CA2283648A1 - Polymeric carrier - Google Patents

Polymeric carrier Download PDF

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Publication number
CA2283648A1
CA2283648A1 CA002283648A CA2283648A CA2283648A1 CA 2283648 A1 CA2283648 A1 CA 2283648A1 CA 002283648 A CA002283648 A CA 002283648A CA 2283648 A CA2283648 A CA 2283648A CA 2283648 A1 CA2283648 A1 CA 2283648A1
Authority
CA
Canada
Prior art keywords
stereoselective
bioactive molecule
biocompatible
polymeric carrier
complementary
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002283648A
Other languages
French (fr)
Other versions
CA2283648C (en
Inventor
Avraham J. Domb
Zeev Zehavi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Efrat Biopolymers Ltd
Original Assignee
Efrat Biopolymers Ltd.
Avraham J. Domb
Zeev Zehavi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Efrat Biopolymers Ltd., Avraham J. Domb, Zeev Zehavi filed Critical Efrat Biopolymers Ltd.
Publication of CA2283648A1 publication Critical patent/CA2283648A1/en
Application granted granted Critical
Publication of CA2283648C publication Critical patent/CA2283648C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule

Abstract

The invention provides a polymeric carrier for delivery of a bioactive molecule, comprising a stereocomplex of at least one biocompatible stereoselective polymer and a bioactive molecule, wherein said bioactive molecule is complexed with at least one complementary biocompatible stereoselective polymer, or said bioactive molecule is entrapped within a stereocomplex composed of at least two complementary stereoselective biocompatible copolymers, each of said copolymers having a stereoselective segment linked to non-polyhydroxy acid segments.
CA002283648A 1998-01-14 1999-01-14 Polymeric carrier Expired - Fee Related CA2283648C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IL122933 1998-01-14
IL12293398A IL122933A (en) 1998-01-14 1998-01-14 Polymeric carrier for delivery of a bioactive molecule
PCT/IL1999/000023 WO1999036100A2 (en) 1998-01-14 1999-01-14 Polymeric carrier

Publications (2)

Publication Number Publication Date
CA2283648A1 true CA2283648A1 (en) 1999-07-22
CA2283648C CA2283648C (en) 2007-04-17

Family

ID=11071088

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002283648A Expired - Fee Related CA2283648C (en) 1998-01-14 1999-01-14 Polymeric carrier

Country Status (6)

Country Link
EP (1) EP0967998A2 (en)
JP (1) JP2001515522A (en)
AU (1) AU1888999A (en)
CA (1) CA2283648C (en)
IL (1) IL122933A (en)
WO (1) WO1999036100A2 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4865947B2 (en) 1999-02-19 2012-02-01 ウニフェルシテイト ユトレヒト Stereo complex hydrogel
EP1156812A4 (en) * 1999-02-23 2004-09-29 Isis Pharmaceuticals Inc Multiparticulate formulation
WO2002083166A1 (en) * 2001-04-10 2002-10-24 Santen Pharmaceutical Co., Ltd. Interferon-polymer complexes and medicinal use thereof
DE10154924A1 (en) * 2001-11-08 2003-05-28 Medinnova Ges Med Innovationen Biodegradable copolymers
PL220850B1 (en) * 2002-05-03 2016-01-29 Janssen Pharmaceutica Nv Polymeric microemulsions
WO2006088248A1 (en) * 2005-02-18 2006-08-24 Nof Corporation Polyoxyalkylene derivative
WO2006129320A2 (en) * 2005-06-01 2006-12-07 Yissum Research Development Company Of The Hebrew University Of Jerusalem Biodegradable polymers having a pre-determined chirality
WO2007088957A1 (en) * 2006-02-03 2007-08-09 National University Corporation Hokkaido University Nanodisk comprising block copolymer
EP2135887B1 (en) 2008-06-18 2010-12-22 Instytut Biopolimeròw I Wlókien Chemicznych Process for producing a polylactic acid stereocomplex powder
CA2804815C (en) * 2010-07-09 2016-06-07 The University Of Tokyo Nucleic acid delivery composition and carrier composition, pharmaceutical composition using the same, and method for nucleic acid delivery
CN108559084B (en) * 2018-04-13 2020-12-04 华东理工大学 Preparation method of polylactic acid-based hydrophobic film
CN109908106A (en) * 2019-03-04 2019-06-21 北京化工大学 It is a kind of can injection for intravenous methotrexate (MTX) Nano capsule and preparation method thereof
JP7050734B2 (en) * 2019-09-30 2022-04-08 鳥居薬品株式会社 Film preparation for sublingual allergen immunotherapy
CN115785471B (en) * 2022-12-16 2023-08-08 华中科技大学 Carbon dioxide-based supermolecular polymer and preparation method and application thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6136321A (en) * 1984-07-27 1986-02-21 Daicel Chem Ind Ltd Novel polymer and its resin composition
US4902515A (en) * 1988-04-28 1990-02-20 E. I. Dupont De Nemours And Company Polylactide compositions
CA2046830C (en) * 1990-07-19 1999-12-14 Patrick P. Deluca Drug delivery system involving inter-action between protein or polypeptide and hydrophobic biodegradable polymer

Also Published As

Publication number Publication date
IL122933A0 (en) 1998-08-16
EP0967998A2 (en) 2000-01-05
WO1999036100A2 (en) 1999-07-22
WO1999036100A3 (en) 1999-09-23
IL122933A (en) 2005-03-20
CA2283648C (en) 2007-04-17
AU1888999A (en) 1999-08-02
JP2001515522A (en) 2001-09-18

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Legal Events

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EEER Examination request
MKLA Lapsed