CA2294342A1 - Procede de synthetisation d'intermediaires de carbapenem a chaine laterale - Google Patents
Procede de synthetisation d'intermediaires de carbapenem a chaine laterale Download PDFInfo
- Publication number
- CA2294342A1 CA2294342A1 CA002294342A CA2294342A CA2294342A1 CA 2294342 A1 CA2294342 A1 CA 2294342A1 CA 002294342 A CA002294342 A CA 002294342A CA 2294342 A CA2294342 A CA 2294342A CA 2294342 A1 CA2294342 A1 CA 2294342A1
- Authority
- CA
- Canada
- Prior art keywords
- compound
- side chain
- formula
- synthesizing
- chain intermediates
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000002194 synthesizing effect Effects 0.000 title abstract 2
- YZBQHRLRFGPBSL-RXMQYKEDSA-N carbapenem Chemical group C1C=CN2C(=O)C[C@H]21 YZBQHRLRFGPBSL-RXMQYKEDSA-N 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 239000012359 Methanesulfonyl chloride Substances 0.000 abstract 1
- UCKMPCXJQFINFW-UHFFFAOYSA-N Sulphide Chemical compound [S-2] UCKMPCXJQFINFW-UHFFFAOYSA-N 0.000 abstract 1
- QPQGTZMAQRXCJW-UHFFFAOYSA-N [chloro(phenyl)phosphoryl]benzene Chemical compound C=1C=CC=CC=1P(=O)(Cl)C1=CC=CC=C1 QPQGTZMAQRXCJW-UHFFFAOYSA-N 0.000 abstract 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 abstract 1
- 125000002843 carboxylic acid group Chemical group 0.000 abstract 1
- QARBMVPHQWIHKH-UHFFFAOYSA-N methanesulfonyl chloride Chemical compound CS(Cl)(=O)=O QARBMVPHQWIHKH-UHFFFAOYSA-N 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5203297P | 1997-07-09 | 1997-07-09 | |
| US60/052,032 | 1997-07-09 | ||
| GB9810184.3 | 1998-05-13 | ||
| GBGB9810184.3A GB9810184D0 (en) | 1998-05-13 | 1998-05-13 | Process for synthisizing carbapenem side chain intermediates |
| PCT/US1998/013738 WO1999002531A1 (fr) | 1997-07-09 | 1998-07-02 | Procede de synthetisation d'intermediaires de carbapenem a chaine laterale |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2294342A1 true CA2294342A1 (fr) | 1999-01-21 |
| CA2294342C CA2294342C (fr) | 2006-03-14 |
Family
ID=26313663
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002294342A Expired - Fee Related CA2294342C (fr) | 1997-07-09 | 1998-07-02 | Procede de synthetisation d'intermediaires de carbapenem a chaine laterale |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1019411A4 (fr) |
| JP (1) | JP2002504156A (fr) |
| AU (1) | AU731586B2 (fr) |
| CA (1) | CA2294342C (fr) |
| WO (1) | WO1999002531A1 (fr) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2294341C (fr) * | 1997-07-10 | 2007-09-25 | Merck & Co., Inc. | Formes cristallines d'intermediaires a chaine laterale antibiotiques |
| CA2401578A1 (fr) * | 2000-03-01 | 2001-09-07 | Merck & Co., Inc. | Formes cristallines d'intermediaires a chaines laterales pour des antibiotiques |
| WO2002040482A1 (fr) * | 2000-11-20 | 2002-05-23 | Sankyo Company, Limited | Procede de production d'un antibacterien de type carbapenem |
| WO2006020573A2 (fr) * | 2004-08-11 | 2006-02-23 | Barbeau Donald L | Composes pharmaceutiques non cardiotoxiques |
| CN102264744A (zh) * | 2008-12-25 | 2011-11-30 | 株式会社钟化 | 碳青霉烯侧链中间体的改良制造方法 |
| CN106565579A (zh) * | 2016-06-26 | 2017-04-19 | 宁夏海诚电化信息科技有限公司 | 一种尔它培南侧链生产工艺 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4340738A (en) * | 1979-06-21 | 1982-07-20 | Janssen Pharmaceutica, N.V. | 2,3-Dihydro-imidazo[2,1-b]benzothiazoles |
| AU644008B2 (en) * | 1990-08-10 | 1993-12-02 | Sumitomo Pharmaceuticals Company, Limited | Beta-lactam compounds, and their production and use |
| JP3091297B2 (ja) * | 1992-01-10 | 2000-09-25 | 住友製薬株式会社 | ピロリジン誘導体およびその製造方法 |
| WO1997006154A1 (fr) * | 1995-08-04 | 1997-02-20 | Merck & Co., Inc. | Procede de synthese de produits intermediaires de chaines laterales de carbapenem |
-
1998
- 1998-07-02 CA CA002294342A patent/CA2294342C/fr not_active Expired - Fee Related
- 1998-07-02 AU AU82821/98A patent/AU731586B2/en not_active Ceased
- 1998-07-02 EP EP98933069A patent/EP1019411A4/fr not_active Withdrawn
- 1998-07-02 WO PCT/US1998/013738 patent/WO1999002531A1/fr active IP Right Grant
- 1998-07-02 JP JP50875599A patent/JP2002504156A/ja not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| AU8282198A (en) | 1999-02-08 |
| AU731586B2 (en) | 2001-04-05 |
| WO1999002531A1 (fr) | 1999-01-21 |
| EP1019411A1 (fr) | 2000-07-19 |
| JP2002504156A (ja) | 2002-02-05 |
| CA2294342C (fr) | 2006-03-14 |
| EP1019411A4 (fr) | 2003-08-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |