CA2266298A1 - Synthese et evaluation de deux 2-nitroimidazoles peptidiques marques par le technetium-99m pour realiser l'imagerie d'hypoxies - Google Patents

Synthese et evaluation de deux 2-nitroimidazoles peptidiques marques par le technetium-99m pour realiser l'imagerie d'hypoxies Download PDF

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Publication number
CA2266298A1
CA2266298A1 CA 2266298 CA2266298A CA2266298A1 CA 2266298 A1 CA2266298 A1 CA 2266298A1 CA 2266298 CA2266298 CA 2266298 CA 2266298 A CA2266298 A CA 2266298A CA 2266298 A1 CA2266298 A1 CA 2266298A1
Authority
CA
Canada
Prior art keywords
hypoxia
tco
isomers
hypoxic
chelator
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA 2266298
Other languages
English (en)
Inventor
Alfred Pollak
A. M. Rauth
Xiuguo Zhang
Zi-Fen Su
John R. Thornback
James R. Ballinger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Resolution Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Resolution Pharmaceuticals Inc filed Critical Resolution Pharmaceuticals Inc
Priority to CA 2266298 priority Critical patent/CA2266298A1/fr
Publication of CA2266298A1 publication Critical patent/CA2266298A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA 2266298 1999-03-19 1999-03-19 Synthese et evaluation de deux 2-nitroimidazoles peptidiques marques par le technetium-99m pour realiser l'imagerie d'hypoxies Abandoned CA2266298A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA 2266298 CA2266298A1 (fr) 1999-03-19 1999-03-19 Synthese et evaluation de deux 2-nitroimidazoles peptidiques marques par le technetium-99m pour realiser l'imagerie d'hypoxies

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA 2266298 CA2266298A1 (fr) 1999-03-19 1999-03-19 Synthese et evaluation de deux 2-nitroimidazoles peptidiques marques par le technetium-99m pour realiser l'imagerie d'hypoxies

Publications (1)

Publication Number Publication Date
CA2266298A1 true CA2266298A1 (fr) 2000-09-19

Family

ID=29588604

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2266298 Abandoned CA2266298A1 (fr) 1999-03-19 1999-03-19 Synthese et evaluation de deux 2-nitroimidazoles peptidiques marques par le technetium-99m pour realiser l'imagerie d'hypoxies

Country Status (1)

Country Link
CA (1) CA2266298A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007079902A1 (fr) * 2005-12-21 2007-07-19 Eberhard-Karls-Universitaet Tuebingen Universitaetsklinikum Derives d'acides amines et de 2-nitro-1,3-imidazole couple a du desoxyribose pour la detection de tissus biologiques hypoxiques
EP2366693A4 (fr) * 2008-10-29 2012-07-11 Jianping Ruan Produits de contraste d hypoxie de nucléide composé d acide aminé de nitroinidazole et leur(s) précurseur(s)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007079902A1 (fr) * 2005-12-21 2007-07-19 Eberhard-Karls-Universitaet Tuebingen Universitaetsklinikum Derives d'acides amines et de 2-nitro-1,3-imidazole couple a du desoxyribose pour la detection de tissus biologiques hypoxiques
EP2366693A4 (fr) * 2008-10-29 2012-07-11 Jianping Ruan Produits de contraste d hypoxie de nucléide composé d acide aminé de nitroinidazole et leur(s) précurseur(s)

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