CA2243392A1 - Use of a texaphyrin in the preparation of a medicament for use with a chemotherapeutic agent in cancer chemosensitization - Google Patents

Use of a texaphyrin in the preparation of a medicament for use with a chemotherapeutic agent in cancer chemosensitization

Info

Publication number
CA2243392A1
CA2243392A1 CA 2243392 CA2243392A CA2243392A1 CA 2243392 A1 CA2243392 A1 CA 2243392A1 CA 2243392 CA2243392 CA 2243392 CA 2243392 A CA2243392 A CA 2243392A CA 2243392 A1 CA2243392 A1 CA 2243392A1
Authority
CA
Canada
Prior art keywords
texaphyrin
medicament
preparation
chemotherapeutic agent
glycoprotein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA 2243392
Other languages
French (fr)
Other versions
CA2243392C (en
Inventor
Richard A. Miller
Stuart W. Young
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacyclics LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/591,318 external-priority patent/US5776925A/en
Application filed by Individual filed Critical Individual
Publication of CA2243392A1 publication Critical patent/CA2243392A1/en
Application granted granted Critical
Publication of CA2243392C publication Critical patent/CA2243392C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Landscapes

  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Methods for cancer chemosensitization are provided. Texaphyrins are new chemosensitizers for enhancing the cytotoxicity of chemotherapeutic agents. The enhancement appears to be P-glycoprotein-independent since texaphyrins are effective in both a P-glycoprotein-expressing and a P-glycoprotein-nonexpressing cell line. Methods are provided for the treatment of cancers such as leukemia, lymphoma, carcinoma, and sarcoma using a texaphyrin as a chemosensitizer.
CA 2243392 1996-01-25 1997-01-23 Use of a texaphyrin in the preparation of a medicament for use with a chemotherapeutic agent in cancer chemosensitization Expired - Fee Related CA2243392C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/591,318 US5776925A (en) 1996-01-25 1996-01-25 Methods for cancer chemosensitization
US08/591,318 1996-01-25
PCT/US1997/000907 WO1997026915A1 (en) 1996-01-25 1997-01-23 Use of a thexaphyrin in the preparation of a medicament for use with a chemotherapeutic agent in cancer chemosensitization

Publications (2)

Publication Number Publication Date
CA2243392A1 true CA2243392A1 (en) 1997-07-31
CA2243392C CA2243392C (en) 2006-11-21

Family

ID=29422856

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2243392 Expired - Fee Related CA2243392C (en) 1996-01-25 1997-01-23 Use of a texaphyrin in the preparation of a medicament for use with a chemotherapeutic agent in cancer chemosensitization

Country Status (1)

Country Link
CA (1) CA2243392C (en)

Also Published As

Publication number Publication date
CA2243392C (en) 2006-11-21

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Effective date: 20130123