CA2294472C - Torsin, torsin genes, and methods of use - Google Patents

Torsin, torsin genes, and methods of use Download PDF

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Publication number
CA2294472C
CA2294472C CA2294472A CA2294472A CA2294472C CA 2294472 C CA2294472 C CA 2294472C CA 2294472 A CA2294472 A CA 2294472A CA 2294472 A CA2294472 A CA 2294472A CA 2294472 C CA2294472 C CA 2294472C
Authority
CA
Canada
Prior art keywords
nucleic acid
torsin
leu
sequence
lys
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2294472A
Other languages
English (en)
French (fr)
Other versions
CA2294472A1 (en
Inventor
Laurie J. Ozelius
Xandra Breakefield
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
General Hospital Corp
Original Assignee
General Hospital Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by General Hospital Corp filed Critical General Hospital Corp
Publication of CA2294472A1 publication Critical patent/CA2294472A1/en
Application granted granted Critical
Publication of CA2294472C publication Critical patent/CA2294472C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CA2294472A 1997-06-19 1998-06-19 Torsin, torsin genes, and methods of use Expired - Lifetime CA2294472C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US5024497P 1997-06-19 1997-06-19
US60/050,244 1997-06-19
US9945498A 1998-06-18 1998-06-18
US09/099,454 1998-06-18
PCT/US1998/012776 WO1998057984A2 (en) 1997-06-19 1998-06-19 Torsin, torsin genes, and methods of use

Publications (2)

Publication Number Publication Date
CA2294472A1 CA2294472A1 (en) 1998-12-23
CA2294472C true CA2294472C (en) 2010-06-15

Family

ID=26728056

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2294472A Expired - Lifetime CA2294472C (en) 1997-06-19 1998-06-19 Torsin, torsin genes, and methods of use

Country Status (5)

Country Link
US (1) US6387616B1 (enExample)
EP (1) EP0989995A2 (enExample)
JP (1) JP4323572B2 (enExample)
CA (1) CA2294472C (enExample)
WO (1) WO1998057984A2 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6921814B2 (en) * 1997-06-19 2005-07-26 The General Hospital Corporation Torsin, torsin-related genes and methods of detecting neuronal disease
WO2001032875A1 (en) * 1999-11-04 2001-05-10 Biogen, Inc. Torsin c nucleic acids and polypeptides
US6306403B1 (en) * 2000-06-14 2001-10-23 Allergan Sales, Inc. Method for treating parkinson's disease with a botulinum toxin
AU2001286120A1 (en) * 2000-09-14 2002-03-26 Pharma Pacific Pty Ltd Interferon-alpha induced gene
US20030235823A1 (en) * 2002-06-24 2003-12-25 The University Of Alabama Nucleotide sequences that code for torsin genes, torsin proteins, and methods of using the same to treat protein-aggregation
US20050255086A1 (en) * 2002-08-05 2005-11-17 Davidson Beverly L Nucleic acid silencing of Huntington's Disease gene
US20080176812A1 (en) * 2002-08-05 2008-07-24 Davidson Beverly L Allele-specific silencing of disease genes
US20050106731A1 (en) * 2002-08-05 2005-05-19 Davidson Beverly L. siRNA-mediated gene silencing with viral vectors
US20080274989A1 (en) 2002-08-05 2008-11-06 University Of Iowa Research Foundation Rna Interference Suppression of Neurodegenerative Diseases and Methods of Use Thereof
US20040023390A1 (en) * 2002-08-05 2004-02-05 Davidson Beverly L. SiRNA-mediated gene silencing with viral vectors
US20050042646A1 (en) * 2002-08-05 2005-02-24 Davidson Beverly L. RNA interference suppresion of neurodegenerative diseases and methods of use thereof
US20040241854A1 (en) * 2002-08-05 2004-12-02 Davidson Beverly L. siRNA-mediated gene silencing
JP2008531019A (ja) * 2005-02-25 2008-08-14 ザ・ボード・オブ・トラスティーズ・オブ・ザ・ユニバーシティー・オブ・アラバマ・フォー・アンド・オン・ビハーフ・オブ・ザ・ユニバーシティー・オブ・アラバマ タンパク質のミスフォールディングおよび凝集の制御因子ならびにその制御因子の使用の方法
CA3027587A1 (en) 2016-06-06 2017-12-14 Vib Vzw Means and methods to treat dystonia

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2016227A1 (en) * 1989-05-18 1990-11-18 Xandra O. Breakefield Genetic diagnosis of torsion dystonia
GB9517780D0 (en) 1995-08-31 1995-11-01 Roslin Inst Edinburgh Biological manipulation

Also Published As

Publication number Publication date
JP4323572B2 (ja) 2009-09-02
WO1998057984A2 (en) 1998-12-23
US6387616B1 (en) 2002-05-14
EP0989995A2 (en) 2000-04-05
WO1998057984A3 (en) 1999-03-11
JP2002514923A (ja) 2002-05-21
CA2294472A1 (en) 1998-12-23

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Effective date: 20180619