CA2261978A1 - Mixing immiscible liquids - Google Patents
Mixing immiscible liquids Download PDFInfo
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- CA2261978A1 CA2261978A1 CA002261978A CA2261978A CA2261978A1 CA 2261978 A1 CA2261978 A1 CA 2261978A1 CA 002261978 A CA002261978 A CA 002261978A CA 2261978 A CA2261978 A CA 2261978A CA 2261978 A1 CA2261978 A1 CA 2261978A1
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- liquid
- dispersion
- mixer
- mixing
- mixers
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Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/40—Mixing liquids with liquids; Emulsifying
- B01F23/41—Emulsifying
- B01F23/4105—Methods of emulsifying
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/30—Injector mixers
- B01F25/31—Injector mixers in conduits or tubes through which the main component flows
- B01F25/313—Injector mixers in conduits or tubes through which the main component flows wherein additional components are introduced in the centre of the conduit
- B01F25/3131—Injector mixers in conduits or tubes through which the main component flows wherein additional components are introduced in the centre of the conduit with additional mixing means other than injector mixers, e.g. screens, baffles or rotating elements
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/80—Mixing plants; Combinations of mixers
- B01F33/82—Combinations of dissimilar mixers
- B01F33/821—Combinations of dissimilar mixers with consecutive receptacles
- B01F33/8212—Combinations of dissimilar mixers with consecutive receptacles with moving and non-moving stirring devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/80—Mixing plants; Combinations of mixers
- B01F33/834—Mixing in several steps, e.g. successive steps
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/80—Mixing plants; Combinations of mixers
- B01F33/81—Combinations of similar mixers, e.g. with rotary stirring devices in two or more receptacles
Abstract
The present invention relates to a process for mixing two immiscible liquids by first mixing the liquids together at a given shear and subsequently mixing a first dispersion formed from mixing the liquids at the same or lower shear.
Description
C6506(C) Goldman et al.
MIXING IMMISCIBLE LIQUIDS
FIELD OF THE INVENTION
The present invention relates to methods or processes of mixing substantially immiscible liquids.
BACKGROUND OF THE INVENTION
The invention is concerned with methods of mixing immiscible liquids in order to produce, for example, detergent compositions. It is commonly desired to provide detergent compositions which comprise at least two immiscible liquids, for example a surfactant composition and a benefit agent dispersed therein. Examples of such detergent compositions are set out in WO 96/02224 and WO 96/02225 as well as WO
96/02229, all of which are incorporated herein by reference.
It is frequently desired to control the average droplet size of the dispersed phase in such mixtures of immiscible liquids. For example, in WO 96/02224 and WO
96/02225, it is desired that the benefit agent has a weight average droplet size in the range 50-500 microns.
Methods and apparatus for mixing substantially immiscible liquids are well known in the art. For example, high shear mixers such as turbine mixers, cavity transfer mixers or static mixers can be used. EP-A-0761724 describes a method for the continuous preparation of organopolysiloxane emulsions which comprises two steps. In C6506(C) the first step, polysiloxane gum, water and emulsifying agent are fed into a mixer having a first stage comprising a turbine-type rotor, a relaxation stage and a final stage comprising a turbine-type rotor. In common with many prior art processes for the production of emulsions, the final stage appears to have the function of reducing the average particle size (i.e., producing a finer emulsion) from the product leaving the first stage. More shear is accordingly applied in the final stage than in the first stage. In the second step, the emulsion of the first step and diluting water are fed into a mixer of generally the same design as used in the first step. In common with many prior art processes, the product of the first step is mixed with another component before entering the second step.
However, in addition to controlling the average droplet size, it may also be desirable to control the distribution of droplet sizes. In particular, it may be particularly desirable to have a narrow droplet size distribution, in which a relatively large percentage of the droplets are within a given range of the average droplet size.
An article by Harold P. Grace entitled "Dispersion phenomena in high viscosity immiscible fluid systems and application of static mixers as dispersion devices in such systems" (Chemical Engineering Communications, Vol. 14, pp 225-277) contains descriptions of experiments in which a mixture of immiscible fluids is passed through two or more static mixers in series, preferably separated by a relaxation zone. In the experiments described on page 256-258, the second mixer applies the same or a higher shear to the mixture than the first mixer and a narrower drop size distribution is obtained than passing the mixture through a single static mixer.
BRIEF DESCRIPTION OF THE INVENTION
The present inventors have discovered that, where a first liquid (the "dispersed phase") is dispersed in a second liquid (the "continuous phase") with which it is C6506(C) substantially immiscible by subjecting it to a first mixing step, the quantity of droplets of size outside a certain range from the average droplet size can be reduced by subjecting the mixture to at least one further mixing step in which the dispersion is subjected to less shear than in the first mixing step.
The discovery applies particularly to the case where substantially no further components are added before the second mixing step.
Accordingly, in a first aspect, the present invention provides a method or process of dispersing a first liquid in a second liquid with which it is substantially immiscible, comprising the steps of subjecting the first and second liquid to a first mixing step, to produce a first dispersion of the first liquid in the second liquid, and subjecting the first dispersion, without addition of substantial quantities of further components, to a second mixing step, to produce a second dispersion of the first liquid in the second liquid, wherein the first dispersion is subjected to same or lower shear, preferably lower, in the second mixing step than is applied to the first dispersion in the first mixing step.
In a second aspect, the present invention provides a method of treating a dispersion of a first liquid in a second liquid with which it is substantially immiscible) to reduce the quantity of droplets of size outside a given range from the average droplet size, comprising subjecting the dispersion to a mixing step of the same shear or lower as the mixing step in which the dispersion was produced.
In the second aspect of the invention, the second mixing step is used to reduce the quantity of droplets of size outside a given range from the average droplet size.
MIXING IMMISCIBLE LIQUIDS
FIELD OF THE INVENTION
The present invention relates to methods or processes of mixing substantially immiscible liquids.
BACKGROUND OF THE INVENTION
The invention is concerned with methods of mixing immiscible liquids in order to produce, for example, detergent compositions. It is commonly desired to provide detergent compositions which comprise at least two immiscible liquids, for example a surfactant composition and a benefit agent dispersed therein. Examples of such detergent compositions are set out in WO 96/02224 and WO 96/02225 as well as WO
96/02229, all of which are incorporated herein by reference.
It is frequently desired to control the average droplet size of the dispersed phase in such mixtures of immiscible liquids. For example, in WO 96/02224 and WO
96/02225, it is desired that the benefit agent has a weight average droplet size in the range 50-500 microns.
Methods and apparatus for mixing substantially immiscible liquids are well known in the art. For example, high shear mixers such as turbine mixers, cavity transfer mixers or static mixers can be used. EP-A-0761724 describes a method for the continuous preparation of organopolysiloxane emulsions which comprises two steps. In C6506(C) the first step, polysiloxane gum, water and emulsifying agent are fed into a mixer having a first stage comprising a turbine-type rotor, a relaxation stage and a final stage comprising a turbine-type rotor. In common with many prior art processes for the production of emulsions, the final stage appears to have the function of reducing the average particle size (i.e., producing a finer emulsion) from the product leaving the first stage. More shear is accordingly applied in the final stage than in the first stage. In the second step, the emulsion of the first step and diluting water are fed into a mixer of generally the same design as used in the first step. In common with many prior art processes, the product of the first step is mixed with another component before entering the second step.
However, in addition to controlling the average droplet size, it may also be desirable to control the distribution of droplet sizes. In particular, it may be particularly desirable to have a narrow droplet size distribution, in which a relatively large percentage of the droplets are within a given range of the average droplet size.
An article by Harold P. Grace entitled "Dispersion phenomena in high viscosity immiscible fluid systems and application of static mixers as dispersion devices in such systems" (Chemical Engineering Communications, Vol. 14, pp 225-277) contains descriptions of experiments in which a mixture of immiscible fluids is passed through two or more static mixers in series, preferably separated by a relaxation zone. In the experiments described on page 256-258, the second mixer applies the same or a higher shear to the mixture than the first mixer and a narrower drop size distribution is obtained than passing the mixture through a single static mixer.
BRIEF DESCRIPTION OF THE INVENTION
The present inventors have discovered that, where a first liquid (the "dispersed phase") is dispersed in a second liquid (the "continuous phase") with which it is C6506(C) substantially immiscible by subjecting it to a first mixing step, the quantity of droplets of size outside a certain range from the average droplet size can be reduced by subjecting the mixture to at least one further mixing step in which the dispersion is subjected to less shear than in the first mixing step.
The discovery applies particularly to the case where substantially no further components are added before the second mixing step.
Accordingly, in a first aspect, the present invention provides a method or process of dispersing a first liquid in a second liquid with which it is substantially immiscible, comprising the steps of subjecting the first and second liquid to a first mixing step, to produce a first dispersion of the first liquid in the second liquid, and subjecting the first dispersion, without addition of substantial quantities of further components, to a second mixing step, to produce a second dispersion of the first liquid in the second liquid, wherein the first dispersion is subjected to same or lower shear, preferably lower, in the second mixing step than is applied to the first dispersion in the first mixing step.
In a second aspect, the present invention provides a method of treating a dispersion of a first liquid in a second liquid with which it is substantially immiscible) to reduce the quantity of droplets of size outside a given range from the average droplet size, comprising subjecting the dispersion to a mixing step of the same shear or lower as the mixing step in which the dispersion was produced.
In the second aspect of the invention, the second mixing step is used to reduce the quantity of droplets of size outside a given range from the average droplet size.
C6506(C) BRIEF DESCRIPTION OF THE FIGURES
Figure 1 shows a schematic illustration of apparatus for use with the method of the first or second aspect of the invention.
Figure 2 shows a suitable means of introducing a flow of first liquid into a flow of second liquid.
Figure 3 shows a schematic illustration of apparatus according to the third aspect of the invention where the liquid may be recycled.
Figures 4, 5 and 6 are graphs of droplet size distribution obtained with the apparatus of Figures 1 and 3.
DETAILED DESCRIPTION OF THE INVENTION
The present invention is suitable for dispersing any liquid in another liquid with which it is immiscible. The present invention is particularly suitable for mixing a liquid surfactant composition selected from anionic, nonionic, zwitterionic and cationic surfactant agents or solutions thereof and a substantially immiscible benefit agent, for example as set out in WO 96/02224. The present invention is particularly suitable for mixing silicone oils) gums and modifications thereof such as linear and cyclic polydimethylsiloxanes, amino, alkyl) alkyl aryl and aryl silicone oils with surfactant compositions.
Other examples of benefit agents are set out in WO 96/02224.
Figure 1 shows a schematic illustration of apparatus for use with the method of the first or second aspect of the invention.
Figure 2 shows a suitable means of introducing a flow of first liquid into a flow of second liquid.
Figure 3 shows a schematic illustration of apparatus according to the third aspect of the invention where the liquid may be recycled.
Figures 4, 5 and 6 are graphs of droplet size distribution obtained with the apparatus of Figures 1 and 3.
DETAILED DESCRIPTION OF THE INVENTION
The present invention is suitable for dispersing any liquid in another liquid with which it is immiscible. The present invention is particularly suitable for mixing a liquid surfactant composition selected from anionic, nonionic, zwitterionic and cationic surfactant agents or solutions thereof and a substantially immiscible benefit agent, for example as set out in WO 96/02224. The present invention is particularly suitable for mixing silicone oils) gums and modifications thereof such as linear and cyclic polydimethylsiloxanes, amino, alkyl) alkyl aryl and aryl silicone oils with surfactant compositions.
Other examples of benefit agents are set out in WO 96/02224.
C6506(C) The relative quantity of first and second liquid is not critical. Preferably, there is a greater quantity by volume of second liquid than first liquid, preferably at least twice the quantity.
The first and second liquid may be of any desired viscosities. The present invention is, however, particularly suitable for mixing liquids with viscosities in the range 0.001 to 100 Pas at a shear rate of 100 s-'.
The first liquid may be partially soluble in the second liquid, as long as at least part of the first liquid forms a separate phase.
The process of the present invention may be used to produce surfactant compositions as set out in WO 96/02224, WO 96/02225 and WO 96/02229 for example.
The surfactant composition produced may comprise a washing composition, shampoo or body washing composition for example.
The present invention may also be used in the production of food stuffs, or personal products such as cosmetics.
The first and second dispersions are preferably of the type which can be described as an emulsion with the first liquid as the dispersed phase and the second liquid as the continuous phase.
The first step is preferably carried out in a relatively high shear mixer such as a cavity transfer mixer, extruder mixer, mixer with stirring element(s), colloid mill, ball mill, turbine-type mixer, or an intensive mixer. More preferably, however, the first step is carried out in a static mixer.
The present invention is particularly concerned with dispersing immiscible liquids using static mixers. Static mixers are will known in the art. They comprise means for C6506(C) mixing media, in which there are substantially no moving parts. Instead, the internal configuration of the static mixer is such that when a fluid medium is passed through it, turbulence and/or shear is generated, whereby mixing or dispersion can occur.
Any suitable kind of static mixer may be used for the first mixing step. In a static mixer, mixing action is achieved by the continuous splitting, extension and transposition of flow components.
The internal configuration of the static mixer may be defined by vanes, baffles, flow splitters and flow dividers, tubes, helixes or any other suitable device.
Suitable static mixers are produced, for example by Kenics (trademark) and Sulzer (trademark).
It is important to note that it is not the absolute speed of the first or second mixer which are critical to the invention but the relative shear imparted by the second mixer relative to the first, e.g., the second must be same or lower, preferably lower.
The first and second liquid may be fed to the static mixer in any suitable manner.
For example, there may be a simple junction pipe before the static mixer.
Alternatively, a stream of the first component may be injected into a stream of the second component through a tube which is arranged at a small angle or substantially parallel to the flow direction. This minimizes mixing before the static mixer and allows improved control of particle size distribution. The first component is preferably injected flowing in the same direction as the second component, but it may be injected flowing in the reverse direction.
Preferably, a relaxation step or low shear step is provided between the first and second mixing steps. In the low shear step, the first dispersion of the first liquid in the second liquid is subjected to equal, preferably less, shear than in the first static mixing step or the second mixing step. The low shear step may comprise feeding the first dispersion into a container. However, the low shear step may simply comprise a pipe C6506(C) length. The first dispersion flowing through the pipe will be subject to a certain amount of pipe shear at the edges) but this may be minimized by having a low flow velocity and most of the dispersion flowing through the pipe will be distant from areas of shear.
Preferably, the pipe length shall be at least 1, preferably at least 3, more preferably 10 diameters in length. In general there is no criticality to the pipe length. In the low shear step, the shearing to which the dispersion is subjected is "relaxed".
The mixer of the second mixing step may comprise a duct having a screen, baffle or nozzle, or a second, lower shear static mixer.
Where static mixers are used for the mixing steps it is particularly preferred that the first and second static mixers are substantially different. For example, they may be of different diameter. Preferably, the second static mixer is of larger diameter than the first static mixer.
According to the present invention, there may be further mixing steps through which the dispersion is passed, preferably each mixing step is separated from the previous mixing step by a relaxation step.
Where a plurality of static mixers are used in series) the last static mixer should preferably be that which applies the lowest shear to the liquid dispersion.
Preferably, each successive mixer applies less shear than the mixer upstream of it.
Instead of passing the mixture through two mixers in series) the inventors have discovered that a similar effect may be obtained if the dispersion is passed at least twice through the same mixer. According to a third aspect of the invention there is provided a method or process of dispersing a first liquid in a second liquid with which it is substantially immiscible, comprising the steps of placing at least one of the first or second liquids in a storage vessel, feeding the liquids to a mixer to provide a first dispersion of the first liquid in the second liquid, the first dispersion being fed from the C6506(C) storage vessel back to the mixer, without addition of substantial quantities of further components to the vessel.
This aspect provides a modification of the invention defined above, in that some of the liquid originally in the vessel may still be present when the first dispersion reaches the vessel. Accordingly, the first dispersion is mixed to a certain extent with addition first or second liquid component from the vessel. However) no substantial addition of further components other than the first and second liquids takes place. This is distinct from known processes where a new component is dosed into the vessel or dispersion after the first dispersion is returned thereto.
In this aspect of the invention, the storage vessel may have a volume which is substantially equal to the volume of liquid in the pipes and static mixer, but is preferably at least 5 times the volume of liquid in the pipes and static mixer.
A low shear mixing device such as a stirrer may be additionally provided in the storage vessel. The mixing device may be any one of a variety of devices which are well known to those skilled in the art.
In this aspect of the present invention, the first dispersion is circulated through the static mixer for a sufficient period of time so that, on average, substantially all of the first liquid and the second liquid pass at least twice through the mixer.
Preferably) this is achieved by ensuring that the volume that has passed through the mixer is equal to at least twice, more preferably at least three times the total volume of first and second liquid.
In this aspect of the invention, the second liquid may be stored in the storage vessel before mixing with the first liquid.
s C6506(C) The process of this aspect of the invention may be run continuously, with dispersion being removed continuously from the storage vessel or from a point down stream of the mixer. The inflow rate of first liquid and second liquid and the removal rate of dispersion thereof may be balanced with the rate of flow of liquid through the static mixer so that, on average, the residence time of liquid in the system is such that it must pass at least twice through the mixer.
The second aspect can provide the use of a first and second mixer to provide a dispersion of a first liquid in a second liquid, which dispersion has substantially the same average droplet size but a narrower droplet size distribution than would be obtainable by passing the first and second liquid through the first or second mixer, comprising passing the first and second liquid through the first and second mixer in sequence.
In the first, second and any subsequent dispersion, the first liquid will exist as droplets (the dispersed phase) in the second liquid (the continuous phase).
The skilled person will be able to select process parameters to ensure that a desired average particle size is obtained. For example, the relative viscosities of the first and second liquid must be taken into account. The flow rate through the mixer, the design of mixer and the length and diameter of the mixer may be altered appropriately.
Alterations to these parameters may be made by the skilled person without inventive experimentation in order to obtain the optimum parameters for any given target droplet distribution.
The droplet size distribution is typically measured by a Malvern Mastersizer (Mastersizer is a Trademark).
The shear rate in the first and second mixing step may be measured or calculated, for example, by one of the following methods:
C6506(C) FOR SMX (SULZER) DESIGN:
shear rate = (K) times (velocity) [_] 1/sec K = f(diameter); K(0.62") = 146 1/inch K(1.02") = 77 f linch In general, any size diameter may be used although of course, different diameters will have different K value which can be obtained, for example, from the manufacturer.
FOR KMS (KENICS) DESIGN:
shear rate = (3) times (shear in empty pipe) _ (3) times (8 times velocity/diameter of pipe) [_] 1 /sec.
C6506(C) The shear rate will depend upon the mixer design and operating conditions as noted in the equations above. However, as no substantial quantity of additional components are added between the first and second steps, it is relatively simple to compare the shear rate in the two mixing steps.
It is acceptable to add minor quantities of additional components such as dye, perfume, further diluent.
The quantity of additional components added should be at such a level that it does not substantially affect the shear applied to the dispersion in any given mixer.
Preferably, the level at which additional component is added is less than 20%
by weight, more preferably less than 10% by weight, based upon the quantity of first dispersion.
The present invention may be used to mix more than two substantially immiscible liquids if necessary) the components being all added to the first mixing step.
The quantity of droplets of size outside a given range from the mean size may be represented by the span, defined as follows:
Span = D(50)I[D(90)-D( 10)]
The terms in the equation are defined as follows:
It is assumed that the droplets have a generally normal particle size dispersion.
It is assumed that the droplets are generally circular. By definition, 50% of the distribution has a droplet size which is smaller than the diameter D(50).
Similarly, 10%
of the droplets in the distribution have a size which is smaller than the diameter D(10) and 90% of the droplets have a size smaller than the diameter D(90).
C6506(C) According to the present invention, there is provided a method of decreasing Span as defined above.
The present invention will be described by way of example only with reference to the accompanying drawing in which:
Figure 1 shows a schematic illustration of apparatus for use with the method of the first or second aspect of the invention.
Figure 2 shows a suitable means of introducing a flow of first liquid into a flow of second liquid.
Figure 3 shows a schematic illustration of apparatus according to the third aspect of the invention.
Figures 4, 5 and 6 are graphs of droplet size distribution obtained with the apparatus of Figures 1 and 3.
The apparatus of Figure 1 comprises a first vessel 1 for containing the first liquid and the second vessel 2 for containing the second liquid. The second vessel 2 may have a stirrer 3 for preventing settling of components in the second liquid.
Pumps 4 and deliver first and second liquid to a junction which will be described further below in relation to Figure 2. The liquids pass from the junction to a first static mixer shown schematically at 6. The pump rates are set, centrally or otherwise, so that the desired ratio by volume of first to second liquid is achieved.
~2 C6506(C) Downstream of the first static mixer 6 there is a pipe 7 of approximately 2 pipe diameters in length. This zone 7 provides a low shear zone in which the dispersion of first liquid in second liquid is subjected to very low shear. Downstream of the low shear zone 7 there is a second static mixer.
It should be understood that a relaxation or low shear zone (i.e., 7) is not required and that the process may be conducted without such a zone being present.
That is, for example, the mixers could be set up back to back, particularly, for example, if the two mixers are of two different designs.
A refined dispersion 9 is collected at the end of the apparatus.
Figure 2 shows a suitable junction arrangement whereby a flow of first liquid may be introduced into a flow of second liquid before being fed into the first static mixer 6.
Flow is in the direction shown by the arrows. In pipe 10 there is a nozzle 12 at the end of a pipe 13 which is arranged generally parallel to the flow direction. First liquid is pumped out of the nozzle 12. Preferably) the flow rate of the first liquid is such that the flow velocity is the same as or greater than the flow velocity of the second liquid to minimize shear before entry into the static mixer.
C6506(C) Figure 3 is a schematic illustration of apparatus according to the third aspect of the invention. As above, there is a first vessel 14 for the first liquid and a second vessel 15 for the second liquid. Pumps 16 and 17 deliver first and second liquid to a junction, 18, which may be as set out in Figure 2. The liquids are then supplied to a static mixer 19. Downstream of the static mixer 19 there is a recycle line 20 which delivers first dispersion 21 back into vessel 15. An agitator 22 is provided in the vessel 15. The agitator is designed so that it applies very low shear to the mixture of first dispersion and second liquid in vessel 15. The agitator is provided in order to ensure that there is a statistically high chance of all parts of the liquid volume contained in vessel 15 being delivered by the pump 16 to the static mixer 19. Suitable design of low shear agitator will be familiar to the person skilled in the art. Delivery means 23 are provided for extracting the liquid dispersion from the vessel 15 or pipe 20 after the dispersion has been passed a sufficient number of times through the static mixer 19.
Except in the operating and comparative examples, or where otherwise explicitly indicated, all numbers in this description indicating amounts or ratios of materials or conditions of reaction, physical properties of materials and/or use are to be understood as indicated by the word "about".
Where used in the specification or claims, the term "comprising" should be understood to include the presence of stated features, integers, steps, components etc., but not to preclude the presence or addition of one or more features, integers, steps components or groups thereof.
C6506(C) EXAMPLES
The present invention will be further described by way of reference only with regard to the following examples. The examples are not intended to be limiting in any way.
Example 1 An apparatus according to Figure 1 was set up with the following conditions.
The first mixer 6 comprised a static mixer having six Sulzer SMX elements. The mixer 8 comprised a twelve inch Kenics (trademark) KMS mixer, which applies lower shear to the dispersion than the mixer 6.
A first liquid comprising silicone oil and a second liquid comprising a Xanthan gum-based shower gel was passed through the mixers at a rate of 2 kg/min.
Comparative Example A
The same liquid was mixed with a single pass through a single mixer comprising six Sulzer SMX elements.
The results of Example 1 and Comparative Example A are shown in Figure 4. It can be seen that the method of the invention allows the droplet size distribution to be narrowed without substantially affecting the average droplet size.
C6506(C) Example 2 An apparatus according to Figure 1 was set up as follows.
The first mixer comprised a relatively high shear mixer comprising 3 sets of 3 Sulzer SMX elements with one inch spacer elements between the sets. The second mixer 8 comprised a six inch Kenics KMS mixer which applies lower shear to the dispersion than the Sulzer SMX elements.
The first liquid comprised silicone oil. The second liquid comprised a liquid hydrogel.
Comparative Example B
The same liquid was passed through an apparatus similar to Figure 1, but in which the mixers 6 and 8 and the pipe length 7 are replaced with a single mixer comprising 3 sets of 3 Sulzer SMX elements with one inch spacers between the sets.
Comparative Example C
The apparatus of Figure 1 was set up with the following modification.
The mixer 6 comprised a relatively low shear mixer comprising a six inch Kenics mixer. The mixer 8 was replaced with a mixer comprising 3 sets of 3 Sulzer SMX
element mixer with one inch spacers between the sets which applied higher shear than the Kenics mixer.
C6506(C) The droplet size distribution of a liquid produced by passing the liquid mixture through the apparatus of Examples 2 and Comparative Examples B and C are shown in Figure 5. It can be seen that the method of the invention yields a narrower droplet size distribution than the single mixer or the lower shear mixer followed by the higher shear mixer.
C6506(C) Example 3 An apparatus according to Figure 3 was set up and used as follows.
Silicone oil of viscosity 60,000 centistokes (cst) was placed in the vessel 14.
A substantially homogeneous liquid mixture comprising the following ingredients (all parts are by weight) was manufactured spear and placed in vessel 15.
Hectorite Clay (Laponite XLS Solution) 1.00 Glycerine (Precerine 9083) 12.0 Potassium Hydroxide Solution (48% by wt.)3.90 Oleic Acid (Priolene 6907) 3.20 Myristic Acid (Prifrac 2940) 6.40 Lauric Acid (Prifrac 2920) 6.40 EDTA Solution 0.1 Cocoamidopropylbetaine (Dehyton k) (30% 5.0 Solutions) Butyl Hydroxy Toluene 0.05 Perfume 1.80 Styrene/Acrylate Copolymer (Lytron 621 0.40 B) Formaldehyde Formalin 0.04 NaCI (25% Solution) up to 2.00 Chlorinated Demineralized Water 30.15 The apparatus was run so that pump 17 delivered five parts by weight of silicone oil while pump 16 delivered 95 parts by weight of the above mentioned liquid mixture.
The static mixture comprised a three element Sulzer SMX static mixer.
The apparatus was run with liquid mixture being recirculated to the vessel.
The re-circulation rate was set at 100 kg/hr.
C6506(C) The apparatus was run until all the silicone oil had been dosed in.
Thereafter, a clock was set to zero and the run continued. The droplet size distribution for the dispersion of first liquid and second liquid was assessed at different times after the clock was started.
The number of re-circulations to which each measurement corresponds is not exact, as it cannot be guaranteed that every part of the material in the vessel 15 is re-circulated each time. However, an approximation was reached by multiplying the re-circulation time in minutes by 0.04. Since the mass of liquid in the vessel is 40 kg. and the re-circulation rate is 100 kg./hr.) the mean re-circulation time per unit mass is approximately 24 minutes.
TimeIMinutes Number of Re-Circulations 7 just commenced 25 1.
The results are shown in Figure 6.
It can be seen from Figure 6 that repeated circulations using the apparatus of Figure 3 result in progressive narrowing of the particle size distribution without substantially altering the average droplet size.
The first and second liquid may be of any desired viscosities. The present invention is, however, particularly suitable for mixing liquids with viscosities in the range 0.001 to 100 Pas at a shear rate of 100 s-'.
The first liquid may be partially soluble in the second liquid, as long as at least part of the first liquid forms a separate phase.
The process of the present invention may be used to produce surfactant compositions as set out in WO 96/02224, WO 96/02225 and WO 96/02229 for example.
The surfactant composition produced may comprise a washing composition, shampoo or body washing composition for example.
The present invention may also be used in the production of food stuffs, or personal products such as cosmetics.
The first and second dispersions are preferably of the type which can be described as an emulsion with the first liquid as the dispersed phase and the second liquid as the continuous phase.
The first step is preferably carried out in a relatively high shear mixer such as a cavity transfer mixer, extruder mixer, mixer with stirring element(s), colloid mill, ball mill, turbine-type mixer, or an intensive mixer. More preferably, however, the first step is carried out in a static mixer.
The present invention is particularly concerned with dispersing immiscible liquids using static mixers. Static mixers are will known in the art. They comprise means for C6506(C) mixing media, in which there are substantially no moving parts. Instead, the internal configuration of the static mixer is such that when a fluid medium is passed through it, turbulence and/or shear is generated, whereby mixing or dispersion can occur.
Any suitable kind of static mixer may be used for the first mixing step. In a static mixer, mixing action is achieved by the continuous splitting, extension and transposition of flow components.
The internal configuration of the static mixer may be defined by vanes, baffles, flow splitters and flow dividers, tubes, helixes or any other suitable device.
Suitable static mixers are produced, for example by Kenics (trademark) and Sulzer (trademark).
It is important to note that it is not the absolute speed of the first or second mixer which are critical to the invention but the relative shear imparted by the second mixer relative to the first, e.g., the second must be same or lower, preferably lower.
The first and second liquid may be fed to the static mixer in any suitable manner.
For example, there may be a simple junction pipe before the static mixer.
Alternatively, a stream of the first component may be injected into a stream of the second component through a tube which is arranged at a small angle or substantially parallel to the flow direction. This minimizes mixing before the static mixer and allows improved control of particle size distribution. The first component is preferably injected flowing in the same direction as the second component, but it may be injected flowing in the reverse direction.
Preferably, a relaxation step or low shear step is provided between the first and second mixing steps. In the low shear step, the first dispersion of the first liquid in the second liquid is subjected to equal, preferably less, shear than in the first static mixing step or the second mixing step. The low shear step may comprise feeding the first dispersion into a container. However, the low shear step may simply comprise a pipe C6506(C) length. The first dispersion flowing through the pipe will be subject to a certain amount of pipe shear at the edges) but this may be minimized by having a low flow velocity and most of the dispersion flowing through the pipe will be distant from areas of shear.
Preferably, the pipe length shall be at least 1, preferably at least 3, more preferably 10 diameters in length. In general there is no criticality to the pipe length. In the low shear step, the shearing to which the dispersion is subjected is "relaxed".
The mixer of the second mixing step may comprise a duct having a screen, baffle or nozzle, or a second, lower shear static mixer.
Where static mixers are used for the mixing steps it is particularly preferred that the first and second static mixers are substantially different. For example, they may be of different diameter. Preferably, the second static mixer is of larger diameter than the first static mixer.
According to the present invention, there may be further mixing steps through which the dispersion is passed, preferably each mixing step is separated from the previous mixing step by a relaxation step.
Where a plurality of static mixers are used in series) the last static mixer should preferably be that which applies the lowest shear to the liquid dispersion.
Preferably, each successive mixer applies less shear than the mixer upstream of it.
Instead of passing the mixture through two mixers in series) the inventors have discovered that a similar effect may be obtained if the dispersion is passed at least twice through the same mixer. According to a third aspect of the invention there is provided a method or process of dispersing a first liquid in a second liquid with which it is substantially immiscible, comprising the steps of placing at least one of the first or second liquids in a storage vessel, feeding the liquids to a mixer to provide a first dispersion of the first liquid in the second liquid, the first dispersion being fed from the C6506(C) storage vessel back to the mixer, without addition of substantial quantities of further components to the vessel.
This aspect provides a modification of the invention defined above, in that some of the liquid originally in the vessel may still be present when the first dispersion reaches the vessel. Accordingly, the first dispersion is mixed to a certain extent with addition first or second liquid component from the vessel. However) no substantial addition of further components other than the first and second liquids takes place. This is distinct from known processes where a new component is dosed into the vessel or dispersion after the first dispersion is returned thereto.
In this aspect of the invention, the storage vessel may have a volume which is substantially equal to the volume of liquid in the pipes and static mixer, but is preferably at least 5 times the volume of liquid in the pipes and static mixer.
A low shear mixing device such as a stirrer may be additionally provided in the storage vessel. The mixing device may be any one of a variety of devices which are well known to those skilled in the art.
In this aspect of the present invention, the first dispersion is circulated through the static mixer for a sufficient period of time so that, on average, substantially all of the first liquid and the second liquid pass at least twice through the mixer.
Preferably) this is achieved by ensuring that the volume that has passed through the mixer is equal to at least twice, more preferably at least three times the total volume of first and second liquid.
In this aspect of the invention, the second liquid may be stored in the storage vessel before mixing with the first liquid.
s C6506(C) The process of this aspect of the invention may be run continuously, with dispersion being removed continuously from the storage vessel or from a point down stream of the mixer. The inflow rate of first liquid and second liquid and the removal rate of dispersion thereof may be balanced with the rate of flow of liquid through the static mixer so that, on average, the residence time of liquid in the system is such that it must pass at least twice through the mixer.
The second aspect can provide the use of a first and second mixer to provide a dispersion of a first liquid in a second liquid, which dispersion has substantially the same average droplet size but a narrower droplet size distribution than would be obtainable by passing the first and second liquid through the first or second mixer, comprising passing the first and second liquid through the first and second mixer in sequence.
In the first, second and any subsequent dispersion, the first liquid will exist as droplets (the dispersed phase) in the second liquid (the continuous phase).
The skilled person will be able to select process parameters to ensure that a desired average particle size is obtained. For example, the relative viscosities of the first and second liquid must be taken into account. The flow rate through the mixer, the design of mixer and the length and diameter of the mixer may be altered appropriately.
Alterations to these parameters may be made by the skilled person without inventive experimentation in order to obtain the optimum parameters for any given target droplet distribution.
The droplet size distribution is typically measured by a Malvern Mastersizer (Mastersizer is a Trademark).
The shear rate in the first and second mixing step may be measured or calculated, for example, by one of the following methods:
C6506(C) FOR SMX (SULZER) DESIGN:
shear rate = (K) times (velocity) [_] 1/sec K = f(diameter); K(0.62") = 146 1/inch K(1.02") = 77 f linch In general, any size diameter may be used although of course, different diameters will have different K value which can be obtained, for example, from the manufacturer.
FOR KMS (KENICS) DESIGN:
shear rate = (3) times (shear in empty pipe) _ (3) times (8 times velocity/diameter of pipe) [_] 1 /sec.
C6506(C) The shear rate will depend upon the mixer design and operating conditions as noted in the equations above. However, as no substantial quantity of additional components are added between the first and second steps, it is relatively simple to compare the shear rate in the two mixing steps.
It is acceptable to add minor quantities of additional components such as dye, perfume, further diluent.
The quantity of additional components added should be at such a level that it does not substantially affect the shear applied to the dispersion in any given mixer.
Preferably, the level at which additional component is added is less than 20%
by weight, more preferably less than 10% by weight, based upon the quantity of first dispersion.
The present invention may be used to mix more than two substantially immiscible liquids if necessary) the components being all added to the first mixing step.
The quantity of droplets of size outside a given range from the mean size may be represented by the span, defined as follows:
Span = D(50)I[D(90)-D( 10)]
The terms in the equation are defined as follows:
It is assumed that the droplets have a generally normal particle size dispersion.
It is assumed that the droplets are generally circular. By definition, 50% of the distribution has a droplet size which is smaller than the diameter D(50).
Similarly, 10%
of the droplets in the distribution have a size which is smaller than the diameter D(10) and 90% of the droplets have a size smaller than the diameter D(90).
C6506(C) According to the present invention, there is provided a method of decreasing Span as defined above.
The present invention will be described by way of example only with reference to the accompanying drawing in which:
Figure 1 shows a schematic illustration of apparatus for use with the method of the first or second aspect of the invention.
Figure 2 shows a suitable means of introducing a flow of first liquid into a flow of second liquid.
Figure 3 shows a schematic illustration of apparatus according to the third aspect of the invention.
Figures 4, 5 and 6 are graphs of droplet size distribution obtained with the apparatus of Figures 1 and 3.
The apparatus of Figure 1 comprises a first vessel 1 for containing the first liquid and the second vessel 2 for containing the second liquid. The second vessel 2 may have a stirrer 3 for preventing settling of components in the second liquid.
Pumps 4 and deliver first and second liquid to a junction which will be described further below in relation to Figure 2. The liquids pass from the junction to a first static mixer shown schematically at 6. The pump rates are set, centrally or otherwise, so that the desired ratio by volume of first to second liquid is achieved.
~2 C6506(C) Downstream of the first static mixer 6 there is a pipe 7 of approximately 2 pipe diameters in length. This zone 7 provides a low shear zone in which the dispersion of first liquid in second liquid is subjected to very low shear. Downstream of the low shear zone 7 there is a second static mixer.
It should be understood that a relaxation or low shear zone (i.e., 7) is not required and that the process may be conducted without such a zone being present.
That is, for example, the mixers could be set up back to back, particularly, for example, if the two mixers are of two different designs.
A refined dispersion 9 is collected at the end of the apparatus.
Figure 2 shows a suitable junction arrangement whereby a flow of first liquid may be introduced into a flow of second liquid before being fed into the first static mixer 6.
Flow is in the direction shown by the arrows. In pipe 10 there is a nozzle 12 at the end of a pipe 13 which is arranged generally parallel to the flow direction. First liquid is pumped out of the nozzle 12. Preferably) the flow rate of the first liquid is such that the flow velocity is the same as or greater than the flow velocity of the second liquid to minimize shear before entry into the static mixer.
C6506(C) Figure 3 is a schematic illustration of apparatus according to the third aspect of the invention. As above, there is a first vessel 14 for the first liquid and a second vessel 15 for the second liquid. Pumps 16 and 17 deliver first and second liquid to a junction, 18, which may be as set out in Figure 2. The liquids are then supplied to a static mixer 19. Downstream of the static mixer 19 there is a recycle line 20 which delivers first dispersion 21 back into vessel 15. An agitator 22 is provided in the vessel 15. The agitator is designed so that it applies very low shear to the mixture of first dispersion and second liquid in vessel 15. The agitator is provided in order to ensure that there is a statistically high chance of all parts of the liquid volume contained in vessel 15 being delivered by the pump 16 to the static mixer 19. Suitable design of low shear agitator will be familiar to the person skilled in the art. Delivery means 23 are provided for extracting the liquid dispersion from the vessel 15 or pipe 20 after the dispersion has been passed a sufficient number of times through the static mixer 19.
Except in the operating and comparative examples, or where otherwise explicitly indicated, all numbers in this description indicating amounts or ratios of materials or conditions of reaction, physical properties of materials and/or use are to be understood as indicated by the word "about".
Where used in the specification or claims, the term "comprising" should be understood to include the presence of stated features, integers, steps, components etc., but not to preclude the presence or addition of one or more features, integers, steps components or groups thereof.
C6506(C) EXAMPLES
The present invention will be further described by way of reference only with regard to the following examples. The examples are not intended to be limiting in any way.
Example 1 An apparatus according to Figure 1 was set up with the following conditions.
The first mixer 6 comprised a static mixer having six Sulzer SMX elements. The mixer 8 comprised a twelve inch Kenics (trademark) KMS mixer, which applies lower shear to the dispersion than the mixer 6.
A first liquid comprising silicone oil and a second liquid comprising a Xanthan gum-based shower gel was passed through the mixers at a rate of 2 kg/min.
Comparative Example A
The same liquid was mixed with a single pass through a single mixer comprising six Sulzer SMX elements.
The results of Example 1 and Comparative Example A are shown in Figure 4. It can be seen that the method of the invention allows the droplet size distribution to be narrowed without substantially affecting the average droplet size.
C6506(C) Example 2 An apparatus according to Figure 1 was set up as follows.
The first mixer comprised a relatively high shear mixer comprising 3 sets of 3 Sulzer SMX elements with one inch spacer elements between the sets. The second mixer 8 comprised a six inch Kenics KMS mixer which applies lower shear to the dispersion than the Sulzer SMX elements.
The first liquid comprised silicone oil. The second liquid comprised a liquid hydrogel.
Comparative Example B
The same liquid was passed through an apparatus similar to Figure 1, but in which the mixers 6 and 8 and the pipe length 7 are replaced with a single mixer comprising 3 sets of 3 Sulzer SMX elements with one inch spacers between the sets.
Comparative Example C
The apparatus of Figure 1 was set up with the following modification.
The mixer 6 comprised a relatively low shear mixer comprising a six inch Kenics mixer. The mixer 8 was replaced with a mixer comprising 3 sets of 3 Sulzer SMX
element mixer with one inch spacers between the sets which applied higher shear than the Kenics mixer.
C6506(C) The droplet size distribution of a liquid produced by passing the liquid mixture through the apparatus of Examples 2 and Comparative Examples B and C are shown in Figure 5. It can be seen that the method of the invention yields a narrower droplet size distribution than the single mixer or the lower shear mixer followed by the higher shear mixer.
C6506(C) Example 3 An apparatus according to Figure 3 was set up and used as follows.
Silicone oil of viscosity 60,000 centistokes (cst) was placed in the vessel 14.
A substantially homogeneous liquid mixture comprising the following ingredients (all parts are by weight) was manufactured spear and placed in vessel 15.
Hectorite Clay (Laponite XLS Solution) 1.00 Glycerine (Precerine 9083) 12.0 Potassium Hydroxide Solution (48% by wt.)3.90 Oleic Acid (Priolene 6907) 3.20 Myristic Acid (Prifrac 2940) 6.40 Lauric Acid (Prifrac 2920) 6.40 EDTA Solution 0.1 Cocoamidopropylbetaine (Dehyton k) (30% 5.0 Solutions) Butyl Hydroxy Toluene 0.05 Perfume 1.80 Styrene/Acrylate Copolymer (Lytron 621 0.40 B) Formaldehyde Formalin 0.04 NaCI (25% Solution) up to 2.00 Chlorinated Demineralized Water 30.15 The apparatus was run so that pump 17 delivered five parts by weight of silicone oil while pump 16 delivered 95 parts by weight of the above mentioned liquid mixture.
The static mixture comprised a three element Sulzer SMX static mixer.
The apparatus was run with liquid mixture being recirculated to the vessel.
The re-circulation rate was set at 100 kg/hr.
C6506(C) The apparatus was run until all the silicone oil had been dosed in.
Thereafter, a clock was set to zero and the run continued. The droplet size distribution for the dispersion of first liquid and second liquid was assessed at different times after the clock was started.
The number of re-circulations to which each measurement corresponds is not exact, as it cannot be guaranteed that every part of the material in the vessel 15 is re-circulated each time. However, an approximation was reached by multiplying the re-circulation time in minutes by 0.04. Since the mass of liquid in the vessel is 40 kg. and the re-circulation rate is 100 kg./hr.) the mean re-circulation time per unit mass is approximately 24 minutes.
TimeIMinutes Number of Re-Circulations 7 just commenced 25 1.
The results are shown in Figure 6.
It can be seen from Figure 6 that repeated circulations using the apparatus of Figure 3 result in progressive narrowing of the particle size distribution without substantially altering the average droplet size.
Claims (9)
1. A process for dispersing a first liquid in a second liquid with which said first liquid is substantially immiscible, wherein said process comprises (1) subjecting the first and the second liquid to a first mixing step to produce a first dispersion of the first liquid in the second liquid; and (2) subjecting the first dispersion, without addition of substantial quantities of further components, to a second mixing step to produce a second dispersion of the first liquid in the second liquid, wherein the first dispersion is subjected to same or lower shear in the second step than the first dispersion experiences in the first step.
2. A method of treating a dispersion of a first liquid in a second liquid with which it is substantially immiscible to reduce the quantity of droplets of size outside a given range from the average size, comprising subjecting the dispersion to a mixing step of same or lower shear than the mixing step in which the dispersion was produced.
3. A process according to claim 1, wherein said process is used for mixing liquid surfactant composition with a substantially immiscible benefit agent.
4. A process according to claims 1 and 3, wherein the first mixing step is carried out in a high shear mixer selected from the group comprising of turbine-type mixers, mixers having stirring elements, extruder mixers, cavity transfer mixers, colloid mills, ball mills or static mixers.
5. A process according to claim 4, wherein the first step is carried out in a static mixer.
6. A process according to claims 1 and 3-5, wherein a relaxation step is provided between the first and second mixing steps.
7. A process according to claim 1 and 3-5, wherein the second step is carried out in a different mixer design than that utilized in the first mixing step.
8. A process of dispersing a first liquid in a second liquid with which it is substantially immiscible, comprising the steps of placing at least one of the first or second liquids in a storage vessel, feeding the liquids to a mixer to provide a first dispersion of the first liquid in the second liquid, the first dispersion being fed from the storage vessel back to the mixer, without addition of substantial quantities of further components to the vessel.
9. A process for dispersing a first liquid as claimed in claim 1 and substantially as described herein.
Applications Claiming Priority (2)
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US2763698A | 1998-02-23 | 1998-02-23 | |
US09/027636 | 1998-02-23 |
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CA2261978A1 true CA2261978A1 (en) | 1999-08-23 |
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CA002261978A Abandoned CA2261978A1 (en) | 1998-02-23 | 1999-02-16 | Mixing immiscible liquids |
Country Status (6)
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EP (1) | EP0937495A3 (en) |
AU (1) | AU1844199A (en) |
BR (1) | BR9900790A (en) |
CA (1) | CA2261978A1 (en) |
ID (1) | ID23622A (en) |
ZA (1) | ZA991299B (en) |
Cited By (1)
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CN112742188A (en) * | 2020-12-11 | 2021-05-04 | 马鞍山市国林建材有限公司 | Preparation method of efficient dry cement desulfurizer for producing Z-shaped concrete hollow blocks |
Families Citing this family (7)
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US6395690B1 (en) * | 2001-02-28 | 2002-05-28 | Unilever Home & Personal Care Usa Division Of Conopco, Inc. | Process for making mild moisturizing liquids containing large oil droplet |
MX2017006148A (en) | 2014-11-10 | 2017-07-27 | Procter & Gamble | Personal care compositions with two benefit phases. |
WO2016077327A1 (en) | 2014-11-10 | 2016-05-19 | The Procter & Gamble Company | Personal care compositions with two benefit phases |
US10966916B2 (en) | 2014-11-10 | 2021-04-06 | The Procter And Gamble Company | Personal care compositions |
WO2019079405A1 (en) | 2017-10-20 | 2019-04-25 | The Procter & Gamble Company | Aerosol foam skin cleanser |
WO2019079409A1 (en) | 2017-10-20 | 2019-04-25 | The Procter & Gamble Company | Aerosol foam skin cleanser |
CN112844180A (en) * | 2020-12-29 | 2021-05-28 | 煤炭科学技术研究院有限公司 | External forced dispersing device for improving dispersing and mixing capacity of stirring kettle |
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US5164429A (en) * | 1987-08-25 | 1992-11-17 | Stranco, Inc. | Polymer activation apparatus |
US5499871A (en) * | 1989-04-21 | 1996-03-19 | Tecno-Bio Co., Ltd. | Device for producing liquid emulsion of hydrophobic and hydrophilic liquid |
US5250576A (en) * | 1991-08-12 | 1993-10-05 | The Procter & Gamble Company | Process for preparing emulsions that are polymerizable to absorbent foam materials |
DE4311445C1 (en) * | 1993-04-07 | 1994-10-06 | Henkel Kgaa | Multiple W / O / W emulsions, process for their preparation and their use |
GB9414574D0 (en) * | 1994-07-19 | 1994-09-07 | Unilever Plc | Detergent composition |
GB9414575D0 (en) * | 1994-07-19 | 1994-09-07 | Unilever Plc | Detergent composition |
JP3439860B2 (en) * | 1995-01-24 | 2003-08-25 | 東レ・ダウコーニング・シリコーン株式会社 | Continuous production method of organopolysiloxane emulsion |
US5741850A (en) * | 1995-08-30 | 1998-04-21 | Dow Corning Toray Silicone Co., Ltd. | Method for the continuous preparation of organopolysiloxane emulsions |
DE19649101A1 (en) * | 1996-09-04 | 1998-03-05 | Henkel Kgaa | Water-in-oil-in-water emulsion production, for cosmetics, pesticides etc. |
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1999
- 1999-02-11 EP EP99301011A patent/EP0937495A3/en not_active Withdrawn
- 1999-02-16 CA CA002261978A patent/CA2261978A1/en not_active Abandoned
- 1999-02-18 ZA ZA9901299A patent/ZA991299B/en unknown
- 1999-02-22 ID IDP990132D patent/ID23622A/en unknown
- 1999-02-23 BR BR9900790-8A patent/BR9900790A/en not_active Application Discontinuation
- 1999-02-26 AU AU18441/99A patent/AU1844199A/en not_active Abandoned
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CN112742188A (en) * | 2020-12-11 | 2021-05-04 | 马鞍山市国林建材有限公司 | Preparation method of efficient dry cement desulfurizer for producing Z-shaped concrete hollow blocks |
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AU1844199A (en) | 1999-09-09 |
EP0937495A3 (en) | 2002-07-10 |
BR9900790A (en) | 2000-01-18 |
EP0937495A2 (en) | 1999-08-25 |
ID23622A (en) | 2000-05-04 |
ZA991299B (en) | 2000-08-18 |
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