CA2294472C - Torsin, torsin genes, and methods of use - Google Patents

Torsin, torsin genes, and methods of use Download PDF

Info

Publication number
CA2294472C
CA2294472C CA2294472A CA2294472A CA2294472C CA 2294472 C CA2294472 C CA 2294472C CA 2294472 A CA2294472 A CA 2294472A CA 2294472 A CA2294472 A CA 2294472A CA 2294472 C CA2294472 C CA 2294472C
Authority
CA
Canada
Prior art keywords
nucleic acid
torsin
leu
sequence
lys
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2294472A
Other languages
English (en)
French (fr)
Other versions
CA2294472A1 (en
Inventor
Laurie J. Ozelius
Xandra Breakefield
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
General Hospital Corp
Original Assignee
General Hospital Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by General Hospital Corp filed Critical General Hospital Corp
Publication of CA2294472A1 publication Critical patent/CA2294472A1/en
Application granted granted Critical
Publication of CA2294472C publication Critical patent/CA2294472C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/05Animals comprising random inserted nucleic acids (transgenic)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CA2294472A 1997-06-19 1998-06-19 Torsin, torsin genes, and methods of use Expired - Lifetime CA2294472C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US5024497P 1997-06-19 1997-06-19
US9945498A 1998-06-18 1998-06-18
US09/099,454 1998-06-18
US60/050,244 1998-06-18
PCT/US1998/012776 WO1998057984A2 (en) 1997-06-19 1998-06-19 Torsin, torsin genes, and methods of use

Publications (2)

Publication Number Publication Date
CA2294472A1 CA2294472A1 (en) 1998-12-23
CA2294472C true CA2294472C (en) 2010-06-15

Family

ID=26728056

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2294472A Expired - Lifetime CA2294472C (en) 1997-06-19 1998-06-19 Torsin, torsin genes, and methods of use

Country Status (5)

Country Link
US (1) US6387616B1 (de)
EP (1) EP0989995A2 (de)
JP (1) JP4323572B2 (de)
CA (1) CA2294472C (de)
WO (1) WO1998057984A2 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6921814B2 (en) * 1997-06-19 2005-07-26 The General Hospital Corporation Torsin, torsin-related genes and methods of detecting neuronal disease
WO2001032875A1 (en) * 1999-11-04 2001-05-10 Biogen, Inc. Torsin c nucleic acids and polypeptides
US6306403B1 (en) * 2000-06-14 2001-10-23 Allergan Sales, Inc. Method for treating parkinson's disease with a botulinum toxin
US20030194732A1 (en) * 2000-09-14 2003-10-16 Jean-Francois Meritet Interferon-alpha induced gene
US20030235823A1 (en) * 2002-06-24 2003-12-25 The University Of Alabama Nucleotide sequences that code for torsin genes, torsin proteins, and methods of using the same to treat protein-aggregation
US20050106731A1 (en) * 2002-08-05 2005-05-19 Davidson Beverly L. siRNA-mediated gene silencing with viral vectors
US20050255086A1 (en) * 2002-08-05 2005-11-17 Davidson Beverly L Nucleic acid silencing of Huntington's Disease gene
US20040023390A1 (en) * 2002-08-05 2004-02-05 Davidson Beverly L. SiRNA-mediated gene silencing with viral vectors
US20080176812A1 (en) * 2002-08-05 2008-07-24 Davidson Beverly L Allele-specific silencing of disease genes
US20040241854A1 (en) 2002-08-05 2004-12-02 Davidson Beverly L. siRNA-mediated gene silencing
US20050042646A1 (en) * 2002-08-05 2005-02-24 Davidson Beverly L. RNA interference suppresion of neurodegenerative diseases and methods of use thereof
US20080274989A1 (en) 2002-08-05 2008-11-06 University Of Iowa Research Foundation Rna Interference Suppression of Neurodegenerative Diseases and Methods of Use Thereof
JP2008531019A (ja) * 2005-02-25 2008-08-14 ザ・ボード・オブ・トラスティーズ・オブ・ザ・ユニバーシティー・オブ・アラバマ・フォー・アンド・オン・ビハーフ・オブ・ザ・ユニバーシティー・オブ・アラバマ タンパク質のミスフォールディングおよび凝集の制御因子ならびにその制御因子の使用の方法
EP3464595A1 (de) 2016-06-06 2019-04-10 VIB vzw Mittel und verfahren zur behandlung von dystonie

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2016227A1 (en) * 1989-05-18 1990-11-18 Xandra O. Breakefield Genetic diagnosis of torsion dystonia
GB9517780D0 (en) 1995-08-31 1995-11-01 Roslin Inst Edinburgh Biological manipulation

Also Published As

Publication number Publication date
JP4323572B2 (ja) 2009-09-02
WO1998057984A3 (en) 1999-03-11
WO1998057984A2 (en) 1998-12-23
US6387616B1 (en) 2002-05-14
CA2294472A1 (en) 1998-12-23
JP2002514923A (ja) 2002-05-21
EP0989995A2 (de) 2000-04-05

Similar Documents

Publication Publication Date Title
CA2294472C (en) Torsin, torsin genes, and methods of use
DE69738637T2 (de) Leptinrezeptor db, den rezeptor kodierende nukleinsäuren und anwendungen desselben
CA2353086C (en) Pgc-1, a novel brown fat ppar.gamma. coactivator
US20020168708A1 (en) Muscarinic receptors and uses therefor
DE69926764T2 (de) Methoden zur bestimmung von komponenten zur modulation des körpergewichts
WO1999002667A1 (en) Mutations in the myostation gene cause double-muscling in mammals
EP1003777A1 (de) PGC-1, EIN NEUARTIGER PPAR-g(g)-KOAKTIVATOR AUS BRAUNEM FETTGEWEBE
US6210921B1 (en) CAR: a novel coxsackievirus and adenovirus receptor
AU699024B2 (en) Alk-7 (activin like kinase), a serine threonine kinase receptor
WO1998021333A2 (en) Nucleic acid encoding schwannomin-binding-proteins and products related thereto
US6921814B2 (en) Torsin, torsin-related genes and methods of detecting neuronal disease
AU673575B2 (en) A novel transport protein gene from the Huntington's disease region
EP0892807A1 (de) Mit neurosensorischen defekten verknüpfte genfamilie
AU2004201496C1 (en) DB the receptor for leptin nucleic acids encoding the receptor, and uses thereof
US7030235B1 (en) Compositions to detect lesions associated with hearing loss in the cochlear gene, COCH5B2
WO1999050298A1 (en) GFRα-X, A NOVEL GLIAL-DERIVED NEUROTROPHIC FACTOR RECEPTOR AND USES THEREFOR
US6268130B1 (en) RP compositions and diagnostic uses therefor
US7148004B1 (en) Oligonucleotides of the OB-R isoforms and methods of diagnosing body weight
US5935851A (en) TPR-containing genes
WO1998012323A1 (en) Nucleic acid encoding congenital heart disease protein and products related thereto
WO1998008861A1 (en) Rp compositions and therapeutic and diagnostic uses therefor
CA2329506A1 (en) Alg-2lp, alg-2 like molecules and uses therefor
JP2006083168A (ja) Alk−7(アクチビン様キナーゼ)、セリンスレオニンキナーゼレセプター
JP2008156359A (ja) Alk−7(アクチビン様キナーゼ)、セリンスレオニンキナーゼレセプター

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20180619