CA2250736A1 - 2'-protected 3'-dimethylamine, 9-etheroxime erythromycin a derivatives - Google Patents

2'-protected 3'-dimethylamine, 9-etheroxime erythromycin a derivatives

Info

Publication number
CA2250736A1
CA2250736A1 CA002250736A CA2250736A CA2250736A1 CA 2250736 A1 CA2250736 A1 CA 2250736A1 CA 002250736 A CA002250736 A CA 002250736A CA 2250736 A CA2250736 A CA 2250736A CA 2250736 A1 CA2250736 A1 CA 2250736A1
Authority
CA
Canada
Prior art keywords
erythromycin
etheroxime
protected
derivatives
dimethylamine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002250736A
Other languages
French (fr)
Other versions
CA2250736C (en
Inventor
Chengxi Yang
Hemantkumar H. Patel
Yi-Yin Ku
Jih-Hua Liu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Chengxi Yang
Hemantkumar H. Patel
Yi-Yin Ku
Jih-Hua Liu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36123395&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2250736(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US08/627,795 external-priority patent/US5719272A/en
Application filed by Abbott Laboratories, Chengxi Yang, Hemantkumar H. Patel, Yi-Yin Ku, Jih-Hua Liu filed Critical Abbott Laboratories
Publication of CA2250736A1 publication Critical patent/CA2250736A1/en
Application granted granted Critical
Publication of CA2250736C publication Critical patent/CA2250736C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

A process of preparing a 6-O-methyl erythromycin A derivative using a 2'-protected, 9-etheroxime erythromycin A intermediate is provided. A preferred protecting group for the 2'-position is acetyl. 2'-protected, 9-etheroxime erythromycin A derivatives are also provided. Also disclosed is a method for inhibiting quaternary salt formation at the 3' amine without the need for 3'N-protecting groups.
CA002250736A 1996-04-02 1997-02-06 2'-protected 3'-dimethylamine, 9-etheroxime erythromycin a derivatives Expired - Fee Related CA2250736C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/627,795 1996-04-02
US08/627,795 US5719272A (en) 1996-04-02 1996-04-02 2'-protected 3'-dimethylamine, 9-etheroxime erythromycin A derivatives
PCT/US1997/001952 WO1997036912A1 (en) 1996-04-02 1997-02-06 2'-protected 3'-dimethylamine, 9-etheroxime erythromycin a derivatives

Publications (2)

Publication Number Publication Date
CA2250736A1 true CA2250736A1 (en) 1997-10-09
CA2250736C CA2250736C (en) 2006-03-28

Family

ID=36123395

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002250736A Expired - Fee Related CA2250736C (en) 1996-04-02 1997-02-06 2'-protected 3'-dimethylamine, 9-etheroxime erythromycin a derivatives

Country Status (1)

Country Link
CA (1) CA2250736C (en)

Also Published As

Publication number Publication date
CA2250736C (en) 2006-03-28

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