CA2264158A1 - Compositions pharmaceutiques et methodes de traitement de troubles d'ordre compulsionnel a l'aide d'un inhibiteur de la naaladase - Google Patents

Compositions pharmaceutiques et methodes de traitement de troubles d'ordre compulsionnel a l'aide d'un inhibiteur de la naaladase Download PDF

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Publication number
CA2264158A1
CA2264158A1 CA002264158A CA2264158A CA2264158A1 CA 2264158 A1 CA2264158 A1 CA 2264158A1 CA 002264158 A CA002264158 A CA 002264158A CA 2264158 A CA2264158 A CA 2264158A CA 2264158 A1 CA2264158 A1 CA 2264158A1
Authority
CA
Canada
Prior art keywords
methyl
pentanedioic acid
straight
branched chain
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002264158A
Other languages
English (en)
Inventor
Barbara S. Slusher
Kevin L. Tays
Paul F. Jackson
Keith M. Maclin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai Corp of North America
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/718,703 external-priority patent/US5824662A/en
Priority claimed from US08/778,733 external-priority patent/US5863536A/en
Priority claimed from US08/775,586 external-priority patent/US5795877A/en
Priority claimed from US08/825,997 external-priority patent/US5962521A/en
Priority claimed from US08/835,572 external-priority patent/US5902817A/en
Priority claimed from US08/842,360 external-priority patent/US6054444A/en
Priority claimed from US08/858,985 external-priority patent/US6025344A/en
Priority claimed from US08/863,624 external-priority patent/US6046180A/en
Priority claimed from US08/884,479 external-priority patent/US6017903A/en
Application filed by Individual filed Critical Individual
Publication of CA2264158A1 publication Critical patent/CA2264158A1/fr
Abandoned legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/665—Phosphorus compounds having oxygen as a ring hetero atom, e.g. fosfomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/301—Acyclic saturated acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3826—Acyclic unsaturated acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Addiction (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Psychiatry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention porte sur une composition pharmaceutique et sur une méthode de traitement de troubles d'ordre compulsionnel à l'aide d'un inhibiteur de la NAALADase.
CA002264158A 1996-09-27 1997-08-15 Compositions pharmaceutiques et methodes de traitement de troubles d'ordre compulsionnel a l'aide d'un inhibiteur de la naaladase Abandoned CA2264158A1 (fr)

Applications Claiming Priority (19)

Application Number Priority Date Filing Date Title
US08/718,703 1996-09-27
US08/718,703 US5824662A (en) 1996-09-27 1996-09-27 Treatment of global and focal ischemia using naaladase inhibitors
US08/778,733 1996-12-31
US08/778,733 US5863536A (en) 1996-12-31 1996-12-31 Phosphoramidate derivatives
US08/775,586 1996-12-31
US08/775,586 US5795877A (en) 1996-12-31 1996-12-31 Inhibitors of NAALADase enzyme activity
US08/825,997 1997-04-04
US08/825,997 US5962521A (en) 1997-04-04 1997-04-04 Hydroxamic acid derivatives
US08/835,572 US5902817A (en) 1997-04-09 1997-04-09 Certain sulfoxide and sulfone derivatives
US08/835,572 1997-04-09
US08/842,360 US6054444A (en) 1997-04-24 1997-04-24 Phosphonic acid derivatives
US08/842,360 1997-04-24
US08/863,624 1997-05-27
US08/858,985 US6025344A (en) 1996-06-17 1997-05-27 Certain dioic acid derivatives useful as NAALADase inhibitors
US08/863,624 US6046180A (en) 1996-06-17 1997-05-27 NAALADase inhibitors
US08/858,985 1997-05-27
US08/884,479 1997-06-27
US08/884,479 US6017903A (en) 1996-09-27 1997-06-27 Pharmaceutical compositions and methods of treating a glutamate abnormality and effecting a neuronal activity in an animal using NAALADase inhibitors
PCT/US1997/014417 WO1998013044A1 (fr) 1996-09-27 1997-08-15 Compositions pharmaceutiques et methodes de traitement de troubles d'ordre compulsionnel a l'aide d'un inhibiteur de la naaladase

Publications (1)

Publication Number Publication Date
CA2264158A1 true CA2264158A1 (fr) 1998-04-02

Family

ID=27578904

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002264158A Abandoned CA2264158A1 (fr) 1996-09-27 1997-08-15 Compositions pharmaceutiques et methodes de traitement de troubles d'ordre compulsionnel a l'aide d'un inhibiteur de la naaladase

Country Status (6)

Country Link
EP (1) EP0949922A1 (fr)
JP (1) JP2002514185A (fr)
AU (1) AU4151897A (fr)
CA (1) CA2264158A1 (fr)
ID (1) ID18382A (fr)
WO (1) WO1998013044A1 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5977090A (en) * 1996-09-27 1999-11-02 Guilford Pharmaceuticals Inc. Pharmaceutical compositions and methods of treating compulsive disorders using NAALADase inhibitors
US6071965A (en) * 1996-06-17 2000-06-06 Guilford Pharmaceuticals Inc. Phosphinic alkanoic acid derivatives
US6054444A (en) * 1997-04-24 2000-04-25 Guilford Pharmaceuticals Inc. Phosphonic acid derivatives
US5962521A (en) * 1997-04-04 1999-10-05 Guilford Pharmaceuticals Inc. Hydroxamic acid derivatives
WO1998053812A1 (fr) * 1997-05-27 1998-12-03 Guilford Pharmaceuticals Inc. Inhibiteurs de l'activite enzymatique de naaladase
ID20347A (id) * 1997-05-27 1998-12-03 Guilford Pharm Inc Inhibitor aktifitas enzim naaladase
CA2658200A1 (fr) * 1998-07-06 2000-01-13 Mgi Gp, Inc. Inhibiteurs de naaladase utiles comme composes et compositions pharmaceutiques
TR200100025T2 (tr) 1998-07-06 2001-12-21 Guilford Pharmaceuticals Inc. Farmasötik bileşikler ve kompozisyonlar olarak faydalı naaladaz inhibitörleri.
US6228888B1 (en) * 1999-07-01 2001-05-08 Guilford Pharmaceuticals Inc. Methods for treating anxiety, anxiety disorders and memory impairment using naaladase inhibitors
US6627625B1 (en) 1999-08-16 2003-09-30 Revaax Pharmaceuticals, Llc Treatment of behavioral disorders with β-lactam compounds
US6313159B1 (en) 1999-08-20 2001-11-06 Guilford Pharmaceuticals Inc. Metabotropic glutamate receptor ligand derivatives as naaladase inhibitors
RU2323223C2 (ru) * 2002-03-21 2008-04-27 Шеринг Акциенгезельшафт Ингибиторы карбоксипептидазы b плазмы (крови)
US20040186081A1 (en) * 2003-03-03 2004-09-23 Guilford Pharmaceuticals Inc. Naaladase inhibitors for treating opioid tolerance
US7781478B2 (en) 2004-07-14 2010-08-24 Ptc Therapeutics, Inc. Methods for treating hepatitis C
JP5259970B2 (ja) * 2007-03-30 2013-08-07 学校法人九州文化学園 薬物依存症治療剤
EP2338892A1 (fr) 2009-12-18 2011-06-29 Bayer Schering Pharma Aktiengesellschaft Inhibiteurs d'antigène de membrane spécifique à la prostate

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5500420A (en) * 1993-12-20 1996-03-19 Cornell Research Foundation, Inc. Metabotropic glutamate receptor agonists in the treatment of cerebral ischemia

Also Published As

Publication number Publication date
EP0949922A1 (fr) 1999-10-20
AU4151897A (en) 1998-04-17
WO1998013044A1 (fr) 1998-04-02
JP2002514185A (ja) 2002-05-14
ID18382A (id) 1998-04-02

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US5977090A (en) Pharmaceutical compositions and methods of treating compulsive disorders using NAALADase inhibitors
US6017903A (en) Pharmaceutical compositions and methods of treating a glutamate abnormality and effecting a neuronal activity in an animal using NAALADase inhibitors
AU733880B2 (en) Naaladase compositions and methods for treating glutamate abnormality and effecting neuronal activity in animals
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AU742418B2 (en) Hydroxamic acid derivatives
EP1066297B1 (fr) Derives d'acide phosphinique
CA2264158A1 (fr) Compositions pharmaceutiques et methodes de traitement de troubles d'ordre compulsionnel a l'aide d'un inhibiteur de la naaladase
EP0954295A1 (fr) Methodes de traitement du cancer a l'aide d'inhibiteurs de la naaladase
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