CA2274959A1 - Individually dosed foil-form presentation which decomposes rapidly on contact with liquid and contains an active substance, in particular an aromatic substance - Google Patents

Individually dosed foil-form presentation which decomposes rapidly on contact with liquid and contains an active substance, in particular an aromatic substance Download PDF

Info

Publication number
CA2274959A1
CA2274959A1 CA002274959A CA2274959A CA2274959A1 CA 2274959 A1 CA2274959 A1 CA 2274959A1 CA 002274959 A CA002274959 A CA 002274959A CA 2274959 A CA2274959 A CA 2274959A CA 2274959 A1 CA2274959 A1 CA 2274959A1
Authority
CA
Canada
Prior art keywords
liquid
active substance
contact
phase
foil
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002274959A
Other languages
French (fr)
Other versions
CA2274959C (en
Inventor
Michael Horstmann
Wolfgang Laux
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LTS Lohmann Therapie Systeme AG
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2274959A1 publication Critical patent/CA2274959A1/en
Application granted granted Critical
Publication of CA2274959C publication Critical patent/CA2274959C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets

Abstract

Individually dosed active substance-containing and, in particular, aromatic-containing, film-shaped administration form, rapidly disintegrating upon contact with a liquid, wherein the aromatic is present as an internal, liposoluble phase in the form of liquid droplets distributed within an outer, solid but water-soluble phase, is characterized in that the said outer phase contains:
- at least 40% (w/w) polyvinyl alcohol - 0 to 30% (w/w) of a surface-active substance, and that the constituent amount of the inner phase, relative to the outer phase, is between 0.1 and 30% (w/w), in each case relative to the water-free portions.
CA002274959A 1996-12-16 1997-11-21 Individually dosed foil-form presentation which decomposes rapidly on contact with liquid and contains an active substance, in particular an aromatic substance Expired - Lifetime CA2274959C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19652257.9 1996-12-16
DE19652257A DE19652257A1 (en) 1996-12-16 1996-12-16 Individually dosed, film-like dosage form that quickly disintegrates on contact with liquid and contains active ingredients and especially flavorings
PCT/EP1997/006533 WO1998026764A1 (en) 1996-12-16 1997-11-21 Individually dosed foil-form presentation which decomposes rapidly on contact with liquid and contains an active substance, in particular an aromatic substance

Publications (2)

Publication Number Publication Date
CA2274959A1 true CA2274959A1 (en) 1998-06-25
CA2274959C CA2274959C (en) 2006-08-08

Family

ID=7814851

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002274959A Expired - Lifetime CA2274959C (en) 1996-12-16 1997-11-21 Individually dosed foil-form presentation which decomposes rapidly on contact with liquid and contains an active substance, in particular an aromatic substance

Country Status (13)

Country Link
US (2) US6682756B1 (en)
EP (1) EP0949909B1 (en)
JP (2) JP4577913B2 (en)
KR (1) KR100493140B1 (en)
AT (1) ATE211648T1 (en)
AU (1) AU727185B2 (en)
CA (1) CA2274959C (en)
DE (2) DE19652257A1 (en)
DK (1) DK0949909T3 (en)
ES (1) ES2171278T3 (en)
NO (1) NO320503B1 (en)
PT (1) PT949909E (en)
WO (1) WO1998026764A1 (en)

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GB2338896B (en) 1998-07-02 2003-05-21 Reckitt & Colmann Prod Ltd Chewable Capsules
US6552024B1 (en) * 1999-01-21 2003-04-22 Lavipharm Laboratories Inc. Compositions and methods for mucosal delivery
US6800329B2 (en) * 1999-02-12 2004-10-05 Lts Lohmann Therapie-Systeme Ag Method for producing film-type dosage
DE19905801B4 (en) * 1999-02-12 2008-03-13 Lts Lohmann Therapie-Systeme Ag Process for the preparation of film-shaped dosage forms
ATE238766T1 (en) 1999-07-02 2003-05-15 Procter & Gamble COMPOSITIONS FOR RELEASE OF ORAL CARE INGREDIENTS CONTAINING ORGANOSILOXANE RESINS BY USING A REMOVABLE CARRIER STRIP
DE10032456A1 (en) 2000-07-04 2002-01-31 Lohmann Therapie Syst Lts Rapidly disintegrating dosage form for the release of active substances in the mouth or in the body cavities
DE10063945A1 (en) * 2000-12-20 2002-07-04 Henkel Kgaa Remineralizing dental adhesive film
DE10107659B4 (en) 2001-02-19 2008-03-13 Lts Lohmann Therapie-Systeme Ag Mucoadhesive disintegratable drug preparation for drug administration in veterinary and human medicine
GB2392446A (en) * 2002-09-02 2004-03-03 Reckitt Benckiser Nv Resin comprising water-soluble polymer and water-soluble filler
US20050019277A1 (en) * 2002-09-11 2005-01-27 The Procter & Gamble Company Tooth whitening products
US8524200B2 (en) 2002-09-11 2013-09-03 The Procter & Gamble Company Tooth whitening products
CA2505833A1 (en) * 2002-11-14 2004-06-03 Innozen, Inc. Edible film for relief of cough or symptoms associated with pharyngitis
US6669929B1 (en) * 2002-12-30 2003-12-30 Colgate Palmolive Company Dentifrice containing functional film flakes
DE10338544B4 (en) * 2003-08-19 2017-08-31 Janssen Pharmaceutica N.V. Buccal formulations of galanthamine and their applications
US6984403B2 (en) * 2003-12-04 2006-01-10 Pfizer Inc. Azithromycin dosage forms with reduced side effects
DE102004017030A1 (en) * 2004-04-02 2005-10-20 Schering Ag Flat system for use in the oral cavity, e.g. for transmucosal drug delivery, comprises an intermediate, active agent-containing layer sealed between two covering layers of higher surface area
ATE469961T1 (en) * 2005-08-18 2010-06-15 Colgate Palmolive Co FILM WITH CLEANING PRODUCT
DE102005058569B4 (en) * 2005-12-08 2010-07-15 Lts Lohmann Therapie-Systeme Ag Foam wafer with polyvinyl alcohol-polyethylene glycol graft copolymer
US20070148213A1 (en) * 2005-12-22 2007-06-28 Sayed Ibrahim Film containing compositions
WO2007130685A1 (en) * 2006-05-05 2007-11-15 The Procter & Gamble Company Films with microcapsules
US7786027B2 (en) * 2006-05-05 2010-08-31 The Procter & Gamble Company Functionalized substrates comprising perfume microcapsules
US20080014393A1 (en) * 2006-05-05 2008-01-17 The Procter & Gamble Company Functionalized substrates comprising perfume microcapsules
DE102006061287A1 (en) * 2006-12-22 2008-06-26 Lts Lohmann Therapie-Systeme Ag Edible foil-shaped preparation with cola flavor
DE102008023345B4 (en) * 2008-05-13 2014-12-04 Lts Lohmann Therapie-Systeme Ag Film-like preparation with oily substances for oral administration
US9265779B2 (en) 2008-05-13 2016-02-23 Lts Lohmann Therapie-Systeme Ag Method of using a film-shaped preparation comprising oily substances for oral administration
DE102010048408A1 (en) 2010-10-15 2012-04-19 Lts Lohmann Therapie-Systeme Ag Laminate with improved water retention behavior
DE102017112527B4 (en) 2017-06-07 2019-01-03 Lts Lohmann Therapie-Systeme Ag Fast disintegrating foam wafers with a high basis weight

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GB1142325A (en) 1965-05-14 1969-02-05 Higham Stanley Russell Means for administering drugs
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DE2449865B2 (en) 1974-10-17 1981-06-19 Schering Ag Berlin Und Bergkamen, 1000 Berlin Film-shaped medicinal product
ZA767136B (en) * 1975-12-15 1977-10-26 Hoffmann La Roche Novel dosage form
AU514195B2 (en) * 1975-12-15 1981-01-29 F. Hoffmann-La Roche & Co. Dosage form
US4119604A (en) * 1976-08-18 1978-10-10 E. I. Du Pont De Nemours And Company Polyvinyl alcohol compositions for use in the preparation of water-soluble films
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Also Published As

Publication number Publication date
EP0949909B1 (en) 2002-01-09
US6682756B1 (en) 2004-01-27
EP0949909A1 (en) 1999-10-20
JP2001505884A (en) 2001-05-08
US8883191B2 (en) 2014-11-11
JP4577913B2 (en) 2010-11-10
NO992908L (en) 1999-06-14
WO1998026764A1 (en) 1998-06-25
AU5654898A (en) 1998-07-15
JP2010270133A (en) 2010-12-02
DE19652257A1 (en) 1998-06-18
KR20000057564A (en) 2000-09-25
ES2171278T3 (en) 2002-09-01
DK0949909T3 (en) 2002-04-22
ATE211648T1 (en) 2002-01-15
DE59706140D1 (en) 2002-02-28
AU727185B2 (en) 2000-12-07
KR100493140B1 (en) 2005-06-02
PT949909E (en) 2002-06-28
CA2274959C (en) 2006-08-08
NO992908D0 (en) 1999-06-14
US20040137027A1 (en) 2004-07-15
NO320503B1 (en) 2005-12-12

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Effective date: 20171121