CA2250567A1 - Antagonistes recepteurs et transporteurs - Google Patents
Antagonistes recepteurs et transporteurs Download PDFInfo
- Publication number
- CA2250567A1 CA2250567A1 CA002250567A CA2250567A CA2250567A1 CA 2250567 A1 CA2250567 A1 CA 2250567A1 CA 002250567 A CA002250567 A CA 002250567A CA 2250567 A CA2250567 A CA 2250567A CA 2250567 A1 CA2250567 A1 CA 2250567A1
- Authority
- CA
- Canada
- Prior art keywords
- receptor
- antagonist
- peptide
- leu
- val
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7158—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for chemokines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
- C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La présente invention concerne des antagonistes spécifiques de protéines intrinsèques procaryotes et eucaryotes. Lesdits antagonistes sont des peptides présentant la séquence d'acides aminés d'un domaine membranaire desdites protéines intrinsèques ou d'une portion ou d'un analogue de ces dernières. On décrit également des procédés permettant de prévenir ou de traiter des troubles caractérisés par des troubles fonctionnels d'une protéine intrinsèque en administrant un peptide antagoniste spécifique de la protéine intrinsèque.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1430696P | 1996-03-27 | 1996-03-27 | |
US60/014,306 | 1996-03-27 | ||
US67011996A | 1996-06-25 | 1996-06-25 | |
US08/670,119 | 1996-06-25 | ||
US2424096P | 1996-08-20 | 1996-08-20 | |
US60/024,240 | 1996-08-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2250567A1 true CA2250567A1 (fr) | 1997-10-02 |
Family
ID=27360064
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002250567A Abandoned CA2250567A1 (fr) | 1996-03-27 | 1997-03-26 | Antagonistes recepteurs et transporteurs |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0906339A2 (fr) |
AU (1) | AU2020497A (fr) |
CA (1) | CA2250567A1 (fr) |
WO (1) | WO1997035881A2 (fr) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6743594B1 (en) | 1995-06-06 | 2004-06-01 | Human Genome Sciences, Inc. | Methods of screening using human G-protein chemokine receptor HDGNR10 (CCR5) |
US6025154A (en) | 1995-06-06 | 2000-02-15 | Human Genome Sciences, Inc. | Polynucleotides encoding human G-protein chemokine receptor HDGNR10 |
CA2259132A1 (fr) * | 1996-07-01 | 1998-01-08 | Biosignal Inc. | Peptides et composes peptidomimetiques affectant l'activite des recepteurs couples a la proteine g par modification de l'oligomerisation des recepteurs |
ES2299242T3 (es) * | 1998-02-27 | 2008-05-16 | The Government Of The Usa As Represented By The Secretary Of Department Of Health And Human Services | Antagonistas de los receptores copulados a proteina g. |
US7105488B1 (en) | 1998-02-27 | 2006-09-12 | The United States Of America As Represented By The Department Of Health And Human Services | G protein-coupled receptor antagonists |
WO2001016182A2 (fr) * | 1999-08-27 | 2001-03-08 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Polypeptides de liaison a la glycoproteine gp120 du virus de l'immunodeficience humaine (vih), acides nucleiques, anticorps et compositions associes, et methodes d'utilisation |
US7304127B2 (en) | 1999-08-27 | 2007-12-04 | United States Of America As Represented By The Secretary, Department Of Health And Human Services | Polypeptides that bind HIV gp120 and related nucleic acids, antibodies, compositions, and methods of use |
WO2001036477A2 (fr) * | 1999-11-18 | 2001-05-25 | The Government Of The United States, As Represented By The Secretary Of The Department Of Health And Human Services | Inhibition de transporteurs de cassette de liaison atp (abc) par des analogues de domaine transmembranaire |
EP1217066A1 (fr) * | 2000-12-21 | 2002-06-26 | Universiteit Gent | Modulation de l'activité de transport d'une cassette de liaison d'ATP |
US7175988B2 (en) | 2001-02-09 | 2007-02-13 | Human Genome Sciences, Inc. | Human G-protein Chemokine Receptor (CCR5) HDGNR10 |
US20030109044A1 (en) * | 2001-10-16 | 2003-06-12 | Millennium Pharmaceuticals, Inc. | Methods of using 279, a human G protein-coupled protein receptor |
US7393934B2 (en) | 2001-12-21 | 2008-07-01 | Human Genome Sciences, Inc. | Human G-protein chemokine receptor (CCR5) HDGNR10 |
US7067113B2 (en) | 2002-01-18 | 2006-06-27 | The Procter & Gamble Company | Methods for identifying compounds for regulating muscle mass or function using dopamine receptors |
ES2228268B1 (es) * | 2003-07-30 | 2006-07-01 | Laboratorios Del Dr. Esteve, S.A. | Combinacion de sustancias activas conteniendo al menos un compuesto con afinidad por el receptor del neuropeptido y (npy) y al menos un compuesto con afinidad por el receptor 5-ht6. |
ES2228267B1 (es) * | 2003-07-30 | 2006-07-01 | Laboratorios Del Dr. Esteve, S.A. | Combinacion de sustancias activas conteniendo al menos un compuesto con afinidad por el receptor del neuropeptido y (npy) y al menos un compuesto con afinidad por el receptor 5-ht6. |
CA2559809A1 (fr) | 2004-03-12 | 2005-11-10 | Human Genome Sciences, Inc. | Anticorps diriges contre le polypeptide humain hdgnr10, un recepteur de chimiokine (ccr5) couple a des proteines-g |
JP2009508937A (ja) * | 2005-09-22 | 2009-03-05 | イエダ リサーチ アンド デベロップメント カンパニー リミテッド | T細胞免疫を調節するためのジアステレオマーペプチド |
PL2121919T3 (pl) | 2007-03-22 | 2012-07-31 | Heptares Therapeutics Ltd | Zmutowane receptory związane z białkiem G i sposoby ich wyboru |
GB0724051D0 (en) | 2007-12-08 | 2008-01-16 | Medical Res Council | Mutant proteins and methods for producing them |
GB0724860D0 (en) | 2007-12-20 | 2008-01-30 | Heptares Therapeutics Ltd | Screening |
GB0802474D0 (en) | 2008-02-11 | 2008-03-19 | Heptares Therapeutics Ltd | Mutant proteins and methods for selecting them |
WO2008068534A2 (fr) * | 2008-03-05 | 2008-06-12 | Heptares Therapeutics Limited | Structure cristalline |
GB0910725D0 (en) | 2009-06-22 | 2009-08-05 | Heptares Therapeutics Ltd | Mutant proteins and methods for producing them |
CA2884220A1 (fr) * | 2012-10-08 | 2014-04-17 | F. Hoffmann-La Roche Ag | Peptides penetrant dans les cellules qui se lient a irf5 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU4855393A (en) * | 1992-09-10 | 1994-03-29 | New York University | Polypeptides of g-coupled receptor proteins, and compositions and methods thereof |
US5559209A (en) * | 1993-02-18 | 1996-09-24 | The General Hospital Corporation | Regulator regions of G proteins |
FR2704235B1 (fr) * | 1993-04-21 | 1995-06-23 | Vetigen Sarl | Séquences nucléotidiques codant pour le récepteur beta3-adrénergique (RAbeta3) bovin et leurs applications. |
ES2168456T3 (es) * | 1995-01-16 | 2002-06-16 | North Sydney Area Health Serv | Peptidos que afectan a los linfocitos t. |
-
1997
- 1997-03-26 WO PCT/CA1997/000203 patent/WO1997035881A2/fr not_active Application Discontinuation
- 1997-03-26 AU AU20204/97A patent/AU2020497A/en not_active Abandoned
- 1997-03-26 EP EP97908101A patent/EP0906339A2/fr not_active Withdrawn
- 1997-03-26 CA CA002250567A patent/CA2250567A1/fr not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO1997035881A3 (fr) | 1998-07-16 |
AU2020497A (en) | 1997-10-17 |
EP0906339A2 (fr) | 1999-04-07 |
WO1997035881A2 (fr) | 1997-10-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Dead |