CA2282302A1 - Proteines morphogeniques - Google Patents

Proteines morphogeniques Download PDF

Info

Publication number
CA2282302A1
CA2282302A1 CA002282302A CA2282302A CA2282302A1 CA 2282302 A1 CA2282302 A1 CA 2282302A1 CA 002282302 A CA002282302 A CA 002282302A CA 2282302 A CA2282302 A CA 2282302A CA 2282302 A1 CA2282302 A1 CA 2282302A1
Authority
CA
Canada
Prior art keywords
protein
bmp
dan
human
nucleic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002282302A
Other languages
English (en)
Inventor
David M. Valenzuela
Aris Economides
Richard M. Harland
David Hsu
Neil Stahl
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
Regeneron Pharmaceuticals Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2282302A1 publication Critical patent/CA2282302A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Audible-Bandwidth Dynamoelectric Transducers Other Than Pickups (AREA)
  • Solid State Image Pick-Up Elements (AREA)
  • Amplifiers (AREA)

Abstract

L'invention concerne des protéines b57 et des acides nucléiques apparentés. Elle concerne également des DAN naturels et des homologues de b57 provenant de plusieurs espèces, ainsi que des protéines comprenant un domaine de DAN ou de b57 et exerçant une activité spécifique, en particulier, d'antagonisme avec une protéine morphogénique osseuse. On peut préparer ces protéines par recombinaison à partir de cellules hôtes transformées avec les acides nucléiques en question. Elle concerne encore des sondes et des amorces d'hybridation isolées capables d'hybridation spécifique avec les gènes objets de l'invention, des agents de fixation spécifique et des procédés de préparation et d'utilisation des compositions décrites.
CA002282302A 1997-02-19 1998-02-19 Proteines morphogeniques Abandoned CA2282302A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3827997P 1997-02-19 1997-02-19
US60/038,279 1997-02-19
PCT/US1998/003283 WO1998037195A1 (fr) 1997-02-19 1998-02-19 Proteines morphogeniques

Publications (1)

Publication Number Publication Date
CA2282302A1 true CA2282302A1 (fr) 1998-08-27

Family

ID=21899037

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002282302A Abandoned CA2282302A1 (fr) 1997-02-19 1998-02-19 Proteines morphogeniques

Country Status (6)

Country Link
EP (1) EP0968285A1 (fr)
JP (1) JP4357003B2 (fr)
AU (1) AU736328B2 (fr)
CA (1) CA2282302A1 (fr)
IL (1) IL131420A0 (fr)
WO (1) WO1998037195A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999049041A1 (fr) * 1998-03-26 1999-09-30 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Proteine secretee drm ayant une activite d'inhibition de la croissance cellulaire, et procedes et composes se rapportant a ladite proteine
AU2005271944B2 (en) * 2004-07-09 2012-02-16 Viacyte, Inc. Preprimitive streak and mesendoderm cells

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT662146E (pt) * 1992-09-03 2000-12-29 Univ California Factor que afecta o tecido dorsal e composicoes
DE69328025T2 (de) * 1992-09-03 2000-11-02 Regeneron Pharmaceuticals, Inc. Dorsalgewebe beeinflussender faktor und zusammensetzungen

Also Published As

Publication number Publication date
JP4357003B2 (ja) 2009-11-04
AU6177998A (en) 1998-09-09
WO1998037195A1 (fr) 1998-08-27
EP0968285A1 (fr) 2000-01-05
IL131420A0 (en) 2001-01-28
AU736328B2 (en) 2001-07-26
JP2001512974A (ja) 2001-08-28

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued
FZDE Discontinued

Effective date: 20080219