CA2233328A1 - Helicobacter pylori protein - Google Patents
Helicobacter pylori protein Download PDFInfo
- Publication number
- CA2233328A1 CA2233328A1 CA002233328A CA2233328A CA2233328A1 CA 2233328 A1 CA2233328 A1 CA 2233328A1 CA 002233328 A CA002233328 A CA 002233328A CA 2233328 A CA2233328 A CA 2233328A CA 2233328 A1 CA2233328 A1 CA 2233328A1
- Authority
- CA
- Canada
- Prior art keywords
- pylori
- coccoid
- antigenic protein
- spiral
- coccoids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 108090000623 proteins and genes Proteins 0.000 title claims abstract description 54
- 102000004169 proteins and genes Human genes 0.000 title claims abstract description 54
- 241000590002 Helicobacter pylori Species 0.000 title description 4
- 229940037467 helicobacter pylori Drugs 0.000 title description 2
- 238000000034 method Methods 0.000 claims abstract description 38
- 230000000890 antigenic effect Effects 0.000 claims abstract description 22
- 229960005486 vaccine Drugs 0.000 claims abstract description 10
- 238000002360 preparation method Methods 0.000 claims abstract description 7
- 238000012258 culturing Methods 0.000 claims abstract description 5
- 239000000427 antigen Substances 0.000 claims description 52
- 102000036639 antigens Human genes 0.000 claims description 52
- 108091007433 antigens Proteins 0.000 claims description 52
- 239000000523 sample Substances 0.000 claims description 20
- 238000001514 detection method Methods 0.000 claims description 15
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 14
- 208000015181 infectious disease Diseases 0.000 claims description 13
- 239000012472 biological sample Substances 0.000 claims description 11
- 238000006243 chemical reaction Methods 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 10
- 238000003745 diagnosis Methods 0.000 claims description 9
- 210000004369 blood Anatomy 0.000 claims description 8
- 239000008280 blood Substances 0.000 claims description 8
- 229910002092 carbon dioxide Inorganic materials 0.000 claims description 7
- 239000001569 carbon dioxide Substances 0.000 claims description 6
- 238000001426 native polyacrylamide gel electrophoresis Methods 0.000 claims description 6
- 238000011282 treatment Methods 0.000 claims description 6
- 239000001963 growth medium Substances 0.000 claims description 5
- 210000003296 saliva Anatomy 0.000 claims description 5
- 210000002700 urine Anatomy 0.000 claims description 5
- 125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 claims description 2
- 239000002671 adjuvant Substances 0.000 claims description 2
- 239000000969 carrier Substances 0.000 claims description 2
- 238000011321 prophylaxis Methods 0.000 claims description 2
- 108010046334 Urease Proteins 0.000 description 23
- 210000004027 cell Anatomy 0.000 description 22
- 230000000694 effects Effects 0.000 description 16
- 230000004083 survival effect Effects 0.000 description 12
- 150000004676 glycans Chemical class 0.000 description 11
- 229920001282 polysaccharide Polymers 0.000 description 11
- 239000005017 polysaccharide Substances 0.000 description 11
- 238000012360 testing method Methods 0.000 description 10
- 238000010186 staining Methods 0.000 description 9
- 241000894006 Bacteria Species 0.000 description 8
- 102000004190 Enzymes Human genes 0.000 description 8
- 108090000790 Enzymes Proteins 0.000 description 8
- 210000003495 flagella Anatomy 0.000 description 8
- 210000002966 serum Anatomy 0.000 description 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
- 238000003556 assay Methods 0.000 description 6
- 210000003743 erythrocyte Anatomy 0.000 description 6
- 230000035931 haemagglutination Effects 0.000 description 6
- 238000002965 ELISA Methods 0.000 description 5
- 108010040721 Flagellin Proteins 0.000 description 5
- 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 description 5
- 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 description 5
- 210000000805 cytoplasm Anatomy 0.000 description 5
- 230000003247 decreasing effect Effects 0.000 description 5
- 239000000499 gel Substances 0.000 description 5
- 239000003550 marker Substances 0.000 description 5
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 5
- 230000001360 synchronised effect Effects 0.000 description 5
- 230000005526 G1 to G0 transition Effects 0.000 description 4
- 241000283973 Oryctolagus cuniculus Species 0.000 description 4
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 4
- 230000002411 adverse Effects 0.000 description 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 4
- 230000001580 bacterial effect Effects 0.000 description 4
- 229910052760 oxygen Inorganic materials 0.000 description 4
- 239000001301 oxygen Substances 0.000 description 4
- 238000002264 polyacrylamide gel electrophoresis Methods 0.000 description 4
- 238000004627 transmission electron microscopy Methods 0.000 description 4
- 108091005804 Peptidases Proteins 0.000 description 3
- 229920000388 Polyphosphate Polymers 0.000 description 3
- 239000004365 Protease Substances 0.000 description 3
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 239000006161 blood agar Substances 0.000 description 3
- 235000019219 chocolate Nutrition 0.000 description 3
- 230000007423 decrease Effects 0.000 description 3
- 238000002405 diagnostic procedure Methods 0.000 description 3
- 230000007613 environmental effect Effects 0.000 description 3
- 239000002054 inoculum Substances 0.000 description 3
- 230000004899 motility Effects 0.000 description 3
- 235000015097 nutrients Nutrition 0.000 description 3
- KHIWWQKSHDUIBK-UHFFFAOYSA-N periodic acid Chemical class OI(=O)(=O)=O KHIWWQKSHDUIBK-UHFFFAOYSA-N 0.000 description 3
- 238000002135 phase contrast microscopy Methods 0.000 description 3
- 239000002953 phosphate buffered saline Substances 0.000 description 3
- 239000001205 polyphosphate Substances 0.000 description 3
- 235000011176 polyphosphates Nutrition 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 239000004382 Amylase Substances 0.000 description 2
- 102000013142 Amylases Human genes 0.000 description 2
- 108010065511 Amylases Proteins 0.000 description 2
- 241001288393 Belgica Species 0.000 description 2
- 102000016938 Catalase Human genes 0.000 description 2
- 108010053835 Catalase Proteins 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- 238000003794 Gram staining Methods 0.000 description 2
- 102000004316 Oxidoreductases Human genes 0.000 description 2
- 108090000854 Oxidoreductases Proteins 0.000 description 2
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 2
- 238000003917 TEM image Methods 0.000 description 2
- IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 241000607598 Vibrio Species 0.000 description 2
- 239000008186 active pharmaceutical agent Substances 0.000 description 2
- 235000019418 amylase Nutrition 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 2
- 230000022131 cell cycle Effects 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 230000034994 death Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 201000006549 dyspepsia Diseases 0.000 description 2
- 210000003608 fece Anatomy 0.000 description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 235000003642 hunger Nutrition 0.000 description 2
- 230000028993 immune response Effects 0.000 description 2
- 230000002163 immunogen Effects 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 239000002609 medium Substances 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 238000000386 microscopy Methods 0.000 description 2
- 238000005497 microtitration Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000000877 morphologic effect Effects 0.000 description 2
- 230000035772 mutation Effects 0.000 description 2
- 230000007170 pathology Effects 0.000 description 2
- 239000008188 pellet Substances 0.000 description 2
- 238000004393 prognosis Methods 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 229910052709 silver Inorganic materials 0.000 description 2
- 239000004332 silver Substances 0.000 description 2
- 238000002798 spectrophotometry method Methods 0.000 description 2
- 230000037351 starvation Effects 0.000 description 2
- 230000035899 viability Effects 0.000 description 2
- PORCFLIWCKPHRW-DKWTVANSSA-N (2r)-2-amino-3-sulfanylpropanoic acid;sulfuric acid Chemical compound OS(O)(=O)=O.SC[C@H](N)C(O)=O PORCFLIWCKPHRW-DKWTVANSSA-N 0.000 description 1
- 208000002109 Argyria Diseases 0.000 description 1
- DWRXFEITVBNRMK-UHFFFAOYSA-N Beta-D-1-Arabinofuranosylthymine Natural products O=C1NC(=O)C(C)=CN1C1C(O)C(O)C(CO)O1 DWRXFEITVBNRMK-UHFFFAOYSA-N 0.000 description 1
- RZZPDXZPRHQOCG-OJAKKHQRSA-O CDP-choline(1+) Chemical compound O[C@@H]1[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OCC[N+](C)(C)C)O[C@H]1N1C(=O)N=C(N)C=C1 RZZPDXZPRHQOCG-OJAKKHQRSA-O 0.000 description 1
- 241000589875 Campylobacter jejuni Species 0.000 description 1
- 241000283707 Capra Species 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 238000007400 DNA extraction Methods 0.000 description 1
- 238000009007 Diagnostic Kit Methods 0.000 description 1
- 208000007882 Gastritis Diseases 0.000 description 1
- 102100035964 Gastrokine-2 Human genes 0.000 description 1
- 101710205776 Gastrokine-2 Proteins 0.000 description 1
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
- 238000003231 Lowry assay Methods 0.000 description 1
- 238000009013 Lowry's assay Methods 0.000 description 1
- 102000018697 Membrane Proteins Human genes 0.000 description 1
- 108010052285 Membrane Proteins Proteins 0.000 description 1
- 241000224453 Mycoplasma coccoides Species 0.000 description 1
- 241000013355 Mycteroperca interstitialis Species 0.000 description 1
- 241000863422 Myxococcus xanthus Species 0.000 description 1
- 102000005348 Neuraminidase Human genes 0.000 description 1
- 108010006232 Neuraminidase Proteins 0.000 description 1
- 208000008469 Peptic Ulcer Diseases 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 108010059712 Pronase Proteins 0.000 description 1
- 229940096437 Protein S Drugs 0.000 description 1
- 102000029301 Protein S Human genes 0.000 description 1
- 108010066124 Protein S Proteins 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 241000607626 Vibrio cholerae Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- QPMSXSBEVQLBIL-CZRHPSIPSA-N ac1mix0p Chemical compound C1=CC=C2N(C[C@H](C)CN(C)C)C3=CC(OC)=CC=C3SC2=C1.O([C@H]1[C@]2(OC)C=CC34C[C@@H]2[C@](C)(O)CCC)C2=C5[C@]41CCN(C)[C@@H]3CC5=CC=C2O QPMSXSBEVQLBIL-CZRHPSIPSA-N 0.000 description 1
- 230000008649 adaptation response Effects 0.000 description 1
- 239000011543 agarose gel Substances 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 238000003149 assay kit Methods 0.000 description 1
- 230000000721 bacterilogical effect Effects 0.000 description 1
- IQFYYKKMVGJFEH-UHFFFAOYSA-N beta-L-thymidine Natural products O=C1NC(=O)C(C)=CN1C1OC(CO)C(O)C1 IQFYYKKMVGJFEH-UHFFFAOYSA-N 0.000 description 1
- SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 description 1
- 238000010256 biochemical assay Methods 0.000 description 1
- 230000029918 bioluminescence Effects 0.000 description 1
- 238000005415 bioluminescence Methods 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 229940041514 candida albicans extract Drugs 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 238000012511 carbohydrate analysis Methods 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000030833 cell death Effects 0.000 description 1
- 230000006037 cell lysis Effects 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 210000003850 cellular structure Anatomy 0.000 description 1
- 239000013611 chromosomal DNA Substances 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 230000001086 cytosolic effect Effects 0.000 description 1
- 230000003412 degenerative effect Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
- 230000005059 dormancy Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000004134 energy conservation Methods 0.000 description 1
- 238000006911 enzymatic reaction Methods 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 125000003630 glycyl group Chemical class [H]N([H])C([H])([H])C(*)=O 0.000 description 1
- 230000001492 haemagglutinating effect Effects 0.000 description 1
- 125000001475 halogen functional group Chemical group 0.000 description 1
- 238000003119 immunoblot Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 229910052816 inorganic phosphate Inorganic materials 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 238000003771 laboratory diagnosis Methods 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- FDZZZRQASAIRJF-UHFFFAOYSA-M malachite green Chemical compound [Cl-].C1=CC(N(C)C)=CC=C1C(C=1C=CC=CC=1)=C1C=CC(=[N+](C)C)C=C1 FDZZZRQASAIRJF-UHFFFAOYSA-M 0.000 description 1
- 229940107698 malachite green Drugs 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 238000010369 molecular cloning Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 230000004660 morphological change Effects 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 238000010979 pH adjustment Methods 0.000 description 1
- 208000011906 peptic ulcer disease Diseases 0.000 description 1
- IYDGMDWEHDFVQI-UHFFFAOYSA-N phosphoric acid;trioxotungsten Chemical compound O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.O=[W](=O)=O.OP(O)(O)=O IYDGMDWEHDFVQI-UHFFFAOYSA-N 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 238000003752 polymerase chain reaction Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000017854 proteolysis Effects 0.000 description 1
- 238000012134 rapid urease test Methods 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-L sulfite Chemical compound [O-]S([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-L 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 229940104230 thymidine Drugs 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 229940118696 vibrio cholerae Drugs 0.000 description 1
- 238000001262 western blot Methods 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/205—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Campylobacter (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K2039/106—Vibrio; Campylobacter; Not used, see subgroups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9519865.1A GB9519865D0 (en) | 1995-09-29 | 1995-09-29 | Protein |
| GB9519865.1 | 1995-09-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2233328A1 true CA2233328A1 (en) | 1997-04-10 |
Family
ID=10781468
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002233328A Abandoned CA2233328A1 (en) | 1995-09-29 | 1996-09-27 | Helicobacter pylori protein |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP0859788A1 (xx) |
| JP (1) | JP2000500123A (xx) |
| KR (1) | KR19990063833A (xx) |
| CN (1) | CN1201464A (xx) |
| AU (1) | AU7137896A (xx) |
| BR (1) | BR9610953A (xx) |
| CA (1) | CA2233328A1 (xx) |
| GB (1) | GB9519865D0 (xx) |
| NO (1) | NO981407L (xx) |
| WO (1) | WO1997012910A1 (xx) |
| ZA (1) | ZA968185B (xx) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6599509B2 (en) * | 1997-09-02 | 2003-07-29 | Massachusetts Institute Of Technology | Compositions and methods comprising helicobacter antigens for treatment and prevention of inflammatory bowel disease |
| MY120554A (en) * | 1997-10-29 | 2005-11-30 | Honda Motor Co Ltd | Valve operating system in internal combustion engine |
| IT1299312B1 (it) * | 1998-02-13 | 2000-03-16 | Consortia Lab Srl | Dosaggio nei liquidi biologici di anticorpi diretti contro uno o piu' antigeni del helicobacter pylori mediante metodo immunologico |
| GB9806039D0 (en) * | 1998-03-20 | 1998-05-20 | Cortecs Ltd | Therapy |
| KR101600867B1 (ko) * | 2008-06-03 | 2016-03-10 | 삼성전자주식회사 | 냉장고 |
-
1995
- 1995-09-29 GB GBGB9519865.1A patent/GB9519865D0/en active Pending
-
1996
- 1996-09-27 EP EP96932692A patent/EP0859788A1/en not_active Withdrawn
- 1996-09-27 JP JP9514063A patent/JP2000500123A/ja active Pending
- 1996-09-27 WO PCT/GB1996/002404 patent/WO1997012910A1/en not_active Application Discontinuation
- 1996-09-27 BR BR9610953-0A patent/BR9610953A/pt not_active Application Discontinuation
- 1996-09-27 ZA ZA9608185A patent/ZA968185B/xx unknown
- 1996-09-27 KR KR1019980702303A patent/KR19990063833A/ko not_active Application Discontinuation
- 1996-09-27 AU AU71378/96A patent/AU7137896A/en not_active Abandoned
- 1996-09-27 CN CN96198105A patent/CN1201464A/zh active Pending
- 1996-09-27 CA CA002233328A patent/CA2233328A1/en not_active Abandoned
-
1998
- 1998-03-27 NO NO981407A patent/NO981407L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU7137896A (en) | 1997-04-28 |
| MX9802486A (es) | 1998-10-31 |
| KR19990063833A (ko) | 1999-07-26 |
| CN1201464A (zh) | 1998-12-09 |
| EP0859788A1 (en) | 1998-08-26 |
| BR9610953A (pt) | 1999-12-21 |
| NO981407L (no) | 1998-05-28 |
| GB9519865D0 (en) | 1995-11-29 |
| ZA968185B (en) | 1998-03-27 |
| NO981407D0 (no) | 1998-03-27 |
| WO1997012910A1 (en) | 1997-04-10 |
| JP2000500123A (ja) | 2000-01-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Elphinstone et al. | Sensitivity of different methods for the detection of Ralstonia solanacearum in potato tuber extracts | |
| Moxon et al. | The role of Haemophilus influenzae in the pathogenesis of pneumonia | |
| Onderdonk et al. | Adherence of Bacteroides fragilis in vivo | |
| Cole et al. | Characterization of mycoplasma strains from cats | |
| Tacker et al. | Intracellular fate of Cryptococcus neoformans | |
| Lawson et al. | The characterisation of Campylobacter sputorum subspecies mucosalis isolated from pigs | |
| Morse et al. | The biology of the gonococcus | |
| Somerville et al. | Urea-mercaptoethanol-soluble protein from spores of Bacillus thuringiensis and other species | |
| Li et al. | Chicken egg yolk antibody (IgY) controls Solobacterium moorei under in vitro and in vivo conditions | |
| CA2233328A1 (en) | Helicobacter pylori protein | |
| Alfa et al. | Haemophilus ducreyi adheres to but does not invade cultured human foreskin cells | |
| Reid et al. | Pathogenesis of urinary tract infection in the elderly: the role of bacterial adherence to uroepithelial cells | |
| Senson et al. | Production of the 57 kDa major surface antigen by a non-agglutinating strain of the fish pathogen Renibacterium salmoninarum | |
| Dom et al. | NAD-independent Actinobacillus pleuropneumoniae strains: production of RTX toxins and interactions with porcine phagocytes | |
| US6884412B1 (en) | Dectection of and methods and composition for prevention and/or treatment of papillomatous digital dermatitis | |
| EP1481666A1 (en) | A composition for re-establishment of the vaginal ecosystem | |
| FI65166C (fi) | Foerfarande foer framstaellning av heterovaccin mot trichomonas-syndrom | |
| FR2871237A1 (fr) | Nouveaux polypeptides pour la mise en evidence in vitro et la prevention des infections staphylococciques sur protheses articulaires et autres materiels etrangers implantes | |
| MXPA98002486A (en) | Helicobacter pyl protein | |
| Chart et al. | Outer membrane characteristics of Campylobacter jejuni grown in chickens | |
| Smith et al. | Comparative characteristics of human and porcine staphylococci and their differentiation in burn xenografting procedures | |
| GUTKIND et al. | Penicillin‐binding proteins in Listeria monocytogenes | |
| Shanahan et al. | Further studies on the morphology of Escherichia coli exposed to penicillin | |
| Dokter et al. | Production of quinoprotein D-glucose dehydrogenase in the culture medium of Acinetobacter calcoaceticus | |
| Jin et al. | Urease activity related to the growth and differentiation of swarmer cells of Proteus mirabilis |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |