CA2246164C - Procede pour la preparation de derives du ganciclovir - Google Patents

Procede pour la preparation de derives du ganciclovir Download PDF

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Publication number
CA2246164C
CA2246164C CA 2246164 CA2246164A CA2246164C CA 2246164 C CA2246164 C CA 2246164C CA 2246164 CA2246164 CA 2246164 CA 2246164 A CA2246164 A CA 2246164A CA 2246164 C CA2246164 C CA 2246164C
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CA
Canada
Prior art keywords
formula
amino
alkyl
group
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA 2246164
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English (en)
Other versions
CA2246164A1 (fr
Inventor
Humberto B. Arzeno
Eric R. Humphreys
Jim-Wah Wong
Christopher R. Roberts
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Priority to CA002547307A priority Critical patent/CA2547307A1/fr
Priority claimed from PCT/EP1997/000238 external-priority patent/WO1997027197A1/fr
Publication of CA2246164A1 publication Critical patent/CA2246164A1/fr
Application granted granted Critical
Publication of CA2246164C publication Critical patent/CA2246164C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

L'invention concerne un procédé et de nouveaux intermédiaires pour préparer l'ester L-monovaline de 2-(2-amino-1,6-dihydro-6-oxo-purine-9-yl)-méthoxy-1,3-propanediol (ganciclovir) et ses sels pharmaceutiquement acceptables. Le présent procédé et les intermédiaires monoester assurent la mono-estérification par un dérivé de L-valine, ce qui donne un monocarboxylate-monovalinate. Ce dernier produit est ensuite hydrolysé sélectivement dans des conditions basiques ou enzymatiques pour donner l'ester monovaline de ganciclovir en grande quantité et avec une pureté élevée. Ces produits sont très utiles comme agents antiviraux et présentent une absorption améliorée.
CA 2246164 1996-01-26 1997-01-20 Procede pour la preparation de derives du ganciclovir Expired - Lifetime CA2246164C (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA002547307A CA2547307A1 (fr) 1996-01-26 1997-01-20 Procede pour la preparation de derives du ganciclovir

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US59228296A 1996-01-26 1996-01-26
US08/592,282 1996-01-26
PCT/EP1997/000238 WO1997027197A1 (fr) 1996-01-26 1997-01-20 Procede pour la preparation de derives du ganciclovir

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA002547307A Division CA2547307A1 (fr) 1996-01-26 1997-01-20 Procede pour la preparation de derives du ganciclovir

Publications (2)

Publication Number Publication Date
CA2246164A1 CA2246164A1 (fr) 1997-07-31
CA2246164C true CA2246164C (fr) 2006-09-12

Family

ID=29421794

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2246164 Expired - Lifetime CA2246164C (fr) 1996-01-26 1997-01-20 Procede pour la preparation de derives du ganciclovir

Country Status (1)

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CA (1) CA2246164C (fr)

Also Published As

Publication number Publication date
CA2246164A1 (fr) 1997-07-31

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