CA2205138A1 - Anticorps humains pour les peptides recepteurs de lymphocytes t et leur methode de preparation - Google Patents

Anticorps humains pour les peptides recepteurs de lymphocytes t et leur methode de preparation

Info

Publication number
CA2205138A1
CA2205138A1 CA002205138A CA2205138A CA2205138A1 CA 2205138 A1 CA2205138 A1 CA 2205138A1 CA 002205138 A CA002205138 A CA 002205138A CA 2205138 A CA2205138 A CA 2205138A CA 2205138 A1 CA2205138 A1 CA 2205138A1
Authority
CA
Canada
Prior art keywords
antibodies
human
bind
tcr
antibody
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002205138A
Other languages
English (en)
Inventor
Douglas F. Lake
William J. Landsperger
John J. Marchalonis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Arizona Board of Regents of University of Arizona
Baxter International Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2205138A1 publication Critical patent/CA2205138A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Préparations d'anticorps humains enrichies pour obtenir des anticorps qui se lient avec les peptides de récepteurs de lymphocytes T humains ou aux déterminants de conformation. L'invention décrit également les méthodes de préparation de ces anticorps à partir de fractions du plasma humain selon Cohn, par purification d'immunoaffinité, à l'aide de protéines de récepteur de lymphocytes T de recombinaison ou de peptides à région variable de récepteurs de lymphocytes T. La purification des anticorps de récepteurs de lymphocytes T à partir de mélanges d'anticorps humains ou animaux est effectuée suivant des procédures d'immunoaffinité qui font appel à des protéines de récepteurs de lymphocytes T humains de recombinaison. Les anticorps purifiés par immunoaffinité peuvent se fixer sur les récepteurs de lymphocytes T intacts liés à la membrane grâce à une sélection des cellules reposant sur la fluorescence et peuvent aussi inhiber la prolifération des lymphocytes T suite à une stimulation par le mithogène. Les anticorps polyclonaux humains purifiés par immunoaffinité peuvent inhiber l'activité lytique des cellules tueuses naturelles sur une ligne de lymphocyte T monoclonaux. Les préparations d'anticorps sont susceptibles d'être utilisées pour diagnostiquer, surveiller et soigner différents syndromes de maladies auto-immunes.
CA002205138A 1994-11-16 1995-11-15 Anticorps humains pour les peptides recepteurs de lymphocytes t et leur methode de preparation Abandoned CA2205138A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34115794A 1994-11-16 1994-11-16
US08/341,157 1994-11-16

Publications (1)

Publication Number Publication Date
CA2205138A1 true CA2205138A1 (fr) 1996-05-23

Family

ID=23336462

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002205138A Abandoned CA2205138A1 (fr) 1994-11-16 1995-11-15 Anticorps humains pour les peptides recepteurs de lymphocytes t et leur methode de preparation

Country Status (5)

Country Link
EP (1) EP0792294A1 (fr)
JP (1) JPH10509948A (fr)
AU (1) AU705010B2 (fr)
CA (1) CA2205138A1 (fr)
WO (1) WO1996015153A1 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9904395D0 (en) * 1999-02-25 1999-04-21 Fluorescience Ltd Protein assay
US6972198B2 (en) 1999-02-26 2005-12-06 Cyclacel, Ltd. Methods and compositions using protein binding partners
AT410636B (de) * 2001-03-23 2003-06-25 Igeneon Krebs Immuntherapie Verfahren zur herstellung eines impfstoffes
US20050084967A1 (en) 2002-06-28 2005-04-21 Xcyte Therapies, Inc. Compositions and methods for eliminating undesired subpopulations of T cells in patients with immunological defects related to autoimmunity and organ or hematopoietic stem cell transplantation
EP1532983A1 (fr) 2003-11-18 2005-05-25 ZLB Bioplasma AG Preparation d'immunoglobulines à stabilité élevée
PL2531218T3 (pl) 2010-02-04 2019-05-31 Csl Behring Ag Preparat immunoglobuliny
EP2361636A1 (fr) 2010-02-26 2011-08-31 CSL Behring AG Préparation d'immunoglobuline et système de stockage pour préparation d'immunoglobuline
WO2013132347A2 (fr) * 2012-03-06 2013-09-12 Calpro As Immunodosage elisa amélioré de la calprotectine
JP6628719B2 (ja) 2013-07-15 2020-01-15 アメリカ合衆国 抗ヒトパピローマウイルス１６ ｅ６ ｔ細胞受容体
AU2016319126A1 (en) 2015-09-10 2018-04-19 Affigen, Inc. Sequencing-directed selection of tumor theranostics

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2018248A1 (fr) * 1989-06-07 1990-12-07 Clyde W. Shearman Anticorps monoclonaux contre le recepteur alpha-beta de cellules t humaines, leur production et leur utilisation
DE69120890T2 (de) * 1990-05-03 1997-02-20 Systemix Inc Menschliches lymph-gewebe in einem wirt mit angegriffenem immunsystem

Also Published As

Publication number Publication date
EP0792294A1 (fr) 1997-09-03
WO1996015153A1 (fr) 1996-05-23
AU705010B2 (en) 1999-05-13
AU4161196A (en) 1996-06-06
JPH10509948A (ja) 1998-09-29

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Legal Events

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