CA2246014C - Food supplements and methods comprising lipoic acid and creatine - Google Patents
Food supplements and methods comprising lipoic acid and creatine Download PDFInfo
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- CA2246014C CA2246014C CA002246014A CA2246014A CA2246014C CA 2246014 C CA2246014 C CA 2246014C CA 002246014 A CA002246014 A CA 002246014A CA 2246014 A CA2246014 A CA 2246014A CA 2246014 C CA2246014 C CA 2246014C
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- derivative
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- lipoic acid
- creative
- athlete
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/385—Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
- A23L33/12—Fatty acids or derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
Abstract
Food supplement compositions comprise lipoic acid or a derivative thereof and creative or a derivative thereof. The compositions optionally, but preferably, further comprise dextrose. The food supplement compositions are suitable for supplementing the diet of as athlete and particularly for enhancing an athlete's muscle size or strength.
Description
The present invention is directed to food supplements which comprise lipoic acid or derivative thereof and creative or a derivative thereof, and to methods far supplementing the diet of an attdete and methods for enhancing an athlete's muscle size or strength, which methods employ these food supplements.
Creative (atso lmown as N-methyl-N-guavyl glycine or (alpha meth~rl guanido) acetic acid) is an amino acid compound produced naturally in the liver and kidneys and obtained from food such as meat and fish. Food supplements containing creative, typically creative tnonohydrate, are commonly used by athletes to allow them to train harder and enhance muscle size and strengfih. Various commercial products comaining creative monohydrate are available.
Lipoic acid (also known as alpha lipoic acid, thioctic acid or 6,$-difbio octanoic acid) is a nutrient that the human body makes in minute quantities and may 1 S be obtained from yeast and liver, Studies have shown that ligoic acid can significantly increase the body's utilization of blood sugar iv type a diabetics and tbat lipoic acid may increase the metabolic clearance rate of glucose by 50 %
in diabetics. In LGUrope, lipoic acid has been used as a substitute for insulin in the treatment of Type iT diabetes.
Food supplements for enhancing an athlete's muscle size and strength have become popular substitutes for steroids and other drugs in various sports and body building regimes. However, as athletes continually strive for improved performance, there is a canting need for non-steroid containing aids for improving muscle size and strength.
Accordingly, it is an object of the present invention to provide new food supplements, It is a more specific object of the invention to provide food supplements particularly adapted for supplementing the diet of an athlete. Tt is another object to provide food supplements which may enhance an athlete's muscle size or strength. It is a farther object of the invention to provide non-steroid containing food supplements and to provide food supplem,eats which zaay be conveniently administered to the diet of an athlete, These and additional objects are provided by the food supplements and methods according to the present invention. The food supplements comprise lipoic acid or a derivative thereof, for example a salt or ester thereof, and crcatine or a derivative thereof, for example a hydrate, salt ar ester thereof. The food supplements may optionally, and preferably, further comprise dextrose. It has been determined that such food supplement compositions are advantageous for supplementing the diet of an athlete and may provide surprising enhancement of an athlete's muscle size or strength when administered to an athlete's diet.
'these and additional objects and advantages will be more fully apparent in view of the following detailed description.
Creative (atso lmown as N-methyl-N-guavyl glycine or (alpha meth~rl guanido) acetic acid) is an amino acid compound produced naturally in the liver and kidneys and obtained from food such as meat and fish. Food supplements containing creative, typically creative tnonohydrate, are commonly used by athletes to allow them to train harder and enhance muscle size and strengfih. Various commercial products comaining creative monohydrate are available.
Lipoic acid (also known as alpha lipoic acid, thioctic acid or 6,$-difbio octanoic acid) is a nutrient that the human body makes in minute quantities and may 1 S be obtained from yeast and liver, Studies have shown that ligoic acid can significantly increase the body's utilization of blood sugar iv type a diabetics and tbat lipoic acid may increase the metabolic clearance rate of glucose by 50 %
in diabetics. In LGUrope, lipoic acid has been used as a substitute for insulin in the treatment of Type iT diabetes.
Food supplements for enhancing an athlete's muscle size and strength have become popular substitutes for steroids and other drugs in various sports and body building regimes. However, as athletes continually strive for improved performance, there is a canting need for non-steroid containing aids for improving muscle size and strength.
Accordingly, it is an object of the present invention to provide new food supplements, It is a more specific object of the invention to provide food supplements particularly adapted for supplementing the diet of an athlete. Tt is another object to provide food supplements which may enhance an athlete's muscle size or strength. It is a farther object of the invention to provide non-steroid containing food supplements and to provide food supplem,eats which zaay be conveniently administered to the diet of an athlete, These and additional objects are provided by the food supplements and methods according to the present invention. The food supplements comprise lipoic acid or a derivative thereof, for example a salt or ester thereof, and crcatine or a derivative thereof, for example a hydrate, salt ar ester thereof. The food supplements may optionally, and preferably, further comprise dextrose. It has been determined that such food supplement compositions are advantageous for supplementing the diet of an athlete and may provide surprising enhancement of an athlete's muscle size or strength when administered to an athlete's diet.
'these and additional objects and advantages will be more fully apparent in view of the following detailed description.
2 The food supphment compositions of the present invention comprise lipoic acid or a derivative thereof and creative or a derivative thereof. Creative and hydrates thereof, partzculaxiy creative monohydrate, are kvowti to improve and/or enhance muscle size andlor strength. The food supplements anti methods of the present invention may provide further and significant muscle size and strength enhancement or improvement as compared with supplements and methods employing only creative or a hydrate thereof. Although the present invernion is not to be limited by any theoretical explanation, it is believed that insulin is a primacy factor that stimulates glucose and creative transport into the muscle cells and that the lipoic acid both mimics and enhances the actions of insult in glucose and creative transport into the muscle cells. In preferred embodiments, the compositions further include dextrose which has been shown to stimulate insulin action.
The food supplements comprise lipoic acid or a derivative thereof, for example a salt or ester thereof. Suitable salts include, but are not limited to, alkali and alkalise earth meral salts, for example sodium, potassium or calcium salts, while suitable esters include, but are not limited to, alkyl esters, for example, methyl, ethyl or propyl esters, or lactone esters.
The food supplement compositions further comprise creative or a derivative thereof, for example a hydrate, salt or ester thereof. Commercially available creative derivatives include creative monohydrate, other creative hydrates, creative citrate and creative pyruvate. The creatirLe which is employed in the food supplement compositions of the present invention preferably comprises creative monohydrate, commercially available from various sources. It is similarly preferred that the creative, creative monohydrate or other creative derivative is a pharmaceutical-grade material. As set forth above, the food supplement compositions also preferably further conagrise dextrose (glucose), with pbarmaceutical~grade dextrose being preferred.
The food supplement COInpOSltIOnS of the present invention may be provided in liquid or powder form, with powders suitable for mixiag with water or other liquids being preferred. The food supplement compositions in powder ox granular form may be provided in accordance with customary processing techniques, for example as spray dried powders, or the like. Owing to the lipoic acid component, the food supplement compositions generally exhibit an acidic pH value.
The lipoic acid or salt, ester or other derivative thereof is employed in the food supplement compositions according to the present invention in an amount sufficient to increase creative transport into the muscle cells. In a preferred embodiment, the food supplement compositions comprise from about 0.1 mg to about i0 mg lipoic acid or derivative thereof per gram of supplement and from about 0.01 g to about 0.5 g of creative, preferably creative monohydrate, or derivative thereof, per gram of supplement. In further preferred embodiments, the food supplement compositions comprise from about 0.5 mg to about 5 mg lipoic acid derivative thereof per gram of supplement and fmm about 0.05 g to about 0.25 g of create or derivative thereof per gram of supplevzevr. Even mare preferably the food supplement compositions comprise fTOm about 1 mg to about 3 mg lipoic acid, salt, ester or other derivative thereof per gram of supplement and from about ! , 0.05 g to about 0.2 g of creatine, cxeatine monohydrate or other derivative thereof per gram of supplement. Food supplement compositions further comprising deztrose preferably include the deztrose in an amount sufficient to stimulate insulin secretion and preferably the food supplement compositions comprise from about 0.1 g to about 0.9 g dextrose per gram of supplement. In fitrther preferred erabodiments, the food supplement compositions cotuprise from about 0.4 g to about 0.9 g dextrose per dram of supplement, and more preferably comprise from about 0.5 g to about 0.$ g dextrose per Gram of supplement. Most preferably, the food supplement compositions comprise about 0.75 g dextrose per gram of supglt, The food supplemem compositions according to the present invention may further contain additional camponents to further increase the speed at or ease with which creative enters the bloodstream and subsequernly the muscle tissue, or to otherwise enhance the effec~s of the creative in the body. For example, additional amino acids may be included in the food supplement compositions. Suitable amino acids include, but are not limited to, glutamine, aIanine, taurine, carnitine, acetyl-~._ carnitine, and the like. These additional amino acids may stimulate cell volumization and protein synthesis and therefore provide further advantages to increasing muscle strength andlor size. These amino acids may be employed individually or in various combinations and in amounts customary in the art, for example in the range of from about 0.01 mg to about 100 mg per p am of food supplement.
In a further preferred embodiment, the food supplement compositions also include a ehromiurn campound. Again, while not intending to be limited by theory, various studies have indicated that chromium supplementing will improve glucose tolerance in insulyn-sensitive individuals by up to 50 ~ and thereby maximize insulin efficiency. Chromium is a~coustituent of a biologically active compound, the glucose tolerance factor (CrTF), found in foods such as organ meats, whale grains, cheese, mushrooms and brewer's yeast. Various chromium compounds may be included in the food supplement compositions, and in amounts effective to improve insulin efficiency. A preferred chromium compound is chromium picolinate, which may be included, for example in an amount of from about SO to about 500 micrograms get 100 grams of supplement. Additional components for the food supplement compositions include additional minerals such as magnesium, potassium, phosphorous, salts thereof, or mixtures thereof in amounts conventional in the art, for example, from about 0.01 mg to about 100 mg per gram of food supplement.
The food supplement compositions also preferably contain ascorbic acid (vitamin C), for example is amounts equal to or exceeding the recommended minimum daily requirements. Another component for use in the food supplements comprises beta-hydroxy, beta-methyl butyrate (H1V1H), in amounts known in the art.
The food supplement compositions may further comprise natural and/or artificial flavoring components, dyes or other coloring additives, preservatives and other conventional food supplement additives ltnown in the art.
The food supplements according to the present invention may be employed in methods for supplementing the diet of an athlete, andlar for enhancing an athlete's muscle size or strength. The food supplement compositions of the present invention are particularly advantageous for creating an increased anabolic environment and obtaining extra growth in lean muscle mass and strength. The amount of the food supplement composition which is administered to the diet of the athlete may vary depending on the desired effect, the body weight and characteristics of the athlete, and the like. >~or example, in preferred methods for supplementing the diet of an S athlete andlor for enhancing an athlete's muscle size or strength, from about 10 mg to about 1,000 mg of Iipoic acid, salt, ester or other derivative thereof and from about 1 g to about 50 g of creative, creative monohydrate, or other derivative thereof are administered to the diet of the athlete on a daily basis. In more preferred embodiments of these methods, from about 50 mg to about 500 zng of lipoic acid or derivative thereof and from about 5 g to about 25 g of creative, creative monohydrate or other derivative thereof are administered to the diet of the athlete on a daily basis. The food supplement may be administered in a single serving or in multiple servings spaced throughout the day. In alternate preferred embodiments, from about I00 mg to about 300 mg of lipoic acid or derivative thereof and from about 5 g to about 20 g of creative, creative monohydrate or other derivative thereof are administered to the diet of the athlete on a daily basis.
To facilitate such administration, preferred embodiments of the food supplement of the invention comprise from about 0. I mg to about IO mg lipoic acid or derivative thereof per gram of supplement and fzom about O.pI g to about O.S g of creative, creative monohydrate, or other derivative thereof per gram of supplemem, and the supplement is administered in as amount of from about I0 g to about 500 g per day, In additional embodiments, such supplements are administered in an amount of from about 50 g to about 300 g per day, in one or multiple servings throughout the day.
rn additional embodiments wherein the supplement furtheZ comprises dextrose, from about 10 mg to about 1,000 mg of upoic acid or derivative thereof, from about 1 g to about 50 g of creative, creative monohydrate or other derivative thereof, and from about 10 g to about 300 g of dextrose are administered to the diet of the athlete on a daily basis, In further preferred embodiments, from about 50 mg to about 500 mg of lipoic acid or derivative thereof, from about S g to about 25 g of creative, creative monohydrate, or other derivative thereof, and. from about 50 g to about 200 g of dextrose administered to the diet of the athlete on a daily basis.
Most preferably, each supplement serving comprises from about 100 mg to about 300 mg lipoic acid or a derivative thereof, from about 5 g to about 20 g of creative, creative monohydrate or other derivative thereof, and ixom about SO g to about g, more preferably about 75 g, of dexanse.
When the food supplement further comprises dextrose, a supglement comprising from about 0.1 mg to about 10 mg lipoic acid or derivative thereof per gram of supplement, from about 0.01 g to about 0.5 g of creative or derivative thereof ger gram of supplement, and from about 0.1 g to about 0.9 g dextrose per gram of supplement, preferably from about 0.5 g to about 0.8 g dextrose per gram of supplement, may be administered in an amount of from about 10 g to about g, more preferably from about 50 g to about 300 g, per day.
rn one embodiment of the methods according to the present invemion, increased servings of the food supplement according to the present invention may be initially administered to the athlete's diet in order to increase ox enhance the athlete's muscle size or strength, followed by a maintenance period in which decreased servings of the food supplement may be administered. The initial period may be at least several days and may extend up to several woks as desired.
Once a desired muscle strength andlor size has been obtained, lower servings of the food supplement may be administered to the athlete's diet in ordez to maintain the increased muscle size andlor strength. These features will be discussed in further detail in the examples. Additionally in order to maximize the effects of the food supplement in enhancing muscle size andlor snength, it is preferred that the food supplement is administered to the diet of the athlete immediately following an exercise period. On non-warlcout days, the food supplement may be administered anytime during the day, although administering the food supplement ugon awakening or otherwise during the morning hours is preferred.
The food supplement compositions and methods of the invention are further illusarated in the following examples. In the examples and throughout the present specification, parts and percentages are by weight unless otherwise specif ed.
In this example, an athlete consumes two servings of the food supplement as described herein daily, are in the morning and the other twelve hours later or immediately after hislher exercise workout. This regime is continued for 8ve days in order to enhance muscle size andlor strength. Each serving of the food supplemem is approximately 100 g and contains the follpwing;
Lipoic Acid 200 mg Creatine Monohydrate 10 g Dextrose 75 g S Taurine 2000 mg Vitamin C 250 mg Magnesium 70 mg Potassium 150 mg Phosphorous 100 mg Chromium Picolinate 300 mcg Each approximate I00 gram serving is mixed with 12 ounces of cold water to provide a liquid drink. An additional 8 ounces of water is consumed aftex the food supplement litncid drink is consumed.
The muscle size alullor strength enhancing regime of Example 1 is modified so that the athlete consumes four servings of the food supplement daily, with each serving being approximately 50 g of the supplement and comprising:
Com ~nent, Lipoic Acid 100 mg Creative Monohydrate 5 g Dextrose 37.5 g Taurine 1000 mg Vitamin C 125 mg Magnesium 35 mg Potassium 75 mg Phosphorous 50 mg Chromium Plcolinate 150 mcg Each supplement serving is mixed with 12 ounces of cold water and the servings are administered at approximately evcnly spaced times through the day, with one serving being consumed immediately after the athlete's exercise workout, Once the regime described in Example 1 is completed, the athlefie cont~s with a maintenance regime wherein one serving of the food supplement composition described in Example I is consumed on a daily basis. The serving is consumed im~diately after an exercise workout or, on non-workout days, upon awakening or otherwise in the morning hours, As described i~t F.xampIe I, the approximate gram serving is mixed with cold water to form a liquid drink, Alternatively, the food supplement is be combined with other liquid drinks or foods as desired.
This maintenance regime is co~inued for at least eight weeps to mairnain enhanced muscle size andlor strength.
1 ~ The servings set forth in these examples are designed for a 2004 calorie diet.
Daily values may be increased or decreased depending on the calorie needs of individual athletes, andlor body weights of individual athletes.
The examples and embodiments set forth in the present application are provided only to illustrate various aspects of the invention and additional, embodiments and advantages of the food supplements and methods of the present invention will be apgarent to those skilled in the art_
The food supplements comprise lipoic acid or a derivative thereof, for example a salt or ester thereof. Suitable salts include, but are not limited to, alkali and alkalise earth meral salts, for example sodium, potassium or calcium salts, while suitable esters include, but are not limited to, alkyl esters, for example, methyl, ethyl or propyl esters, or lactone esters.
The food supplement compositions further comprise creative or a derivative thereof, for example a hydrate, salt or ester thereof. Commercially available creative derivatives include creative monohydrate, other creative hydrates, creative citrate and creative pyruvate. The creatirLe which is employed in the food supplement compositions of the present invention preferably comprises creative monohydrate, commercially available from various sources. It is similarly preferred that the creative, creative monohydrate or other creative derivative is a pharmaceutical-grade material. As set forth above, the food supplement compositions also preferably further conagrise dextrose (glucose), with pbarmaceutical~grade dextrose being preferred.
The food supplement COInpOSltIOnS of the present invention may be provided in liquid or powder form, with powders suitable for mixiag with water or other liquids being preferred. The food supplement compositions in powder ox granular form may be provided in accordance with customary processing techniques, for example as spray dried powders, or the like. Owing to the lipoic acid component, the food supplement compositions generally exhibit an acidic pH value.
The lipoic acid or salt, ester or other derivative thereof is employed in the food supplement compositions according to the present invention in an amount sufficient to increase creative transport into the muscle cells. In a preferred embodiment, the food supplement compositions comprise from about 0.1 mg to about i0 mg lipoic acid or derivative thereof per gram of supplement and from about 0.01 g to about 0.5 g of creative, preferably creative monohydrate, or derivative thereof, per gram of supplement. In further preferred embodiments, the food supplement compositions comprise from about 0.5 mg to about 5 mg lipoic acid derivative thereof per gram of supplement and fmm about 0.05 g to about 0.25 g of create or derivative thereof per gram of supplevzevr. Even mare preferably the food supplement compositions comprise fTOm about 1 mg to about 3 mg lipoic acid, salt, ester or other derivative thereof per gram of supplement and from about ! , 0.05 g to about 0.2 g of creatine, cxeatine monohydrate or other derivative thereof per gram of supplement. Food supplement compositions further comprising deztrose preferably include the deztrose in an amount sufficient to stimulate insulin secretion and preferably the food supplement compositions comprise from about 0.1 g to about 0.9 g dextrose per gram of supplement. In fitrther preferred erabodiments, the food supplement compositions cotuprise from about 0.4 g to about 0.9 g dextrose per dram of supplement, and more preferably comprise from about 0.5 g to about 0.$ g dextrose per Gram of supplement. Most preferably, the food supplement compositions comprise about 0.75 g dextrose per gram of supglt, The food supplemem compositions according to the present invention may further contain additional camponents to further increase the speed at or ease with which creative enters the bloodstream and subsequernly the muscle tissue, or to otherwise enhance the effec~s of the creative in the body. For example, additional amino acids may be included in the food supplement compositions. Suitable amino acids include, but are not limited to, glutamine, aIanine, taurine, carnitine, acetyl-~._ carnitine, and the like. These additional amino acids may stimulate cell volumization and protein synthesis and therefore provide further advantages to increasing muscle strength andlor size. These amino acids may be employed individually or in various combinations and in amounts customary in the art, for example in the range of from about 0.01 mg to about 100 mg per p am of food supplement.
In a further preferred embodiment, the food supplement compositions also include a ehromiurn campound. Again, while not intending to be limited by theory, various studies have indicated that chromium supplementing will improve glucose tolerance in insulyn-sensitive individuals by up to 50 ~ and thereby maximize insulin efficiency. Chromium is a~coustituent of a biologically active compound, the glucose tolerance factor (CrTF), found in foods such as organ meats, whale grains, cheese, mushrooms and brewer's yeast. Various chromium compounds may be included in the food supplement compositions, and in amounts effective to improve insulin efficiency. A preferred chromium compound is chromium picolinate, which may be included, for example in an amount of from about SO to about 500 micrograms get 100 grams of supplement. Additional components for the food supplement compositions include additional minerals such as magnesium, potassium, phosphorous, salts thereof, or mixtures thereof in amounts conventional in the art, for example, from about 0.01 mg to about 100 mg per gram of food supplement.
The food supplement compositions also preferably contain ascorbic acid (vitamin C), for example is amounts equal to or exceeding the recommended minimum daily requirements. Another component for use in the food supplements comprises beta-hydroxy, beta-methyl butyrate (H1V1H), in amounts known in the art.
The food supplement compositions may further comprise natural and/or artificial flavoring components, dyes or other coloring additives, preservatives and other conventional food supplement additives ltnown in the art.
The food supplements according to the present invention may be employed in methods for supplementing the diet of an athlete, andlar for enhancing an athlete's muscle size or strength. The food supplement compositions of the present invention are particularly advantageous for creating an increased anabolic environment and obtaining extra growth in lean muscle mass and strength. The amount of the food supplement composition which is administered to the diet of the athlete may vary depending on the desired effect, the body weight and characteristics of the athlete, and the like. >~or example, in preferred methods for supplementing the diet of an S athlete andlor for enhancing an athlete's muscle size or strength, from about 10 mg to about 1,000 mg of Iipoic acid, salt, ester or other derivative thereof and from about 1 g to about 50 g of creative, creative monohydrate, or other derivative thereof are administered to the diet of the athlete on a daily basis. In more preferred embodiments of these methods, from about 50 mg to about 500 zng of lipoic acid or derivative thereof and from about 5 g to about 25 g of creative, creative monohydrate or other derivative thereof are administered to the diet of the athlete on a daily basis. The food supplement may be administered in a single serving or in multiple servings spaced throughout the day. In alternate preferred embodiments, from about I00 mg to about 300 mg of lipoic acid or derivative thereof and from about 5 g to about 20 g of creative, creative monohydrate or other derivative thereof are administered to the diet of the athlete on a daily basis.
To facilitate such administration, preferred embodiments of the food supplement of the invention comprise from about 0. I mg to about IO mg lipoic acid or derivative thereof per gram of supplement and fzom about O.pI g to about O.S g of creative, creative monohydrate, or other derivative thereof per gram of supplemem, and the supplement is administered in as amount of from about I0 g to about 500 g per day, In additional embodiments, such supplements are administered in an amount of from about 50 g to about 300 g per day, in one or multiple servings throughout the day.
rn additional embodiments wherein the supplement furtheZ comprises dextrose, from about 10 mg to about 1,000 mg of upoic acid or derivative thereof, from about 1 g to about 50 g of creative, creative monohydrate or other derivative thereof, and from about 10 g to about 300 g of dextrose are administered to the diet of the athlete on a daily basis, In further preferred embodiments, from about 50 mg to about 500 mg of lipoic acid or derivative thereof, from about S g to about 25 g of creative, creative monohydrate, or other derivative thereof, and. from about 50 g to about 200 g of dextrose administered to the diet of the athlete on a daily basis.
Most preferably, each supplement serving comprises from about 100 mg to about 300 mg lipoic acid or a derivative thereof, from about 5 g to about 20 g of creative, creative monohydrate or other derivative thereof, and ixom about SO g to about g, more preferably about 75 g, of dexanse.
When the food supplement further comprises dextrose, a supglement comprising from about 0.1 mg to about 10 mg lipoic acid or derivative thereof per gram of supplement, from about 0.01 g to about 0.5 g of creative or derivative thereof ger gram of supplement, and from about 0.1 g to about 0.9 g dextrose per gram of supplement, preferably from about 0.5 g to about 0.8 g dextrose per gram of supplement, may be administered in an amount of from about 10 g to about g, more preferably from about 50 g to about 300 g, per day.
rn one embodiment of the methods according to the present invemion, increased servings of the food supplement according to the present invention may be initially administered to the athlete's diet in order to increase ox enhance the athlete's muscle size or strength, followed by a maintenance period in which decreased servings of the food supplement may be administered. The initial period may be at least several days and may extend up to several woks as desired.
Once a desired muscle strength andlor size has been obtained, lower servings of the food supplement may be administered to the athlete's diet in ordez to maintain the increased muscle size andlor strength. These features will be discussed in further detail in the examples. Additionally in order to maximize the effects of the food supplement in enhancing muscle size andlor snength, it is preferred that the food supplement is administered to the diet of the athlete immediately following an exercise period. On non-warlcout days, the food supplement may be administered anytime during the day, although administering the food supplement ugon awakening or otherwise during the morning hours is preferred.
The food supplement compositions and methods of the invention are further illusarated in the following examples. In the examples and throughout the present specification, parts and percentages are by weight unless otherwise specif ed.
In this example, an athlete consumes two servings of the food supplement as described herein daily, are in the morning and the other twelve hours later or immediately after hislher exercise workout. This regime is continued for 8ve days in order to enhance muscle size andlor strength. Each serving of the food supplemem is approximately 100 g and contains the follpwing;
Lipoic Acid 200 mg Creatine Monohydrate 10 g Dextrose 75 g S Taurine 2000 mg Vitamin C 250 mg Magnesium 70 mg Potassium 150 mg Phosphorous 100 mg Chromium Picolinate 300 mcg Each approximate I00 gram serving is mixed with 12 ounces of cold water to provide a liquid drink. An additional 8 ounces of water is consumed aftex the food supplement litncid drink is consumed.
The muscle size alullor strength enhancing regime of Example 1 is modified so that the athlete consumes four servings of the food supplement daily, with each serving being approximately 50 g of the supplement and comprising:
Com ~nent, Lipoic Acid 100 mg Creative Monohydrate 5 g Dextrose 37.5 g Taurine 1000 mg Vitamin C 125 mg Magnesium 35 mg Potassium 75 mg Phosphorous 50 mg Chromium Plcolinate 150 mcg Each supplement serving is mixed with 12 ounces of cold water and the servings are administered at approximately evcnly spaced times through the day, with one serving being consumed immediately after the athlete's exercise workout, Once the regime described in Example 1 is completed, the athlefie cont~s with a maintenance regime wherein one serving of the food supplement composition described in Example I is consumed on a daily basis. The serving is consumed im~diately after an exercise workout or, on non-workout days, upon awakening or otherwise in the morning hours, As described i~t F.xampIe I, the approximate gram serving is mixed with cold water to form a liquid drink, Alternatively, the food supplement is be combined with other liquid drinks or foods as desired.
This maintenance regime is co~inued for at least eight weeps to mairnain enhanced muscle size andlor strength.
1 ~ The servings set forth in these examples are designed for a 2004 calorie diet.
Daily values may be increased or decreased depending on the calorie needs of individual athletes, andlor body weights of individual athletes.
The examples and embodiments set forth in the present application are provided only to illustrate various aspects of the invention and additional, embodiments and advantages of the food supplements and methods of the present invention will be apgarent to those skilled in the art_
Claims (34)
1. A food supplement, comprising a mixture of lipoic acid or a derivative thereof, and creatine or a derivative thereof.
2. A food supplement according to claim 1, comprising a mixture of lipoic acid or a salt or ester thereof and creatine or a hydrate, salt or ester thereof.
3. A food supplement according to claim1, comprising lipoic acid or a derivative thereof and creative monohydrate.
4. A food supplement according to claim1, comprising from 0.1 mg to mg lipoic acid or a derivative thereof per gram of supplement and from 0.01 g to 0.5 g of creative or a derivative thereof per gram of supplement.
5. A food supplement according to claim 1, comprising from 0.5 mg to 5 mg lipoic acid or a derivative thereof per gram of supplement and from 0.05 g to 0.25 g of creative or a derivative thereof per gram of supplement.
6. A food supplement according to claim1, comprising from 1 mg to 3 mg lipoic acid or derivative thereof per gram of supplement and from 0.05 g to 0.2 g of creative or a derivative thereof per gram of supplement.
7. A food supplement according to claim 1, further comprising dextrose.
8. A food supplement according to claim 7, comprising from 0.1 mg to mg lipoic acid or a derivative thereof per gram of supplement, from 0.01 g to 0.5 g of creatine or a derivative thereof per gram of supplement, and from 0.1 g to 0.9 g dextrose per gram of supplement.
9. A food supplement according to claim 7, comprising from 0.5 mg to 5 mg lipoic acid or derivative thereof per gram of supplement, from 0.05 g to 0.25 g of creatine or a derivative thereof per gram of supplement, and from 0.4 g to 0.9 g dextrose per gram of supplement.
10. A food supplement according to claim 7, comprising from 1 mg to 3 mg lipoic acid or a derivative thereof per gram of supplement, from 0.05 g to 0.2 g of creatine or a derivative thereof per gram of supplement, and from 0.5 g to 0.8 g dextrose per gram of supplement.
11. A food supplement according to claim 1, further comprising ascorbic acid, taurine, magnesium, potassium, phosphorus, chromium, salts thereof, or mixtures thereof.
12. A food supplement according to claim 7, further comprising ascorbic acid, taurine, magnesium, potassium, phosphorus, chromium, salts thereof, or mixtures thereof.
13. A food supplement according to claim 1, comprising lipoic acid or a derivative thereof, creative or a derivative thereof, dextrose, taurine, chromium picolinate and ascorbic acid.
14. A method for supplementing the diet of an athlete, comprising administering to the diet of the athlete a supplement comprising a mixture of lipoic acid or a derivative thereof, and creative or a derivative thereof.
15. A method according to claim 14, wherein from 10 mg to 1000 mg of lipoic acid or a derivative thereof and from 1 g to 50 g of creative or a derivative thereof are administered to the diet of the athlete on a daily basis.
16. A method according to claim 14, wherein from 50 mg to 500 mg of lipoic acid or a derivative thereof and from 5 g to 25 g of creative or a derivative thereof are administered to the diet of the athlete on a daily basis.
17. A method according to claim 14, wherein from 100 mg to 300 mg of lipoic acid or a derivative thereof and from 5 g to 20 g of creative or a derivative thereof are administered to the diet of the athlete on a daily basis.
18. A method according to claim 14, wherein the supplement comprises from 0.1 mg to 10 mg lipoic acid or a derivative thereof per gram of supplement and from 0.01 g to 0.5 g of creative or a derivative thereof per gram of supplement, and further wherein the supplement is administered in an amount from 10 g to 500 g per day.
19. A method according to claim 18, wherein the supplement is administered in an amount from 50 g to 300 g per day.
20. A method according to claim 14, wherein the supplement further comprises dextrose.
21. A method according to claim 20, wherein from 10 mg to 1000 mg of lipoic acid or a derivative thereof, from 1 g to 50 g of creative or a derivative thereof, and from 10 g to 300 g of dextrose are administered to the diet of the athlete on a daily basis.
22. A method according to claim 20, wherein from 50 mg to 500 mg of lipoic acid or a derivative thereof, from 5 g to 25 g of creative or a derivative thereof, and from 50 g to 200 g of dextrose are administered to the diet of the athlete on a daily basis.
23. A method according to claim 20, wherein the supplement is administered in a serving which comprises from 100 mg to 300 mg lipoic acid or a derivative thereof, from 5 g to 20 g of creative or a derivative thereof, and from 50 g to 90 g dextrose.
24. A method according to claim 14, wherein the food supplement is mixed with water to provide a liquid drink.
25. A method for enhancing an athlete's muscle size or strength, comprising administering to the diet of the athlete a supplement comprising a mixture of lipoic acid or a derivative thereof, and creative or a derivative thereof.
26. A method according to claim 25, wherein from 10 mg to 1000 mg of lipoic acid or a derivative thereof and from 1 g to 50 g of creative or a derivative thereof are administered to the diet of the athlete on a daily basis.
27. A method according to claim 25, wherein from 50 mg to 500 mg of lipoic acid or a derivative thereof and from 5 g to 25 g of creative or a derivative thereof are administered to the diet of the athlete on a daily basis.
28. A method according to claim 25, wherein from 100 mg to 300 mg of lipoic acid or a derivative thereof and from 5 g to 20 g of creative or a derivative thereof are administered to the diet of the athlete on a daily basis.
29. A method according to claim 25, wherein the supplement comprises from about 0.1 mg to 10 mg lipoic acid or a derivative thereof per gram of supplement and from 0.01 g to 0.5 g of creatine or a derivative thereof per gram of supplement, and further wherein the supplement is administered in an amount from 10 g to 500 g per day.
30. A method according to claim 29, wherein the supplement is administered in an amount from 50 g to 300 g per day.
31. A method according to claim 25, wherein the supplement further comprises dextrose.
32. A method according to claim 31, wherein from 10 mg to 1000 mg of lipoic acid or a derivative thereof, from 1 g to 50 g of creatine or a derivative thereof, and from 10 g to 300 g of dextrose are administered to the diet of the athlete on a daily basis.
33. A method according to claim 31, wherein from 50 mg to 500 mg of lipoic acid or a derivative thereof, from 5 g to 25 g of creatine or a derivative thereof, and from 50 g to 200 g of dextrose are administered to the diet of the athlete on a daily basis.
34. A method according to claim 31, wherein the supplement is administered in a serving which comprises from 100 mg to 300 mg lipoic acid or a derivative thereof, from 5 g to 20 g of creatine or a derivative thereof, and from 50 g to 90 g dextrose.
Priority Applications (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA002246014A CA2246014C (en) | 1998-08-21 | 1998-08-21 | Food supplements and methods comprising lipoic acid and creatine |
| ES99939286T ES2285855T3 (en) | 1998-08-21 | 1999-08-20 | FOOD SUPPLEMENTS THAT INCLUDE LIPOIC ACID AND CREATININE, METHODS FOR USE. |
| EP99939286A EP1093337B1 (en) | 1998-08-21 | 1999-08-20 | Food supplements comprising lipoic acid and creatine and methods for their use |
| AU53666/99A AU5366699A (en) | 1998-08-21 | 1999-08-20 | Food supplements comprising lipoic acid and creatine and methods for their use |
| PCT/CA1999/000772 WO2000010408A1 (en) | 1998-08-21 | 1999-08-20 | Food supplements comprising lipoic acid and creatine and methods for their use |
| PT99939286T PT1093337E (en) | 1998-08-21 | 1999-08-20 | Food supplements comprising lipoic acid and creatine and methods for their use |
| DK99939286T DK1093337T3 (en) | 1998-08-21 | 1999-08-20 | Food supplements comprising lipoic acid and creatine as well as methods for their use |
| DE69936056T DE69936056T2 (en) | 1998-08-21 | 1999-08-20 | FOOD SUPPLEMENT CONTAINING LIPONIC ACID AND CREATINE AND METHODS FOR THEIR APPLICATION |
| AT99939286T ATE361677T1 (en) | 1998-08-21 | 1999-08-20 | FOOD SUPPLEMENT CONTAINING LIPONIC ACID AND CREATINE AND METHODS OF USE THEREOF |
| HK01107121A HK1036203A1 (en) | 1998-08-21 | 2001-10-11 | Food supplements comprising lipoic acid and creatine and methods for their use |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA002246014A CA2246014C (en) | 1998-08-21 | 1998-08-21 | Food supplements and methods comprising lipoic acid and creatine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2246014A1 CA2246014A1 (en) | 2000-01-19 |
| CA2246014C true CA2246014C (en) | 2001-12-11 |
Family
ID=4162776
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002246014A Expired - Lifetime CA2246014C (en) | 1998-08-21 | 1998-08-21 | Food supplements and methods comprising lipoic acid and creatine |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2246014C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018157258A1 (en) * | 2017-03-03 | 2018-09-07 | Exerkine Corporation | Multi-nutrient composition |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1255454A2 (en) * | 2000-02-01 | 2002-11-13 | Muscletech Research and Development Inc. | Alpha lipoic acid based food supplement to increase lean muscle mass and strength |
| WO2007053943A1 (en) * | 2005-11-08 | 2007-05-18 | Multi Formulations Ltd. | The use of compositions comprising ketoacids and amino acids for increasing muscle mass and muscle performance |
| JP2009527504A (en) * | 2006-02-23 | 2009-07-30 | イオメディックス スリープ インターナショナル エスアールエル | Compositions and methods for induction and maintenance of good quality sleep |
| WO2009079740A1 (en) * | 2007-12-21 | 2009-07-02 | Multi Formulations Ltd. | Compositions and methods for enhancing hypertrophy in skeletal muscle |
-
1998
- 1998-08-21 CA CA002246014A patent/CA2246014C/en not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018157258A1 (en) * | 2017-03-03 | 2018-09-07 | Exerkine Corporation | Multi-nutrient composition |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2246014A1 (en) | 2000-01-19 |
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