CA2305312C - Mammalian genes involved in viral infection and tumor suppression - Google Patents
Mammalian genes involved in viral infection and tumor suppression Download PDFInfo
- Publication number
- CA2305312C CA2305312C CA2305312A CA2305312A CA2305312C CA 2305312 C CA2305312 C CA 2305312C CA 2305312 A CA2305312 A CA 2305312A CA 2305312 A CA2305312 A CA 2305312A CA 2305312 C CA2305312 C CA 2305312C
- Authority
- CA
- Canada
- Prior art keywords
- seq
- gene
- nucleic acid
- cell
- dna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 108090000623 proteins and genes Proteins 0.000 title claims abstract description 338
- 230000009385 viral infection Effects 0.000 title claims abstract description 53
- 208000036142 Viral infection Diseases 0.000 title claims abstract description 50
- 230000005760 tumorsuppression Effects 0.000 title description 4
- 150000007523 nucleic acids Chemical class 0.000 claims abstract description 112
- 238000000034 method Methods 0.000 claims abstract description 106
- 102000039446 nucleic acids Human genes 0.000 claims abstract description 105
- 108020004707 nucleic acids Proteins 0.000 claims abstract description 105
- 230000001413 cellular effect Effects 0.000 claims abstract description 45
- 230000012010 growth Effects 0.000 claims abstract description 29
- 230000003612 virological effect Effects 0.000 claims abstract description 20
- 238000012216 screening Methods 0.000 claims abstract description 14
- 210000004027 cell Anatomy 0.000 claims description 256
- 241000700605 Viruses Species 0.000 claims description 89
- 102000004169 proteins and genes Human genes 0.000 claims description 76
- 239000000203 mixture Substances 0.000 claims description 36
- 150000001875 compounds Chemical class 0.000 claims description 35
- 241000282414 Homo sapiens Species 0.000 claims description 33
- 238000009396 hybridization Methods 0.000 claims description 29
- 230000004083 survival effect Effects 0.000 claims description 29
- 239000002773 nucleotide Substances 0.000 claims description 22
- 125000003729 nucleotide group Chemical group 0.000 claims description 22
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 21
- 230000002401 inhibitory effect Effects 0.000 claims description 20
- 230000000694 effects Effects 0.000 claims description 18
- 229920001184 polypeptide Polymers 0.000 claims description 18
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 18
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 17
- 230000014509 gene expression Effects 0.000 claims description 17
- 230000008030 elimination Effects 0.000 claims description 12
- 238000003379 elimination reaction Methods 0.000 claims description 12
- 238000005406 washing Methods 0.000 claims description 12
- 208000037065 Subacute sclerosing leukoencephalitis Diseases 0.000 claims description 9
- 206010042297 Subacute sclerosing panencephalitis Diseases 0.000 claims description 9
- 230000002829 reductive effect Effects 0.000 claims description 9
- 230000006364 cellular survival Effects 0.000 claims description 8
- 230000007423 decrease Effects 0.000 claims description 8
- 230000000295 complement effect Effects 0.000 claims description 7
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims description 6
- 230000035772 mutation Effects 0.000 claims description 5
- 230000000840 anti-viral effect Effects 0.000 claims description 4
- 238000004113 cell culture Methods 0.000 abstract description 20
- 206010028980 Neoplasm Diseases 0.000 abstract description 9
- 201000011510 cancer Diseases 0.000 abstract description 4
- 108020004414 DNA Proteins 0.000 description 136
- 241000700157 Rattus norvegicus Species 0.000 description 129
- 210000002966 serum Anatomy 0.000 description 91
- 239000013598 vector Substances 0.000 description 27
- 208000015181 infectious disease Diseases 0.000 description 25
- 239000002299 complementary DNA Substances 0.000 description 22
- 239000000523 sample Substances 0.000 description 21
- 239000012634 fragment Substances 0.000 description 20
- 241000702263 Reovirus sp. Species 0.000 description 19
- 230000005764 inhibitory process Effects 0.000 description 19
- 235000003642 hunger Nutrition 0.000 description 18
- 239000003550 marker Substances 0.000 description 18
- 108020004999 messenger RNA Proteins 0.000 description 18
- 241000700159 Rattus Species 0.000 description 17
- 230000003211 malignant effect Effects 0.000 description 17
- 108091028043 Nucleic acid sequence Proteins 0.000 description 16
- 230000037351 starvation Effects 0.000 description 16
- 230000006870 function Effects 0.000 description 15
- 238000010561 standard procedure Methods 0.000 description 15
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 14
- 241001465754 Metazoa Species 0.000 description 14
- 230000002018 overexpression Effects 0.000 description 14
- 241001430294 unidentified retrovirus Species 0.000 description 14
- 108010017384 Blood Proteins Proteins 0.000 description 13
- 102000004506 Blood Proteins Human genes 0.000 description 13
- 230000001105 regulatory effect Effects 0.000 description 13
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 12
- 230000002779 inactivation Effects 0.000 description 11
- 239000002609 medium Substances 0.000 description 11
- 230000008569 process Effects 0.000 description 11
- 238000012163 sequencing technique Methods 0.000 description 11
- 239000002502 liposome Substances 0.000 description 10
- 210000001519 tissue Anatomy 0.000 description 10
- 230000029812 viral genome replication Effects 0.000 description 10
- 108020005544 Antisense RNA Proteins 0.000 description 9
- 108700008625 Reporter Genes Proteins 0.000 description 9
- 239000000243 solution Substances 0.000 description 9
- 102000005221 Cleavage Stimulation Factor Human genes 0.000 description 8
- 108010081236 Cleavage Stimulation Factor Proteins 0.000 description 8
- 108091026890 Coding region Proteins 0.000 description 8
- 102100039436 DNA-binding protein inhibitor ID-3 Human genes 0.000 description 8
- 101710152064 DNA-binding protein inhibitor ID-3 Proteins 0.000 description 8
- 241000699660 Mus musculus Species 0.000 description 8
- 239000003184 complementary RNA Substances 0.000 description 8
- 239000001963 growth medium Substances 0.000 description 8
- 238000002955 isolation Methods 0.000 description 8
- 241000725303 Human immunodeficiency virus Species 0.000 description 7
- 102000005881 S100 Calcium Binding Protein A6 Human genes 0.000 description 7
- 108010005260 S100 Calcium Binding Protein A6 Proteins 0.000 description 7
- 239000003795 chemical substances by application Substances 0.000 description 7
- 238000000605 extraction Methods 0.000 description 7
- 101150071146 COX2 gene Proteins 0.000 description 6
- 241000699666 Mus <mouse, genus> Species 0.000 description 6
- 230000004071 biological effect Effects 0.000 description 6
- 238000001727 in vivo Methods 0.000 description 6
- 230000002101 lytic effect Effects 0.000 description 6
- 210000000056 organ Anatomy 0.000 description 6
- 229920001817 Agar Polymers 0.000 description 5
- 101100114534 Caenorhabditis elegans ctc-2 gene Proteins 0.000 description 5
- 229930193140 Neomycin Natural products 0.000 description 5
- 206010061309 Neoplasm progression Diseases 0.000 description 5
- 101150000187 PTGS2 gene Proteins 0.000 description 5
- 102000044209 Tumor Suppressor Genes Human genes 0.000 description 5
- 108700025716 Tumor Suppressor Genes Proteins 0.000 description 5
- 101150082045 U3 gene Proteins 0.000 description 5
- 239000008272 agar Substances 0.000 description 5
- 108010070113 alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase I Proteins 0.000 description 5
- 150000001413 amino acids Chemical class 0.000 description 5
- 230000027455 binding Effects 0.000 description 5
- 239000003937 drug carrier Substances 0.000 description 5
- 101150110946 gatC gene Proteins 0.000 description 5
- 230000002458 infectious effect Effects 0.000 description 5
- 239000003112 inhibitor Substances 0.000 description 5
- 238000003780 insertion Methods 0.000 description 5
- 230000037431 insertion Effects 0.000 description 5
- 150000002632 lipids Chemical class 0.000 description 5
- 229960004927 neomycin Drugs 0.000 description 5
- 230000009467 reduction Effects 0.000 description 5
- 241000894007 species Species 0.000 description 5
- 230000001225 therapeutic effect Effects 0.000 description 5
- 238000011282 treatment Methods 0.000 description 5
- 230000005751 tumor progression Effects 0.000 description 5
- 102100028505 6-pyruvoyl tetrahydrobiopterin synthase Human genes 0.000 description 4
- 108010045523 6-pyruvoyltetrahydropterin synthase Proteins 0.000 description 4
- 102100033350 ATP-dependent translocase ABCB1 Human genes 0.000 description 4
- 108700028369 Alleles Proteins 0.000 description 4
- 241000711573 Coronaviridae Species 0.000 description 4
- 102000004190 Enzymes Human genes 0.000 description 4
- 108090000790 Enzymes Proteins 0.000 description 4
- 208000031886 HIV Infections Diseases 0.000 description 4
- 241000713340 Human immunodeficiency virus 2 Species 0.000 description 4
- 108010047230 Member 1 Subfamily B ATP Binding Cassette Transporter Proteins 0.000 description 4
- 102100030608 Mothers against decapentaplegic homolog 7 Human genes 0.000 description 4
- 101700026522 SMAD7 Proteins 0.000 description 4
- 125000002091 cationic group Chemical group 0.000 description 4
- 238000001514 detection method Methods 0.000 description 4
- 239000005546 dideoxynucleotide Substances 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 239000007924 injection Substances 0.000 description 4
- 238000002347 injection Methods 0.000 description 4
- 230000000670 limiting effect Effects 0.000 description 4
- 230000004048 modification Effects 0.000 description 4
- 238000012986 modification Methods 0.000 description 4
- 238000010369 molecular cloning Methods 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 4
- 239000012679 serum free medium Substances 0.000 description 4
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 3
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 3
- 101000795753 Homo sapiens mRNA decay activator protein ZFP36 Proteins 0.000 description 3
- 241000713772 Human immunodeficiency virus 1 Species 0.000 description 3
- 241000699670 Mus sp. Species 0.000 description 3
- 241000150452 Orthohantavirus Species 0.000 description 3
- 208000037581 Persistent Infection Diseases 0.000 description 3
- 102000040945 Transcription factor Human genes 0.000 description 3
- 108091023040 Transcription factor Proteins 0.000 description 3
- 108010065850 Tristetraprolin Proteins 0.000 description 3
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 3
- 238000007792 addition Methods 0.000 description 3
- 210000004102 animal cell Anatomy 0.000 description 3
- 125000000129 anionic group Chemical group 0.000 description 3
- 238000013459 approach Methods 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 238000012217 deletion Methods 0.000 description 3
- 230000037430 deletion Effects 0.000 description 3
- 230000001419 dependent effect Effects 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- -1 e.g. Substances 0.000 description 3
- 239000000499 gel Substances 0.000 description 3
- 230000003993 interaction Effects 0.000 description 3
- 102100031622 mRNA decay activator protein ZFP36 Human genes 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 108010082117 matrigel Proteins 0.000 description 3
- 238000002844 melting Methods 0.000 description 3
- 230000008018 melting Effects 0.000 description 3
- 230000036961 partial effect Effects 0.000 description 3
- 230000008488 polyadenylation Effects 0.000 description 3
- 238000006467 substitution reaction Methods 0.000 description 3
- 238000013518 transcription Methods 0.000 description 3
- 230000035897 transcription Effects 0.000 description 3
- 238000012546 transfer Methods 0.000 description 3
- 238000011144 upstream manufacturing Methods 0.000 description 3
- 230000035899 viability Effects 0.000 description 3
- 239000013603 viral vector Substances 0.000 description 3
- 239000011701 zinc Substances 0.000 description 3
- 229910052725 zinc Inorganic materials 0.000 description 3
- VWEWCZSUWOEEFM-WDSKDSINSA-N Ala-Gly-Ala-Gly Chemical compound C[C@H](N)C(=O)NCC(=O)N[C@@H](C)C(=O)NCC(O)=O VWEWCZSUWOEEFM-WDSKDSINSA-N 0.000 description 2
- 102000004149 Annexin A2 Human genes 0.000 description 2
- 108090000668 Annexin A2 Proteins 0.000 description 2
- 241000712891 Arenavirus Species 0.000 description 2
- 241000271566 Aves Species 0.000 description 2
- 241000713704 Bovine immunodeficiency virus Species 0.000 description 2
- 241000713756 Caprine arthritis encephalitis virus Species 0.000 description 2
- 101150051240 DLX2 gene Proteins 0.000 description 2
- 241000712471 Dhori virus Species 0.000 description 2
- 108010036466 E2F2 Transcription Factor Proteins 0.000 description 2
- 241001115402 Ebolavirus Species 0.000 description 2
- 241000709661 Enterovirus Species 0.000 description 2
- 241000713730 Equine infectious anemia virus Species 0.000 description 2
- 241000713800 Feline immunodeficiency virus Species 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 241000282412 Homo Species 0.000 description 2
- 101000782302 Homo sapiens Zinc finger protein 823 Proteins 0.000 description 2
- 241000598171 Human adenovirus sp. Species 0.000 description 2
- 241000430519 Human rhinovirus sp. Species 0.000 description 2
- 101150047228 Id3 gene Proteins 0.000 description 2
- 206010061598 Immunodeficiency Diseases 0.000 description 2
- 208000029462 Immunodeficiency disease Diseases 0.000 description 2
- 208000032420 Latent Infection Diseases 0.000 description 2
- 108700026244 Open Reading Frames Proteins 0.000 description 2
- 241001631646 Papillomaviridae Species 0.000 description 2
- 241000709664 Picornaviridae Species 0.000 description 2
- 241000125945 Protoparvovirus Species 0.000 description 2
- 241000702670 Rotavirus Species 0.000 description 2
- 241000713311 Simian immunodeficiency virus Species 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 241001665167 Solter Species 0.000 description 2
- 210000001744 T-lymphocyte Anatomy 0.000 description 2
- 102100024024 Transcription factor E2F2 Human genes 0.000 description 2
- 101710138758 Transcription factor E2F2 Proteins 0.000 description 2
- 108010030743 Tropomyosin Proteins 0.000 description 2
- 241000713325 Visna/maedi virus Species 0.000 description 2
- 102100035804 Zinc finger protein 823 Human genes 0.000 description 2
- 108091007916 Zinc finger transcription factors Proteins 0.000 description 2
- 102000038627 Zinc finger transcription factors Human genes 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 125000000539 amino acid group Chemical group 0.000 description 2
- 238000010171 animal model Methods 0.000 description 2
- 239000003443 antiviral agent Substances 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 244000309743 astrovirus Species 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- 238000012512 characterization method Methods 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 210000000349 chromosome Anatomy 0.000 description 2
- 210000004748 cultured cell Anatomy 0.000 description 2
- 230000002950 deficient Effects 0.000 description 2
- 238000002405 diagnostic procedure Methods 0.000 description 2
- 239000003085 diluting agent Substances 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 208000037771 disease arising from reactivation of latent virus Diseases 0.000 description 2
- 239000003623 enhancer Substances 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000012091 fetal bovine serum Substances 0.000 description 2
- BRZYSWJRSDMWLG-CAXSIQPQSA-N geneticin Chemical compound O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](C(C)O)O2)N)[C@@H](N)C[C@H]1N BRZYSWJRSDMWLG-CAXSIQPQSA-N 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 230000013595 glycosylation Effects 0.000 description 2
- 238000006206 glycosylation reaction Methods 0.000 description 2
- 208000006454 hepatitis Diseases 0.000 description 2
- 231100000283 hepatitis Toxicity 0.000 description 2
- 230000007813 immunodeficiency Effects 0.000 description 2
- 230000002055 immunohistochemical effect Effects 0.000 description 2
- 208000037797 influenza A Diseases 0.000 description 2
- 208000037798 influenza B Diseases 0.000 description 2
- 208000037799 influenza C Diseases 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 230000002452 interceptive effect Effects 0.000 description 2
- 230000000968 intestinal effect Effects 0.000 description 2
- 238000010255 intramuscular injection Methods 0.000 description 2
- 239000007927 intramuscular injection Substances 0.000 description 2
- 238000007834 ligase chain reaction Methods 0.000 description 2
- 210000004962 mammalian cell Anatomy 0.000 description 2
- 210000005075 mammary gland Anatomy 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 230000010412 perfusion Effects 0.000 description 2
- 230000002688 persistence Effects 0.000 description 2
- 230000002085 persistent effect Effects 0.000 description 2
- 239000008177 pharmaceutical agent Substances 0.000 description 2
- 239000002953 phosphate buffered saline Substances 0.000 description 2
- 238000003752 polymerase chain reaction Methods 0.000 description 2
- 230000000644 propagated effect Effects 0.000 description 2
- 230000001902 propagating effect Effects 0.000 description 2
- 230000020978 protein processing Effects 0.000 description 2
- 108020003175 receptors Proteins 0.000 description 2
- 102000005962 receptors Human genes 0.000 description 2
- 230000010076 replication Effects 0.000 description 2
- 230000000241 respiratory effect Effects 0.000 description 2
- 210000002345 respiratory system Anatomy 0.000 description 2
- 150000003384 small molecules Chemical class 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 230000008685 targeting Effects 0.000 description 2
- 108091008743 testicular receptors 4 Proteins 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 238000001890 transfection Methods 0.000 description 2
- 238000002054 transplantation Methods 0.000 description 2
- 210000004881 tumor cell Anatomy 0.000 description 2
- 230000004614 tumor growth Effects 0.000 description 2
- 241001529453 unidentified herpesvirus Species 0.000 description 2
- 241000712461 unidentified influenza virus Species 0.000 description 2
- LDGWQMRUWMSZIU-LQDDAWAPSA-M 2,3-bis[(z)-octadec-9-enoxy]propyl-trimethylazanium;chloride Chemical compound [Cl-].CCCCCCCC\C=C/CCCCCCCCOCC(C[N+](C)(C)C)OCCCCCCCC\C=C/CCCCCCCC LDGWQMRUWMSZIU-LQDDAWAPSA-M 0.000 description 1
- 208000030507 AIDS Diseases 0.000 description 1
- 108010085238 Actins Proteins 0.000 description 1
- 208000010370 Adenoviridae Infections Diseases 0.000 description 1
- 206010060931 Adenovirus infection Diseases 0.000 description 1
- 108020004491 Antisense DNA Proteins 0.000 description 1
- 208000002109 Argyria Diseases 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 241000701822 Bovine papillomavirus Species 0.000 description 1
- 241000283707 Capra Species 0.000 description 1
- 102000014914 Carrier Proteins Human genes 0.000 description 1
- 241000700199 Cavia porcellus Species 0.000 description 1
- 108010031896 Cell Cycle Proteins Proteins 0.000 description 1
- 102000005483 Cell Cycle Proteins Human genes 0.000 description 1
- 108700010070 Codon Usage Proteins 0.000 description 1
- 206010009944 Colon cancer Diseases 0.000 description 1
- 108020004635 Complementary DNA Proteins 0.000 description 1
- 238000007399 DNA isolation Methods 0.000 description 1
- 241000450599 DNA viruses Species 0.000 description 1
- 102000052510 DNA-Binding Proteins Human genes 0.000 description 1
- 101710096438 DNA-binding protein Proteins 0.000 description 1
- 241000283073 Equus caballus Species 0.000 description 1
- 241000701959 Escherichia virus Lambda Species 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 102000008857 Ferritin Human genes 0.000 description 1
- 108050000784 Ferritin Proteins 0.000 description 1
- 238000008416 Ferritin Methods 0.000 description 1
- 101710099785 Ferritin, heavy subunit Proteins 0.000 description 1
- 108700007698 Genetic Terminator Regions Proteins 0.000 description 1
- 206010071602 Genetic polymorphism Diseases 0.000 description 1
- 108010010369 HIV Protease Proteins 0.000 description 1
- 229920002971 Heparan sulfate Polymers 0.000 description 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- 101001055092 Homo sapiens Mitogen-activated protein kinase kinase kinase 7 Proteins 0.000 description 1
- 101001124305 Homo sapiens Nuclear receptor subfamily 2 group C member 2 Proteins 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 108010031792 IGF Type 2 Receptor Proteins 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 102100034343 Integrase Human genes 0.000 description 1
- 102000014150 Interferons Human genes 0.000 description 1
- 108010050904 Interferons Proteins 0.000 description 1
- 108020004509 Intracisternal A-Particle Genes Proteins 0.000 description 1
- 150000008575 L-amino acids Chemical group 0.000 description 1
- 241000710789 Lactate dehydrogenase-elevating virus Species 0.000 description 1
- 241000829100 Macaca mulatta polyomavirus 1 Species 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 102000019218 Mannose-6-phosphate receptors Human genes 0.000 description 1
- 101100063504 Mus musculus Dlx2 gene Proteins 0.000 description 1
- 101100476480 Mus musculus S100a8 gene Proteins 0.000 description 1
- 108010077850 Nuclear Localization Signals Proteins 0.000 description 1
- 108020004711 Nucleic Acid Probes Proteins 0.000 description 1
- 108091005461 Nucleic proteins Proteins 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 241000009328 Perro Species 0.000 description 1
- 108090000459 Prostaglandin-endoperoxide synthases Proteins 0.000 description 1
- 108020005067 RNA Splice Sites Proteins 0.000 description 1
- 108010092799 RNA-directed DNA polymerase Proteins 0.000 description 1
- 108090000244 Rat Proteins Proteins 0.000 description 1
- 241000700162 Rattus sp. Species 0.000 description 1
- 208000008104 Reoviridae Infections Diseases 0.000 description 1
- MIVWVMMAZAALNA-IJLUTSLNSA-N SCB2 Chemical compound CCCCCCC[C@@H](O)[C@H]1[C@H](CO)COC1=O MIVWVMMAZAALNA-IJLUTSLNSA-N 0.000 description 1
- MIVWVMMAZAALNA-UHFFFAOYSA-N SCB2 Natural products CCCCCCCC(O)C1C(CO)COC1=O MIVWVMMAZAALNA-UHFFFAOYSA-N 0.000 description 1
- 108020004487 Satellite DNA Proteins 0.000 description 1
- 101100335937 Schizosaccharomyces pombe (strain 972 / ATCC 24843) gas5 gene Proteins 0.000 description 1
- 108010051611 Signal Recognition Particle Proteins 0.000 description 1
- 102000013598 Signal recognition particle Human genes 0.000 description 1
- 206010072170 Skin wound Diseases 0.000 description 1
- 108091081024 Start codon Proteins 0.000 description 1
- 241000282898 Sus scrofa Species 0.000 description 1
- 108700005078 Synthetic Genes Proteins 0.000 description 1
- 102000005937 Tropomyosin Human genes 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- 102000011731 Vacuolar Proton-Translocating ATPases Human genes 0.000 description 1
- 108010037026 Vacuolar Proton-Translocating ATPases Proteins 0.000 description 1
- ISXSJGHXHUZXNF-LXZPIJOJSA-N [(3s,8s,9s,10r,13r,14s,17r)-10,13-dimethyl-17-[(2r)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-3-yl] n-[2-(dimethylamino)ethyl]carbamate;hydrochloride Chemical compound Cl.C1C=C2C[C@@H](OC(=O)NCCN(C)C)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 ISXSJGHXHUZXNF-LXZPIJOJSA-N 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 208000009956 adenocarcinoma Diseases 0.000 description 1
- 208000011589 adenoviridae infectious disease Diseases 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 239000003816 antisense DNA Substances 0.000 description 1
- 229940121357 antivirals Drugs 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
- 101150010487 are gene Proteins 0.000 description 1
- 210000001106 artificial yeast chromosome Anatomy 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 108091008324 binding proteins Proteins 0.000 description 1
- 238000004166 bioassay Methods 0.000 description 1
- 238000010170 biological method Methods 0.000 description 1
- 210000002459 blastocyst Anatomy 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 210000002798 bone marrow cell Anatomy 0.000 description 1
- 239000007975 buffered saline Substances 0.000 description 1
- 244000309464 bull Species 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000022131 cell cycle Effects 0.000 description 1
- 230000030833 cell death Effects 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 230000006037 cell lysis Effects 0.000 description 1
- 230000009134 cell regulation Effects 0.000 description 1
- 238000004182 chemical digestion Methods 0.000 description 1
- 210000004978 chinese hamster ovary cell Anatomy 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 238000010367 cloning Methods 0.000 description 1
- 208000029742 colonic neoplasm Diseases 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 230000001351 cycling effect Effects 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000002939 deleterious effect Effects 0.000 description 1
- 238000004925 denaturation Methods 0.000 description 1
- 230000036425 denaturation Effects 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 239000000032 diagnostic agent Substances 0.000 description 1
- 229940039227 diagnostic agent Drugs 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
- 241001493065 dsRNA viruses Species 0.000 description 1
- 102000013035 dynein heavy chain Human genes 0.000 description 1
- 108060002430 dynein heavy chain Proteins 0.000 description 1
- 238000004520 electroporation Methods 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000007824 enzymatic assay Methods 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 210000003527 eukaryotic cell Anatomy 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 239000013604 expression vector Substances 0.000 description 1
- 239000012894 fetal calf serum Substances 0.000 description 1
- 230000001605 fetal effect Effects 0.000 description 1
- 210000002458 fetal heart Anatomy 0.000 description 1
- 238000005194 fractionation Methods 0.000 description 1
- 101150077246 gas5 gene Proteins 0.000 description 1
- 238000012268 genome sequencing Methods 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 244000052637 human pathogen Species 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000000415 inactivating effect Effects 0.000 description 1
- 230000001524 infective effect Effects 0.000 description 1
- 230000010365 information processing Effects 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 229940047124 interferons Drugs 0.000 description 1
- 239000007928 intraperitoneal injection Substances 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 238000004255 ion exchange chromatography Methods 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 231100000518 lethal Toxicity 0.000 description 1
- 230000001665 lethal effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000006193 liquid solution Substances 0.000 description 1
- 239000006194 liquid suspension Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 102000004356 mRNA Cleavage and Polyadenylation Factors Human genes 0.000 description 1
- 108010042176 mRNA Cleavage and Polyadenylation Factors Proteins 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000011987 methylation Effects 0.000 description 1
- 238000007069 methylation reaction Methods 0.000 description 1
- 238000000520 microinjection Methods 0.000 description 1
- 238000002941 microtiter virus yield reduction assay Methods 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 239000003607 modifier Substances 0.000 description 1
- 230000009456 molecular mechanism Effects 0.000 description 1
- 210000001616 monocyte Anatomy 0.000 description 1
- 210000002864 mononuclear phagocyte Anatomy 0.000 description 1
- 238000002703 mutagenesis Methods 0.000 description 1
- 231100000350 mutagenesis Toxicity 0.000 description 1
- 230000000869 mutational effect Effects 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 239000002853 nucleic acid probe Substances 0.000 description 1
- 210000004940 nucleus Anatomy 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 238000012261 overproduction Methods 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 230000026731 phosphorylation Effects 0.000 description 1
- 238000006366 phosphorylation reaction Methods 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 238000007747 plating Methods 0.000 description 1
- 238000002264 polyacrylamide gel electrophoresis Methods 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 210000001236 prokaryotic cell Anatomy 0.000 description 1
- 238000000159 protein binding assay Methods 0.000 description 1
- 230000012846 protein folding Effects 0.000 description 1
- 230000009145 protein modification Effects 0.000 description 1
- 238000001742 protein purification Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 108010014186 ras Proteins Proteins 0.000 description 1
- 230000007420 reactivation Effects 0.000 description 1
- 238000010188 recombinant method Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 230000001177 retroviral effect Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 201000009410 rhabdomyosarcoma Diseases 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 230000037432 silent mutation Effects 0.000 description 1
- 206010040882 skin lesion Diseases 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 230000009870 specific binding Effects 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000001308 synthesis method Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 210000003437 trachea Anatomy 0.000 description 1
- 230000002103 transcriptional effect Effects 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 241000701161 unidentified adenovirus Species 0.000 description 1
- 108700026220 vif Genes Proteins 0.000 description 1
- 230000017613 viral reproduction Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1051—Gene trapping, e.g. exon-, intron-, IRES-, signal sequence-trap cloning, trap vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1082—Preparation or screening gene libraries by chromosomal integration of polynucleotide sequences, HR-, site-specific-recombination, transposons, viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
- C12N2720/00011—Details
- C12N2720/12011—Reoviridae
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/60—Vectors containing traps for, e.g. exons, promoters
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Physics & Mathematics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Virology (AREA)
- Plant Pathology (AREA)
- Veterinary Medicine (AREA)
- Microbiology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA2696653A CA2696653A1 (en) | 1997-10-10 | 1998-10-08 | Mammalian genes involved in viral infection and tumor suppression |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6202197P | 1997-10-10 | 1997-10-10 | |
| US60/062,021 | 1997-10-10 | ||
| PCT/US1998/021276 WO1999019481A2 (en) | 1997-10-10 | 1998-10-08 | Mammalian genes involved in viral infection and tumor suppression |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2696653A Division CA2696653A1 (en) | 1997-10-10 | 1998-10-08 | Mammalian genes involved in viral infection and tumor suppression |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2305312A1 CA2305312A1 (en) | 1999-04-22 |
| CA2305312C true CA2305312C (en) | 2010-03-23 |
Family
ID=22039706
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2305312A Expired - Fee Related CA2305312C (en) | 1997-10-10 | 1998-10-08 | Mammalian genes involved in viral infection and tumor suppression |
| CA2696653A Abandoned CA2696653A1 (en) | 1997-10-10 | 1998-10-08 | Mammalian genes involved in viral infection and tumor suppression |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2696653A Abandoned CA2696653A1 (en) | 1997-10-10 | 1998-10-08 | Mammalian genes involved in viral infection and tumor suppression |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1021536A2 (https=) |
| JP (2) | JP2001520012A (https=) |
| AU (1) | AU9604198A (https=) |
| CA (2) | CA2305312C (https=) |
| WO (1) | WO1999019481A2 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001016323A2 (en) * | 1999-09-01 | 2001-03-08 | Subsidiary N0.3, Inc. | Compositions and methods for inhibiting human immunodeficiency virus infection by down-regulating human cellular genes |
| JP2002300900A (ja) * | 2001-04-05 | 2002-10-15 | National Institute Of Advanced Industrial & Technology | 腫瘍悪性化因子および腫瘍悪性化を抑制する化合物のスクリーニング方法 |
| EP1409736A4 (en) * | 2001-06-29 | 2004-07-21 | Subsidiary N0 3 Inc | COMPOSITIONS AND METHODS FOR INHIBITING HUMAN IMMUNODEFICIENCY VIRUS INFECTION BY NEGATIVE REGULATION OF HUMAN CELL GENES |
| US7691599B2 (en) | 2002-05-02 | 2010-04-06 | Zirus, Inc. | Mammalian genes involved in viral infection and tumor suppression |
| EP2339009A1 (en) * | 2009-12-22 | 2011-06-29 | Sandoz Ag | Cold inducible promoter sequences |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2046607C (en) * | 1989-02-14 | 2002-04-16 | Rima Kaddurah-Daouk | Inhibiting transformation of cells having elevated purine metabolic enzyme activity |
| US5364783A (en) * | 1990-05-14 | 1994-11-15 | Massachusetts Institute Of Technology | Retrovirus promoter-trap vectors |
| US5350835A (en) * | 1991-11-05 | 1994-09-27 | Board Of Regents, University Of Texas | Cellular nucleic acid binding protein and uses thereof in regulating gene expression and in the treatment of aids |
| WO1997039119A1 (en) * | 1996-04-15 | 1997-10-23 | Vanderbilt University | Mammalian genes involved in viral infection and tumor suppression |
-
1998
- 1998-10-08 AU AU96041/98A patent/AU9604198A/en not_active Abandoned
- 1998-10-08 JP JP2000516033A patent/JP2001520012A/ja not_active Withdrawn
- 1998-10-08 WO PCT/US1998/021276 patent/WO1999019481A2/en not_active Ceased
- 1998-10-08 EP EP98949800A patent/EP1021536A2/en not_active Withdrawn
- 1998-10-08 CA CA2305312A patent/CA2305312C/en not_active Expired - Fee Related
- 1998-10-08 CA CA2696653A patent/CA2696653A1/en not_active Abandoned
-
2009
- 2009-02-16 JP JP2009033300A patent/JP2009100780A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO1999019481A2 (en) | 1999-04-22 |
| JP2001520012A (ja) | 2001-10-30 |
| CA2696653A1 (en) | 1999-04-22 |
| JP2009100780A (ja) | 2009-05-14 |
| WO1999019481A3 (en) | 1999-11-04 |
| CA2305312A1 (en) | 1999-04-22 |
| EP1021536A2 (en) | 2000-07-26 |
| AU9604198A (en) | 1999-05-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US7122373B1 (en) | Human genes and gene expression products V | |
| EP1440981A2 (en) | Full-length human cdna | |
| KR101126560B1 (ko) | 약제 반응 예측 방법 | |
| Xiao et al. | The lncRNA Malat1 is trafficked to the cytoplasm as a localized mRNA encoding a small peptide in neurons | |
| Kirmizis et al. | Genomic approaches that aid in the identification of transcription factor target genes | |
| EP1309679A2 (en) | Human genes and gene expression products | |
| WO2001066753A2 (en) | Human genes and gene expression products | |
| JP2008301825A (ja) | ウイルス感染および腫瘍抑制に関与する哺乳動物遺伝子 | |
| CA2305312C (en) | Mammalian genes involved in viral infection and tumor suppression | |
| US6777177B1 (en) | Mammalian genes involved in viral infection and tumor suppression | |
| WO2000059933A2 (en) | HUMAN MESENCHYMAL DNAs AND EXPRESSION PRODUCTS | |
| AU2006220384A1 (en) | Mammalian Genes Involved in Viral Infection and Tumor Suppression | |
| JPH10502535A (ja) | ｃ−ｆｏｓプロモーター活性化タンパク質をコードする核酸を同定する方法 | |
| US5851821A (en) | DNA Replication-regulating genes | |
| WO2001072781A9 (en) | Human genes and expression products | |
| Qi et al. | Isolation of novel differentially expressed genes related to human glioma using cDNA microarray and characterizations of two novel full-length genes | |
| EP4350005A1 (en) | Method for screening externally-introduced mrna capable of existing for long time in cell | |
| Zhu | A Functional Tandem Repeat VNTR2-1 in Human Telomerase Gene Regulation | |
| WO2000032630A2 (en) | Nucleic acids and polypeptides derived from activated eosinophil cells and use thereof | |
| AU780210B2 (en) | Mammalian genes involved in viral infection and tumor suppression | |
| EP1075531A1 (en) | Genomic sequences upstream of the coding region of the ifn-alpha2 gene for protein production and delivery | |
| Smith | Identification and characterization of a shared murine tumor antigen | |
| Thornton | Regulation of Human TMnm alternative pre-mRNA splicing | |
| McMahon | Multiple mechanisms of polyadenylation site choice in male germ cells | |
| Wongpalee | Molecular Assembly of Exon Definition Complex and Its Regulation for Alternative Precursor-messenger RNA Splicing by Polypyrimidine-tract Binding Protein PTBP1 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20131009 |