CA2258074A1 - Derives d'esters d'acide benzoylpropionique - Google Patents

Derives d'esters d'acide benzoylpropionique Download PDF

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Publication number
CA2258074A1
CA2258074A1 CA002258074A CA2258074A CA2258074A1 CA 2258074 A1 CA2258074 A1 CA 2258074A1 CA 002258074 A CA002258074 A CA 002258074A CA 2258074 A CA2258074 A CA 2258074A CA 2258074 A1 CA2258074 A1 CA 2258074A1
Authority
CA
Canada
Prior art keywords
compound
formula
amino
oxo
dichlorophenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002258074A
Other languages
English (en)
Inventor
Massimo Cini
Antonio Giordani
Alberto Bianchetti
Carmela Speciale
Mario Varasi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2258074A1 publication Critical patent/CA2258074A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Cette invention se rapporte à des dérivés d'esters d'acide benzoylpropionique représentés par la formule (I), où R représente alkyle C¿1?-C¿4? ou benzyle, et aux sels de ces dérivés acceptables sur le plan pharmaceutique, qui agissent comme inhibiteurs de l'enzyme kynurénine-3-hydroxylase et sont utiles dans le traitement des maladies neuro-dégénératives. Cette invention présente également un procédé pour préparer des composés représentés par la formule (I) et des compositions pharmaceutiques comprenant ces composés.
CA002258074A 1996-07-23 1997-07-03 Derives d'esters d'acide benzoylpropionique Abandoned CA2258074A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9615441.4A GB9615441D0 (en) 1996-07-23 1996-07-23 Benzoylpropionic acid ester derivatives
GB9615441.4 1996-07-23

Publications (1)

Publication Number Publication Date
CA2258074A1 true CA2258074A1 (fr) 1998-01-29

Family

ID=10797362

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002258074A Abandoned CA2258074A1 (fr) 1996-07-23 1997-07-03 Derives d'esters d'acide benzoylpropionique

Country Status (8)

Country Link
EP (1) EP0915830A1 (fr)
JP (1) JP2000515143A (fr)
AR (1) AR007946A1 (fr)
AU (1) AU4009697A (fr)
CA (1) CA2258074A1 (fr)
GB (1) GB9615441D0 (fr)
WO (1) WO1998003469A1 (fr)
ZA (1) ZA976429B (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2950053B1 (fr) * 2009-09-11 2014-08-01 Fournier Lab Sa Utilisation de derives d'indole benzoique comme activateurs de nurr-1, pour le traitement de la maladie de parkinson

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1265101B1 (it) * 1993-07-23 1996-10-30 Erba Carlo Spa Derivati dell'acido 2-ammino-4-fenil-4-osso butirrico

Also Published As

Publication number Publication date
EP0915830A1 (fr) 1999-05-19
ZA976429B (en) 1998-02-18
AR007946A1 (es) 1999-11-24
GB9615441D0 (en) 1996-09-04
WO1998003469A1 (fr) 1998-01-29
JP2000515143A (ja) 2000-11-14
AU4009697A (en) 1998-02-10

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Legal Events

Date Code Title Description
FZDE Dead