CA2288821C - Modulation of human mast cell activation - Google Patents
Modulation of human mast cell activation Download PDFInfo
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- CA2288821C CA2288821C CA002288821A CA2288821A CA2288821C CA 2288821 C CA2288821 C CA 2288821C CA 002288821 A CA002288821 A CA 002288821A CA 2288821 A CA2288821 A CA 2288821A CA 2288821 C CA2288821 C CA 2288821C
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- purinoceptor
- mast cells
- atp
- ligand
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- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 229940048086 sodium pyrophosphate Drugs 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- FIAFUQMPZJWCLV-UHFFFAOYSA-N suramin Chemical compound OS(=O)(=O)C1=CC(S(O)(=O)=O)=C2C(NC(=O)C3=CC=C(C(=C3)NC(=O)C=3C=C(NC(=O)NC=4C=C(C=CC=4)C(=O)NC=4C(=CC=C(C=4)C(=O)NC=4C5=C(C=C(C=C5C(=CC=4)S(O)(=O)=O)S(O)(=O)=O)S(O)(=O)=O)C)C=CC=3)C)=CC=C(S(O)(=O)=O)C2=C1 FIAFUQMPZJWCLV-UHFFFAOYSA-N 0.000 description 1
- 229960005314 suramin Drugs 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 229960001967 tacrolimus Drugs 0.000 description 1
- 235000019818 tetrasodium diphosphate Nutrition 0.000 description 1
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 description 1
- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 230000014616 translation Effects 0.000 description 1
- VZPXDCIISFTYOM-UHFFFAOYSA-K trisodium;1-amino-4-[4-[[4-chloro-6-(3-sulfonatoanilino)-1,3,5-triazin-2-yl]amino]-3-sulfonatoanilino]-9,10-dioxoanthracene-2-sulfonate Chemical compound [Na+].[Na+].[Na+].C1=2C(=O)C3=CC=CC=C3C(=O)C=2C(N)=C(S([O-])(=O)=O)C=C1NC(C=C1S([O-])(=O)=O)=CC=C1NC(N=1)=NC(Cl)=NC=1NC1=CC=CC(S([O-])(=O)=O)=C1 VZPXDCIISFTYOM-UHFFFAOYSA-K 0.000 description 1
- 239000002753 trypsin inhibitor Substances 0.000 description 1
- 230000009959 type I hypersensitivity Effects 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 230000008728 vascular permeability Effects 0.000 description 1
- 230000024883 vasodilation Effects 0.000 description 1
- 230000009278 visceral effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Pulmonology (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
- Amplifiers (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4146197P | 1997-03-25 | 1997-03-25 | |
| US60/041,461 | 1997-03-25 | ||
| PCT/US1998/005922 WO1998042353A1 (en) | 1997-03-25 | 1998-03-24 | Modulation of human mast cell activation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2288821A1 CA2288821A1 (en) | 1998-10-01 |
| CA2288821C true CA2288821C (en) | 2008-10-14 |
Family
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002288821A Expired - Fee Related CA2288821C (en) | 1997-03-25 | 1998-03-24 | Modulation of human mast cell activation |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US6372724B1 (enExample) |
| EP (1) | EP1011686B9 (enExample) |
| JP (1) | JP2001518118A (enExample) |
| AT (1) | ATE470441T1 (enExample) |
| AU (1) | AU741713B2 (enExample) |
| CA (1) | CA2288821C (enExample) |
| DE (1) | DE69841711D1 (enExample) |
| DK (1) | DK1011686T3 (enExample) |
| WO (1) | WO1998042353A1 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2288821C (en) * | 1997-03-25 | 2008-10-14 | Allegheny University Of The Health Sciences | Modulation of human mast cell activation |
| AU770975B2 (en) * | 1999-06-18 | 2004-03-11 | Alcon Laboratories, Inc. | Topical ophthalmic mast cell stabilizers for treating allergic eye diseases |
| GB9916757D0 (en) | 1999-07-17 | 1999-09-15 | Glaxo Group Ltd | Method |
| WO2001071342A2 (en) * | 2000-03-23 | 2001-09-27 | Novartis Ag | Identification of mast cell/basophil activation inhibitors |
| US20040077654A1 (en) * | 2001-01-15 | 2004-04-22 | Bouillot Anne Marie Jeanne | Aryl piperidine and piperazine derivatives as inducers of ldl-receptor expression |
| US20040072865A1 (en) * | 2001-01-15 | 2004-04-15 | Bouillot Anne Marie Jeanne | Aryl piperidine derivatives as inducers of ldl-receptor expression |
| EP1351937A1 (en) * | 2001-01-15 | 2003-10-15 | Glaxo Group Limited | Aryl piperidine derivatives as inducers of ldl-receptor expression |
| JP2005532254A (ja) * | 2001-11-06 | 2005-10-27 | インスパイアー ファーマシューティカルズ，インコーポレイティド | 炎症性疾患を治療又は予防する方法 |
| WO2003070902A2 (en) * | 2002-02-20 | 2003-08-28 | Incyte Corporation | Receptors and membrane-associated proteins |
| US20070276126A1 (en) * | 2002-08-13 | 2007-11-29 | Incyte Corporation | Cell adhesion and extracellular matrix proteins |
| US20070219353A1 (en) * | 2002-09-03 | 2007-09-20 | Incyte Corporation | Immune Response Associated Proteins |
| WO2004033636A2 (en) * | 2002-10-04 | 2004-04-22 | Incyte Corporation | Protein modification and maintenance molecules |
| US20070009886A1 (en) * | 2002-11-12 | 2007-01-11 | Incyte Corporation | Carbohydrate-associated proteins |
| WO2004044165A2 (en) * | 2002-11-13 | 2004-05-27 | Incyte Corporation | Lipid-associated proteins |
| WO2004048550A2 (en) * | 2002-11-26 | 2004-06-10 | Incyte Corporation | Immune response associated proteins |
| WO2004098539A2 (en) | 2003-04-30 | 2004-11-18 | Incyte Corporation | Kinases and phosphatases |
| JP2008507368A (ja) * | 2004-07-22 | 2008-03-13 | デュスカ サイエンティフィック カンパニー | 肺疾患を診断、モニタリングおよび治療するための方法 |
| DK2407484T3 (en) | 2005-06-24 | 2016-09-05 | The Walter And Eliza Hall Inst Of Medical Res | Therapeutic pro-apoptotic BH3-like molecules, and methods of generating and / or selecting those |
| GB0601058D0 (en) * | 2006-01-19 | 2006-03-01 | Univ Southampton | Mast Cell Carboxypeptidase As A Marker For Anaphylaxis And Mastocytosis |
| CA2680801A1 (en) * | 2007-03-14 | 2008-09-18 | Sierra Molecular Corporation | Compositions, systems, and methods for preservation and/or stabilizationof a cell and/or macromolecule |
| US10517839B2 (en) * | 2008-06-09 | 2019-12-31 | Cornell University | Mast cell inhibition in diseases of the retina and vitreous |
| US10107795B2 (en) | 2012-10-25 | 2018-10-23 | The United States Of America As Represented By The Department Of Veterans Affairs | Composition and methods for the prevention and treatment of diet-induced obesity |
| US10614684B2 (en) | 2017-01-31 | 2020-04-07 | The United States Government As Represented By The | Treatment of kidney diseases associated with elevated AVP |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS53148539A (en) * | 1977-05-30 | 1978-12-25 | Fujisawa Pharmaceut Co Ltd | Antiallergic agnet |
| US5158940A (en) * | 1990-02-14 | 1992-10-27 | The United States Government As Represented By The Secretary, Dhhs | Use of suramin to treat rheumatologic diseases |
| US5504090A (en) * | 1994-03-30 | 1996-04-02 | Trustees Of The University Of Pennsylvania | Compositions and methods for the prevention and treatment of ischemia-reperfusion organ injury |
| US5985603A (en) * | 1994-05-27 | 1999-11-16 | Glaxo Group Limited | P2x receptor DNA and protein sequence |
| US5733916A (en) | 1995-03-24 | 1998-03-31 | The Trustees Of The University Of Pennsylvania | Prevention and treatment of ischemia-reperfusion and endotoxin-related injury using adenosine and purino receptor antagonists |
| US5874420A (en) | 1995-12-26 | 1999-02-23 | Allegheny University Of The Health Sciences | Process for regulating vagal tone |
| CA2288821C (en) * | 1997-03-25 | 2008-10-14 | Allegheny University Of The Health Sciences | Modulation of human mast cell activation |
-
1998
- 1998-03-24 CA CA002288821A patent/CA2288821C/en not_active Expired - Fee Related
- 1998-03-24 JP JP54597398A patent/JP2001518118A/ja not_active Ceased
- 1998-03-24 EP EP98917959A patent/EP1011686B9/en not_active Expired - Lifetime
- 1998-03-24 US US09/381,692 patent/US6372724B1/en not_active Expired - Fee Related
- 1998-03-24 AU AU70985/98A patent/AU741713B2/en not_active Ceased
- 1998-03-24 DK DK98917959.3T patent/DK1011686T3/da active
- 1998-03-24 DE DE69841711T patent/DE69841711D1/de not_active Expired - Lifetime
- 1998-03-24 WO PCT/US1998/005922 patent/WO1998042353A1/en not_active Ceased
- 1998-03-24 AT AT98917959T patent/ATE470441T1/de active
-
2001
- 2001-12-20 US US10/027,052 patent/US6465441B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DK1011686T3 (da) | 2010-10-11 |
| AU7098598A (en) | 1998-10-20 |
| AU741713B2 (en) | 2001-12-06 |
| US6465441B2 (en) | 2002-10-15 |
| JP2001518118A (ja) | 2001-10-09 |
| WO1998042353A1 (en) | 1998-10-01 |
| US20020055515A1 (en) | 2002-05-09 |
| EP1011686A4 (en) | 2003-03-19 |
| DE69841711D1 (de) | 2010-07-22 |
| CA2288821A1 (en) | 1998-10-01 |
| EP1011686B9 (en) | 2011-02-09 |
| EP1011686B1 (en) | 2010-06-09 |
| ATE470441T1 (de) | 2010-06-15 |
| EP1011686A1 (en) | 2000-06-28 |
| US6372724B1 (en) | 2002-04-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20130325 |