CA2257461C - Hearing aid with improved percentile estimator - Google Patents

Hearing aid with improved percentile estimator Download PDF

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Publication number
CA2257461C
CA2257461C CA002257461A CA2257461A CA2257461C CA 2257461 C CA2257461 C CA 2257461C CA 002257461 A CA002257461 A CA 002257461A CA 2257461 A CA2257461 A CA 2257461A CA 2257461 C CA2257461 C CA 2257461C
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Prior art keywords
control
integrator
signal
stage
output
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CA002257461A
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French (fr)
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CA2257461A1 (en
Inventor
Lars Baekgaard
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Topholm and Westermann ApS
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Topholm and Westermann ApS
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Priority to DK96943123T priority Critical patent/DK0945044T3/en
Priority to CA002257461A priority patent/CA2257461C/en
Priority to AU11953/97A priority patent/AU725726B2/en
Priority to AT96943123T priority patent/ATE193797T1/en
Priority to JP09528774A priority patent/JP3131226B2/en
Priority to DE69608822T priority patent/DE69608822T2/en
Priority to PCT/EP1996/005623 priority patent/WO1998027787A1/en
Priority to US09/194,639 priority patent/US6748092B1/en
Application filed by Topholm and Westermann ApS filed Critical Topholm and Westermann ApS
Priority to EP96943123A priority patent/EP0945044B1/en
Publication of CA2257461A1 publication Critical patent/CA2257461A1/en
Application granted granted Critical
Publication of CA2257461C publication Critical patent/CA2257461C/en
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    • HELECTRICITY
    • H04ELECTRIC COMMUNICATION TECHNIQUE
    • H04RLOUDSPEAKERS, MICROPHONES, GRAMOPHONE PICK-UPS OR LIKE ACOUSTIC ELECTROMECHANICAL TRANSDUCERS; DEAF-AID SETS; PUBLIC ADDRESS SYSTEMS
    • H04R25/00Deaf-aid sets, i.e. electro-acoustic or electro-mechanical hearing aids; Electric tinnitus maskers providing an auditory perception
    • H04R25/50Customised settings for obtaining desired overall acoustical characteristics
    • H04R25/505Customised settings for obtaining desired overall acoustical characteristics using digital signal processing
    • HELECTRICITY
    • H04ELECTRIC COMMUNICATION TECHNIQUE
    • H04RLOUDSPEAKERS, MICROPHONES, GRAMOPHONE PICK-UPS OR LIKE ACOUSTIC ELECTROMECHANICAL TRANSDUCERS; DEAF-AID SETS; PUBLIC ADDRESS SYSTEMS
    • H04R25/00Deaf-aid sets, i.e. electro-acoustic or electro-mechanical hearing aids; Electric tinnitus maskers providing an auditory perception
    • H04R25/50Customised settings for obtaining desired overall acoustical characteristics
    • H04R25/502Customised settings for obtaining desired overall acoustical characteristics using analog signal processing

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Otolaryngology (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Acoustics & Sound (AREA)
  • Signal Processing (AREA)
  • Tone Control, Compression And Expansion, Limiting Amplitude (AREA)
  • Measurement Of Mechanical Vibrations Or Ultrasonic Waves (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Electroluminescent Light Sources (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)

Abstract

The invention relates to a hearing aid, preferably a programmable hearing aid, having at least one microphone (1), at least one signal processor with at least one channel, an output amplifier (9) and an output transducer (10), at least one of the channels containing a signal processing circuit (4) with at least one percentile estimator (6) for the continuous determination or calculation of at least one percentile value of the input signal from a continuous analysis and evaluation of the frequency and/or amplitude distribution of the input signal, whereby the percentile value(s) serve either directly or indirectly as control signals for controlling the gain and/or the frequency response of the electronic processing circuit, the percentile estimator (6) consisting essentially of a comparator stage (12) with two inputs and two outputs, the first input being directly or indirectly connected to the input of the hearing aid, its two outputs controlling a first control stage (13) the output signals of which control a first integrator (14), the output of which, directly or indirectly, conveys a control signal to the signal processing circuit (5) and the second input of the comparator stage.
The invention comprises at least a second control stage (16) connected to the first control stage (13), and at least one additional integrator (17) controlled by the second control stage (16), the output of which is connected to a further input of the second control stage (16) and to a multiplier stage (15) interconnected between the first control stage (13) and the first integrator (14).

Description

HEARING AID WITH IMPROVED PERCENTILE ESTIMATOR
The invention relates to a hearing aid, preferably to a programmable hearing aid.
Percentile estimators which may also be used in hearing aids, are known in principle from US-A 4.204.260.
Clinical tests have shown, that the use of correctly fitted hearing aids, i.e.
hearing aids with constant gain, independent of signal-levels, in noisy as well as quiet surroundings are superior to hearing aids with an automatic gain control, with respect to speech comprehension. However, while linear hearing aids require the user to adjust the volume control dependent on the actual listening environment, hearing aids with automatic gain control adapt themselves to the environment and thereby clearly improve the ease-of-use.
Based on the clinical tests mentioned above, the percentile estimators have to work very slowly to achieve an almost constant gain for speech signals.
This works very well if one stays in an environment where the level of sound does not vary too much, but the long response times of the system will in some cases not adapt fast enough to changes in environment, resulting in phrases not being heard.
A common problem is the situation where the user of the hearing aid is yelling a message to a distant person. This will increase the percentile estimate and hence reduce the gain in the hearing aid. Since the percentile estimator works slowly, the gain stays reduced for a while, and the hearing aid user will not be able to hear the distant person answering, because the resulting output of the hearing aid will be very low, perhaps even below the user's hearing threshold level.
On the other hand one could let the percentile estimators work fast, which obviously will make the system adapt faster to changes in environment, but the gain can then not be considered constant for the speech signals. The fast gain adjustment of the system will cause "pumping" -effects, which can be very annoying for the user, especially in noisy surroundings, and may result in loss of speech comprehension.

In an automatic gain control system for hearing aids, percentile estimators operating on the present signal in one or more channels may be used for controlling the gain of the electronic signal processors. Such a system is f.i.
disclosed in WO 95/15668 of applicant.
According to an aspect of the present invention there is provided a programmable hearing aid having at least one microphone, at least one signal processor with at least one channel, an output amplifier and an output transducer, at least one of the channels containing a signal processing circuit with at least one percentile estimator for the continuous determination or calculation of at least one percentile value of the input signal from a continuous analysis and evaluation of the frequency and/or amplitude distribution of the input signal, whereby the percentile values) serve either directly or indirectly as control signals for controlling the gain and/or the frequency response of the electronic processing circuit, the percentile estimator consisting essentially of a comparator stage with two inputs and two outputs, the first input being directly or indirectly connected to the input of the hearing aid, its two outputs controlling a first control stage the output signals of which control a first integrator, the output of which, directly or indirectly, conveys a control signal to the signal processing circuit and the second input of the comparator stage.
It is an object of the present invention to create an improved percentile estimator, particularly for use in hearing aids of the kind referred to above, which makes it possible for the hearing aid to adapt quickly to changes in the environment, while maintaining a slow response when operating on continuous signals, e.g. speech signals in a steady environment.
This is achieved in a hearing aid in accordance with the present invention with a percentile estimator structure having at least a second control stage connected to the first control stage, and at least one additional integrator controlled by the second control stage, the output of which is connected to a further input of the second control stage as well as to a multiplier stage, interconnected between the first control stage and the first integrator.
It is of particular importance that the second control stage supplies a rectified and scaled version of the predefined parameters of the first control stage, generating a positive control signal for the second integrator and a forward reset signal to said second integrator for establishing a predefined minimum value of said integrator whenever the output signal of the first control stage changes.
Furthermore, in accordance with a second aspect of the present invention there is provided a hearing aid having at least one microphone for providing an input signal, at least one signal processing channel receiving and processing at least a portion of said input signal to produce at least one output signal, an output amplifier for amplifying said at least one output signal, and an output transducer responsive to the amplified output signal, said at least one channel including a signal processing circuit for processing said input signal portion in accordance with an output signal from a percentile estimator, said percentile estimator including a comparator stage for comparing said input signal portion to an integrated value, a first control stage responsive to an output signal from said comparator stage for providing an integrator control signal in accordance with said comparison, and a first integrator responsive to said integrator control signal, providing said integrated value representing a value and a direction of integration to said comparator stage, and, as said output signal to said signal processing circuit, wherein a multiplier stage is interconnected between the output of said first control stage and the input of said first integrator for modifying said value of the integrator control signal of said first control stage, and a second control stage is provided responsive to the integrator control signal of said first control stage for controlling a second integrator for providing a modification signal to the multiplier stage.
The present invention will be further described with reference to the drawings in which:
Figure 1 shows a schematic circuit diagram of a multichannel hearing aid using percentile estimators;
Figure 2 shows a schematic diagram of the principle of a percentile estimator;
Figure 3 shows, schematically, an improved percentile estimator for hearing aids with two levels in accordance with the present invention;
Figure 4 shows, schematically, an improved percentile estimator for hearing aids with three levels in accordance with the invention; and Figure 5 shows a diagram of the operation of a traditional percentile estimator in comparison with the operation of the improved percentile estimator on an actual sound example.
Figure 1 shows a principle circuit diagram of a multi-channel hearing aid with one microphone 1 and preamplifier 2, a band split filter 3 for splitting the signals into a number of channels (here 3 are shown), each having a signal processing circuit 4 consisting of a signal processor 5 and a percentile estimator 6, a register 7 for storing parameters related to the basic hearing aid performance, a summing circuit 8, an output amplifier 9 and a receiver 10.
Figure 2 shows the principle of a traditional percentile estimator 6. Such percentile estimators are known from US-A 4.204.260.
The input signal for the specific channel is led into a detector stage 11, which is not essential for the operation of the percentile estimator, but is preferably used. It could include a rectification for determining the envelope of the input signal, and also a logarithmic conversion to obtain the envelope on a dB-scale, which is commonly used in hearing aids. The output signal from the detector 11 is supplied to a comparator 12 with its two inputs connected to the output from the detector 11 and an integrator 14.
The result of the comparison is supplied to the control stage 13, which in case of the output of the integrator 14 being greater than the output of the detector 11 holds a predefined negative value at its output, causing a decrease of the value stored in the integrator 14, and in the opposite case holds a predefined positive value at its output, causing an increase of the integrator value.
In this way the value present at the output of the integrator 14 will be percentile estimate of the input signal of the detector 11 and the signal processor 5, the percentile value being dependent on the actual predefined values of the control stage 13.
The output of the percentile estimator 6 is used for controlling the signal processor 5. Clearly, it is possible to include more than one percentile estimator 6 in each channel and let the signal processor be controlled by all of these in combination. In that case, a combination and control logic may be used to combine the output signals of the different percentile estimators.
Figure 3 shows the principle of an improved percentile estimator in accordance with the invention.
The traditional percentile estimator is modified with a multiplier 15, with its output supplying the integrator 14 and its inputs connected to the output of the control stage 13 and the output of an integrator 17. The integrator 17 is controlled by a control stage 16 which includes a rectifier 21 and a gain block 22# for rectifying and scaling the predefined parameters of the control stage 13 and thereby modifying the timing of the increase and decrease of the integrator 14 and thus the response time of the percentile estimator.
The control stage includes a zero-cross detector 23 which provides a reset pulse for the integrator, which then resets to a predefined minimum value whenever the output from the control stage 13 changes, hence whenever the input sound crosses the percentile estimator level.
The control stage 16 further may include a comparator 24 for checking if the output of the integrator 17 is less than a predefined maximum allowable value 25, in which case the transmission control 26 passes the output of the gain block 22 on to the integrator 17, and in the opposite case passes a value of zero or less on to the integrator 17 in order to prevent further increase of the integrator output.
The effect is an "accelerating" percentile estimator. The short term percentile estimator response time is long, dependent on the minimum value of the integrator 17 and will be dominant when the environment is characterized by a relatively constant sound level, where the input sound level crosses the percentile estimate frequently. The long term response time is relatively short because of the acceleration, and this effect will be of use in cases where the sound level changes, e.g. when communicating with a distant person, as mentioned earlier.
Figure 4 shows an expansion of the improved percentile estimator by another level by adding a multiplier 18 with its output supplying the integrator 17 and its inputs connected to the output of the control stage 16 and the output of an integrator 20, which again is controlled by a control stage 19 similar to control stage 16.
Clearly it is possible to expand the number of levels in the improved percentile estimator even more than the three levels shown.
For the traditional percentile estimator of Figure 2 a percentile level of p percent is obtained by the following formula:
p = 100 u/( u-d) where a is the upward integration value (positive) d is the downward integration value (negative) Both a and d in the formula above are defined by the predefined values of the control stage 13.
In the improved percentile estimator, the integration # speeds are time dependent. The upward integration speed is determined by t t a a uresult a ~ k16 ~ lul. k~9 . ~ul dt......dt and the downward integration speed is td td dresult d~ klb ~ ~d~' klg ' ~d' dt......dt where k,s and k,9 are the scaling factors in the control stages 16 and 19.
In a "stationary" sound environment, i.e. when the percentile estimate is stable, we have lu ~ ~ to = Id ~ ~ td = constant where t~ and td are the collective time intervals over this stable time period in which the integrator integrates upwards and downwards, respectively.
This simplifies the integrations in the formulas above, and yields the following expressions for the integration speeds of the improved percentile estimator:
uresult - a ~ k~b. ~u/ ~k~9 ~~u~ .tu......tu - a ~ k~b ~ k~9 . . . . . , constant , dresult - d kt6~~d~~kt9~~d~.td ......td - d ~ k~b. k~9 ....., constant Hence, for stationary environments, even though the integration speeds are time dependent, the percentile level can be obtained by the same formula as for the traditional percentile estimator, since a constant multiplied to the integration speeds a and d does not change this formula.
Figure 5 shows the function of a 2-level improved 90% percentile estimator with an increase from a minimum odB/sec growing 207.36 dB/sec2 to a maximum of 57.6 dB/sec and a decrease from a minimum odB/sec growing 2,56 dB/sec2 to a maximum of 6.4 dB/sec.
This is achieved by using a digital implementation with:
a 32 kHz sampling frequency an upward integration step of a = 5e - 4 in the control stage 13 a downward integration step of d = - 5e - 5 in the control stage 13 a scaling factor of k,s = 1 in the control stage 16 a predefined minimum value of 0 of the integrator 17 a predefined maximum allowable value of 4 of the integrator 17 The function is compared with a traditional 90% percentile estimatorwith an increase of 14.4 dB/sec and a decrease of 1.6 dB/sec.
The comparison is performed on an actual sound example with a duration of 32 secs. The sound level is stepped down 20 dB after approximately 7 secs to simulate a change of sound environment.
Note that the improved percentile estimator, because of the increasing integration speed, adapts much faster to change in an environment than the traditional one, with respect to sound level increases (see the first 2 seconds) as well as sound level decreases (see the signal behaviour around 7 seconds).
Still, the improved percentile estimator behaves similar to the traditional one in the time range where the percentile estimation in both cases has become "stationary", i.e. from approximately 20 secs to 32 secs. This is due to the signal crossing the output of the improved percentile estimator, which generates a frequent reset of the integrator speed, and hereby keeps the response time of the percentile estimator long for this signal.
Finally, it may be pointed out that all the parameters of control stages 13 and the scaling factors of control stages 16 and 19 may be preset, may be programmable or may even be program controlled.
The steady progress in the design of very highly integrated circuits may lead to an extremely compact design of hearing aids, incorporating not only the improved percentile estimators for one or several channels but also the micro-processor and storage means for the necessary operational tools, such as algorithms.
Furthermore it is to be understood that the register 7 in Figure 1 should comprise all necessary control parameters for the control of the transfer characteristic of the hearing aid, possibly also for various different programmed or programmable environmental listening situations.
_g_

Claims (13)

THE EMBODIMENTS OF THE INVENTION IN WHICH AN EXCLUSIVE
PROPERTY OR PRIVILEGE IS CLAIMED ARE DEFINED AS FOLLOWS:
1. In a hearing aid having at least one microphone for providing an input signal, at least one signal processing channel receiving and processing at least a portion of said input signal to produce at least one output signal, an output amplifier for amplifying said at least one output signal, and an output transducer responsive to the amplified output signal, said at least one channel including a signal processing circuit for processing said input signal portion in accordance with an output signal from a percentile estimator, said percentile estimator including a comparator stage for comparing said input signal portion to an integrated value, a first control stage responsive to an output signal from said comparator stage for providing an integrator control signal in accordance with said comparison, and a first integrator responsive to said integrator control signal, providing said integrated value representing a value and a direction of integration to said comparator stage, and, as said output signal to said signal processing circuit, wherein a multiplier stage is interconnected between the output of said first control stage and the input of said first integrator for modifying said value of the integrator control signal of said first control stage, and a second control stage is provided responsive to the integrator control signal of said first control stage for controlling a second integrator for providing a modification signal to the multiplier stage.
2. Hearing aid in accordance with claim 1, wherein the output of the second integrator provides an integrated value signal to a further input of the second control stage.
3. Hearing aid in accordance with claim 1, wherein the second control stage supplies a rectified and scaled version of predefined control parameters of the first control stage, generating a positive control signal for the second integrator and a forward reset signal to said second integrator for establishing a predefined minimum value of said integrator whenever the output signal of the first control stage changes.
4. Hearing aid in accordance with claim 1 or 2, wherein the second control stage contains a zero-cross-detector stage coupled between the input of said second control stage and a second input of the second integrator, providing the reset signal for said second integrator for resetting said second integrator to a predefined minimum value, whenever the output of the first control stage changes, hence whenever the input sound of the hearing aid crosses the percentile estimator value.
5. Hearing aid in accordance with claim 1, wherein the second control stage additionally comprises a rectifier stage, a gain block and a transmission control stage controlling the second integrator, for rectifying and scaling the predetermined control parameters of the first control stage for controlling the second integrator, the output of which is connected with the input of the second control stage by means of a comparator stage for comparing its output with a predefined maximum allowable value to control the passage of the output of the gain block to the second integrator by means of the transmission control stage.
6. Hearing aid in accordance with claim 1, and comprising a third control stage connected to the first control stage for controlling a third integrator, and a second multiplier connected between the second control stage and the second integrator and also with the output of the third integrator, the output of which is further connected to the third control stage for rectifying and scaling the predetermined control parameters of the first control stage, generating a positive control signal for the third integrator and a forward reset signal to said integrator for establishing a predefined minimum value of the integrator whenever the sign of the output signal of the first control stage changes.
7. Hearing aid in accordance with claim 1, wherein the values of the predefined parameters and the predefined scaling factors of the control stages for the control of the integrators may be preset, programmed or program controlled.
8. Hearing aid in accordance with claim 1, wherein the values of the predefined parameters or the predefined scaling factors of the control stages forthe control of the integrators may be preset, programmed or program controlled.
9. Hearing aid in accordance with claim 1 wherein the values of the output signals of the control stages are equal for the positive or negative changes to be effected in the integrators.
10. Hearing aid in accordance with claim 1 wherein the values of the output signals of the control stages are not equal for the positive or negative changes to be effected in the integrators.
11. Hearing aid in accordance with claim 1, wherein for the purpose of the continuous determination of a signal sequence from the input signal, a detector stage is connected between the input of the hearing aid and the input of the percentile estimator for mathematical processing of the input signal by way of predefined or predefinable algorithms or calculating rules.
12. Hearing aid in accordance with claim 1, wherein for the purpose of the continuous determination of the envelope of the input signal, a rectifier is connected between the input of the hearing aid and the input of the percentile estimator as a detector stage.
13. Hearing aid in accordance with claim 1 with at least two channels, wherein at least two percentile estimators are connected in parallel in at least two parallel channels covering essentially adjacent frequency bands and in which the outputs of the integrators of these percentile estimators of the respective channels are connected with the inputs of a combination and control logic, said combination and control logic being connected in turn to the signal processor of the respective channel via at least one control line.
CA002257461A 1996-12-14 1996-12-14 Hearing aid with improved percentile estimator Expired - Fee Related CA2257461C (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
AU11953/97A AU725726B2 (en) 1996-12-14 1996-12-14 Hearing aid with improved percentile estimator
AT96943123T ATE193797T1 (en) 1996-12-14 1996-12-14 HEARING AID WITH IMPROVED PERCENTILE GENERATOR
JP09528774A JP3131226B2 (en) 1996-12-14 1996-12-14 Hearing aid with improved percentile predictor
DE69608822T DE69608822T2 (en) 1996-12-14 1996-12-14 HEARING AID WITH IMPROVED PERCENTAGE GENERATOR
DK96943123T DK0945044T3 (en) 1996-12-14 1996-12-14 Hearing aid with improved percentile estimator
US09/194,639 US6748092B1 (en) 1996-12-14 1996-12-14 Hearing aid with improved percentile estimator
CA002257461A CA2257461C (en) 1996-12-14 1996-12-14 Hearing aid with improved percentile estimator
EP96943123A EP0945044B1 (en) 1996-12-14 1996-12-14 Hearing aid with improved percentile estimator
PCT/EP1996/005623 WO1998027787A1 (en) 1996-12-14 1996-12-14 Hearing aid with improved percentile estimator

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CA002257461A CA2257461C (en) 1996-12-14 1996-12-14 Hearing aid with improved percentile estimator
PCT/EP1996/005623 WO1998027787A1 (en) 1996-12-14 1996-12-14 Hearing aid with improved percentile estimator

Publications (2)

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CA2257461A1 CA2257461A1 (en) 1998-06-25
CA2257461C true CA2257461C (en) 2001-04-17

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CA002257461A Expired - Fee Related CA2257461C (en) 1996-12-14 1996-12-14 Hearing aid with improved percentile estimator

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EP (1) EP0945044B1 (en)
JP (1) JP3131226B2 (en)
AT (1) ATE193797T1 (en)
AU (1) AU725726B2 (en)
CA (1) CA2257461C (en)
DE (1) DE69608822T2 (en)
DK (1) DK0945044T3 (en)
WO (1) WO1998027787A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000047014A1 (en) * 1999-02-05 2000-08-10 The University Of Melbourne Adaptive dynamic range optimisation sound processor
US7366315B2 (en) 1999-02-05 2008-04-29 Hearworks Pty, Limited Adaptive dynamic range optimization sound processor
DK1219138T3 (en) * 1999-10-07 2004-04-13 Widex As Method and signal processor for intensifying speech signal components in a hearing aid
ATE331417T1 (en) 2000-04-04 2006-07-15 Gn Resound As A HEARING PROSTHESIS WITH AUTOMATIC HEARING ENVIRONMENT CLASSIFICATION
US6862359B2 (en) 2001-12-18 2005-03-01 Gn Resound A/S Hearing prosthesis with automatic classification of the listening environment
DE602006014572D1 (en) * 2005-10-14 2010-07-08 Gn Resound As OPTIMIZATION FOR HEARING EQUIPMENT PARAMETERS
CA2625329C (en) * 2005-10-18 2013-07-23 Widex A/S A hearing aid and a method of operating a hearing aid
KR101419193B1 (en) 2010-12-08 2014-07-14 비덱스 에이/에스 Hearing aid and a method of enhancing speech reproduction

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4204260A (en) * 1977-06-14 1980-05-20 Unisearch Limited Recursive percentile estimator
US4823795A (en) * 1987-03-13 1989-04-25 Minnesota Mining And Manufacturing Company Signal processor for and an auditory prosthesis having spectral to temporal transformation
US5027410A (en) * 1988-11-10 1991-06-25 Wisconsin Alumni Research Foundation Adaptive, programmable signal processing and filtering for hearing aids
DE4340817A1 (en) * 1993-12-01 1995-06-08 Toepholm & Westermann Circuit arrangement for the automatic control of hearing aids

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Publication number Publication date
EP0945044A1 (en) 1999-09-29
EP0945044B1 (en) 2000-06-07
WO1998027787A1 (en) 1998-06-25
JP2000511367A (en) 2000-08-29
CA2257461A1 (en) 1998-06-25
AU1195397A (en) 1998-07-15
DE69608822T2 (en) 2000-11-30
JP3131226B2 (en) 2001-01-31
DE69608822D1 (en) 2000-07-13
AU725726B2 (en) 2000-10-19
DK0945044T3 (en) 2000-10-16
ATE193797T1 (en) 2000-06-15

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