CA2259008A1 - Antagonistes des recepteurs d'il-8 - Google Patents

Antagonistes des recepteurs d'il-8 Download PDF

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Publication number
CA2259008A1
CA2259008A1 CA 2259008 CA2259008A CA2259008A1 CA 2259008 A1 CA2259008 A1 CA 2259008A1 CA 2259008 CA2259008 CA 2259008 CA 2259008 A CA2259008 A CA 2259008A CA 2259008 A1 CA2259008 A1 CA 2259008A1
Authority
CA
Canada
Prior art keywords
alkyl
4alkyl
optionally substituted
heterocyclic
alkenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA 2259008
Other languages
English (en)
Inventor
Katherine L. Widdowson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CA 2259008 priority Critical patent/CA2259008A1/fr
Publication of CA2259008A1 publication Critical patent/CA2259008A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
    • C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/42—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Cette invention se rapporte à l'utilisation des urées phényliques répondant à la formule (I) dans le traitement d'états pathologiques dont le médiateur est la chimiokine, appelée interleukine-8 (IL-8). L'invention définit les variables de (I).
CA 2259008 1996-06-27 1997-06-24 Antagonistes des recepteurs d'il-8 Abandoned CA2259008A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA 2259008 CA2259008A1 (fr) 1996-06-27 1997-06-24 Antagonistes des recepteurs d'il-8

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2065596P 1996-06-27 1996-06-27
US60/020,655 1996-06-27
CA 2259008 CA2259008A1 (fr) 1996-06-27 1997-06-24 Antagonistes des recepteurs d'il-8

Publications (1)

Publication Number Publication Date
CA2259008A1 true CA2259008A1 (fr) 1997-12-31

Family

ID=25680735

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2259008 Abandoned CA2259008A1 (fr) 1996-06-27 1997-06-24 Antagonistes des recepteurs d'il-8

Country Status (1)

Country Link
CA (1) CA2259008A1 (fr)

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Dead