA-N 0.000 description 1
- 206010008263 Cervical dysplasia Diseases 0.000 description 1
- 208000006994 Precancerous Conditions Diseases 0.000 description 1
- 238000001069 Raman spectroscopy Methods 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- 230000003318 acetowhitening effect Effects 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 229960002749 aminolevulinic acid Drugs 0.000 description 1
- 238000001574 biopsy Methods 0.000 description 1
- 208000035269 cancer or benign tumor Diseases 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 210000003850 cellular structure Anatomy 0.000 description 1
- 208000007951 cervical intraepithelial neoplasia Diseases 0.000 description 1
- 238000003759 clinical diagnosis Methods 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 238000007405 data analysis Methods 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 231100000517 death Toxicity 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 230000003292 diminished effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000000295 emission spectrum Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 210000005002 female reproductive tract Anatomy 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 230000002962 histologic effect Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 230000036210 malignancy Effects 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000004660 morphological change Effects 0.000 description 1
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 description 1
- BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 description 1
- 239000013307 optical fiber Substances 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 229950003776 protoporphyrin Drugs 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 238000007790 scraping Methods 0.000 description 1
- 206010041823 squamous cell carcinoma Diseases 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/43—Detecting, measuring or recording for evaluating the reproductive systems
- A61B5/4306—Detecting, measuring or recording for evaluating the reproductive systems for evaluating the female reproductive systems, e.g. gynaecological evaluations
- A61B5/4318—Evaluation of the lower reproductive system
- A61B5/4331—Evaluation of the lower reproductive system of the cervix
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N2015/1488—Methods for deciding
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Pathology (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- Medical Informatics (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- General Physics & Mathematics (AREA)
- Surgery (AREA)
- Biophysics (AREA)
- Heart & Thoracic Surgery (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6292297P | 1997-10-20 | 1997-10-20 | |
| US60/062,922 | 1997-10-20 | ||
| US7698598P | 1998-03-05 | 1998-03-05 | |
| US60/076,985 | 1998-03-05 | ||
| PCT/US1998/022218 WO1999020314A1 (en) | 1997-10-20 | 1998-10-20 | Acetic acid as a signal enhancing contrast agent in fluorescence spectroscopy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2306795A1 CA2306795A1 (en) | 1999-04-29 |
| CA2306795C true CA2306795C (en) | 2009-01-20 |
Family
ID=26742863
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002306795A Expired - Fee Related CA2306795C (en) | 1997-10-20 | 1998-10-20 | Acetic acid as contrast agent in fluorescence spectroscopy |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US6187289B1 (de) |
| EP (1) | EP1071473B1 (de) |
| JP (1) | JP2001520393A (de) |
| CN (1) | CN1302210A (de) |
| AU (2) | AU1108399A (de) |
| CA (1) | CA2306795C (de) |
| DE (1) | DE69838560T2 (de) |
| WO (2) | WO1999020314A1 (de) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9042967B2 (en) | 2008-05-20 | 2015-05-26 | University Health Network | Device and method for wound imaging and monitoring |
| US10438356B2 (en) | 2014-07-24 | 2019-10-08 | University Health Network | Collection and analysis of data for diagnostic purposes |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7236815B2 (en) * | 1995-03-14 | 2007-06-26 | The Board Of Regents Of The University Of Texas System | Method for probabilistically classifying tissue in vitro and in vivo using fluorescence spectroscopy |
| US20010041843A1 (en) * | 1999-02-02 | 2001-11-15 | Mark Modell | Spectral volume microprobe arrays |
| US20030148354A1 (en) * | 1996-10-02 | 2003-08-07 | Saftest, Inc. | Devices and methods for isolating and detecting specific substances in complex matrices |
| US6847490B1 (en) * | 1997-01-13 | 2005-01-25 | Medispectra, Inc. | Optical probe accessory device for use in vivo diagnostic procedures |
| US6826422B1 (en) * | 1997-01-13 | 2004-11-30 | Medispectra, Inc. | Spectral volume microprobe arrays |
| CA2356195A1 (en) * | 1998-12-23 | 2000-06-29 | Medispectra, Inc. | Optical methods and systems for cervical screening |
| JP2002533142A (ja) * | 1998-12-23 | 2002-10-08 | メディスペクトラ， インコーポレイテッド | サンプルの光学的試験のためのシステムおよび方法 |
| US6720547B1 (en) | 1999-03-18 | 2004-04-13 | Lucid, Inc. | System and method for enhancing confocal reflectance images of tissue specimens |
| US20020007122A1 (en) * | 1999-12-15 | 2002-01-17 | Howard Kaufman | Methods of diagnosing disease |
| US7187810B2 (en) * | 1999-12-15 | 2007-03-06 | Medispectra, Inc. | Methods and systems for correcting image misalignment |
| US7260248B2 (en) * | 1999-12-15 | 2007-08-21 | Medispectra, Inc. | Image processing using measures of similarity |
| GR1004180B (el) * | 2000-03-28 | 2003-03-11 | ����������� ����� ��������� (����) | Μεθοδος και συστημα χαρακτηρισμου και χαρτογραφησης αλλοιωσεων των ιστων |
| AU2001251114A1 (en) | 2000-03-28 | 2001-10-08 | Board Of Regents, The University Of Texas System | Enhancing contrast in biological imaging |
| US7139122B1 (en) * | 2000-10-17 | 2006-11-21 | Lucid, Inc. | System and method for enhancing confocal reflectance images of tissue specimens |
| US7003345B1 (en) * | 2000-10-17 | 2006-02-21 | Lucid, Inc. | System and method for enhancing microscope images of tissue using citric acid and agents of the like |
| US7194118B1 (en) | 2000-11-10 | 2007-03-20 | Lucid, Inc. | System for optically sectioning and mapping surgically excised tissue |
| US6839661B2 (en) * | 2000-12-15 | 2005-01-04 | Medispectra, Inc. | System for normalizing spectra |
| ATE419536T1 (de) | 2002-03-05 | 2009-01-15 | Univ Texas | Biospezifische kontrastmittel |
| US20040133112A1 (en) * | 2002-03-08 | 2004-07-08 | Milind Rajadhyaksha | System and method for macroscopic and confocal imaging of tissue |
| US7128894B1 (en) * | 2002-06-27 | 2006-10-31 | The United States Of America As Represented By The United States Department Of Energy | Contrast enhancing solution for use in confocal microscopy |
| US20040208390A1 (en) * | 2003-04-18 | 2004-10-21 | Medispectra, Inc. | Methods and apparatus for processing image data for use in tissue characterization |
| US7459696B2 (en) * | 2003-04-18 | 2008-12-02 | Schomacker Kevin T | Methods and apparatus for calibrating spectral data |
| US7136518B2 (en) * | 2003-04-18 | 2006-11-14 | Medispectra, Inc. | Methods and apparatus for displaying diagnostic data |
| US6818903B2 (en) | 2002-07-09 | 2004-11-16 | Medispectra, Inc. | Method and apparatus for identifying spectral artifacts |
| US20040209237A1 (en) * | 2003-04-18 | 2004-10-21 | Medispectra, Inc. | Methods and apparatus for characterization of tissue samples |
| US6933154B2 (en) * | 2002-07-09 | 2005-08-23 | Medispectra, Inc. | Optimal windows for obtaining optical data for characterization of tissue samples |
| US7282723B2 (en) * | 2002-07-09 | 2007-10-16 | Medispectra, Inc. | Methods and apparatus for processing spectral data for use in tissue characterization |
| US7309867B2 (en) * | 2003-04-18 | 2007-12-18 | Medispectra, Inc. | Methods and apparatus for characterization of tissue samples |
| US7469160B2 (en) * | 2003-04-18 | 2008-12-23 | Banks Perry S | Methods and apparatus for evaluating image focus |
| US20040208385A1 (en) * | 2003-04-18 | 2004-10-21 | Medispectra, Inc. | Methods and apparatus for visually enhancing images |
| US6768918B2 (en) | 2002-07-10 | 2004-07-27 | Medispectra, Inc. | Fluorescent fiberoptic probe for tissue health discrimination and method of use thereof |
| US7157545B2 (en) * | 2002-08-27 | 2007-01-02 | Acushnet Company | Compositions for golf equipment |
| US20040064053A1 (en) * | 2002-09-30 | 2004-04-01 | Chang Sung K. | Diagnostic fluorescence and reflectance |
| AU2004323582A1 (en) * | 2004-09-28 | 2006-04-06 | Zila Pharmaceuticals, Inc. | Methods for detecting abnormal epithelial tissue |
| GB0427050D0 (en) * | 2004-12-10 | 2005-01-12 | Amersham Biosciences Uk Ltd | Method of,and apparatus and computer software for,imaging biological objects |
| US7307774B1 (en) | 2005-01-24 | 2007-12-11 | The Board Of Trustees Of The Leland Standford Junior University | Micro-optical analysis system and approach therefor |
| US8346346B1 (en) | 2005-01-24 | 2013-01-01 | The Board Of Trustees Of The Leland Stanford Junior University | Optical analysis system and approach therefor |
| US8788021B1 (en) | 2005-01-24 | 2014-07-22 | The Board Of Trustees Of The Leland Stanford Junior Univerity | Live being optical analysis system and approach |
| WO2007006039A2 (en) * | 2005-07-05 | 2007-01-11 | The Board Of Regents Of The University Of Texas System | Depth-resolved spectroscopy method and apparatus |
| EP1924192A2 (de) | 2005-08-15 | 2008-05-28 | The Board of Regents of The University of Texas System | Nadelbiopsie-darstellungssystem |
| US8289503B2 (en) * | 2005-09-27 | 2012-10-16 | Chemimage Corporation | System and method for classifying a disease state using representative data sets |
| WO2007038679A2 (en) * | 2005-09-27 | 2007-04-05 | Chemimage Corporation | Method for correlating spectroscopic measurements with digital images of contrast enhanced tissue |
| CN1967196B (zh) * | 2006-09-14 | 2010-05-12 | 绵竹市人民医院 | 简易薄层液基细胞学细胞涂片制备方法 |
| WO2010006513A1 (zh) * | 2008-07-15 | 2010-01-21 | Zeng Kun | 便携式子宫颈癌癌前病变诊断装置 |
| CN103323314A (zh) * | 2013-05-24 | 2013-09-25 | 深圳市华中生物药械有限公司 | 一种复合醋酸染色剂及采用该染色剂的多功能染色棉签 |
| WO2023283091A1 (en) * | 2021-07-08 | 2023-01-12 | The Regents Of The University Of California | Biopsy-free in vivo virtual histology of tissue using deep learning |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4300570A (en) * | 1980-04-24 | 1981-11-17 | The Medical College Of Wisconsin, Inc. | Diagnostic method |
| JPS5940830A (ja) * | 1982-08-31 | 1984-03-06 | 浜松ホトニクス株式会社 | レ−ザ光パルスを用いた癌の診断装置 |
| US5179938A (en) * | 1983-02-17 | 1993-01-19 | The Trylon Corporation | Apparatus for endoscopic examination of body cavity using chemiluminescent light source |
| US5116328A (en) * | 1990-07-16 | 1992-05-26 | Oclassen Pharmaceuticals, Inc. | Diagnostic kit for the detection of atypical epithelia |
| US5697373A (en) | 1995-03-14 | 1997-12-16 | Board Of Regents, The University Of Texas System | Optical method and apparatus for the diagnosis of cervical precancers using raman and fluorescence spectroscopies |
| US5648216A (en) * | 1995-03-27 | 1997-07-15 | Cornell Research Foundation, Inc. | Method for identifying canine chromosomes |
| US5733739A (en) * | 1995-06-07 | 1998-03-31 | Inphocyte, Inc. | System and method for diagnosis of disease by infrared analysis of human tissues and cells |
| US5842995A (en) | 1996-06-28 | 1998-12-01 | Board Of Regents, The Univerisity Of Texas System | Spectroscopic probe for in vivo measurement of raman signals |
| US5836877A (en) * | 1997-02-24 | 1998-11-17 | Lucid Inc | System for facilitating pathological examination of a lesion in tissue |
-
1998
- 1998-10-20 EP EP98953808A patent/EP1071473B1/de not_active Expired - Lifetime
- 1998-10-20 WO PCT/US1998/022218 patent/WO1999020314A1/en active IP Right Grant
- 1998-10-20 WO PCT/US1998/022217 patent/WO1999020313A1/en active Application Filing
- 1998-10-20 AU AU11083/99A patent/AU1108399A/en not_active Abandoned
- 1998-10-20 US US09/175,234 patent/US6187289B1/en not_active Expired - Lifetime
- 1998-10-20 US US09/175,232 patent/US6241662B1/en not_active Expired - Lifetime
- 1998-10-20 DE DE69838560T patent/DE69838560T2/de not_active Expired - Lifetime
- 1998-10-20 AU AU11084/99A patent/AU1108499A/en not_active Abandoned
- 1998-10-20 CA CA002306795A patent/CA2306795C/en not_active Expired - Fee Related
- 1998-10-20 JP JP2000516708A patent/JP2001520393A/ja not_active Withdrawn
- 1998-10-20 CN CN98812458.0A patent/CN1302210A/zh active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9042967B2 (en) | 2008-05-20 | 2015-05-26 | University Health Network | Device and method for wound imaging and monitoring |
| US11154198B2 (en) | 2008-05-20 | 2021-10-26 | University Health Network | Method and system for imaging and collection of data for diagnostic purposes |
| US11284800B2 (en) | 2008-05-20 | 2022-03-29 | University Health Network | Devices, methods, and systems for fluorescence-based endoscopic imaging and collection of data with optical filters with corresponding discrete spectral bandwidth |
| US11375898B2 (en) | 2008-05-20 | 2022-07-05 | University Health Network | Method and system with spectral filtering and thermal mapping for imaging and collection of data for diagnostic purposes from bacteria |
| US10438356B2 (en) | 2014-07-24 | 2019-10-08 | University Health Network | Collection and analysis of data for diagnostic purposes |
| US11676276B2 (en) | 2014-07-24 | 2023-06-13 | University Health Network | Collection and analysis of data for diagnostic purposes |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2306795A1 (en) | 1999-04-29 |
| WO1999020314A1 (en) | 1999-04-29 |
| CN1302210A (zh) | 2001-07-04 |
| JP2001520393A (ja) | 2001-10-30 |
| EP1071473B1 (de) | 2007-10-10 |
| AU1108499A (en) | 1999-05-10 |
| US6187289B1 (en) | 2001-02-13 |
| WO1999020313A1 (en) | 1999-04-29 |
| AU1108399A (en) | 1999-05-10 |
| EP1071473A4 (de) | 2005-10-19 |
| DE69838560T2 (de) | 2008-08-14 |
| DE69838560D1 (de) | 2007-11-22 |
| EP1071473A1 (de) | 2001-01-31 |
| US6241662B1 (en) | 2001-06-05 |
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