CA2243863A1 - Gastrointestinal drug delivery system - Google Patents
Gastrointestinal drug delivery systemInfo
- Publication number
- CA2243863A1 CA2243863A1 CA 2243863 CA2243863A CA2243863A1 CA 2243863 A1 CA2243863 A1 CA 2243863A1 CA 2243863 CA2243863 CA 2243863 CA 2243863 A CA2243863 A CA 2243863A CA 2243863 A1 CA2243863 A1 CA 2243863A1
- Authority
- CA
- Canada
- Prior art keywords
- core
- drug
- release
- insoluble
- gastrointestinal tract
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000012377 drug delivery Methods 0.000 title 1
- 239000004083 gastrointestinal agent Substances 0.000 title 1
- 229940127227 gastrointestinal drug Drugs 0.000 title 1
- 239000011162 core material Substances 0.000 abstract 5
- 239000003814 drug Substances 0.000 abstract 5
- 229940079593 drug Drugs 0.000 abstract 5
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract 3
- 239000011248 coating agent Substances 0.000 abstract 2
- 238000000576 coating method Methods 0.000 abstract 2
- 239000013618 particulate matter Substances 0.000 abstract 2
- 239000012876 carrier material Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000002496 gastric effect Effects 0.000 abstract 1
- 239000002198 insoluble material Substances 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000036962 time dependent Effects 0.000 abstract 1
Abstract
A gastrointestinal delivery system is provided. The system comprises a drug in combination with a core material, the core being surrounded by a water-insoluble or relatively water-insoluble coating material in which particulate water-insoluble material is embedded.
When the delivery device enters the gastrointestinal tract, the particulate matter takes up liquid, thus forming channels interconnecting the drug-containing core with the outside of the delivery device. These channels allow the release of drug from the core into the gastrointestinal tract. By controlling parameters in the device, such as the core material, carrier material in the coating, and particulate matter, the location of release of the drug can be carefully controlled. Thus, the invention is also directed to a method of using the device for the treatment of disease by the release of drugs in the gastrointestinal tract in a location-and time-dependent manner.
When the delivery device enters the gastrointestinal tract, the particulate matter takes up liquid, thus forming channels interconnecting the drug-containing core with the outside of the delivery device. These channels allow the release of drug from the core into the gastrointestinal tract. By controlling parameters in the device, such as the core material, carrier material in the coating, and particulate matter, the location of release of the drug can be carefully controlled. Thus, the invention is also directed to a method of using the device for the treatment of disease by the release of drugs in the gastrointestinal tract in a location-and time-dependent manner.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/588,247 | 1996-01-18 | ||
| US08/588,247 US5840332A (en) | 1996-01-18 | 1996-01-18 | Gastrointestinal drug delivery system |
| PCT/IB1997/000037 WO1997025979A1 (en) | 1996-01-18 | 1997-01-17 | Gastrointestinal drug delivery system |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2243863A1 true CA2243863A1 (en) | 1997-07-24 |
| CA2243863C CA2243863C (en) | 2006-08-29 |
Family
ID=29422203
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA 2243863 Expired - Fee Related CA2243863C (en) | 1996-01-18 | 1997-01-17 | Gastrointestinal drug delivery system |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2243863C (en) |
-
1997
- 1997-01-17 CA CA 2243863 patent/CA2243863C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2243863C (en) | 2006-08-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MY133883A (en) | Gastrointestinal drug delivery system | |
| CA2305762A1 (en) | Delayed total release gastrointestinal drug delivery system | |
| CA2375714A1 (en) | Delayed total release two pulse gastrointestinal drug delivery system | |
| HUP0003121A3 (en) | Method for producing orally administered, solid pharmaceutical products with controlled release of the active substance | |
| AU2827095A (en) | Controlled release oral drug delivery system | |
| ATE270880T1 (en) | STOMACH-RESIDING MICROSPHERES WITH CONTROLLED RELEASE FOR IMPROVED DRUG DELIVERY | |
| AU5914999A (en) | Controlled release drug delivery | |
| IL121275A (en) | Controlled release formulation for poorly soluble basic drugs | |
| WO2002078601A3 (en) | Drug release from polymer matrices through mechanical stimulation | |
| EP1027888A3 (en) | Osmotic system for delivery of solid amorphous dispersions of drugs | |
| CA2301685A1 (en) | Sustained release drug delivery devices | |
| AU8781798A (en) | Sustained release drug delivery system suitable for oral administration | |
| AU6140598A (en) | Multipathway electronically-controlled drug delivery system | |
| HK1037967A1 (en) | Orally administered controlled drug delivery system providing temporal and spatial control | |
| WO1998023262A3 (en) | Lozenge for the modified releasing of active substances in the gastrointestinal tract | |
| AU7032500A (en) | A process for the preparation of a controlled drug delivery system containing pseudoephedrine and a long acting antihistamine | |
| ZA97976B (en) | Uniform drug delivery theraphy. | |
| AU7569796A (en) | Multivalent polymers, processes for their preparation, and their use for preparing biologically active compounds. | |
| AU5820900A (en) | Capsule for the controlled release of active substances | |
| CA2243863A1 (en) | Gastrointestinal drug delivery system | |
| AU2918297A (en) | Medical device for drug controlled release in the mouth | |
| ZA200103829B (en) | Methods for preparing coated drug particles and pharmaceutical formulations thereof. | |
| ZA942806B (en) | Controlled release drug delivery device | |
| AU5887796A (en) | Patient controlled drug delivery device | |
| AUPN814196A0 (en) | Patient controlled drug delivery device |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20140117 |