CA2285161A1 - Tissu de ligament cultive in vitro et methode pour sa production - Google Patents

Tissu de ligament cultive in vitro et methode pour sa production Download PDF

Info

Publication number
CA2285161A1
CA2285161A1 CA 2285161 CA2285161A CA2285161A1 CA 2285161 A1 CA2285161 A1 CA 2285161A1 CA 2285161 CA2285161 CA 2285161 CA 2285161 A CA2285161 A CA 2285161A CA 2285161 A1 CA2285161 A1 CA 2285161A1
Authority
CA
Canada
Prior art keywords
tendon
scaffold
ligament
fibroblasts
collagen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA 2285161
Other languages
English (en)
Inventor
Rita Kandel
Lindsay King
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
1218122 ONTARIO Inc
Original Assignee
1218122 ONTARIO INC.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 1218122 ONTARIO INC. filed Critical 1218122 ONTARIO INC.
Priority to CA 2285161 priority Critical patent/CA2285161A1/fr
Publication of CA2285161A1 publication Critical patent/CA2285161A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A61L27/3843—Connective tissue
    • A61L27/386—Ligaments, tendons
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/066—Tenocytes; Tendons, Ligaments
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0697—Artificial constructs associating cells of different lineages, e.g. tissue equivalents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/10—Materials or treatment for tissue regeneration for reconstruction of tendons or ligaments

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Rheumatology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Rehabilitation Therapy (AREA)
  • Botany (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Vascular Medicine (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)
CA 2285161 1999-10-06 1999-10-06 Tissu de ligament cultive in vitro et methode pour sa production Abandoned CA2285161A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA 2285161 CA2285161A1 (fr) 1999-10-06 1999-10-06 Tissu de ligament cultive in vitro et methode pour sa production

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA 2285161 CA2285161A1 (fr) 1999-10-06 1999-10-06 Tissu de ligament cultive in vitro et methode pour sa production

Publications (1)

Publication Number Publication Date
CA2285161A1 true CA2285161A1 (fr) 2001-04-06

Family

ID=4164312

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2285161 Abandoned CA2285161A1 (fr) 1999-10-06 1999-10-06 Tissu de ligament cultive in vitro et methode pour sa production

Country Status (1)

Country Link
CA (1) CA2285161A1 (fr)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009086313A2 (fr) * 2007-12-20 2009-07-09 Zimmer Orthobiologics, Inc. Compositions et procédés destinés à réparer un tissu conjonctif
WO2008103377A3 (fr) * 2007-02-20 2009-09-17 Shriners Hospitals For Children Fixation hydraulique in vivo comprenant des rivets biologiques et utilisant des fibres biocompatibles extensibles
US7901455B2 (en) 2006-12-27 2011-03-08 Shriners Hospitals For Children Tendon or ligament bioprostheses and methods of making same
US8163554B2 (en) 2000-06-29 2012-04-24 Mount Sinai Hospital Intervertebral disc
US8367148B2 (en) 2008-10-09 2013-02-05 Mimedx Group, Inc. Methods of making biocomposite medical constructs and related constructs including artificial tissues, vessels and patches
US8986378B2 (en) 2011-11-02 2015-03-24 Mimedx Group, Inc. Implantable collagen devices and related methods and systems of making same
US9216077B2 (en) 2008-05-16 2015-12-22 Mimedx Group, Inc. Medical constructs of twisted lengths of collagen fibers and methods of making same
US9636209B2 (en) 2011-03-08 2017-05-02 Mimedx Group, Inc. Collagen fiber ribbons with integrated fixation sutures and methods of making the same
US9681869B2 (en) 2008-02-22 2017-06-20 Mimedx Group, Inc. Biostaples suitable for wrist, hand and other ligament replacements or repairs
US9694106B2 (en) 2011-07-11 2017-07-04 Mimedx Group, Inc. Synthetic collagen threads for cosmetic uses including skin wrinkle treatments and associated methods

Cited By (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8163554B2 (en) 2000-06-29 2012-04-24 Mount Sinai Hospital Intervertebral disc
US7901455B2 (en) 2006-12-27 2011-03-08 Shriners Hospitals For Children Tendon or ligament bioprostheses and methods of making same
US9603968B2 (en) 2006-12-27 2017-03-28 Shriners Hospitals For Children Methods of making high-strength NDGA polymerized collagen fibers and related collagen-prep methods, medical devices and constructs
US10472409B2 (en) 2006-12-27 2019-11-12 Shriners Hospitals For Children Methods of making high-strength NDGA polymerized collagen fibers and related collagen-prep methods, medical devices and constructs
US8177839B2 (en) 2006-12-27 2012-05-15 Shriners Hospitals For Children Woven and/or braided fiber implants and methods of making same
US9888996B2 (en) 2007-02-20 2018-02-13 Shriners Hospitals For Children In vivo hydraulic fixation including bio-rivets using biocompatible expandable fibers
WO2008103377A3 (fr) * 2007-02-20 2009-09-17 Shriners Hospitals For Children Fixation hydraulique in vivo comprenant des rivets biologiques et utilisant des fibres biocompatibles extensibles
AU2008219006B2 (en) * 2007-02-20 2013-04-18 Shriners Hospitals For Children In vivo hydraulic fixation including bio-rivets using biocompatible expandable fibers
US8858633B2 (en) 2007-02-20 2014-10-14 Shriners Hospital For Children In vivo hydraulic fixation including bio-rivets using biocompatible expandable fibers
US9393105B2 (en) 2007-02-20 2016-07-19 Shriners Hospitals For Children In vivo hydraulic fixation including bio-rivets using biocompatible expandable fibers
US20110111028A1 (en) * 2007-12-20 2011-05-12 Hali Wang Composition and Methods For Repair of Connective Tissue
WO2009086313A3 (fr) * 2007-12-20 2010-03-25 Zimmer Orthobiologics, Inc. Compositions et procédés destinés à réparer un tissu conjonctif
WO2009085769A3 (fr) * 2007-12-20 2010-03-25 Zimmer Orthobiologics, Inc. Compositions et procédés de réparation de tissu conjonctif
US9339587B2 (en) 2007-12-20 2016-05-17 Zimmer Orthobiologics, Inc. Composition and methods for repair of connective tissue
WO2009085769A2 (fr) * 2007-12-20 2009-07-09 Zimmer Orthobiologics, Inc. Compositions et procédés de réparation de tissu conjonctif
WO2009086313A2 (fr) * 2007-12-20 2009-07-09 Zimmer Orthobiologics, Inc. Compositions et procédés destinés à réparer un tissu conjonctif
US9681869B2 (en) 2008-02-22 2017-06-20 Mimedx Group, Inc. Biostaples suitable for wrist, hand and other ligament replacements or repairs
US9216077B2 (en) 2008-05-16 2015-12-22 Mimedx Group, Inc. Medical constructs of twisted lengths of collagen fibers and methods of making same
US10149918B2 (en) 2008-05-16 2018-12-11 Mimedx Group, Inc. Medical constructs of twisted lengths of collagen fibers and methods of making same
US10238773B2 (en) 2008-10-09 2019-03-26 Mimedx Group, Inc. Methods of making collagen fiber medical constructs and related medical constructs, including nerve guides and patches
US9078775B2 (en) 2008-10-09 2015-07-14 Mimedx Group, Inc. Methods of making collagen fiber medical constructs and related medical constructs, including nerve guides and patches
US9801978B2 (en) 2008-10-09 2017-10-31 Mimedx Group, Inc. Medical constructs including tubes and collagen fibers
US9125759B2 (en) 2008-10-09 2015-09-08 Mimedx Group, Inc. Biocomposite medical constructs including artificial tissues, vessels and patches
US9179976B2 (en) 2008-10-09 2015-11-10 Mimedx Group, Inc. Methods of making collagen fiber medical constructs and related medical constructs, including tubes
US8367148B2 (en) 2008-10-09 2013-02-05 Mimedx Group, Inc. Methods of making biocomposite medical constructs and related constructs including artificial tissues, vessels and patches
US9636209B2 (en) 2011-03-08 2017-05-02 Mimedx Group, Inc. Collagen fiber ribbons with integrated fixation sutures and methods of making the same
US10653514B2 (en) 2011-03-08 2020-05-19 Mimedx Group, Inc. Collagen fiber ribbons with integrated fixation sutures and methods of making the same
US9694106B2 (en) 2011-07-11 2017-07-04 Mimedx Group, Inc. Synthetic collagen threads for cosmetic uses including skin wrinkle treatments and associated methods
US10933161B2 (en) 2011-07-11 2021-03-02 Mimedx Group, Inc. Synthetic collagen threads for cosmetic uses including skin wrinkle treatments and associated methods
US9873861B2 (en) 2011-11-02 2018-01-23 Mimedx Group, Inc. Methods of making implantable collagen fiber
US8986378B2 (en) 2011-11-02 2015-03-24 Mimedx Group, Inc. Implantable collagen devices and related methods and systems of making same
US10689621B2 (en) 2011-11-02 2020-06-23 Mimedx Group, Inc. Kits and materials for implantable collagen devices

Similar Documents

Publication Publication Date Title
US5916265A (en) Method of producing a biological extracellular matrix for use as a cell seeding scaffold and implant
JP5244093B2 (ja) 強化型生体組織
US6398819B1 (en) Method and construct for producing graft tissue from an extracellular matrix
Goulet et al. Tendons and ligaments
EP1242129B1 (fr) Produit de synthese biologique pour articulation
Lin et al. Ligament tissue engineering using synthetic biodegradable fiber scaffolds
Glowacki A review of osteoinductive testing methods and sterilization processes for demineralized bone
ES2847409T3 (es) Método para el tratamiento enzimático de productos de tejidos
EP0952792B1 (fr) Reconstitution biomatricielle de tissus
DE69725592T2 (de) Verfahren zur gewinnung einer gereignigten matrix auf kollagenbasis aus submukosa gewebe
US6737053B1 (en) Tissue-engineered ligament
EP0739631B1 (fr) Support d'os laminaire pour la croissance du cartilage
US6902932B2 (en) Helically organized silk fibroin fiber bundles for matrices in tissue engineering
US6123727A (en) Tissue engineered tendons and ligaments
US9981063B2 (en) Biosynthetic composite for osteochondral defect repair
CN104780850B (zh) 用于将柔性元件，特别是天然或合成的韧带或肌腱固定到骨头上的设备
CN1735685A (zh) 用未分化的间充质细胞治疗组织
US20020183857A1 (en) Vascular tissue composition
CA2285161A1 (fr) Tissu de ligament cultive in vitro et methode pour sa production
Seo et al. The biocompatibility of silk scaffold for tissue engineered ligaments
WO2001034065A1 (fr) Ligament obtenu par genie tissulaire
ten Koppel et al. Efficacy of perichondrium and a trabecular demineralized bone matrix for generating cartilage
Hancox et al. Cross-species grafts of deproteinised bone
CN109475403B (zh) 用于旋转袖修复的工程化肌腱移植物
Goulet et al. Tissue-engineered ligament

Legal Events

Date Code Title Description
FZDE Dead