CA2270913A1 - Recepteur tr2 du facteur de necrose tumorale chez l'homme - Google Patents
Recepteur tr2 du facteur de necrose tumorale chez l'hommeInfo
- Publication number
- CA2270913A1 CA2270913A1 CA002270913A CA2270913A CA2270913A1 CA 2270913 A1 CA2270913 A1 CA 2270913A1 CA 002270913 A CA002270913 A CA 002270913A CA 2270913 A CA2270913 A CA 2270913A CA 2270913 A1 CA2270913 A1 CA 2270913A1
- Authority
- CA
- Canada
- Prior art keywords
- amino acid
- seq
- acid sequence
- polypeptide
- receptor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
La présente invention concerne de nouveaux membres de la famille des récepteurs du facteur de nécrose tumorale. L'invention concerne des molécules isolées d'acide nucléique codant un récepteur TR2 humain et deux variantes épissées dudit récepteur. L'invention concerne aussi des polypeptides TR2, ainsi que des vecteurs, cellules hôtes et procédés de recombinaison permettant de produire lesdits éléments. L'invention concerne également des méthodes de sélection permettant d'identifier des agonistes et antagonistes de l'activité du récepteur TR2. L'invention concerne en outre des méthodes diagnostiques pour dépister des pathologies liées à l'expression aberrante de récepteurs TR2, ainsi que des méthodes thérapeutiques pour traiter des pathologies liées à une prolifération ou différenciation aberrante de cellules exprimant des récepteurs TR2.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US1996/018540 WO1998018824A1 (fr) | 1996-10-30 | 1996-10-30 | Recepteur tr2 du facteur de necrose tumorale chez l'homme |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2270913A1 true CA2270913A1 (fr) | 1998-05-07 |
CA2270913C CA2270913C (fr) | 2011-05-24 |
Family
ID=22256163
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2270913A Expired - Fee Related CA2270913C (fr) | 1996-10-30 | 1996-10-30 | Recepteur tr2 du facteur de necrose tumorale chez l'homme |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0961782A4 (fr) |
JP (1) | JP2001502912A (fr) |
CA (1) | CA2270913C (fr) |
WO (1) | WO1998018824A1 (fr) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7427492B1 (en) | 1995-06-05 | 2008-09-23 | Human Genome Sciences, Inc. | Polynucleotides encoding human tumor necrosis factor receptor-like2 |
US6291207B1 (en) | 1995-07-28 | 2001-09-18 | Northwestern University | Herpes virus entry receptor protein |
US6998108B1 (en) | 1997-07-07 | 2006-02-14 | La Jolla Institute For Allergy And Immunology | Antibodies to p30 polypeptides and methods making and using same |
US6140467A (en) * | 1997-07-07 | 2000-10-31 | La Jolla Institute For Allergy And Immunology | Ligand for herpes simplex virus entry mediator and methods of use |
US7118742B2 (en) | 1997-07-07 | 2006-10-10 | La Jolla Institute For Allergy And Immunology | Ligand for herpes simplex virus entry mediator and methods of use |
US6346388B1 (en) | 1997-08-13 | 2002-02-12 | Smithkline Beecham Corporation | Method of identifying agonist and antagonists for tumor necrosis related receptors TR1 and TR2 |
AU5804499A (en) * | 1998-09-03 | 2000-03-27 | Millennium Pharmaceuticals, Inc. | Novel molecules of the herpes virus-entry-mediator-related protein family and uses thereof |
US6287808B1 (en) | 1998-09-03 | 2001-09-11 | Millennium Pharmaceuticals, Inc. | Molecules of the herpesvirus-entry-mediator-related protein family and uses thereof |
TR200504220T2 (tr) | 1998-12-17 | 2007-04-24 | Biogen Idec Ma Inc. | Aktif limfotoksin-beta reseptör imunoglobülin şimeAktif limfotoksin-beta reseptör imunoglobülin şimerik proteinlerinin yüksek düzey ifadesi ve saflaştrik proteinlerinin yüksek düzey ifadesi ve saflaştırılması için bir yöntem.ırılması için bir yöntem. |
EP1263788A2 (fr) * | 2000-02-11 | 2002-12-11 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Identification d'un nouveau domaine dans la famille des recepteurs du facteur de necrose tumorale mediant l'assemblage et la fonction du recepteur de pre-ligand |
WO2001079496A2 (fr) * | 2000-03-13 | 2001-10-25 | La Jolla Institute For Allergy And Immunology | Ligand pour mediateur d'entree du virus herpes simplex et procedes de mise en oeuvre |
EP1674575B1 (fr) * | 2000-04-12 | 2010-10-06 | La Jolla Institute For Allergy And Immunology | Ligand du médiateur d'accès du virus de l'herpès simplex et procédés d'utilisation |
US20040235173A1 (en) * | 2000-07-03 | 2004-11-25 | Gala Design, Inc. | Production of host cells containing multiple integrating vectors by serial transduction |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE289350T1 (de) * | 1989-04-21 | 2005-03-15 | Amgen Inc | Tnf-rezeptor, tnf bindende proteine und dafür kodierende dnas |
US5395760A (en) * | 1989-09-05 | 1995-03-07 | Immunex Corporation | DNA encoding tumor necrosis factor-α and -β receptors |
US5464938A (en) * | 1990-04-09 | 1995-11-07 | Immunex Corporation | Isolated viral protein TNF antagonists |
WO1996034095A1 (fr) * | 1995-04-27 | 1996-10-31 | Human Genome Sciences, Inc. | Recepteurs du facteur de necrose tumorale chez l'homme |
-
1996
- 1996-10-30 CA CA2270913A patent/CA2270913C/fr not_active Expired - Fee Related
- 1996-10-30 WO PCT/US1996/018540 patent/WO1998018824A1/fr not_active Application Discontinuation
- 1996-10-30 JP JP10520413A patent/JP2001502912A/ja not_active Ceased
- 1996-10-30 EP EP96942776A patent/EP0961782A4/fr not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
WO1998018824A1 (fr) | 1998-05-07 |
JP2001502912A (ja) | 2001-03-06 |
WO1998018824A9 (fr) | 1999-09-30 |
EP0961782A4 (fr) | 2003-07-16 |
EP0961782A1 (fr) | 1999-12-08 |
CA2270913C (fr) | 2011-05-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |
Effective date: 20151030 |