CA2294428A1 - Systeme et procede permettant de simuler, modeliser et programmer des operations de support de processus dans des installations de production biopharmaceutiques a traitement discontinu - Google Patents
Systeme et procede permettant de simuler, modeliser et programmer des operations de support de processus dans des installations de production biopharmaceutiques a traitement discontinu Download PDFInfo
- Publication number
- CA2294428A1 CA2294428A1 CA002294428A CA2294428A CA2294428A1 CA 2294428 A1 CA2294428 A1 CA 2294428A1 CA 002294428 A CA002294428 A CA 002294428A CA 2294428 A CA2294428 A CA 2294428A CA 2294428 A1 CA2294428 A1 CA 2294428A1
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- CA
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- Prior art keywords
- equipment
- preparation
- solution
- solution preparation
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- XINQFOMFQFGGCQ-UHFFFAOYSA-L (2-dodecoxy-2-oxoethyl)-[6-[(2-dodecoxy-2-oxoethyl)-dimethylazaniumyl]hexyl]-dimethylazanium;dichloride Chemical compound [Cl-].[Cl-].CCCCCCCCCCCCOC(=O)C[N+](C)(C)CCCCCC[N+](C)(C)CC(=O)OCCCCCCCCCCCC XINQFOMFQFGGCQ-UHFFFAOYSA-L 0.000 description 1
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- 239000002351 wastewater Substances 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0006—Controlling or regulating processes
-
- G—PHYSICS
- G05—CONTROLLING; REGULATING
- G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
- G05B17/00—Systems involving the use of models or simulators of said systems
- G05B17/02—Systems involving the use of models or simulators of said systems electric
-
- G—PHYSICS
- G05—CONTROLLING; REGULATING
- G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
- G05B19/00—Programme-control systems
- G05B19/02—Programme-control systems electric
- G05B19/418—Total factory control, i.e. centrally controlling a plurality of machines, e.g. direct or distributed numerical control [DNC], flexible manufacturing systems [FMS], integrated manufacturing systems [IMS] or computer integrated manufacturing [CIM]
- G05B19/41865—Total factory control, i.e. centrally controlling a plurality of machines, e.g. direct or distributed numerical control [DNC], flexible manufacturing systems [FMS], integrated manufacturing systems [IMS] or computer integrated manufacturing [CIM] characterised by job scheduling, process planning, material flow
-
- G—PHYSICS
- G05—CONTROLLING; REGULATING
- G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
- G05B19/00—Programme-control systems
- G05B19/02—Programme-control systems electric
- G05B19/418—Total factory control, i.e. centrally controlling a plurality of machines, e.g. direct or distributed numerical control [DNC], flexible manufacturing systems [FMS], integrated manufacturing systems [IMS] or computer integrated manufacturing [CIM]
- G05B19/41885—Total factory control, i.e. centrally controlling a plurality of machines, e.g. direct or distributed numerical control [DNC], flexible manufacturing systems [FMS], integrated manufacturing systems [IMS] or computer integrated manufacturing [CIM] characterised by modeling, simulation of the manufacturing system
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06Q—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES; SYSTEMS OR METHODS SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES, NOT OTHERWISE PROVIDED FOR
- G06Q10/00—Administration; Management
- G06Q10/06—Resources, workflows, human or project management; Enterprise or organisation planning; Enterprise or organisation modelling
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00002—Chemical plants
- B01J2219/00004—Scale aspects
- B01J2219/00006—Large-scale industrial plants
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00002—Chemical plants
- B01J2219/00004—Scale aspects
- B01J2219/00015—Scale-up
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00002—Chemical plants
- B01J2219/00027—Process aspects
- B01J2219/00029—Batch processes
-
- G—PHYSICS
- G05—CONTROLLING; REGULATING
- G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
- G05B2219/00—Program-control systems
- G05B2219/30—Nc systems
- G05B2219/32—Operator till task planning
- G05B2219/32234—Maintenance planning
-
- G—PHYSICS
- G05—CONTROLLING; REGULATING
- G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
- G05B2219/00—Program-control systems
- G05B2219/30—Nc systems
- G05B2219/32—Operator till task planning
- G05B2219/32354—Divide, analyse process into subprocesses, until elementary unit operations
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P90/00—Enabling technologies with a potential contribution to greenhouse gas [GHG] emissions mitigation
- Y02P90/02—Total factory control, e.g. smart factories, flexible manufacturing systems [FMS] or integrated manufacturing systems [IMS]
Landscapes
- Engineering & Computer Science (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
- Manufacturing & Machinery (AREA)
- Automation & Control Theory (AREA)
- Quality & Reliability (AREA)
- Business, Economics & Management (AREA)
- Economics (AREA)
- Strategic Management (AREA)
- General Engineering & Computer Science (AREA)
- Human Resources & Organizations (AREA)
- Entrepreneurship & Innovation (AREA)
- Chemical & Material Sciences (AREA)
- Game Theory and Decision Science (AREA)
- General Business, Economics & Management (AREA)
- Tourism & Hospitality (AREA)
- Theoretical Computer Science (AREA)
- Operations Research (AREA)
- Marketing (AREA)
- Educational Administration (AREA)
- Development Economics (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Factory Administration (AREA)
- Management, Administration, Business Operations System, And Electronic Commerce (AREA)
Abstract
L'invention se rapporte à un système et à un procédé permettant de simuler, modéliser et programmer des opérations de support de processus dans une installation de production biopharmaceutique. Parmi ces opérations, on trouve celles qui sont associées à l'installation de production mettant en oeuvre un traitement discontinu (par exemple, l'entretien et l'étalonnage de l'équipement, ainsi que l'échantillonnage et les essais liés au contrôle de la qualité ) et celles qui sont associées au processus de production biopharmaceutique utilisant un traitement discontinu au sein de l'installation (par exemple, la préparation de la solution et de l'équipement). Ce système et ce procédé sont destinés aux opérations de support du processus associées à l'installation de production. Ledit procédé consiste à identifier les données pertinentes (par exemple, l'entretien, l'étalonnage ou l'essai) associées à l'équipement du processus de production biopharmaceutique. Après l'identification des données, l'équipement du processus de production biopharmaceutique est utilisé pour générer une table des données concernant l'équipement et des éléments associés. Cette table est ensuite comparée à un schéma temporel des procédures en vue de déterminer la programmation des tâches que doit remplir l'équipement au cours du processus de production biopharmaceutique. En ce qui concerne les opérations de support du processus associées au processus de fabrication au sein de l'installation, ce procédé consiste à identifier la solution et son volume, ou à identifier l'équipement sali et les procédures de sa préparation. Après cette identification, des informations de programmation sont identifiées sur la base de dates de départ de la solution ou des protocoles relatifs à l'équipement. La durée de la procédure de préparation de la solution est alors déterminée sur la base de l'affectation d'une cuve de préparation et des informations de programmation. Un schéma temporel de la préparation de l'équipement est également généré sur la base de la taille et de la capacité de l'équipement de préparation et des informations de programmation.
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5029097P | 1997-06-20 | 1997-06-20 | |
| US5028597P | 1997-06-20 | 1997-06-20 | |
| US5029997P | 1997-06-20 | 1997-06-20 | |
| US5029497P | 1997-06-20 | 1997-06-20 | |
| US60/050,294 | 1997-06-20 | ||
| US60/050,299 | 1997-06-20 | ||
| US60/050,285 | 1997-06-20 | ||
| US60/050,290 | 1997-06-20 | ||
| PCT/US1998/013055 WO1998059285A2 (fr) | 1997-06-20 | 1998-06-22 | Systeme et procede permettant de simuler, modeliser et programmer des operations de support de processus dans des installations de production biopharmaceutiques a traitement discontinu |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2294428A1 true CA2294428A1 (fr) | 1998-12-30 |
Family
ID=27489328
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002294428A Abandoned CA2294428A1 (fr) | 1997-06-20 | 1998-06-22 | Systeme et procede permettant de simuler, modeliser et programmer des operations de support de processus dans des installations de production biopharmaceutiques a traitement discontinu |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1050001A4 (fr) |
| JP (1) | JP2002518981A (fr) |
| AU (1) | AU8261798A (fr) |
| CA (1) | CA2294428A1 (fr) |
| WO (1) | WO1998059285A2 (fr) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60045129D1 (de) * | 1999-08-13 | 2010-12-02 | Peter G Brown | Simulation, modellierung und planung von stapelverarbeitungsprozessen in produktionseinrichtungen mit hilfe von prozesszeit-intervallen |
| GB2362484B (en) * | 2000-05-17 | 2005-02-23 | Biopharm Services Ltd | Methods and apparatus for simulating industrial processes |
| GB0219954D0 (en) * | 2002-08-29 | 2002-10-02 | Amersham Health R & D Ab | Method and apparatus for producing contrast agents for magnetic resonance imaging |
| US7343211B2 (en) | 2003-04-09 | 2008-03-11 | Brown Peter G | Use of sub (partial) cycles, nested cluster cycles, and lot cycles for determining equipment capacities in a batch manufacturing facility |
| CN103218256B (zh) * | 2013-04-18 | 2016-04-13 | 中国工商银行股份有限公司 | 一种主机批量的回退方法以及系统 |
| US10372100B2 (en) | 2016-08-29 | 2019-08-06 | Ge Healthcare Bio-Sciences Corp. | Manufacturing system for biopharmaceutical products |
| CN110321288B (zh) * | 2019-06-21 | 2023-05-12 | 北京机电工程研究所 | 一种用于飞行器上信息处理系统的仿真测试方法 |
| CN112101701A (zh) * | 2020-07-28 | 2020-12-18 | 重庆华森制药股份有限公司 | 一种生产聚乙二醇电解质散的智能制造系统及制造方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4383298A (en) * | 1980-04-10 | 1983-05-10 | Ciba-Geigy Corporation | Plant maintenance control system |
| US4796194A (en) * | 1986-08-20 | 1989-01-03 | Atherton Robert W | Real world modeling and control process |
| US5148370A (en) * | 1987-06-17 | 1992-09-15 | The Standard Oil Company | Expert system and method for batch production scheduling and planning |
| US5164905A (en) * | 1987-08-12 | 1992-11-17 | Hitachi, Ltd. | Production system with order of processing determination |
| US5079731A (en) * | 1989-10-17 | 1992-01-07 | Alcon Laboratories, Inc. | Method and apparatus for process control validation |
| US5495417A (en) * | 1990-08-14 | 1996-02-27 | Kabushiki Kaisha Toshiba | System for automatically producing different semiconductor products in different quantities through a plurality of processes along a production line |
| US5402367A (en) * | 1993-07-19 | 1995-03-28 | Texas Instruments, Incorporated | Apparatus and method for model based process control |
| US5737581A (en) * | 1995-08-30 | 1998-04-07 | Keane; John A. | Quality system implementation simulator |
-
1998
- 1998-06-22 EP EP98932817A patent/EP1050001A4/fr not_active Ceased
- 1998-06-22 CA CA002294428A patent/CA2294428A1/fr not_active Abandoned
- 1998-06-22 AU AU82617/98A patent/AU8261798A/en not_active Abandoned
- 1998-06-22 JP JP50499399A patent/JP2002518981A/ja active Pending
- 1998-06-22 WO PCT/US1998/013055 patent/WO1998059285A2/fr not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1050001A4 (fr) | 2000-12-06 |
| EP1050001A2 (fr) | 2000-11-08 |
| WO1998059285A2 (fr) | 1998-12-30 |
| WO1998059285A3 (fr) | 1999-08-12 |
| AU8261798A (en) | 1999-01-04 |
| JP2002518981A (ja) | 2002-06-25 |
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