CA2258066A1 - Isolation and purification of paclitaxel, and other related taxanes by industrial preparative low pressure chromatography on a polymeric resin column - Google Patents
Isolation and purification of paclitaxel, and other related taxanes by industrial preparative low pressure chromatography on a polymeric resin column Download PDFInfo
- Publication number
- CA2258066A1 CA2258066A1 CA 2258066 CA2258066A CA2258066A1 CA 2258066 A1 CA2258066 A1 CA 2258066A1 CA 2258066 CA2258066 CA 2258066 CA 2258066 A CA2258066 A CA 2258066A CA 2258066 A1 CA2258066 A1 CA 2258066A1
- Authority
- CA
- Canada
- Prior art keywords
- low pressure
- polymeric resin
- purification
- paclitaxel
- isolation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229940123237 Taxane Drugs 0.000 title abstract 2
- 239000002952 polymeric resin Substances 0.000 title abstract 2
- 238000000746 purification Methods 0.000 title abstract 2
- 229920003002 synthetic resin Polymers 0.000 title abstract 2
- 229930012538 Paclitaxel Natural products 0.000 title 1
- 238000004587 chromatography analysis Methods 0.000 title 1
- 238000002955 isolation Methods 0.000 title 1
- 229960001592 paclitaxel Drugs 0.000 title 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- 239000012528 membrane Substances 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
Abstract
A high yield and high purity method for obtaining taxane analogues from a source containing taxanes. The method employs a polymeric resin membrane for separating the analogues under low pressure without the use of complex and expensive separation/purification steps currently provided in the art.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA 2258066 CA2258066C (en) | 1999-01-07 | 1999-01-07 | Isolation and purification of paclitaxel, and other related taxanes by industrial preparative low pressure chromatography on a polymeric resin column |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA 2258066 CA2258066C (en) | 1999-01-07 | 1999-01-07 | Isolation and purification of paclitaxel, and other related taxanes by industrial preparative low pressure chromatography on a polymeric resin column |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2258066A1 true CA2258066A1 (en) | 2000-07-07 |
| CA2258066C CA2258066C (en) | 2009-06-16 |
Family
ID=29554916
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA 2258066 Expired - Fee Related CA2258066C (en) | 1999-01-07 | 1999-01-07 | Isolation and purification of paclitaxel, and other related taxanes by industrial preparative low pressure chromatography on a polymeric resin column |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2258066C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6878832B2 (en) | 2000-11-13 | 2005-04-12 | Lahu Saiji | Isolation of taxanes |
-
1999
- 1999-01-07 CA CA 2258066 patent/CA2258066C/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6878832B2 (en) | 2000-11-13 | 2005-04-12 | Lahu Saiji | Isolation of taxanes |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2258066C (en) | 2009-06-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |