CA2305183A1 - Postsurgical treatment with dichloroacetate - Google Patents

Postsurgical treatment with dichloroacetate Download PDF

Info

Publication number
CA2305183A1
CA2305183A1 CA002305183A CA2305183A CA2305183A1 CA 2305183 A1 CA2305183 A1 CA 2305183A1 CA 002305183 A CA002305183 A CA 002305183A CA 2305183 A CA2305183 A CA 2305183A CA 2305183 A1 CA2305183 A1 CA 2305183A1
Authority
CA
Canada
Prior art keywords
dichloroacetate
treatment
postsurgical
postsurgical treatment
permitting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002305183A
Other languages
French (fr)
Other versions
CA2305183C (en
Inventor
Gary Lopaschuk
Ruth Collins-Nakai
Koon Teo
Jason R.B. Dyck
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Alberta
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2305183A1 publication Critical patent/CA2305183A1/en
Application granted granted Critical
Publication of CA2305183C publication Critical patent/CA2305183C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

A method is described relating to the field of cardiovascular disease and in particular the prevention and treatment of poor cardiac function following surgery. An optimum dose of dichloroacetate is described, permitting the continuous maintenance of blood therapeutic levels.
CA002305183A 1997-10-03 1998-09-30 Postsurgical treatment with dichloroacetate Expired - Fee Related CA2305183C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6091297P 1997-10-03 1997-10-03
US60/060,912 1997-10-03
PCT/US1998/020394 WO1999017763A1 (en) 1997-10-03 1998-09-30 Postsurgical treatment with dichloroacetate

Publications (2)

Publication Number Publication Date
CA2305183A1 true CA2305183A1 (en) 1999-04-15
CA2305183C CA2305183C (en) 2008-09-23

Family

ID=22032515

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002305183A Expired - Fee Related CA2305183C (en) 1997-10-03 1998-09-30 Postsurgical treatment with dichloroacetate

Country Status (4)

Country Link
JP (1) JP2001523635A (en)
AU (1) AU9590698A (en)
CA (1) CA2305183C (en)
WO (1) WO1999017763A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006063446A1 (en) * 2004-12-15 2006-06-22 The Governors Of The University Of Alberta Methods of cardioprotection using dichloroacetate in combination with an inotrope

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6727284B2 (en) 1997-10-03 2004-04-27 University Of Alberta Postsurgical treatment with dichloroacetate
KR20030034171A (en) 2001-07-06 2003-05-01 엔도 파마슈티걸즈, 인크. Oxymorphone controlled release formulations
JP2005533796A (en) * 2002-06-20 2005-11-10 ザ・ガバナーズ・オブ・ザ・ユニバーシティ・オブ・アルバータ Dichloroacetate in combination with cardioprotective or hemodynamic drugs
EP1908462A3 (en) * 2002-06-20 2008-06-25 The Governors Of The University Of Alberta Dichloroacetate in combination with cardioprotective or hemodynamic drugs
US6693133B1 (en) 2002-10-07 2004-02-17 University Of Alberta Methods of cardioprotection using dichloroacetate in combination with an inotrope
CA2489853A1 (en) * 2004-01-16 2005-07-16 The Governors Of The University Of Alberta Methods of cardioprotection using dichloroacetate in combination with an inotrope
WO2011159658A2 (en) 2010-06-14 2011-12-22 University Of Florida Research Foundation, Inc. Methods,assays, and kits related to dichloroacetate (dca)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0786993B1 (en) * 1994-10-17 2002-06-05 Peter W. Stacpoole Compositions comprising carbonate/bicarbonate buffered dichloroacetic acid and their use in the treatment of metabolic and cardiovascular disorders
US5587397A (en) * 1995-06-08 1996-12-24 Cypros Pharmaceutical Corporation Reduction of elevated blood lactate using twice-daily dichloroacetate

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006063446A1 (en) * 2004-12-15 2006-06-22 The Governors Of The University Of Alberta Methods of cardioprotection using dichloroacetate in combination with an inotrope
WO2007030944A2 (en) * 2005-09-16 2007-03-22 The Governors Of The University Of Alberta Methods of cardioprotection using dichloroacetate in combination with an inotrope
WO2007030944A3 (en) * 2005-09-16 2007-05-03 Univ Alberta Methods of cardioprotection using dichloroacetate in combination with an inotrope

Also Published As

Publication number Publication date
AU9590698A (en) 1999-04-27
WO1999017763A1 (en) 1999-04-15
JP2001523635A (en) 2001-11-27
CA2305183C (en) 2008-09-23

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