CA2241080A1 - Regulation de synthese de proteines et procede de criblage pour agents pharmaceutiques - Google Patents

Regulation de synthese de proteines et procede de criblage pour agents pharmaceutiques Download PDF

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Publication number
CA2241080A1
CA2241080A1 CA002241080A CA2241080A CA2241080A1 CA 2241080 A1 CA2241080 A1 CA 2241080A1 CA 002241080 A CA002241080 A CA 002241080A CA 2241080 A CA2241080 A CA 2241080A CA 2241080 A1 CA2241080 A1 CA 2241080A1
Authority
CA
Canada
Prior art keywords
pkb
kinase
phosphorylation
peptide
gsk3
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002241080A
Other languages
English (en)
Inventor
Philip Cohen
Dario Alessi
Darren Cross
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Dundee
Medical Research Council
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9526083.2A external-priority patent/GB9526083D0/en
Priority claimed from GBGB9610272.8A external-priority patent/GB9610272D0/en
Priority claimed from GBGB9615066.9A external-priority patent/GB9615066D0/en
Application filed by Individual filed Critical Individual
Publication of CA2241080A1 publication Critical patent/CA2241080A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Procédé de criblage d'agents capables d'affecter l'activité des kinases GSK3 et PKB, qui consiste à évaluer la phosphorylation de PKB sur deux acides aminés sur la molécule de PKB en particulier.
CA002241080A 1995-12-20 1996-12-20 Regulation de synthese de proteines et procede de criblage pour agents pharmaceutiques Abandoned CA2241080A1 (fr)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GB9526083.2 1995-12-20
GBGB9526083.2A GB9526083D0 (en) 1995-12-20 1995-12-20 Method
GBGB9610272.8A GB9610272D0 (en) 1996-05-16 1996-05-16 Method
GB9610272.8 1996-05-16
GB9615066.9 1996-07-18
GBGB9615066.9A GB9615066D0 (en) 1996-07-18 1996-07-18 Method

Publications (1)

Publication Number Publication Date
CA2241080A1 true CA2241080A1 (fr) 1997-06-26

Family

ID=27268041

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002241080A Abandoned CA2241080A1 (fr) 1995-12-20 1996-12-20 Regulation de synthese de proteines et procede de criblage pour agents pharmaceutiques

Country Status (5)

Country Link
EP (1) EP0868195A2 (fr)
JP (1) JP2000502097A (fr)
AU (1) AU1200497A (fr)
CA (1) CA2241080A1 (fr)
WO (1) WO1997022360A2 (fr)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9525702D0 (en) * 1995-12-15 1996-02-14 Ciba Geigy Ag Process for activating a kinase
US6057117A (en) * 1996-04-04 2000-05-02 Chiron Corporation Identification and use of selective inhibitors of glycogen synthase kinase 3
WO1998016528A1 (fr) * 1996-10-11 1998-04-23 Chiron Corporation Inhibiteurs puriques de glycogene synthase kinase 3 (gsk3)
US7361336B1 (en) 1997-09-18 2008-04-22 Ivan Bergstein Methods of cancer therapy targeted against a cancer stem line
EP1017826A2 (fr) * 1997-09-26 2000-07-12 Onyx Pharmaceuticals Compositions et techniques permettant d'identifier les inhibiteurs de la kinase de la pkb
US6682920B1 (en) 1997-09-26 2004-01-27 Onyx Pharmaceuticals, Inc. Compositions and methods for identifying PKB kinase inhibitors
SE9801530D0 (sv) * 1998-04-30 1998-04-30 Pharmacia & Upjohn Ab Method for screening
WO1999064062A1 (fr) * 1998-06-08 1999-12-16 Pharmacia & Upjohn Ab Nouvelle utilisation therapeutique d'amplificateurs de l'activite de la proteine kinase b (picb)
ATE262347T1 (de) * 1999-11-23 2004-04-15 Regeneron Pharma Verfahren zur hemmung der atrophie oder förderung der hypertrophie
CZ2003555A3 (en) 2000-07-27 2004-03-17 F. Hoffmann-La Roche Ag 3-indolyl-4-phenyl-1h-pyrrole-2,5-dione derivatives as inhibitors of glycogen synthase kinase-3beta
AU2001287914A1 (en) * 2000-09-22 2002-04-02 University Of Dundee The Protein kinase regulation
IL144583A0 (en) 2001-07-26 2002-05-23 Peptor Ltd Chimeric protein kinase inhibitors
WO2003086279A2 (fr) 2002-04-08 2003-10-23 Merck & Co., Inc. Inhibiteurs de l'activite de akt
WO2003086404A1 (fr) 2002-04-08 2003-10-23 Merck & Co., Inc. Derives de quinolaxine fusionnee comme inhibiteurs de l'activite d'akt
CA2480880C (fr) 2002-04-08 2011-03-22 Merck & Co., Inc. Inhibiteurs de l'activite de akt
EP1496896A4 (fr) 2002-04-08 2007-10-31 Merck & Co Inc Inhibiteurs de l'activite akt
GB0213614D0 (en) 2002-06-13 2002-07-24 Novartis Forschungsstiftlung Z Purified PKB Kinae and uses thereof
DE60336576D1 (de) 2002-10-30 2011-05-12 Merck Sharp & Dohme Hemmer der akt aktivität
WO2004096131A2 (fr) 2003-04-24 2004-11-11 Merck & Co., Inc. Inhibiteurs de l'activite akt
WO2004096129A2 (fr) 2003-04-24 2004-11-11 Merck & Co., Inc. Inhibiteurs de l'activite de l'akt
US7638530B2 (en) 2003-04-24 2009-12-29 Merck & Co., Inc. Inhibitors of Akt activity
CN1809536A (zh) 2003-04-24 2006-07-26 麦克公司 Akt活性抑制剂
ES2400689T3 (es) 2004-10-18 2013-04-11 Amgen, Inc Compuestos de tiadiazol y métodos de uso
AU2008276521B2 (en) 2007-07-17 2011-11-03 Amgen Inc. Heterocyclic modulators of PKB
CA2693473A1 (fr) 2007-07-17 2009-01-22 Amgen Inc. Thiadiazoles modulateurs de l'activite de pkb
WO2009125798A1 (fr) * 2008-04-09 2009-10-15 萬有製薬株式会社 Procédé d'identification par criblage d'une substance pharmaceutique candidate pour le traitement du cancer par activation de la voie de signalisation hedgehog
JP7022746B2 (ja) 2016-10-24 2022-02-18 ノヴォ ノルディスク アー／エス インスリン製剤のためのバイオアッセイ

Also Published As

Publication number Publication date
EP0868195A2 (fr) 1998-10-07
AU1200497A (en) 1997-07-14
WO1997022360A2 (fr) 1997-06-26
JP2000502097A (ja) 2000-02-22
WO1997022360A3 (fr) 1997-07-31

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Publication Publication Date Title
CA2241080A1 (fr) Regulation de synthese de proteines et procede de criblage pour agents pharmaceutiques
Alessi et al. Mechanism of activation of protein kinase B by insulin and IGF‐1.
Kobayashi et al. Activation of serum-and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2
Woods et al. The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site
Casamayor et al. Phosphorylation of Ser-241 is essential for the activity of 3-phosphoinositide-dependent protein kinase-1: identification of five sites of phosphorylation in vivo
Alessi et al. Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase
FLEMING et al. Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7
Walker et al. Activation of protein kinase B β and γ isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B α
Stokoe et al. MAPKAP kinase‐2; a novel protein kinase activated by mitogen‐activated protein kinase.
Sutherland et al. Inactivation of glycogen synthase kinase-3 β by phosphorylation: new kinase connections in insulin and growth-factor signalling
Haribabu et al. Human calcium‐calmodulin dependent protein kinase I: cDNA cloning, domain structure and activation by phosphorylation at threonine‐177 by calcium‐calmodulin dependent protein kinase I kinase.
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Klippel et al. Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways
Douville et al. EGF induced SOS phosphorylation in PC12 cells involves P90 RSK-2
Kobayashi et al. Characterization of the structure and regulation of two novel isoforms of serum-and glucocorticoid-induced protein kinase
Ben‐Levy et al. Identification of novel phosphorylation sites required for activation of MAPKAP kinase‐2.
Kanematsu et al. A new inositol 1, 4, 5-trisphosphate binding protein similar to phospholipase C-δ1
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SCHMITZ-PEIFFER et al. Activated protein kinase C α associates with annexin VI from skeletal muscle
US20070196883A1 (en) Enzyme
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