CA2271560C - Forme galenique pharmaceutique concue pour etre administree dans le colon - Google Patents

Forme galenique pharmaceutique concue pour etre administree dans le colon Download PDF

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Publication number
CA2271560C
CA2271560C CA002271560A CA2271560A CA2271560C CA 2271560 C CA2271560 C CA 2271560C CA 002271560 A CA002271560 A CA 002271560A CA 2271560 A CA2271560 A CA 2271560A CA 2271560 C CA2271560 C CA 2271560C
Authority
CA
Canada
Prior art keywords
colon
dosage form
active agent
therapeutically active
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002271560A
Other languages
English (en)
Other versions
CA2271560A1 (fr
Inventor
Gary Lee Manring
Gary Robert Kelm
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mayo Foundation for Medical Education and Research
Original Assignee
Mayo Foundation for Medical Education and Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mayo Foundation for Medical Education and Research filed Critical Mayo Foundation for Medical Education and Research
Publication of CA2271560A1 publication Critical patent/CA2271560A1/fr
Application granted granted Critical
Publication of CA2271560C publication Critical patent/CA2271560C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4891—Coated capsules; Multilayered drug free capsule shells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention concerne une composition pharmaceutique sous une forme galénique conçue pour être administrée par voie orale chez l'homme ou l'animal possédant un tube digestif composé d'un intestin grêle et d'un côlon, ainsi que d'une lumière présentant une entrée dans le côlon depuis l'intestin grêle. Cette composition contient (a) une quantité efficace et sans danger d'un agent actif sur le plan thérapeutique incorporé dans une forme galénique ou revêtant la surface de ladite forme galénique sélectionnée dans le groupe constitué par un substrat sphérique, un substrat elliptique, une gélule dure ou un comprimé et présentant un diamètre maximum de 3mm à 10mm; (b) un matériau de revêtement entérique polymère; ladite forme galénique présentant une surface lisse exempte de bords ou de courbes aiguës; le substrat elliptique et la gélule dure présentant un rapport entre diamètres court et long non supérieur à 1,5; l'agent actif sur le plan thérapeutique étant libéré au niveau d'un point situé à proximité de l'entrée du côlon ou à l'intérieur du côlon; chacune des couches intérieures de revêtement étant constituée par un polymère entérique commençant à se dissoudre dans un milieu aqueux à un pH situé entre 5 et 6,3 et le matériau de revêtement entérique polymère possédant une épaisseur d'au moins 250 µm.
CA002271560A 1996-11-15 1996-11-15 Forme galenique pharmaceutique concue pour etre administree dans le colon Expired - Fee Related CA2271560C (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1996/018257 WO1998022095A1 (fr) 1996-11-15 1996-11-15 Forme galenique pharmaceutique conçue pour etre administree dans le colon

Publications (2)

Publication Number Publication Date
CA2271560A1 CA2271560A1 (fr) 1998-05-28
CA2271560C true CA2271560C (fr) 2003-09-23

Family

ID=22256126

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002271560A Expired - Fee Related CA2271560C (fr) 1996-11-15 1996-11-15 Forme galenique pharmaceutique concue pour etre administree dans le colon

Country Status (4)

Country Link
KR (1) KR20000053327A (fr)
AU (1) AU739031B2 (fr)
CA (1) CA2271560C (fr)
WO (1) WO1998022095A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1594471B1 (fr) * 2003-02-20 2009-03-25 Constant Research & Development Limited Procédé de fabrication d'une formulation contenant de la dexaméthasone pour administration orale
KR101705204B1 (ko) 2009-09-11 2017-02-09 롯데정밀화학 주식회사 장용성 경질 캡슐용 수성 조성물, 장용성 경질 캡슐의 제조방법 및 장용성 경질 캡슐

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8903914D0 (sv) * 1989-11-22 1989-11-22 Draco Ab Oral composition for the treatment of inflammatory bowel diseases
JPH04368321A (ja) * 1991-06-17 1992-12-21 Kanegafuchi Chem Ind Co Ltd 大腸崩壊性コーティング剤および大腸崩壊性製剤
US5651983A (en) * 1993-02-26 1997-07-29 The Procter & Gamble Company Bisacodyl dosage form for colonic delivery
WO1994018973A1 (fr) * 1993-02-26 1994-09-01 The Procter & Gamble Company Forme galenique du bisacodyle
GB9412394D0 (en) * 1994-06-21 1994-08-10 Danbiosyst Uk Colonic drug delivery composition
US5686106A (en) * 1995-05-17 1997-11-11 The Procter & Gamble Company Pharmaceutical dosage form for colonic delivery

Also Published As

Publication number Publication date
KR20000053327A (ko) 2000-08-25
CA2271560A1 (fr) 1998-05-28
WO1998022095A1 (fr) 1998-05-28
AU739031B2 (en) 2001-10-04
AU7732496A (en) 1998-06-10

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Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed