CA2299267A1 - Procede de production de derives de lh-rh - Google Patents

Procede de production de derives de lh-rh Download PDF

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Publication number
CA2299267A1
CA2299267A1 CA002299267A CA2299267A CA2299267A1 CA 2299267 A1 CA2299267 A1 CA 2299267A1 CA 002299267 A CA002299267 A CA 002299267A CA 2299267 A CA2299267 A CA 2299267A CA 2299267 A1 CA2299267 A1 CA 2299267A1
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CA
Canada
Prior art keywords
ser
leu
arg
pro
tyr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002299267A
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English (en)
Inventor
Kazuhisa Kashimoto
Yumiko Nagano
Akiko Ohata
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Itoham Foods Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority claimed from PCT/JP1997/002705 external-priority patent/WO1999007874A1/fr
Publication of CA2299267A1 publication Critical patent/CA2299267A1/fr
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

L'invention a trait à un procédé de production de dérivés de LH-RH représentés par la formule générale (3): pGlu-His-Trp-Ser-Tyr-X-Leu-Arg-Pro-Y. Dans cette formule, X représente un acide aminé issu du groupe constitué par des acides aminés-D, tels que D-Leu, D-Ser (But), D-Trp et (2-naphtyl)-D-Ala et Gly, Y représente Gly-NH¿2?, Azgly(azaglycine)-NH¿2? ou NHR?2¿, R?2¿ représentant un alkyle de faible poids moléculaire. Ce procédé se caractérise par la réaction d'un fragment peptidique représenté par la formule générale (1): pGlu-His-Trp-OR?1¿, dans laquelle R?1¿ représente un alkyle de faible poids moléculaire, avec un autre fragment peptidique représenté par la formule générale (2): H-Ser-Tyr-X-Leu-Arg-Pro-Y, cette réaction ayant lieu en présence de chymotrypsine ou d'une enzyme du type chymotrypsine. Ce procédé, qui se révèle des plus utile au plan industriel dans la mesure où les dérivés de LH-RH peuvent être aisément séparés et purifiés et ce, avec un rendement élevé, sans que ne se produise de réaction secondaire telle qu'une racémisation, permet également de récupérer les fragments peptidiques n'ayant pas réagi et de les réutiliser.
CA002299267A 1997-08-04 1997-08-04 Procede de production de derives de lh-rh Abandoned CA2299267A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/JP1997/002705 WO1999007874A1 (fr) 1996-06-13 1997-08-04 Procede de production de derives de lh-rh

Publications (1)

Publication Number Publication Date
CA2299267A1 true CA2299267A1 (fr) 1999-02-18

Family

ID=14180932

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002299267A Abandoned CA2299267A1 (fr) 1997-08-04 1997-08-04 Procede de production de derives de lh-rh

Country Status (3)

Country Link
KR (1) KR20010022632A (fr)
AU (1) AU3708697A (fr)
CA (1) CA2299267A1 (fr)

Also Published As

Publication number Publication date
AU3708697A (en) 1999-03-01
KR20010022632A (ko) 2001-03-26

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