CA2215936A1 - Compositions liquides de gonadotrophine chorionique de l'homme - Google Patents

Compositions liquides de gonadotrophine chorionique de l'homme Download PDF

Info

Publication number
CA2215936A1
CA2215936A1 CA002215936A CA2215936A CA2215936A1 CA 2215936 A1 CA2215936 A1 CA 2215936A1 CA 002215936 A CA002215936 A CA 002215936A CA 2215936 A CA2215936 A CA 2215936A CA 2215936 A1 CA2215936 A1 CA 2215936A1
Authority
CA
Canada
Prior art keywords
hcg
liquid pharmaceutical
pharmaceutical composition
buffer
mannitol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002215936A
Other languages
English (en)
Inventor
Fabrizio Samaritani
Patrizia Natale
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Serono SA
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CA002215936A priority Critical patent/CA2215936A1/fr
Publication of CA2215936A1 publication Critical patent/CA2215936A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Reproductive Health (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention porte sur des compositions pharmaceutiques liquides contenant de la gonadotrophine chorionique stabilisée avec un polyalcool ou un sucre non réductif. De préférence, les compositions sont stabilisées avec du mannitol. Dans les représentations préférées, ces compositions sont des solutions aqueuses à une solution-tampon au phosphate à un pH de 7. Ces compositions sont prêtes à injecter et, par conséquent, l'étape de la reconstitution de la poudre lyophilisée peut être évitée, ce qui simplifie le mode d'emploi.
CA002215936A 1995-03-21 1995-03-21 Compositions liquides de gonadotrophine chorionique de l'homme Abandoned CA2215936A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA002215936A CA2215936A1 (fr) 1995-03-21 1995-03-21 Compositions liquides de gonadotrophine chorionique de l'homme

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA002215936A CA2215936A1 (fr) 1995-03-21 1995-03-21 Compositions liquides de gonadotrophine chorionique de l'homme

Publications (1)

Publication Number Publication Date
CA2215936A1 true CA2215936A1 (fr) 1996-09-26

Family

ID=4161498

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002215936A Abandoned CA2215936A1 (fr) 1995-03-21 1995-03-21 Compositions liquides de gonadotrophine chorionique de l'homme

Country Status (1)

Country Link
CA (1) CA2215936A1 (fr)

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued