CA2287901A1 - Agents antithrombotiques - Google Patents

Agents antithrombotiques Download PDF

Info

Publication number
CA2287901A1
CA2287901A1 CA002287901A CA2287901A CA2287901A1 CA 2287901 A1 CA2287901 A1 CA 2287901A1 CA 002287901 A CA002287901 A CA 002287901A CA 2287901 A CA2287901 A CA 2287901A CA 2287901 A1 CA2287901 A1 CA 2287901A1
Authority
CA
Canada
Prior art keywords
compound
formula
methoxy
mmol
benzo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002287901A
Other languages
English (en)
Inventor
Jefferson Ray Mccowan
Ho-Shen Lin
Alan David Palkowitz
Richard Waltz Harper
Michael Robert Wiley
Minsheng Zhang
Todd Jonathan Kohn
Daniel Jon Sall
Nickolay Yuri Chirgadze
Kumiko Takeuchi
Gerald Floyd Smith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2287901A1 publication Critical patent/CA2287901A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

La présente invention concerne de nouveaux composés représentés par la formule (I) (et leurs sels pharmaceutiquement acceptables), tels que définis dans la description, des procédés et des intermédiaires pour leur préparation. La présente invention concerne également des formulations pharmaceutiques comprenant les nouveaux composés, et leur utilisation comme inhibiteurs de thrombine.
CA002287901A 1997-04-30 1998-04-30 Agents antithrombotiques Abandoned CA2287901A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4517397P 1997-04-30 1997-04-30
US60/045,173 1997-04-30
PCT/US1998/008700 WO1998048798A1 (fr) 1997-04-30 1998-04-30 Agents antithrombotiques

Publications (1)

Publication Number Publication Date
CA2287901A1 true CA2287901A1 (fr) 1998-11-05

Family

ID=21936403

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002287901A Abandoned CA2287901A1 (fr) 1997-04-30 1998-04-30 Agents antithrombotiques

Country Status (5)

Country Link
EP (1) EP0993300A4 (fr)
JP (1) JP2001523255A (fr)
AU (1) AU7563598A (fr)
CA (1) CA2287901A1 (fr)
WO (1) WO1998048798A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2009282747B2 (en) 2008-08-22 2015-04-02 Takeda Pharmaceutical Company Limited Polymeric benzyl carbonate-derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4133814A (en) * 1975-10-28 1979-01-09 Eli Lilly And Company 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
ZA928276B (en) * 1991-10-31 1993-05-06 Daiichi Seiyaku Co Aromatic amidine derivates and salts thereof.

Also Published As

Publication number Publication date
JP2001523255A (ja) 2001-11-20
EP0993300A1 (fr) 2000-04-19
EP0993300A4 (fr) 2002-07-31
WO1998048798A1 (fr) 1998-11-05
AU7563598A (en) 1998-11-24

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Legal Events

Date Code Title Description
FZDE Dead