CA2204415A1 - N-aryle et n-heteroaryle-1,2-diaminocyclobuten-3,4-diones substituees presentant des activites relaxant les muscles lisses - Google Patents

N-aryle et n-heteroaryle-1,2-diaminocyclobuten-3,4-diones substituees presentant des activites relaxant les muscles lisses

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Publication number
CA2204415A1
CA2204415A1 CA 2204415 CA2204415A CA2204415A1 CA 2204415 A1 CA2204415 A1 CA 2204415A1 CA 2204415 CA2204415 CA 2204415 CA 2204415 A CA2204415 A CA 2204415A CA 2204415 A1 CA2204415 A1 CA 2204415A1
Authority
CA
Canada
Prior art keywords
carbon atoms
alkyl
compound
hydrogen
cyclobut
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA 2204415
Other languages
English (en)
Inventor
Schuyler Adam Antane
Bradford Hammond Hirth
John Anthony Butera
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/334,475 external-priority patent/US5466712A/en
Application filed by Individual filed Critical Individual
Publication of CA2204415A1 publication Critical patent/CA2204415A1/fr
Abandoned legal-status Critical Current

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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

L'invention concerne les composés de la formule (I). Dans cette formule, R¿1? est un hydrogène, un C¿1-10? alkyle à chaîne droite ou ramifiée, un C¿3?-¿10? alkyle cyclique ou bicyclique, un alcanoyle à 2-7 atomes de carbone, un alkylsulfonyle à 1-7 atomes de carbone, un aroyle à 7-12 atomes de carbone, un arylalcénoyle à 9-20 atomes de carbone, un arylsulfonyle à 6-12 atomes de carbone, un arylalcanoyle à 8-12 atomes de carbone ou un arylalkylsulfonyle à 7-12 atomes de carbone; R¿2? est un hydrogène, un C¿1-10? alkyle à chaîne droite ou ramifiée ou un C¿3-10? alkyle cyclique ou bicyclique; A est un groupe de la formule (II). Dans cette formule, R¿7? et R¿8? sont choisis d'une manière indépendante parmi les groupes cyano, nitro, amino, C¿1-6? alkyle, C¿1-6? perfluoroalkyle, C¿1-6? alcoxy, C¿1-6? perfluoroalcoxy, amino, C¿1-12? mono- ou dialkylamino, sulfonamide, C¿1-6? alkylsulfonamido, C¿6-12? arylsulfonamido, C¿2-6? alkylcarboxamido, C¿7-12? arylcarboxyamido, C¿1-6? alkylsulfonyle, C¿1-6? perfluoroalkylsulfonyle, C¿6-12? arylsulfonyle, chloro, bromo, fluoro, iodo, 1-imidazolyle, carboxyle, carboalcoxy à 2-7 atomes de carbone, hydroxyle ou hydrogène. A peut également être un groupe Het choisi parmi les groupes de formules (a), (b), (c), (d), (e), (f), (g), (h), (i), (j), (k), (l), (m), (n), (o), (p). Dans ces formules, R¿9? est un hydrogène, un C¿1-6? alkyle, un C¿1-6? perfluoroalkyle, un C¿1-6? alcoxy, un C¿1-6? perfluoroalcoxy, un amino, un C¿1-12? mono- ou dialkylamino, un C¿1-6? alkylsulfonamido, un C¿2-6? alkylcarboxyamido, un nitro, un cyano, un carboxyle, un chloro, un bromo, un fluoro ou un iodo; n est un nombre entier entre 0 et 6; R¿3? et R¿4? sont d'une manière indépendante un hydrogène, un C¿1-10? alkyle à chaîne droite ou ramifiée, ou un C¿3-10? alkyle cyclique ou bicyclique; un C¿1-10? perfluoroalkyle, un C¿1-10? hydroxyalkyle, un C¿2-10? alcoxyalkyle, un fluoro ou, pris, ensemble, ils forment un groupe spirocyclique contenant en tout 3-7 atomes de carbone; R¿5? et R¿6? sont choisis d'une manière indépendante parmi les groupes suivants: cyano, nitro, amino, C¿1-6? alkyle, C¿1-6? perfluoroalkyle, C¿1-6? alcoxy, C¿1-6? perfluoroalcoxy, amino, C¿1-12? mono- ou dialkylamino, sulfonamide, C¿1-6? alkylsulfonamido, C¿6-12? arylsulfonamido, C¿2-6? alkylcarboxamido, C¿7-12? arylcarboxamido, C¿1-6? alkylsulfonyle, C¿1-6? perfluoroalkylsulfonyle, C¿6-12? arylsulfonyle, chloro, bromo, fluoro, iodo, 1-imidazolyle, carboxyle, C¿2-7? carboalcoxy, hydroxyle ou hydrogène. L'invention concerne également les sels de ces composés acceptables sur le plan pharmaceutique.
CA 2204415 1994-11-04 1995-10-25 N-aryle et n-heteroaryle-1,2-diaminocyclobuten-3,4-diones substituees presentant des activites relaxant les muscles lisses Abandoned CA2204415A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/334,475 1994-11-04
US08/334,475 US5466712A (en) 1994-11-04 1994-11-04 Substituted n-aryl-1,2-diaminocyclobutene-3,4-diones
PCT/US1995/014597 WO1996014300A1 (fr) 1994-11-04 1995-10-25 N-aryle et n-heteroaryle-1,2-diaminocyclobuten-3,4-diones substituees presentant des activites relaxant les muscles lisses

Publications (1)

Publication Number Publication Date
CA2204415A1 true CA2204415A1 (fr) 1996-05-17

Family

ID=29405840

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2204415 Abandoned CA2204415A1 (fr) 1994-11-04 1995-10-25 N-aryle et n-heteroaryle-1,2-diaminocyclobuten-3,4-diones substituees presentant des activites relaxant les muscles lisses

Country Status (1)

Country Link
CA (1) CA2204415A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112759549A (zh) * 2019-11-05 2021-05-07 中国医学科学院药物研究所 3-取代氨基-4-((取代吡啶基)氨基)环丁-3-烯-1,2-二酮类化合物

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112759549A (zh) * 2019-11-05 2021-05-07 中国医学科学院药物研究所 3-取代氨基-4-((取代吡啶基)氨基)环丁-3-烯-1,2-二酮类化合物
CN112759549B (zh) * 2019-11-05 2023-07-28 中国医学科学院药物研究所 3-取代氨基-4-((取代吡啶基)氨基)环丁-3-烯-1,2-二酮类化合物

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