CA2236001C - Ligands biologiquement actifs de la famille des eph - Google Patents

Ligands biologiquement actifs de la famille des eph Download PDF

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Publication number
CA2236001C
CA2236001C CA002236001A CA2236001A CA2236001C CA 2236001 C CA2236001 C CA 2236001C CA 002236001 A CA002236001 A CA 002236001A CA 2236001 A CA2236001 A CA 2236001A CA 2236001 C CA2236001 C CA 2236001C
Authority
CA
Canada
Prior art keywords
efl
ligand
protein
sequence
nucleic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002236001A
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English (en)
Other versions
CA2236001A1 (fr
Inventor
Samuel Davis
Nicholas W. Gale
George D. Yancopoulos
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Regeneron Pharmaceuticals Inc
Original Assignee
Regeneron Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharmaceuticals Inc filed Critical Regeneron Pharmaceuticals Inc
Priority claimed from PCT/US1996/017201 external-priority patent/WO1997015667A1/fr
Publication of CA2236001A1 publication Critical patent/CA2236001A1/fr
Application granted granted Critical
Publication of CA2236001C publication Critical patent/CA2236001C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Selon l'invention, un nouveau ligand (Efl-6) qui fixe la sous-famille Elk des récepteurs Eph a été identifié. L'invention concerne également des procédés permettant de produire le ligand Elf-6 soluble sous une forme biologiquement active. Un clone d'ADNc codant cette nouvelle protéine permet la production de la protéine de recombinaison, laquelle est utile pour soutenir les populations de cellules neuronales et autres portant les récepteurs Eph.
CA002236001A 1995-10-25 1996-10-25 Ligands biologiquement actifs de la famille des eph Expired - Fee Related CA2236001C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US701595P 1995-10-25 1995-10-25
US60/007,015 1995-10-25
PCT/US1996/017201 WO1997015667A1 (fr) 1995-10-25 1996-10-25 Ligands biologiquement actifs de la famille des eph

Publications (2)

Publication Number Publication Date
CA2236001A1 CA2236001A1 (fr) 1997-05-01
CA2236001C true CA2236001C (fr) 2007-04-10

Family

ID=29405581

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002236001A Expired - Fee Related CA2236001C (fr) 1995-10-25 1996-10-25 Ligands biologiquement actifs de la famille des eph

Country Status (1)

Country Link
CA (1) CA2236001C (fr)

Also Published As

Publication number Publication date
CA2236001A1 (fr) 1997-05-01

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Legal Events

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EEER Examination request
MKLA Lapsed
MKLA Lapsed

Effective date: 20121025