CA2269668A1 - Famille de taxanes canadensol, preparation semi-synthetique et usage therapeutique de ces derniers - Google Patents

Famille de taxanes canadensol, preparation semi-synthetique et usage therapeutique de ces derniers Download PDF

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Publication number
CA2269668A1
CA2269668A1 CA002269668A CA2269668A CA2269668A1 CA 2269668 A1 CA2269668 A1 CA 2269668A1 CA 002269668 A CA002269668 A CA 002269668A CA 2269668 A CA2269668 A CA 2269668A CA 2269668 A1 CA2269668 A1 CA 2269668A1
Authority
CA
Canada
Prior art keywords
compound
methyl
propyl
hydroxy
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002269668A
Other languages
English (en)
Inventor
Lolita Zamir
Gaetan Caron
Yi Feng Zheng
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut National de La Recherche Scientifique INRS
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CA 2188714 external-priority patent/CA2188714A1/fr
Priority claimed from CA 2197369 external-priority patent/CA2197369A1/fr
Application filed by Individual filed Critical Individual
Priority to CA002269668A priority Critical patent/CA2269668A1/fr
Priority claimed from PCT/CA1997/000790 external-priority patent/WO1998017656A1/fr
Publication of CA2269668A1 publication Critical patent/CA2269668A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

La présente invention concerne un nouveau taxane présentant la structure décrite dans la formule (I) et ses analogues décrits dans la formule (II) et la formule (III). La présente invention comprend de nouveaux procédés semi-synthétiques et d'isolement permettant de préparer ces nouveaux taxanes. Plus particulièrement, l'invention se rapporte à un nouveau taxane Canadensol isolé à partir des plantes du genre Taxus, en particulier Taxus canadensis. L'invention concerne également l'utilisation de ces nouveaux taxanes comme agents anticancéreux.
CA002269668A 1996-10-24 1997-10-24 Famille de taxanes canadensol, preparation semi-synthetique et usage therapeutique de ces derniers Abandoned CA2269668A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA002269668A CA2269668A1 (fr) 1996-10-24 1997-10-24 Famille de taxanes canadensol, preparation semi-synthetique et usage therapeutique de ces derniers

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
CA 2188714 CA2188714A1 (fr) 1996-10-24 1996-10-24 Taxanes, methode de preparation et compositions pharmaceutiques a base de ces produits
CA2,188,714 1996-10-24
CA2,197,369 1997-02-12
CA 2197369 CA2197369A1 (fr) 1997-02-12 1997-02-12 Nouvelles taxanes, leur preparation et compositions pharmaceutiques en contenant
CA002269668A CA2269668A1 (fr) 1996-10-24 1997-10-24 Famille de taxanes canadensol, preparation semi-synthetique et usage therapeutique de ces derniers
PCT/CA1997/000790 WO1998017656A1 (fr) 1996-10-24 1997-10-24 Famille de taxanes canadensol, preparation semi-synthetique et usage therapeutique de ces derniers

Publications (1)

Publication Number Publication Date
CA2269668A1 true CA2269668A1 (fr) 1998-04-30

Family

ID=29715691

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002269668A Abandoned CA2269668A1 (fr) 1996-10-24 1997-10-24 Famille de taxanes canadensol, preparation semi-synthetique et usage therapeutique de ces derniers

Country Status (1)

Country Link
CA (1) CA2269668A1 (fr)

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued