CA2266298A1 - Synthese et evaluation de deux 2-nitroimidazoles peptidiques marques par le technetium-99m pour realiser l'imagerie d'hypoxies - Google Patents
Synthese et evaluation de deux 2-nitroimidazoles peptidiques marques par le technetium-99m pour realiser l'imagerie d'hypoxies Download PDFInfo
- Publication number
- CA2266298A1 CA2266298A1 CA 2266298 CA2266298A CA2266298A1 CA 2266298 A1 CA2266298 A1 CA 2266298A1 CA 2266298 CA2266298 CA 2266298 CA 2266298 A CA2266298 A CA 2266298A CA 2266298 A1 CA2266298 A1 CA 2266298A1
- Authority
- CA
- Canada
- Prior art keywords
- hypoxia
- tco
- isomers
- hypoxic
- chelator
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA 2266298 CA2266298A1 (fr) | 1999-03-19 | 1999-03-19 | Synthese et evaluation de deux 2-nitroimidazoles peptidiques marques par le technetium-99m pour realiser l'imagerie d'hypoxies |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA 2266298 CA2266298A1 (fr) | 1999-03-19 | 1999-03-19 | Synthese et evaluation de deux 2-nitroimidazoles peptidiques marques par le technetium-99m pour realiser l'imagerie d'hypoxies |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2266298A1 true CA2266298A1 (fr) | 2000-09-19 |
Family
ID=29588604
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA 2266298 Abandoned CA2266298A1 (fr) | 1999-03-19 | 1999-03-19 | Synthese et evaluation de deux 2-nitroimidazoles peptidiques marques par le technetium-99m pour realiser l'imagerie d'hypoxies |
Country Status (1)
Country | Link |
---|---|
CA (1) | CA2266298A1 (fr) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007079902A1 (fr) * | 2005-12-21 | 2007-07-19 | Eberhard-Karls-Universitaet Tuebingen Universitaetsklinikum | Derives d'acides amines et de 2-nitro-1,3-imidazole couple a du desoxyribose pour la detection de tissus biologiques hypoxiques |
EP2366693A4 (fr) * | 2008-10-29 | 2012-07-11 | Jianping Ruan | Produits de contraste d hypoxie de nucléide composé d acide aminé de nitroinidazole et leur(s) précurseur(s) |
-
1999
- 1999-03-19 CA CA 2266298 patent/CA2266298A1/fr not_active Abandoned
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007079902A1 (fr) * | 2005-12-21 | 2007-07-19 | Eberhard-Karls-Universitaet Tuebingen Universitaetsklinikum | Derives d'acides amines et de 2-nitro-1,3-imidazole couple a du desoxyribose pour la detection de tissus biologiques hypoxiques |
EP2366693A4 (fr) * | 2008-10-29 | 2012-07-11 | Jianping Ruan | Produits de contraste d hypoxie de nucléide composé d acide aminé de nitroinidazole et leur(s) précurseur(s) |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AU634167B2 (en) | Macrocyclic bifunctional chelants, complexes thereof and their antibody conjugates | |
US6565828B2 (en) | Macrocyclic chelants for metallopharmaceuticals | |
NZ521246A (en) | Matrix metalloproteinase inhibitors as targeting components in diagnostic agents | |
Maresca et al. | Small molecule inhibitors of PSMA incorporating technetium-99m for imaging prostate cancer: effects of chelate design on pharmacokinetics | |
HRP960250A2 (en) | Stable reagents for the preparation of radiopharmaceuticals | |
US10646598B2 (en) | Cage-like bifunctional chelators, copper-64 radiopharmaceuticals and PET imaging using the same | |
CZ20032597A3 (cs) | Analogy kyseliny askorbové pro metaloradiofarmaceutika | |
DE69431052T2 (de) | Radiomarkierte verbindungen zur thrombus-bilderzeugung | |
Shetty et al. | Synthesis of novel 68Ga-labeled amino acid derivatives for positron emission tomography of cancer cells | |
EP1268497B1 (fr) | Complexes avec de ligand ternaire utiles en tant que produits radiopharmaceutiques | |
Liu | 6-Hydrazinonicotinamide derivatives as bifunctional coupling agents for 99m Tc-labeling of small biomolecules | |
Paparidis et al. | Synthesis and evaluation of 99mTc/Re-tricarbonyl complexes of the triphenylphosphonium cation for mitochondrial targeting | |
AU2022288744A9 (en) | Trislinker-conjugated dimeric labelling precursors and radiotracers derived therefrom | |
Kim et al. | Synthesis and characterization of a 68Ga-labeled N-(2-diethylaminoethyl) benzamide derivative as potential PET probe for malignant melanoma | |
WO2011100829A1 (fr) | Agents chélateurs bifonctionnels | |
Mallia et al. | Evaluation of 99mTc (CO) 3 complex of 2-methyl-5-nitroimidazole as an agent for targeting tumor hypoxia | |
JP2002510705A (ja) | 感染および炎症の撮像、ならびに癌の撮像および治療のための放射性医薬品 | |
Baishya et al. | Synthesis and Evaluation of Technetium‐99m‐Labeled Bioreductive Pharmacophores Conjugated with Amino Acids and Peptides for Tumor Imaging | |
Su et al. | Synthesis and evaluation of two technetium-99m-labeled peptidic 2-nitroimidazoles for imaging hypoxia | |
TWI381852B (zh) | 生物素二胺基衍生物類及其與大環螯合劑之共軛物 | |
CA3118743A1 (fr) | Composes radiomarques derives de la bombesine pour l'imagerie in vivo du recepteur du peptide liberant de la gastrine (grpr) et traitement des troubles lies au grpr | |
Mizuno et al. | Aryl isocyanide derivative for one-pot synthesis of purification-free 99mTc-labeled hexavalent targeting probe | |
CA2266298A1 (fr) | Synthese et evaluation de deux 2-nitroimidazoles peptidiques marques par le technetium-99m pour realiser l'imagerie d'hypoxies | |
Xu et al. | Synthesis and evaluation of hydroxamamide-based tetradentate ligands as a new class of thiol-free chelating molecules for 99mTc radiopharmaceuticals | |
KR101743727B1 (ko) | Peg 및 dota 함유 rgd 유도체, 그 제조방법 및 그것을 포함하는 pet 조영제 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Dead |