CA2244142C - Antifungal compound from hormonema sp. - Google Patents

Antifungal compound from hormonema sp. Download PDF

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Publication number
CA2244142C
CA2244142C CA002244142A CA2244142A CA2244142C CA 2244142 C CA2244142 C CA 2244142C CA 002244142 A CA002244142 A CA 002244142A CA 2244142 A CA2244142 A CA 2244142A CA 2244142 C CA2244142 C CA 2244142C
Authority
CA
Canada
Prior art keywords
compound
hormonema
culture
antifungal
medium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA002244142A
Other languages
English (en)
French (fr)
Other versions
CA2244142A1 (en
Inventor
Robert E. Schwartz
Gerald F. Bills
Robert A. Giacobbe
Wendy S. Horn
Jerrold M. Liesch
Maria S. Meinz
Sandra A. Morris
Janet C. Onishi
Deborah L. Zink
Angeles Cabello
Teresa Diez
Isabella Martin
Francisca Vicente
Fernando Pelaez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9604168.6A external-priority patent/GB9604168D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of CA2244142A1 publication Critical patent/CA2244142A1/en
Application granted granted Critical
Publication of CA2244142C publication Critical patent/CA2244142C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
CA002244142A 1996-01-31 1997-01-27 Antifungal compound from hormonema sp. Expired - Lifetime CA2244142C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US1093496P 1996-01-31 1996-01-31
US60/010,934 1996-01-31
GBGB9604168.6A GB9604168D0 (en) 1996-02-28 1996-02-28 Antifungal agent
GB9604168.6 1996-02-28
PCT/US1997/001598 WO1997027860A1 (en) 1996-01-31 1997-01-27 Antifungal agent

Publications (2)

Publication Number Publication Date
CA2244142A1 CA2244142A1 (en) 1997-08-07
CA2244142C true CA2244142C (en) 2005-03-29

Family

ID=26308817

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002244142A Expired - Lifetime CA2244142C (en) 1996-01-31 1997-01-27 Antifungal compound from hormonema sp.

Country Status (8)

Country Link
EP (1) EP0877618B1 (enExample)
JP (1) JP3834062B2 (enExample)
AT (1) ATE230268T1 (enExample)
AU (1) AU703925B2 (enExample)
CA (1) CA2244142C (enExample)
DE (1) DE69718141T2 (enExample)
ES (1) ES2188899T3 (enExample)
WO (1) WO1997027860A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007126900A2 (en) 2006-04-03 2007-11-08 Merck & Co., Inc. Antifungal agents
JP5562853B2 (ja) * 2007-09-28 2014-07-30 サイネクシス，インコーポレーテッド 抗真菌剤
PE20110676A1 (es) * 2008-08-12 2011-09-23 Merck Sharp & Dohme Compuestos derivados de enfumafungina con actividad antifungica
CA2731941C (en) 2008-08-12 2016-09-27 Merck Sharp & Dohme Corp. Derivatives of enfumafungin as inhibitors of(1,3)-beta.-d-glucan synthase

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4870165A (en) * 1987-02-02 1989-09-26 Bristol-Myers Company Antifungal antibiotics

Also Published As

Publication number Publication date
DE69718141D1 (de) 2003-02-06
CA2244142A1 (en) 1997-08-07
JP2000504563A (ja) 2000-04-18
AU703925B2 (en) 1999-04-01
WO1997027860A1 (en) 1997-08-07
EP0877618A4 (enExample) 1998-12-02
JP3834062B2 (ja) 2006-10-18
AU2252997A (en) 1997-08-22
EP0877618B1 (en) 2003-01-02
DE69718141T2 (de) 2003-08-21
ES2188899T3 (es) 2003-07-01
EP0877618A1 (en) 1998-11-18
ATE230268T1 (de) 2003-01-15

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Effective date: 20170127