CA2223936C - Nouvelles imidazolones d'aryle et de cycloalkyle substituees; nouvelle classe de ligands du recepteur gaba du cerveau - Google Patents

Nouvelles imidazolones d'aryle et de cycloalkyle substituees; nouvelle classe de ligands du recepteur gaba du cerveau Download PDF

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Publication number
CA2223936C
CA2223936C CA002223936A CA2223936A CA2223936C CA 2223936 C CA2223936 C CA 2223936C CA 002223936 A CA002223936 A CA 002223936A CA 2223936 A CA2223936 A CA 2223936A CA 2223936 C CA2223936 C CA 2223936C
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CA
Canada
Prior art keywords
alkyl
compound according
lower alkyl
halogen
mono
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002223936A
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English (en)
Other versions
CA2223936A1 (fr
Inventor
Robert W. Desimone
Charles A. Blum
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Neurogen Corp
Original Assignee
Neurogen Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/462,674 external-priority patent/US5637725A/en
Priority claimed from US08/461,641 external-priority patent/US5637724A/en
Application filed by Neurogen Corp filed Critical Neurogen Corp
Publication of CA2223936A1 publication Critical patent/CA2223936A1/fr
Application granted granted Critical
Publication of CA2223936C publication Critical patent/CA2223936C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Composés de la formule (I) dans laquelle T représente NH, O ou S; X représente hydrogène, hydroxyle, alkyle inférieur ou un amide éventuellement substitué; le noyau W est un groupe aryle ou hétéroaryle éventuellement substitué; et (a) représente un groupe benzo éventuellement substitué ou un noyau éventuellement substitué à 5, 6, 7 ou 8 chaînons. Ces composés sont des agonistes, antagonistes ou agonistes inverses à haute sélectivité pour les récepteurs GABAa du cerveau ou des promédicaments d'agonistes, antagonistes ou agonistes inverses des récepteurs GABAa du cerveau. Ces composés peuvent être utilisés dans le cadre du diagnostic ou du traitement de l'anxiété, de troubles du sommeil, des attaques et d'une surdose de médicaments à base de benzodiazépine ainsi que pour améliorer la mémoire.
CA002223936A 1995-06-05 1996-06-04 Nouvelles imidazolones d'aryle et de cycloalkyle substituees; nouvelle classe de ligands du recepteur gaba du cerveau Expired - Fee Related CA2223936C (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US08/461,641 1995-06-05
US08/462,674 US5637725A (en) 1995-06-05 1995-06-05 Substituted aryl and cycloalkyl imidazolones; a new class of GABA brain receptor ligands
US08/461,641 US5637724A (en) 1995-06-05 1995-06-05 Substituted aryl and cycloalkyl imidazolones; a new class of GABA brain receptor ligands
US08/462,674 1995-06-05
PCT/US1996/010214 WO1996039404A1 (fr) 1995-06-05 1996-06-04 Nouvelles imidazolones d'aryle et de cycloalkyle substituees; nouvelle classe de ligands du recepteur gaba du cerveau

Publications (2)

Publication Number Publication Date
CA2223936A1 CA2223936A1 (fr) 1996-12-12
CA2223936C true CA2223936C (fr) 2004-01-20

Family

ID=27040073

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002223936A Expired - Fee Related CA2223936C (fr) 1995-06-05 1996-06-04 Nouvelles imidazolones d'aryle et de cycloalkyle substituees; nouvelle classe de ligands du recepteur gaba du cerveau

Country Status (4)

Country Link
EP (1) EP0830359A1 (fr)
AU (1) AU717630B2 (fr)
CA (1) CA2223936C (fr)
WO (1) WO1996039404A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6271241B1 (en) 1999-04-02 2001-08-07 Neurogen Corporation Cycloalkyl and aryl fused aminoalkyl-imidazole derivatives: modulators and GLP-1 receptors
US6380210B1 (en) 1999-04-02 2002-04-30 Neurogen Corporation Heteroaryl fused aminoalkyl-imidazole derivatives: selective modulators of GABAa receptors
US6281237B1 (en) 1999-04-02 2001-08-28 Neurogen Corporation N-phenyl benzimidazolecarboxamide and N-phenyl indolecarboxamide derivatives
US6627624B1 (en) 1999-04-02 2003-09-30 Neurogen Corporation Aryl fused aminoalkyl-imidazole derivatives: selective modulators of GABAa receptors
EP1506194B1 (fr) * 2002-05-17 2006-07-19 Neurogen Corporation Derives d'imidazole a cycles fusionnes se fixant aux recepteurs gaba sb a /sb , ligands des recepteurs gaba sb a /sb
GB0401334D0 (en) * 2004-01-21 2004-02-25 Novartis Ag Organic compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57149277A (en) * 1981-03-10 1982-09-14 Taiho Yakuhin Kogyo Kk Heterocyclic compound
US5484944A (en) * 1993-10-27 1996-01-16 Neurogen Corporation Certain fused pyrrolecarboxanilides and their use as GABA brain receptor ligands

Also Published As

Publication number Publication date
CA2223936A1 (fr) 1996-12-12
WO1996039404A1 (fr) 1996-12-12
EP0830359A1 (fr) 1998-03-25
AU6174396A (en) 1996-12-24
AU717630B2 (en) 2000-03-30

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