CA2228844A1 - Biological fluid analysis using distance outlier detection - Google Patents

Biological fluid analysis using distance outlier detection

Info

Publication number
CA2228844A1
CA2228844A1 CA002228844A CA2228844A CA2228844A1 CA 2228844 A1 CA2228844 A1 CA 2228844A1 CA 002228844 A CA002228844 A CA 002228844A CA 2228844 A CA2228844 A CA 2228844A CA 2228844 A1 CA2228844 A1 CA 2228844A1
Authority
CA
Canada
Prior art keywords
data
calibration
outliers
biological fluid
remove
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002228844A
Other languages
French (fr)
Other versions
CA2228844C (en
Inventor
John F. Price
James R. Long
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics Operations Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/587,017 external-priority patent/US5606164A/en
Application filed by Individual filed Critical Individual
Publication of CA2228844A1 publication Critical patent/CA2228844A1/en
Application granted granted Critical
Publication of CA2228844C publication Critical patent/CA2228844C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/27—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration
    • G01N21/274—Calibration, base line adjustment, drift correction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
    • G01N21/359—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using near infrared light
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J2003/2866—Markers; Calibrating of scan

Abstract

A method and apparatus for measuring the concentration of an analyte present in a biological fluid is disclosed. The method includes the steps of applying NIR radiation to calibration samples to produce calibration data, analyzing calibration data to identify and remove outliers, constructing a calibration model collecting and analyzing unknown samples to identify and remove outliers, and predicting analyte concentration of non-outliers from the calibration model. Analysis of calibration data includes data pretreatment, data decomposition to remove redundant data, and identification and removal of outliers using generalized distances. The apparatus (100) includes a pump (102) which circulates a sample through tubing (104) to fill a flowcell (106). Light from a NIR source (114) is synchronized with a detector (110), facilitating light and dark measurements, and passes through a monochrometer (120) and the flowcell (106) and strikes the detector (110), whereby radiation transmitted through the sample is measured.
CA002228844A 1995-08-07 1996-08-02 Biological fluid analysis using distance outlier detection Expired - Fee Related CA2228844C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US195095P 1995-08-07 1995-08-07
US08/587,017 1996-01-16
US60/001,950 1996-01-16
US08/587,017 US5606164A (en) 1996-01-16 1996-01-16 Method and apparatus for biological fluid analyte concentration measurement using generalized distance outlier detection
PCT/US1996/012625 WO1997006418A1 (en) 1995-08-07 1996-08-02 Biological fluid analysis using distance outlier detection

Publications (2)

Publication Number Publication Date
CA2228844A1 true CA2228844A1 (en) 1997-02-20
CA2228844C CA2228844C (en) 2006-03-14

Family

ID=26669720

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002228844A Expired - Fee Related CA2228844C (en) 1995-08-07 1996-08-02 Biological fluid analysis using distance outlier detection

Country Status (5)

Country Link
EP (1) EP0846253A4 (en)
JP (1) JP3323512B2 (en)
AU (1) AU711324B2 (en)
CA (1) CA2228844C (en)
WO (1) WO1997006418A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113702317A (en) * 2021-08-30 2021-11-26 中国农业科学院农业信息研究所 Drainage basin non-point source pollution component sensor, monitoring system and method

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5822219A (en) * 1996-05-13 1998-10-13 Foss Nirsystems, Inc. System for identifying materials by NIR spectrometry
US6115673A (en) * 1997-08-14 2000-09-05 Instrumentation Metrics, Inc. Method and apparatus for generating basis sets for use in spectroscopic analysis
US7383069B2 (en) 1997-08-14 2008-06-03 Sensys Medical, Inc. Method of sample control and calibration adjustment for use with a noninvasive analyzer
DE19810917A1 (en) * 1998-03-13 1999-09-16 Buehler Ag Calibration method used in evaluation of measured spectra
SE512540C2 (en) * 1998-06-22 2000-04-03 Umetri Ab Method and apparatus for calibrating input data
CA2382113A1 (en) * 1999-08-31 2001-03-08 Cme Telemetrix Inc. Method of calibrating a spectroscopic device
JP4054853B2 (en) * 2000-10-17 2008-03-05 独立行政法人農業・食品産業技術総合研究機構 Blood analysis using near infrared spectroscopy
JP4406287B2 (en) 2002-03-27 2010-01-27 ジーイー・ヘルスケア・バイオ−サイエンシーズ・アーベー Method, system and computer program for detection of molecular binding interactions, including control of response curve quality
WO2003083757A2 (en) * 2002-03-28 2003-10-09 Epigenomics Ag Methods and computer program products for the quality control of nucleic acid assays
WO2005029077A1 (en) * 2003-09-24 2005-03-31 Biacore Ab Method and system for molecular interaction analysis
US8260556B2 (en) * 2008-08-21 2012-09-04 Bio-Rad Laboratories, Inc. Calibration surface method for determination on of analyte ratios
JP5206251B2 (en) * 2008-09-05 2013-06-12 株式会社ニコン Use object recommendation device, use object recommendation method and program
CN102353643A (en) * 2011-06-22 2012-02-15 中国林业科学研究院林产化学工业研究所 Method for rapid determination of oil content in Camellia oleifera seeds by using near-infrared diffuse reflectance spectroscopy (NIRS)
US9606055B2 (en) * 2013-01-09 2017-03-28 Ppg Industries Ohio, Inc. Systems and methods for statistical measurement control of spectrophotometric data
WO2018060967A1 (en) * 2016-09-29 2018-04-05 Inesc Tec - Instituto De Engenharia De Sistemas E Computadores, Tecnologia E Ciência Big data self-learning methodology for the accurate quantification and classification of spectral information under complex varlability and multi-scale interference
CN106596465A (en) * 2017-03-03 2017-04-26 东北农业大学 Method for recognizing abnormal samples in near infrared spectrum analysis
EP3620983B1 (en) * 2018-09-05 2023-10-25 Sartorius Stedim Data Analytics AB Computer-implemented method, computer program product and system for data analysis
DE102019135877B4 (en) * 2019-12-30 2021-09-30 TRUMPF Venture GmbH System for measuring the presence and / or concentration of an analytical substance dissolved in body fluid
CN111967742B (en) * 2020-08-05 2024-01-23 中国矿业大学(北京) Quick discrimination technique for mine water inrush source grade
CN112229863A (en) * 2020-09-30 2021-01-15 上海海关工业品与原材料检测技术中心 Method for identifying country or brand of origin of iron ore

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5121338A (en) * 1988-03-10 1992-06-09 Indiana University Foundation Method for detecting subpopulations in spectral analysis
US4975581A (en) * 1989-06-21 1990-12-04 University Of New Mexico Method of and apparatus for determining the similarity of a biological analyte from a model constructed from known biological fluids
EP0535700B1 (en) * 1991-10-04 1997-03-26 The Perkin-Elmer Corporation Method and apparatus for comparing spectra

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113702317A (en) * 2021-08-30 2021-11-26 中国农业科学院农业信息研究所 Drainage basin non-point source pollution component sensor, monitoring system and method
CN113702317B (en) * 2021-08-30 2023-10-27 中国农业科学院农业信息研究所 River basin non-point source pollution component sensor, monitoring system and method

Also Published As

Publication number Publication date
AU711324B2 (en) 1999-10-14
MX9801056A (en) 1998-05-31
WO1997006418A1 (en) 1997-02-20
EP0846253A1 (en) 1998-06-10
CA2228844C (en) 2006-03-14
AU6644896A (en) 1997-03-05
EP0846253A4 (en) 2009-11-11
JPH11510604A (en) 1999-09-14
JP3323512B2 (en) 2002-09-09

Similar Documents

Publication Publication Date Title
CA2228844A1 (en) Biological fluid analysis using distance outlier detection
US6195158B1 (en) Apparatus and method for rapid spectrophotometric pre-test screen of specimen for a blood analyzer
US6174497B1 (en) Detection systems and methods for predicting the dissolution curve of a drug from a pharmaceutical dosage form
CA2093015A1 (en) A method of calibrating a spectrometer using correlation between calibration sample spectra and measured spectra
TW356516B (en) A method for analyzing glucose in a biological matrix
AU2303195A (en) Process and device for the analysis of glucose in a biological sample
WO2003050513A3 (en) Sample collection and testing system
JP2005513498A5 (en)
CN106596436B (en) Multi-parameter water quality real-time online monitoring device based on spectrum method
US6522398B2 (en) Apparatus for measuring hematocrit
EP1199554A3 (en) Analytical method and apparatus for blood using near infrared spectroscopy
IT1306112B1 (en) METHOD FOR THE QUANTITATIVE ANALYSIS OF THE ATOMIC COMPONENTS OF MATERIALS BY MEANS OF LIBS SPECTROSCOPY MEASURES WITHOUT CALIBRATION
JP2003508748A (en) In situ method for measuring release of a substance from a dosage form
US20210364512A1 (en) Method and apparatus to provide connected, in-situ, comprehensive, and accurate lateral flow assays
AU729814B2 (en) Improvements in detection systems and methods for predicting the dissolution curve of a drug from a pharmaceutical dosage form
AU2003272932A1 (en) Analysis method, analysis device and production method therefor
WO1997046860A9 (en) Improvements in detection systems and methods for predicting the dissolution curve of a drug from a pharmaceutical dosage form
NO973853L (en) Procedure for Checking a Glass Container
EP0187675B1 (en) Method of detection and quantitative determination of sulfur and sulfur monitor using the method
BR9607917A (en) Oximeter standardization process and for reporting results
JP2002228658A (en) Analyzer
CN1458529A (en) Colorimetric component analysis method and its device based on image technology
CN103398966A (en) Method for detecting TMC concentration in organic solution by using spectrometer
EP1455177A3 (en) A sample testing device and method
ATE245282T1 (en) IMPROVE ANALYZER THROUGHPUT USING PIPETTE TIP ANALYSIS

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed