CA2239018C - Measurement of gastric emptying - Google Patents
Measurement of gastric emptying Download PDFInfo
- Publication number
- CA2239018C CA2239018C CA002239018A CA2239018A CA2239018C CA 2239018 C CA2239018 C CA 2239018C CA 002239018 A CA002239018 A CA 002239018A CA 2239018 A CA2239018 A CA 2239018A CA 2239018 C CA2239018 C CA 2239018C
- Authority
- CA
- Canada
- Prior art keywords
- labeled
- biscuit
- uniformly
- patient
- food
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000030136 gastric emptying Effects 0.000 title claims abstract description 18
- 238000005259 measurement Methods 0.000 title claims abstract description 8
- 235000015895 biscuits Nutrition 0.000 claims abstract description 17
- 240000002900 Arthrospira platensis Species 0.000 claims abstract description 8
- 235000016425 Arthrospira platensis Nutrition 0.000 claims abstract description 8
- 210000000813 small intestine Anatomy 0.000 claims abstract description 6
- 238000000034 method Methods 0.000 claims description 16
- 235000013305 food Nutrition 0.000 claims description 12
- 238000012360 testing method Methods 0.000 claims description 8
- 230000000243 photosynthetic effect Effects 0.000 claims description 5
- 235000018102 proteins Nutrition 0.000 claims description 5
- 102000004169 proteins and genes Human genes 0.000 claims description 5
- 108090000623 proteins and genes Proteins 0.000 claims description 5
- 235000014633 carbohydrates Nutrition 0.000 claims description 4
- 150000001720 carbohydrates Chemical class 0.000 claims description 4
- 239000003925 fat Substances 0.000 claims 4
- 230000037406 food intake Effects 0.000 claims 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 108010001949 Algal Proteins Proteins 0.000 claims 1
- 235000015097 nutrients Nutrition 0.000 claims 1
- 230000000737 periodic effect Effects 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 abstract description 4
- 230000029087 digestion Effects 0.000 abstract description 2
- 239000007790 solid phase Substances 0.000 description 9
- 210000002784 stomach Anatomy 0.000 description 8
- 239000007791 liquid phase Substances 0.000 description 7
- 235000012054 meals Nutrition 0.000 description 7
- 239000000700 radioactive tracer Substances 0.000 description 7
- 239000007788 liquid Substances 0.000 description 5
- 235000013312 flour Nutrition 0.000 description 4
- 210000004051 gastric juice Anatomy 0.000 description 4
- 239000003550 marker Substances 0.000 description 4
- 239000002245 particle Substances 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- 102000002322 Egg Proteins Human genes 0.000 description 3
- 108010000912 Egg Proteins Proteins 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 208000035475 disorder Diseases 0.000 description 3
- 235000019197 fats Nutrition 0.000 description 3
- 235000015203 fruit juice Nutrition 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 235000007265 Myrrhis odorata Nutrition 0.000 description 2
- 240000004760 Pimpinella anisum Species 0.000 description 2
- 235000012550 Pimpinella anisum Nutrition 0.000 description 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 235000013351 cheese Nutrition 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 230000003111 delayed effect Effects 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 210000002969 egg yolk Anatomy 0.000 description 2
- 235000013345 egg yolk Nutrition 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 235000013379 molasses Nutrition 0.000 description 2
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 2
- 239000012071 phase Substances 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000002285 radioactive effect Effects 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 235000021055 solid food Nutrition 0.000 description 2
- 229940082787 spirulina Drugs 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- YSGQGNQWBLYHPE-CFUSNLFHSA-N (7r,8r,9s,10r,13s,14s,17s)-17-hydroxy-7,13-dimethyl-2,6,7,8,9,10,11,12,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-3-one Chemical compound C1C[C@]2(C)[C@@H](O)CC[C@H]2[C@@H]2[C@H](C)CC3=CC(=O)CC[C@@H]3[C@H]21 YSGQGNQWBLYHPE-CFUSNLFHSA-N 0.000 description 1
- QCVGEOXPDFCNHA-UHFFFAOYSA-N 5,5-dimethyl-2,4-dioxo-1,3-oxazolidine-3-carboxamide Chemical compound CC1(C)OC(=O)N(C(N)=O)C1=O QCVGEOXPDFCNHA-UHFFFAOYSA-N 0.000 description 1
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- 206010000060 Abdominal distension Diseases 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 208000018522 Gastrointestinal disease Diseases 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 206010021518 Impaired gastric emptying Diseases 0.000 description 1
- 102000004895 Lipoproteins Human genes 0.000 description 1
- 108090001030 Lipoproteins Proteins 0.000 description 1
- 101150054830 S100A6 gene Proteins 0.000 description 1
- 102000007562 Serum Albumin Human genes 0.000 description 1
- 108010071390 Serum Albumin Proteins 0.000 description 1
- 241000209140 Triticum Species 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 240000000359 Triticum dicoccon Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- OBETXYAYXDNJHR-UHFFFAOYSA-N alpha-ethylcaproic acid Natural products CCCCC(CC)C(O)=O OBETXYAYXDNJHR-UHFFFAOYSA-N 0.000 description 1
- 235000015278 beef Nutrition 0.000 description 1
- 208000024330 bloating Diseases 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 239000002771 cell marker Substances 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 235000014103 egg white Nutrition 0.000 description 1
- 210000000969 egg white Anatomy 0.000 description 1
- 235000013601 eggs Nutrition 0.000 description 1
- 238000001976 enzyme digestion Methods 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 229920002457 flexible plastic Polymers 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 230000005251 gamma ray Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 238000009206 nuclear medicine Methods 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 235000021400 peanut butter Nutrition 0.000 description 1
- 210000001187 pylorus Anatomy 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 235000011888 snacks Nutrition 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 210000005070 sphincter Anatomy 0.000 description 1
- 235000013547 stew Nutrition 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
- A61K51/1206—Administration of radioactive gases, aerosols or breath tests
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Optics & Photonics (AREA)
- Atmospheric Sciences (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/619,140 US5707602A (en) | 1996-03-25 | 1996-03-25 | Measurement of gastric emptying |
| US08/619,140 | 1996-03-25 | ||
| PCT/US1997/000486 WO1997035622A1 (en) | 1996-03-25 | 1997-01-10 | Measurement of gastric emptying |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2239018A1 CA2239018A1 (en) | 1997-10-02 |
| CA2239018C true CA2239018C (en) | 2001-05-08 |
Family
ID=24480631
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002239018A Expired - Lifetime CA2239018C (en) | 1996-03-25 | 1997-01-10 | Measurement of gastric emptying |
Country Status (9)
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU6631296A (en) * | 1995-08-08 | 1997-03-05 | Otsuka Pharmaceutical Co., Ltd. | Diagnostic and diagnosis method for central nervous abnormality and phenylketonuria |
| US5785949A (en) * | 1996-09-05 | 1998-07-28 | Meretek Diagnostics | Measurement of liquid phase gastric emptying |
| US6284219B1 (en) | 1998-06-30 | 2001-09-04 | Phenome Sciences Inc. | In vivo determination of metabolic function for use in therapy management |
| US6740305B1 (en) * | 1999-04-09 | 2004-05-25 | Xanthus Life Scienes, Inc. | Assessment of gastric emptying disorders |
| US6548043B1 (en) | 1999-08-03 | 2003-04-15 | Metabolic Solutions, Inc. | Measurement of gastric emptying |
| GB2360845A (en) * | 2000-03-27 | 2001-10-03 | Leuven K U Res & Dev | Measuring gastric emptying |
| CA2409223A1 (en) * | 2000-05-02 | 2002-11-18 | Otsuka Pharmaceutical Co., Ltd. | Preparations for evaluating eliminative ability of stomach |
| US6432382B1 (en) | 2000-10-20 | 2002-08-13 | The Nemours Foundation | Measurement of gastric emptying using stable isotopes |
| GB0103097D0 (en) * | 2001-02-08 | 2001-03-28 | Univ Dundee | Gastric emptying |
| US6797256B2 (en) * | 2001-03-13 | 2004-09-28 | Otsuka Pharmaceutical Co. Ltd. | Composition for determining pyrimidine metabolizing activity |
| ES2375123T3 (es) * | 2002-05-10 | 2012-02-27 | Advanced Breath Diagnostics, Llc | Alimento comestible liofilizado que incorpora un marcador. |
| US8178315B2 (en) * | 2002-05-10 | 2012-05-15 | Advanced Breath Diagnostics, Llc | Lyophilized edible food incorporating a marker and methods of making |
| EP1536841A1 (en) * | 2002-09-12 | 2005-06-08 | The University of Chicago | Monitoring and diagnosis of gastric emptying and gastroparesis |
| ATE368478T1 (de) * | 2002-10-26 | 2007-08-15 | Infai Inst Fuer Biomedizinisch | Verfahren zur bestimmung der magenentleerung mit einer 13c-markierten testmahlze |
| US6872516B2 (en) * | 2003-04-16 | 2005-03-29 | Advanced Breath Diagnostics, Llc | Methods of producing carbon-13 labeled biomass |
| US20070014718A1 (en) | 2005-04-01 | 2007-01-18 | Atomic Energy Council - Institute Of Nuclear Energy Research | Kits for gastric emptying measurement |
| RU2429883C2 (ru) * | 2005-07-25 | 2011-09-27 | Оцука Фармасьютикал Ко., Лтд. | Композиция для перорального приема, эффективная в оценке способности метаболизировать пиридин |
| ES2488412T3 (es) | 2006-04-13 | 2014-08-27 | Otsuka Pharmaceutical Co., Ltd. | Agente de ensayo para el diagnóstico de la dispepsia |
| US8317718B2 (en) * | 2007-05-10 | 2012-11-27 | Advanced Breath Diagnostics, Llc | Methods of testing digestive functions using both a breath test and a scintigraphy test, and methods of using a breath test as an overall digestive health assessment |
| EP2152159A4 (en) * | 2007-05-10 | 2014-05-28 | Advanced Breath Diagnostics Llc | METHOD AND SYSTEMS FOR THE EVALUATION OF MAGENTAL EMISSIONS |
| AU2009257513B2 (en) * | 2008-06-10 | 2014-07-03 | Advanced Breath Diagnostics, Llc | Fluid bed meal containing a marker and methods of making |
| LT5613B (lt) * | 2009-03-16 | 2009-11-25 | Vytas Rimkus | Sausas, birus pašarinis priedas su melsvadumbliu spirulina platensis |
| US10228365B2 (en) | 2012-08-20 | 2019-03-12 | Otsuka Pharmaceutical Co., Ltd. | Method for measuring carbohydrate metabolism ability, and composition for use in said method |
| US10772534B2 (en) | 2013-03-13 | 2020-09-15 | Advanced Breath Diagnostics, Llc | Single-point gastric emptying breath tests |
| CN105051533B (zh) | 2013-03-15 | 2019-03-26 | 大塚制药株式会社 | 基于脂肪酸燃烧的测定胰岛素抵抗性的方法及用于该方法的组合物 |
| US11134883B2 (en) * | 2013-06-25 | 2021-10-05 | Advanced Breath Diagnostics, Llc | Gastric emptying breath tests |
| EP3223688B1 (en) * | 2014-11-26 | 2019-04-24 | ART Healthcare Ltd. | Closed loop system and method for optimal enteral feeding and a personalized nutrition plan |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR241633A1 (es) * | 1982-12-30 | 1992-10-30 | Goemar Lab Sa | Procedimiento para la preparacion de un extracto fisiologico de algas o plantas. |
| US5164308A (en) * | 1990-05-21 | 1992-11-17 | Martek Corporation | Preparation of labelled triglyceride oils by cultivation of microorganisms |
| US5233997A (en) * | 1991-04-04 | 1993-08-10 | Baylor College Of Medicine | Non-invasive measure of intestinal transit time and uses thereof |
| US5140993A (en) * | 1991-12-27 | 1992-08-25 | Baylor College Of Medicine | Device for collecting a breath sample |
| US5785949A (en) * | 1996-09-05 | 1998-07-28 | Meretek Diagnostics | Measurement of liquid phase gastric emptying |
-
1996
- 1996-03-25 US US08/619,140 patent/US5707602A/en not_active Expired - Lifetime
-
1997
- 1997-01-10 EP EP97902912A patent/EP0889739B1/en not_active Expired - Lifetime
- 1997-01-10 JP JP53437297A patent/JP4271261B2/ja not_active Expired - Lifetime
- 1997-01-10 CA CA002239018A patent/CA2239018C/en not_active Expired - Lifetime
- 1997-01-10 ES ES97902912T patent/ES2281909T3/es not_active Expired - Lifetime
- 1997-01-10 AT AT97902912T patent/ATE355086T1/de not_active IP Right Cessation
- 1997-01-10 AU AU16975/97A patent/AU708697B2/en not_active Expired
- 1997-01-10 WO PCT/US1997/000486 patent/WO1997035622A1/en active IP Right Grant
- 1997-01-10 DE DE69737412T patent/DE69737412T2/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US5707602A (en) | 1998-01-13 |
| EP0889739A4 (en) | 2004-05-06 |
| DE69737412T2 (de) | 2007-11-29 |
| EP0889739A1 (en) | 1999-01-13 |
| AU1697597A (en) | 1997-10-17 |
| JP4271261B2 (ja) | 2009-06-03 |
| JP2000507264A (ja) | 2000-06-13 |
| ES2281909T3 (es) | 2007-10-01 |
| DE69737412D1 (de) | 2007-04-12 |
| WO1997035622A1 (en) | 1997-10-02 |
| EP0889739B1 (en) | 2007-02-28 |
| CA2239018A1 (en) | 1997-10-02 |
| ATE355086T1 (de) | 2006-03-15 |
| AU708697B2 (en) | 1999-08-12 |
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| Publication | Publication Date | Title |
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| CA2239018C (en) | Measurement of gastric emptying | |
| US5785949A (en) | Measurement of liquid phase gastric emptying | |
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| Choi et al. | [13C] octanoic acid breath test for gastric emptying of solids: accuracy, reproducibility, and comparison with scintigraphy | |
| Tougas et al. | Assessment of gastric emptying using a low fat meal: establishment of international control values | |
| Bromer et al. | Simultaneous measurement of gastric emptying with a simple muffin meal using [13C] octanoate breath test and scintigraphy in normal subjects and patients with dyspeptic symptoms | |
| JP5539791B2 (ja) | マーカーを組み込んだ凍結乾燥食品 | |
| US6548043B1 (en) | Measurement of gastric emptying | |
| GB2360845A (en) | Measuring gastric emptying | |
| US8317718B2 (en) | Methods of testing digestive functions using both a breath test and a scintigraphy test, and methods of using a breath test as an overall digestive health assessment | |
| US20070014718A1 (en) | Kits for gastric emptying measurement | |
| Harris et al. | Breath tests for the assessment of gastroparesis | |
| Kim et al. | Stable isotope breath test and gastric emptying | |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKEX | Expiry |
Effective date: 20170110 |