CA2239296A1 - Glyconconjugues comme inhibiteurs d'adherence cellulaire virale - Google Patents

Glyconconjugues comme inhibiteurs d'adherence cellulaire virale Download PDF

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Publication number
CA2239296A1
CA2239296A1 CA 2239296 CA2239296A CA2239296A1 CA 2239296 A1 CA2239296 A1 CA 2239296A1 CA 2239296 CA2239296 CA 2239296 CA 2239296 A CA2239296 A CA 2239296A CA 2239296 A1 CA2239296 A1 CA 2239296A1
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Canada
Prior art keywords
compounds
formula
accordance
substituted
bonding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA 2239296
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English (en)
Inventor
Mikhail Matrosovich
Nikolai Bovin
Alexandr Tuzikov
Alexandr Chinarev
James Robertson
Alexandra Gambarian
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntesome Gesellschaft fur Med Biochemie Mbh
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Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19640791A external-priority patent/DE19640791A1/de
Application filed by Individual filed Critical Individual
Publication of CA2239296A1 publication Critical patent/CA2239296A1/fr
Abandoned legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)

Abstract

L'adhérence de virus humains de la grippe à des cellules hôte est inhibée par de nouveaux composés de la formule générale (1), où R?1¿ représente un acyle ou un groupe thioacyle; R?2¿ représente hydroxyle, Z-alkyle, Z-alkyle substitué, Z-aryle, Z-aryle substitué et où Z correspond à O, S ou NH; R?3¿ représente un acyle ou un groupe thioacyle; R?4¿ représente H ou acyl; X représente O, S, SH¿2? ou un sucre; W est un espaceur bifonctionnel; P est un vecteur multivalent constitué de l'une des substances suivantes: polyacrylate, polyacrylamide, polyacrylamide substitué en N, métacrylamide, métalcrylamide substitué en N, acide polyacryle, polycarbonate, polyester, polyamide, polyanhydride, polyiminocarbonate, polyorthoester, polydioxanone, polyphosphazène, acide carboxylique polyhydroxy, acide polyaminé, polysaccharide, protéine, dextrane, chitosane, glucane, liposome, microparticules. Les nouveaux composés en question ont la propriété de lier d'authentiques virus humains des groupes A (H1 et H3) et B, non adaptés par culture dans des oeufs de poules.
CA 2239296 1996-10-02 1997-10-01 Glyconconjugues comme inhibiteurs d'adherence cellulaire virale Abandoned CA2239296A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19640791.5 1996-10-02
DE19640791A DE19640791A1 (de) 1996-10-02 1996-10-02 Glycokonjugate als Inhibitoren der viralen Zelladhäsion
PCT/EP1997/005389 WO1998014215A2 (fr) 1996-10-02 1997-10-01 Glyconconjugues comme inhibiteurs d'adherence cellulaire virale

Publications (1)

Publication Number Publication Date
CA2239296A1 true CA2239296A1 (fr) 1998-04-09

Family

ID=29403686

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2239296 Abandoned CA2239296A1 (fr) 1996-10-02 1997-10-01 Glyconconjugues comme inhibiteurs d'adherence cellulaire virale

Country Status (1)

Country Link
CA (1) CA2239296A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100168366A1 (en) * 2007-06-28 2010-07-01 Shizuoka Prefectural Universities Corporation Novel synthetic n-linked sialo-glycan-containing polymer and method for producing the same

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100168366A1 (en) * 2007-06-28 2010-07-01 Shizuoka Prefectural Universities Corporation Novel synthetic n-linked sialo-glycan-containing polymer and method for producing the same
US8450441B2 (en) 2007-06-28 2013-05-28 National University Corporation Shizuoka University Synthetic N-linked sialo-glycan-containing polymer and method for producing the same

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