CA2299610A1 - Inhibiteurs selectifs du facteur xa - Google Patents
Inhibiteurs selectifs du facteur xa Download PDFInfo
- Publication number
- CA2299610A1 CA2299610A1 CA002299610A CA2299610A CA2299610A1 CA 2299610 A1 CA2299610 A1 CA 2299610A1 CA 002299610 A CA002299610 A CA 002299610A CA 2299610 A CA2299610 A CA 2299610A CA 2299610 A1 CA2299610 A1 CA 2299610A1
- Authority
- CA
- Canada
- Prior art keywords
- group
- 6alkyl
- compound
- aryl
- 4alkylaryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
La présente invention concerne de nouveaux composés, ainsi que leurs sels et leurs compositions, efficaces contre le facteur Xa mammalien. Ces composés, représentés par la formule (I), sont utiles in vitro et in vivo pour prévenir ou traiter les troubles de la coagulation.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8418497P | 1997-08-11 | 1997-08-11 | |
US90803197A | 1997-08-11 | 1997-08-11 | |
US60/084,184 | 1997-08-11 | ||
US08/908,031 | 1997-08-11 | ||
PCT/US1998/016705 WO1999007731A1 (fr) | 1997-08-11 | 1998-08-11 | INHIBITEURS SELECTIFS DU FACTEUR Xa |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2299610A1 true CA2299610A1 (fr) | 1999-02-18 |
Family
ID=26770690
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002299610A Abandoned CA2299610A1 (fr) | 1997-08-11 | 1998-08-11 | Inhibiteurs selectifs du facteur xa |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0994894A1 (fr) |
JP (1) | JP2001515842A (fr) |
CA (1) | CA2299610A1 (fr) |
NZ (1) | NZ502876A (fr) |
WO (1) | WO1999007731A1 (fr) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6194435B1 (en) | 1996-10-11 | 2001-02-27 | Cor Therapeutics, Inc. | Lactams as selective factor Xa inhibitors |
US6063794A (en) | 1996-10-11 | 2000-05-16 | Cor Therapeutics Inc. | Selective factor Xa inhibitors |
US6369080B2 (en) | 1996-10-11 | 2002-04-09 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
US6262047B1 (en) | 1996-10-11 | 2001-07-17 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
JP2001521524A (ja) * | 1997-04-14 | 2001-11-06 | シーオーアール セラピューティクス インコーポレイテッド | 選択的Xa因子阻害剤 |
EP0975625A1 (fr) | 1997-04-14 | 2000-02-02 | Cor Therapeutics, Inc. | INHIBITEURS SELECTIFS DU FACTEUR Xa |
JP2001523226A (ja) | 1997-04-14 | 2001-11-20 | シーオーアール セラピューティクス インコーポレイテッド | 選択的Xa因子阻害剤 |
WO1998046627A1 (fr) | 1997-04-14 | 1998-10-22 | Cor Therapeutics, Inc. | INHIBITEURS SELECTIFS DU FACTEUR Xa |
US6333321B1 (en) | 1997-08-11 | 2001-12-25 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
US6228854B1 (en) | 1997-08-11 | 2001-05-08 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
US6218382B1 (en) | 1997-08-11 | 2001-04-17 | Cor Therapeutics, Inc | Selective factor Xa inhibitors |
WO2000038618A2 (fr) | 1998-12-24 | 2000-07-06 | Du Pont Pharmaceuticals Company | BENZODIAZEPINES SUCCINOYLAMINO UTILISEES COMME INHIBITEURS DE LA PRODUCTION DE PROTEINE A$g(b) |
EP1156803A4 (fr) | 1999-02-09 | 2004-03-17 | Bristol Myers Squibb Co | Inhibiteurs lactame de fxa et methode |
MXPA02002657A (es) | 1999-09-13 | 2002-10-28 | Dimensional Pharm Inc | Inhibidores de azacicloalcanona serina proteasa. |
US6503902B2 (en) | 1999-09-13 | 2003-01-07 | Bristol-Myers Squibb Pharma Company | Hydroxyalkanoylaminolactams and related structures as inhibitors of a β protein production |
US6960576B2 (en) | 1999-09-13 | 2005-11-01 | Bristol-Myers Squibb Pharma Company | Hydroxyalkanoylaminolactams and related structures as inhibitors of Aβ protein production |
CA2387493A1 (fr) | 1999-10-08 | 2001-04-19 | Lorin Andrew Thompson | Amino sulfonamides de lactame utilises comme inhibiteurs de la production de proteine a.beta. |
WO2001060826A2 (fr) | 2000-02-17 | 2001-08-23 | Bristol-Myers Squibb Pharma Company | CARBOCYCLES ET HETEROCYCLES SUCCINOYLAMINO UTILISES EN TANT QU'INHIBITEURS DE LA PRODUCTION DE LA PROTEINE A$g(b) |
US6495540B2 (en) | 2000-03-28 | 2002-12-17 | Bristol - Myers Squibb Pharma Company | Lactams as inhibitors of A-β protein production |
MXPA02009729A (es) | 2000-04-03 | 2003-03-27 | Bristol Myers Squibb Pharma Co | Lactamas ciclicas como inhibidores de la produccion de la proteina a-beta. |
BR0107532A (pt) | 2000-04-03 | 2004-11-03 | Bristol Myers Squibb Pharma Co | Composto, uso do composto, método para o tratamento de disfunções neurológicas associadas com a produção de b-amilóide, método de inibição da atividade de y-secretase e composição farmacêutica |
AU2001257006A1 (en) | 2000-04-11 | 2001-10-23 | Du Pont Pharmaceuticals Company | Substituted lactams as inhibitors of abeta protein production |
AU2001255408A1 (en) * | 2000-04-14 | 2001-10-30 | Corvas International, Inc. | Tetrahydro-azepinone derivatives as thrombin inhibitors |
BR0106717A (pt) | 2000-06-01 | 2002-04-16 | Bristol Myers Squibb Pharma Co | Compostos, composição farmacêutica e usos dos compostos de lactama inovadora |
US6511973B2 (en) | 2000-08-02 | 2003-01-28 | Bristol-Myers Squibb Co. | Lactam inhibitors of FXa and method |
US7479502B2 (en) | 2002-12-03 | 2009-01-20 | Pharmacyclics, Inc. | 2-(2-hydroxybiphenyl-3-yl)-1H-benzoimidazole-5-carboxamidine derivatives as factor VIIA inhibitors |
WO2005011611A2 (fr) * | 2003-07-31 | 2005-02-10 | Irm, Llc | Composes bicycliques et compositions utilisees comme inhibiteurs pdf |
CN109071504B (zh) | 2016-02-05 | 2022-03-08 | 戴纳立制药公司 | 受体相互作用蛋白激酶1的抑制剂 |
DK3552017T3 (da) | 2016-12-09 | 2022-05-16 | Denali Therapeutics Inc | Forbindelser, der er anvendelige som ripk1-inhibitorer |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995035311A1 (fr) * | 1994-06-17 | 1995-12-28 | Corvas International, Inc. | Derives de l'acide 3-amino-2-oxo-1-piperidineacetique |
CA2208773A1 (fr) * | 1994-12-22 | 1996-06-27 | John Dimaio | Peptides de cetoarginine heterocycliques utilises comme inhibiteurs de thrombine |
CA2268281A1 (fr) * | 1996-10-11 | 1998-04-23 | Cor Therapeutics, Inc. | Inhibiteurs competitifs du facteur xa |
-
1998
- 1998-08-11 EP EP98939912A patent/EP0994894A1/fr not_active Withdrawn
- 1998-08-11 JP JP2000506233A patent/JP2001515842A/ja active Pending
- 1998-08-11 WO PCT/US1998/016705 patent/WO1999007731A1/fr not_active Application Discontinuation
- 1998-08-11 NZ NZ502876A patent/NZ502876A/en unknown
- 1998-08-11 CA CA002299610A patent/CA2299610A1/fr not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
NZ502876A (en) | 2001-11-30 |
EP0994894A1 (fr) | 2000-04-26 |
WO1999007731A1 (fr) | 1999-02-18 |
JP2001515842A (ja) | 2001-09-25 |
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US6262047B1 (en) | Selective factor Xa inhibitors | |
US6369063B1 (en) | Selective factor Xa inhibitors | |
US6228854B1 (en) | Selective factor Xa inhibitors | |
US6525076B1 (en) | Selective factor Xa inhibitors | |
US6333321B1 (en) | Selective factor Xa inhibitors | |
US6369080B2 (en) | Selective factor Xa inhibitors | |
US6194435B1 (en) | Lactams as selective factor Xa inhibitors | |
WO1998016524A1 (fr) | DERIVES HETEROCYCLIQUES UTILISES COMME INHIBITEURS DE FACTEUR Xa | |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Dead |