CA2265455A1 - Variante de la proteine-2 chimiotactique de granulocytes - Google Patents

Variante de la proteine-2 chimiotactique de granulocytes Download PDF

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Publication number
CA2265455A1
CA2265455A1 CA002265455A CA2265455A CA2265455A1 CA 2265455 A1 CA2265455 A1 CA 2265455A1 CA 002265455 A CA002265455 A CA 002265455A CA 2265455 A CA2265455 A CA 2265455A CA 2265455 A1 CA2265455 A1 CA 2265455A1
Authority
CA
Canada
Prior art keywords
ngcp
sequence
seq
expression
sequences
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002265455A
Other languages
English (en)
Inventor
Olga Bandman
Roger Coleman
Lynn E. Murry
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Incyte Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2265455A1 publication Critical patent/CA2265455A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/521—Chemokines
    • C07K14/522—Alpha-chemokines, e.g. NAP-2, ENA-78, GRO-alpha/MGSA/NAP-3, GRO-beta/MIP-2alpha, GRO-gamma/MIP-2beta, IP-10, GCP-2, MIG, PBSF, PF-4, KC
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention porte sur un polynucléotide qui identifie et code une nouvelle variante de la protéine-2 chimiotactique de granulocytes chez l'homme (NGCP). L'invention concerne des vecteurs d'expression et des cellules hôtes, obtenus par génie génétique, qui comprennent la séquence nucléotidique codant pour NGCP. L'invention se rapporte également à la production et à l'utilisation de NGCP sensiblement purifiée dans des compositions pharmaceutiques destinées à stopper la division cellulaire dans les cellules cancéreuses. L'invention concerne des méthodes diagnostiques dans lesquelles on utilise le polynucléotide à des fins d'hybridation avec les transcrits codant pour NGCP et pour les anticorps anti-NGCP se liant spécifiquement à NGCP.
CA002265455A 1996-09-12 1997-09-10 Variante de la proteine-2 chimiotactique de granulocytes Abandoned CA2265455A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US71328896A 1996-09-12 1996-09-12
US08/713,288 1996-09-12
PCT/US1997/016034 WO1998011227A1 (fr) 1996-09-12 1997-09-10 Variante de la proteine-2 chimiotactique de granulocytes

Publications (1)

Publication Number Publication Date
CA2265455A1 true CA2265455A1 (fr) 1998-03-19

Family

ID=24865558

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002265455A Abandoned CA2265455A1 (fr) 1996-09-12 1997-09-10 Variante de la proteine-2 chimiotactique de granulocytes

Country Status (5)

Country Link
EP (1) EP0958365A1 (fr)
JP (1) JP2001500019A (fr)
AU (1) AU4266197A (fr)
CA (1) CA2265455A1 (fr)
WO (1) WO1998011227A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6410268B1 (en) 1996-03-18 2002-06-25 Human Genome Sciences, Inc. Polynucleotides encoding chemokine alpha-3
EP1312614A1 (fr) * 2001-11-16 2003-05-21 GenOdyssee Polynucleotides et polypeptides du gène GCP-2

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994012537A2 (fr) * 1992-11-27 1994-06-09 Rega Institute Leuven University Proteine a chimiotaxie selective pour les granulocytes

Also Published As

Publication number Publication date
WO1998011227A1 (fr) 1998-03-19
EP0958365A1 (fr) 1999-11-24
JP2001500019A (ja) 2001-01-09
AU4266197A (en) 1998-04-02

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